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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2D 14
AGC CDC42BPG 71
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK3 13
CMGC DYRK2 222
Other EIF2AK2 267
AGC GRK4 187
CMGC GSK3B 56
CMGC MAPK4 20
CAMK MKNK2 84
AGC PDPK1 82
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCQ 380
AGC RPS6KB1 91
Other SBK1 53
CAMK SIK2 20
STE SLK 34
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
Other STK36 4
Other ULK3 14
-KVT---SQVLGLGINGKVLQIFN---K-RTQEKFALKMLQDCP-KAR--------R------EVELHWRASQ------CPHIVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT--SKRPNA-ILKLTDFGFAKE--------TTSHN-SLTTPCYTPYYVAPEVLG-----PEKYDKSCDMWSLGVIMYILLC-GY-PPFY-SN-----------HGLAIS-PGMKTRIRMGQYEFPNPEWS-EVS----------------------------------------------------EEVKMLIRNLLKTEPTQ--RMT-------IT-EFMNHPWI--------------
----FEIGRPLGKGKFGNVYLARE---K-QSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-R------HPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG--SAGEL----KIADFGWSV---------HAPSS-RRTTLCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------------TY-QETYKRISRVEFTFPDFVT---------------------------------------------------------EGARDLISRLLKHNPSQ--RPM-------LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNVYLARE---K-KSHFIVALKVLFKSQ-IEKEGVE-HQLR-----REIEIQAHL-H------HPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG--LKGEL----KIADFGWSV---------HAPSL-RRKTMCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GN-PPFE-SA---------------SH-NETYRRIVKVDLKFPASVP---------------------------------------------------------MGAQDLISKLLRHNPSE--RLP-------LA-QVSAHPWV--------------
----FEIGRPLGKGKFGNVYLARL---K-ESHFIVALKVLFKSQ-IEKEGLE-HQLR-----REIEIQAHL-Q------HPNILRLYNYFHD-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG--FRGEV----KIADFGWSV---------HTPSL-RRKTMCGTLDYLPPEMIE-----GRTYDEKVDLWCIGVLCYELLV-GY-PPFE-SA---------------SH-SETYRRILKVDVRFPLSMP---------------------------------------------------------LGARDLISRLLRYQPLE--RLP-------LA-QILKHPWV--------------
----YQLFEELGKGAFSVVRRCMK---I-PTGQEYAAKIINTKK-LSARDHQ-KLER------EARICRLL-K------HPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV-------QGDQQ-AWFGFAGTPGYLSPEVLR-----KDPYGKPVDMWACGVILYILLV-GY-PPFW-DE---------------DQ-HRLYQQIKAGAYDFPSPEWD-TVT----------------------------------------------------PEAKDLINKMLTINPAK--RIT-------AS-EALKHPWI--------------
----FEILKVIGRGAFGEVTVVRQ---R-DTGQIFAMKMLHKWE-MLKRAET-ACFR-----EERDVLVKG-D------SRWVTTLHYAFQD-----------------------------EEYLY--LVMDYYAGG--DLLTLLS---RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLD--VNGHI----RLADFGSCLRL-------NTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLF-GE-TPFY-AE------------SLVET-YGKIM---NHEDHLQFPPDVPDVP----------------------------------------------------ASAQDLIRQLLCRQEERLGRGG-------LD-DFRNHPFF--------------
----YEKLEKIGEGTYGTVFKAKN---R-ETHEIVALKRVRLDD-DDEGVPS-SALR------EICLLKEL-K------HKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN--RNGEL----KLADFGLARAF-------GIPVR-CYSAEVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGR-PLFP-GN------------DVDDQ-LKRIFRLLGTPTEEQWPSMT-KLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-------AE-EALQHPYF--------------
