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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
CAMK CHEK2 220
CMGC GSK3A 119
CMGC GSK3B 56
CAMK MAPKAPK3 44
CAMK MAPKAPK5 22
Other NEK2 8
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCA 339
AGC PRKCZ 252
CAMK STK11 49
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELHWRASQCPH--IVRIVDVYENLY------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-RHPN--ILRLYGYFHD----------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE------------------GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN-------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI--------------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-NHPC--IIKIKNFF-D----------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS---------------VGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
---YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCN--IVRLRYFFYSSG------EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF-----------------GATDYTSSIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PLEACAHSFF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCN--IVRLRYFFYSSG------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF-----------------GATDYTSSIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF--------------
QLS---KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP-KARQ--------------EVDHHWQASGGPH--IVCILDVYENMH------HGKRCLL--IIMECMEGG--ELFSRIQE--RGDQAFTEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT-SKEKDA-VLKLTDFGFAK----ETTQNALQTPCYTPYYVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGFPPFYSN---TGQAISPGMKRRIRLGQYGFPNPEWSEVS----------------------EDAKQLIRLLLKTDPTERLT------ITQFMNHPWI--------------
INW---TQKLGAGISGPVRVCVKKSTQERFALKILLDRP-KAR--------N------EVRLHMMCATHPN--IVQIIEVFANSVQFPHESSPRARLL--IVMEMMEGG--ELFHRIS----QHRHFTEKQASQVTKQIALALRHCHLL-----NIAHRDLKPENLLFK-DNS-LDAPVKLCDFGFAK-----IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKH--HSRTIPKDMRRKIMTGSFEFPEEEWSQIS----------------------EMAKDVVRKLLKVKPEERLT------IEGVLDHPWL--------------
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLLREL-KHPN--IVRYYDRIIDR--------TNTTLY--IVMEYCEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN------------------RMSYNEKSDIWSLGCLLYELCALMPPFTAF-------SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I-------------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-DHPF--FVKLYFTFQD----------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT------------------EKSACKSSDLWALGCIIYQLVAGLPPFRAG-------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF---
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER----------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM--------------
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIHRSL-AHQH--VVGFHGFFED----------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS------------------KKGHSFEVDVWSIGCIMYTLLVGKPPFETS-------CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV-VIQDDDV-ECTM-----VEKRVLALLDKPPF--LTQLHSCFQT----------VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA------------------YQPYGKSVDWWAYGVLLYEMLAGQPPFDGE-------DEDELFQSIMEHNVSYPKSLS--------------------------KEAVSVCKGLMTKHPAKRLG------C---------GPEGERDVREHAFF
--F-DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL-VHDDEDI-DWVQ-----TEKHVFEQASSNPF--LVGLHSCFQT----------TSRLF--LVIEYVNGG--DLMFHMQ----RQRKLPEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD-ADGHI----KLTDYGMCKEG--LGPGDTTSTFCGTPNYIAPEILR------------------GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLS--------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF-----
YLM---GDLLGEGSYGKVKEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLLRRL-RHKN--VIQLVDVLYNE--------EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN----------------GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGD-------NIYKLFENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF--------------
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