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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
TK JAK2 849
TK JAK3 822
TK LTK 510
TK NTRK2 538
TK NTRK3 538
TK RET 724
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIRNE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM-YDKEYYS------------VHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I--
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQHSTE-EHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQDKEYY--------------KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQHSGPDQ-QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLDKDYY--------------VVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP--QL-
V-TLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLRHSRP-----------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI-YRASYY--------------RRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP---------------YPGR-TNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL---
I-VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAELLTNLQHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLRAHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV-YSTDYY--------------RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-SNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L--
I-VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA-RKDFQREAELLTNLQHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV-YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP---------------WFQL-SNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL---
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV-YEEDSY--------------VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
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