---W-DLVQTLGEGAYGEVQLAVN---R-VTEEAVAVKIVDMKR-AVDCPEN-I-KK------EICINKML-N------HENVVKFYGHRRE-----------------------------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD--ERDNL----KISDFGLATVFR-----YNNRER-LLNKMCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GE-LPWD-QP--------------SDS-CQEYSDWKEKKTYLNPWKKI---D----------------------------------------------------SAPLALLHKILVENPSA--RIT-------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEVKLAFE---R-KTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-N------HPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI--------LGETS-LMRTLCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--------------RTQ-VSLKDQITSGKYNFIPEVWA-EVS----------------------------------------------------EKALDLVKKLLVVDPKA--RFT-------TE-EALRHPWL--------------
----YQLVRKLGRGKYSEVFEAIN---I-TNNEKVVVKILKPVK-KKKIKR------------EIKILENLRG------GPNIITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID-HEHRKL----RLIDWGLAEF--------YHPGQ-EYNVRVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGH------------DNYDQ-LVRIAKVLGTEDLYDYIDKY-NIELDPRFNDILGRHSRK----------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-------AR-EAMEHPYF--------------
----YEMGEELGSGQFAIVRKCRQ---K-GTGKEYAAKFIKKRR-LSSSRRG-VSREEI--EREVNILREI-R------HPNIITLHDIFEN-----------------------------KTDVV--LILELVSGG--ELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK--------IEAGN-EFKNIFGTPEFVAPEIVN-----YEPLGLEADMWSIGVITYILLS-GA-SPFL-GE---------------TK-QETLTNISAVNYDFDEEYFS-NTS----------------------------------------------------ELAKDFIRRLLVKDPKR--RMT-------IA-QSLEHSWI--------------
----YEVLKVIGKGSFGQVVKAYD---H-KVHQHVALKMVRNEK-RFHRQAA-E---------EIRILEHL-RKQDKDNTMNVIHMLENFTF-----------------------------RNHIC--MTFELLSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK--QQGRSG--IKVIDFGSSC----------YEHQ-RVYTYIQSRFYRAPEVIL-----GARYGMPIDMWSLGCILAELLT-GY-PLLP-GE------------DEGDQ-LACMIELLGMPSQKLLDASK-RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAV--RMT-------PG-QALRHPWL--------------
---F-KEIELIGSGGFGQVFKAKH---R-IDGKTYVIKRVKYNN-EKAER-------------EVKALAKL-D------HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV--DTKQV----KIGDFGLVTS--------LKNDG-KRTRSKGTLRYMSPEQIS-----SQDYGKEVDLYALGLILAELLH-VCDTAFE-T--------------------SKFFTDLRDGIISDIFDK----------------------------------------------------------KEKTLLQKLLSKKPED--RPN-------TS-EILR----TLT-----------
--FR--HYRVLGKGGFGEVCACQV---R-ATGKMYACKKLQKKR-IKKRKGE-AMAL-----NEKRILEKV-Q------SRFVVSLAYAYET-----------------------------KDALC--LVLTIMNGG--DLKFHIYN--LGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD--DRGHI----RISDLGLATE--------IPEGQ-RVRGRVGTVGYMAPEVVN-----NEKYTFSPDWWGLGCLIYEMIQ-GH-SPFK-KY------------KEKVK-WEEVDQRIKNDTEEYSE----KFS----------------------------------------------------EDAKSICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F-------------
----YTDTKVIGNGSFGVVYQAKL---C-DSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-D------HCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ--------LVRGE-PNVSYICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------------SGVDQ-LVEIIKVLGTPTREQIREMN-PNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-------PL-EACAHSFF--------------
-FVD---FQPLGFGVNGLVLSAVD---S-RACRKVAVKKIALSD-ARSMKH---ALR------EIKIIRRL-D------HDNIVKVYEVLGPKGTDL------------------QGELFKFSVAY--IVQEYMET---DLARLLE-----QGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFIS-TEDLVL----KIGDFGLARIVD----QHYSHKG-YLSEGLVTKWYRSPRLLL----SPNNYTKAIDMWAAGCILAEMLT-GR-MLFA-GA------------HELEQ-MQLILETIPVIREEDKDELL-RVMPSFVSSTWEVK------------------------------RPLRKLLPEVNSEAIDFLEKILTFNPMD--RLT-------AE-MGLQHPYM--------------
