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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK3 203
Other AURKA 133
CMGC CDK4 6
CAMK CHEK2 220
CAMK MAPKAPK2 64
QLS---KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP-KAR---Q-------------EVDHHWQASG---GPHIVCILDVYENMH-HGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVS--------------------EDAKQLIRLLLKTDPTERLTITQFMNHPWI
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR------EVEIQSHL-R---HPNILRLYGYFHD-----ATRVYLILEYAPLGTVYRELQ--KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV-HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN----TYQETYKRISRVEFTFPDFVT------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
--Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR------EVALLRRL-EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMALTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAI---GSAREADPALNVETEIEILKKL-N---HPCIIKIKNFF-D-----AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS--------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR----------R------EVELHWRASQ---CPHIVRIVDVYENLY-AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS--------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI
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