QLQE----DVLGEGAHARVQTCIN---L-ITSQEYAVKIIEKQP-GHIRSR---VFR------EVEMLYQCQG------HRNVLELIEFFEE-----------------------------EDRFY--LVFEKMRGG--SILSHIH----KRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCE--HPNQVS-PVKICDFDLGSGIKLNGDCSPISTP-ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GY-PPFV-GRCGSDCGWDRGEACPACQ-NMLFESIQEGKYEFPDKDWA-HIS----------------------------------------------------CAAKDLISKLLVRDAKQ--RLS-------AA-QVLQHPWV--------------
---F-KFGKILGEGSFSTVVLARE---L-ATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-D------HPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS-----PESKQA-RANSFVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------------NE-YLIFQKIIKLEYDFPEKFF---------------------------------------------------------PKARDLVEKLLVLDATK--RLG-------CE-EM------EGYGPLKAHPF---
---F-NFLMVLGKGSFGKVMLSER---K-GTDELYAVKILKKDV-VIQDDDV-ECTM-----VEKRVLALPGK------PPFLTQLHSCFQT-----------------------------MDRLY--FVMEYVNGG--DLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEN-------IWDGV-TTKTFCGTPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLA-GQ-APFE-GE---------------DE-DELFQSIMEHNVAYPKSMS---------------------------------------------------------KEAVAICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKVLLGEL---K-GRGEYFAIKALKKDV-VLIDDDV-ECTM-----VEKRVLTLAAE------NPFLTHLICTFQT-----------------------------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD--RDGHI----KIADFGMCKEN-------IFGES-RASTFCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLI-GQ-SPFH-GD---------------DE-DELFESIRVDTPHYPRWIT---------------------------------------------------------KESKDILEKLFEREPTK--RLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKVMLAEL---K-GKDEVYAVKVLKKDV-ILQDDDV-DCTM-----TEKRILALARK------HPYLTQLYCCFQT-----------------------------KDRLF--FVMEYVNGG--DLMFQIQ----RSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLD--AEGHC----KLADFGMCKEG-------ILNGV-TTTTFCGTPDYIAPEILQ-----ELEYGPSVDWWALGVLMYEMMA-GQ-PPFE-AD---------------NE-DDLFESILHDDVLYPVWLS---------------------------------------------------------KEAVSILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF------------
----FEFIRVLGKGSFGKVMLARV---K-ETGDLYAVKVLKKDV-ILQDDDV-ECTM-----TEKRILSLARN------HPFLTQLFCCFQT-----------------------------PDRLF--FVMEFVNGG--DLMFHIQ----KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD--HEGHC----KLADFGMCKEG-------ICNGV-TTATFCGTPDYIAPEILQ-----EMLYGPAVDWWAMGVLLYEMLC-GH-APFE-AE---------------NE-DDLFEAILNDEVVYPTWLH---------------------------------------------------------EDATGILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-------------
--FI--LHKMLGKGSFGKVFLAEF---K-KTNQFFAIKALKKDV-VLMDDDV-ECTM-----VEKRVLSLAWE------HPFLTHMFCTFQT-----------------------------KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN-------MLGDA-KTNTFCGTPDYIAPEILL-----GQKYNHSVDWWSFGVLLYEMLI-GQ-SPFH-GQ---------------DE-EELFHSIRMDNPFYPRWLE---------------------------------------------------------KEAKDLLVKLFVREPEK--RLG-------VRGDIRQHPLF--------------
----FELLRVLGKGGYGKVFQVRKVTGA-NTGKIFAMKVLKKAM-IVRNAKD-TAHTK----AERNILEEV-K------HPFIVDLIYAFQT-----------------------------GGKLY--LILEYLSGG--ELFMQLE----REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN--HQGHV----KLTDFGLCKES-------IHDGT-VTHTFCGTIEYMAPEILM-----RSGHNRAVDWWSLGALMYDMLT-GA-PPFT-GE---------------NR-KKTIDKILKCKLNLPPYLT---------------------------------------------------------QEARDLLKKLLKRNAAS--RLGAG--PGDAG-EVQAHPFF--------------
----YELVRELGKGTYGKVDLVVY---K-GTGTKMALKFVNKSK-TKLKNF----LR------EVSITNSLSS------SPFIIKVFDVVFE----------------------------TEDCYV--FAQEYAPAG--DLFDIIP----PQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRV----KLADFGMTR----------RVGC-RVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLT-GN-FPWE-AA------------SGADAFFEEFVRWQRGRLPGLPSQWR-RFT----------------------------------------------------EPALRMFQRLLALEPER--RGP-------AK-EVF-----RFLKH---------
----YDIEGTLGKGNFAVVKLGRH---R-ITKTEVAIKIIDKSQ-LDAVNLE-KIYR------EVQIMKML-D------HPHIIKLYQVMET-----------------------------KSMLY--LVTEYAKNG--EIFDYLA----NHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLD--NNMNI----KIADFGFGNF--------FKSGE-LLATWCGSPPYAAPEVFE----GQQYEGPQLDIWSMGVVLYVLVC-GA-LPFD-GP---------------TL-PILRQRVLEGRFRIPYFMS---------------------------------------------------------EDCEHLIRRMLVLDPSK--RLT-------IA-QIKEHKWM--------------
----WEIIGELGDGAFGKVYKAQN---K-ETSVLAAAKVIDTKS-EEELEDY-M--V------EIDILASC-D------HPNIVKLLDAFYY-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN-------TRTIQ-RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PPHH-EL------------NPMRV-LLKIAKSEPPTLAQPSRWS---------------------------------------------------------SNFKDFLKKCLEKNVDA--RWT-------TS-QLLQHPFV--------------
----WEIVGELGDGAFGKVYKAKN---K-ETGALAAAKVIETKS-EEELEDY-I--V------EIEILATC-D------HPYIVKLLGAYYH-----------------------------DGKLW--IMIEFCPGG--AVDAIML---ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMT--LEGDI----RLADFGVSAKN-------LKTLQ-KRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ-IE-PPHH-EL------------NPMRV-LLKIAKSDPPTLLTPSKWS---------------------------------------------------------VEFRDFLKIALDKNPET--RPS-------AA-QLLEHPFV--------------
-LCP---GRELGRGKFAVVRKCIK---K-DSGKEFAAKFMRKRR-KGQDCRM-EIIH------EIAVLELAQD------NPWVINLHEVYET-----------------------------ASEMI--LVLEYAAGG--EIFDQCVA--DREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI--------LKNSE-ELREIMGTPEYVAPEILS-----YDPISMATDMWSIGVLTYVMLT-GI-SPFL-GN---------------DK-QETFLNISQMNLSYSEEEFD-VLS----------------------------------------------------ESAVDFIRTLLVKKPED--RAT-------AE-ECLKHPWL--------------
-ILT---SKELGRGKFAVVRQCIS---K-STGQEYAAKFLKKRR-RGQDCRA-EILH------EIAVLELAKS------CPRVINLHEVYEN-----------------------------TSEII--LILEYAAGG--EIFSLCLP--ELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK--------IGHAC-ELREIMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLT-HT-SPFV-GE---------------DN-QETYLNISQVNVDYSEETFS-SVS----------------------------------------------------QLATDFIQSLLVKNPEK--RPT-------AE-ICLSHSWL--------------
----YHVLEMIGEGSFGRVYKGRR---K-YSAQVVALKFIPKLG-RSEKELR-NLQR------EIEIMRGL-R------HPNIVHMLDSFET-----------------------------DKEVV--VVTDYAEG---ELFQILE----DDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA--KGGGI----KLCDFGFARAM-------STNTM-VLTSIKGTPLYMSPELVE-----ERPYDHTADLWSVGCILYELAV-GT-PPFY-AT---------------SI-FQLVSLILKDPVRWPSTIS---------------------------------------------------------PCFKNFLQGLLTKDPRQ--RLS-------WP-DLLYHPFI--------------
--FI--LTERLGSGTYATVYKAYA---KKDTREVVAIKCVAKKS-LNKASVE-NLLT------EIEILKGI-R------HPHIVQLKDFQWD-----------------------------SDNIY--LIMEFCAGG--DLSRFIH----TRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHL----KLADFGFAQH--------MSPWD-EKHVLRGSPLYMAPEMVC-----QRQYDARVDLWSMGVILYEALF-GQ-PPFA-SR------------SFSEL-EEKIRSNRVIELPLRPLLS---------------------------------------------------------RDCRDLLQRLLERDPSR--RIS-------FQ-DFFAHPWV--------------
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