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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
TK ABL1 261
TK ALK 1116
TK BTK 402
TK CSF1R 582
TK DDR1 572
TK EGFR 712
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FLT4 845
TK INSR 1023
TKL IRAK1 212
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK LTK 510
TKL MAP3K7 36
TK MUSK 575
Other NEK2 8
TK NTRK2 538
TK NTRK3 538
CMGC PCTK2 192
TK PTK2 422
TK RET 724
TKL RIPK4 22
TK ROS1 1945
STE STK24 24
STE STK25 20
TK TNK1 116
TK TNK2 150
STE YSK4 1162
----VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL---N-R--ITD-IGEVS-QFL-T----EGIIMKDF-SHPNVLSLLGICL-RS--EGS--PLVVLPYMKHGDLRNFIR-----NE--------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLASK-----K---FVHRDLAARNCMLDE-----KF-TVKVADFGLARDM-----Y-----D--KEYYS------------VHNKTGAKLPVKWMALESLQ--TQKFTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQGRR---LLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--DTM-EV--E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--R--EPP--FYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEKK-----N---FIHRDLAARNCLVGE-----NH-LVKVADFGLSRLM-----------T--GDTY--------------TAHAGAKFPIKWTAPESLA--YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EKDYR---MERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--VCS-EQDEL-DFL-M----EALIISKF-NHQNIVRCIGVSL--Q--SLP--RFILLELMAGGDLKSFLR-----ETRP--------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEEN-----H---FIHRDIAARNCLLTCP--GPGR-VAKIGDFGMARDI-----Y-----R--ASYY--------------RKGGCAMLPVKWMPPEAFM--EGIFTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TSGGR---MDPPKNCP-------------------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--GSM-SE--D-EFI-E----EAKVMMNL-SHEKLVQLYGVCT--K--QRP--IFIITEYMANGCLLNYLR-----EM--------------------------------------------------------------------R-HRFQTQQLLEMCKDVCEAMEYLESK-----Q---FLHRDLAARNCLVND-----QG-VVKVSDFGLSRYV-----------L--DDEY--------------TSSVGSKFPVRWSPPEVLM--YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQGLR---LYRPHLAS-------------------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I-----
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--TAH-ADEKE-ALM-S----ELKIMSHLGQHENIVNLLGACT--H--GGP--VLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLASK-----N---CIHRDVAARNVLLTN-----GH-VAKIGDFGLARDI-----M-----N--DSNY--------------IVKGNARLPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KDGYQ---MAQPAFAP-------------------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL-------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNARN-DFL-K----EVKIMSRL-KDPNIIRLLGVCV--Q--DDP--LCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLATL-----N---FVHRDLATRNCLVGE-----NF-TIKIADFGMSRNL-----Y-----A--GDYY--------------RVQGRAVLPIRWMAWECIL--MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRDQGRQVYLSRPPACP-------------------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL-------
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--ATS-PKANK-EIL-D----EAYVMASV-DNPHVCRLLGICL-----TST--VQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLEDR-----R---LVHRDLAARNVLVKT-----PQ-HVKITDFGLAKLL-----G-----A--EEKE--------------YHAEGGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EKGER---LPQPPICT-------------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--DLP-QELKI-KFL-Q----EAKILKQY-DHPNIVKLIGVCT--Q--RQP--VYIIMELVSGGDFLTFLR-----RK--------------------------------------------------------------------K-DELKLKQLVKFSLDAAAGMLYLESK-----N---CIHRDLAARNCLVGE-----NN-VLKISDFGMSRQE-----------D--GGVY--------------SSSGLKQIPIKWTAPEALN--YGRYSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ERGYR---MSAPQHCP-------------------------------------------EDISKIMMKCWDYKPENRPKFSELQKEL-------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--TLP-PDLKA-KFL-Q----EARILKQY-SHPNIVRLIGVCT--Q--KQP--IYIVMELVQGGDFLTFLR-----TE--------------------------------------------------------------------G-ARLRVKTLLQMVGDAAAGMEYLESK-----C---CIHRDLAARNCLVTE-----KN-VLKISDFGMSREE-----A-----D--GVYA--------------ASGGLRQVPVKWTAPEALN--YGRYSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EKGGR---LPCPELCP-------------------------------------------DAVFRLMEQCWAYEPGQRPSFSTIYQEL-------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--DAT-EKDLS-DLI-S----EMEMMKMIGKHKNIINLLGACT--Q--DGP--LYVIVEYASKGNLREYLQ-----ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASK-----K---CIHRDLAARNVLVTE-----DN-VMKIADFGLARDI-----H-----H--IDYY--------------KKTTNGRLPVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KEGHR---MDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--DAT-EKDLS-DLV-S----EMEMMKMIGKHKNIINLLGACT--Q--DGP--LYVIVEYASKGNLREYLR-----ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLASQ-----K---CIHRDLAARNVLVTE-----NN-VMKIADFGLARDI-----N-----N--IDYY--------------KKTTNGRLPVKWMAPEALF--DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KEGHR---MDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--DAT-DKDLS-DLV-S----EMEMMKMIGKHKNIINLLGACT--Q--GGP--LYVLVEYAAKGNLREFLR-----ARRPPGLDY-----------------------------------------------------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLASQ-----K---CIHRDLAARNVLVTE-----DN-VMKIADFGLARDV-----H-----N--LDYY--------------KKTTNGRLPVKWMAPEALF--DRVYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KEGHR---MDKPANCT-------------------------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL-------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--NAS-DKDLA-DLV-S----EMEVMKLIGRHKNIINLLGVCT--Q--EGP--LYVIVECAAKGNLREFLR-----ARRPPGPDL-----------------------------------------------------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLESR-----K---CIHRDLAARNVLVTE-----DN-VMKIADFGLARGV-----H-----H--IDYY--------------KKTSNGRLPVKWMAPEALF--DRVYTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----REGHR---MDRPPHCP-------------------------------------------PELYGLMRECWHAAPSQRPTFKQLVEAL-------
----LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML---K-E--GAT-ASEHR-ALM-S----ELKILIHIGNHLNVVNLLGACT-KP--QGP--LMVIVEFCKYGNLSNFLR-----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPLTMEDLVCYSFQVARGMEFLASR-----K---CIHRDLAARNILLSE-----SD-VVKICDFGLARDI-----Y-----K--DPDY--------------VRKGSARLPLKWMAPESIF--DKVYTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q-INEEFCQRL----RDGTR---MRAPELAT-------------------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL-------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--SAS-LRERI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--K--GQP--TLVVMELMAHGDLKSYLR-----SLRPEA-----------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNAK-----K---FVHRDLAARNCMVAH-----DF-TVKIGDFGMTRDI-----Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MDGGY---LDQPDNCP-------------------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------
FSEE----LKIGEGGFGCVYRAVMR----------------NTV--YAVKRL---KEN--ADLEWT--A-VKQSFL--TEVEQLSRF-RHPNIVDFAGYCA--Q--NGF--YCLVYGFLPNGSLEDRLHCQTQACP-----------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS---PS---LIHGDIKSSNVLLDE-----RL-TPKLGDFGLARFSRFAG--SSPSQSSMVART--------------QT---VRGTLAYLPEEYIK--TGRLAVDTDTFSFGVVVLETLA-GQ-RA---------------VKTHG-AR-TKYLKDL----VEEEA---EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYE----RL---
-VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKL---AAM--VDITTE--ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--D--GDD--LCLVYVYMPNGSLLDRLSC-LDGTP-----------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN-----H---HIHRDIKSANILLDE-----AF-TAKISDFGLARASE---------KFAQTVMT--------------SR---IVGTTAYMAPEALR---GEITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH---REPQLLLDI----KEEIE---DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--GAM-SE--E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--E--QAP--ICLVFEFMEHGCLSDYLR-----TQ--------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEEA-----C---VIHRDLAARNCLVGE-----NQ-VIKVSDFGMTRFV-----------L--DDQY--------------TSSTGTKFPVKWASPEVFS--FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----STGFR---LYKPRLAS-------------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL-------
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--ESG-GNHIA-DLK-K----EIEILRNL-YHENIVKYKGICT-ED---GGNGIKLIMEFLPSGSLKEYLP-----KN--------------------------------------------------------------------K-NKINLKQQLKYAVQICKGMDYLGSR-----Q---YVHRDLAARNVLVES-----EH-QVKIGDFGLTKAI----ET-----D--KEYY--------------TVKDDRDSPVFWYAPECLM--QSKFYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---TVTRLVNTL----KEGKR---LPCPPNCP-------------------------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF----
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--STE--EHLR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAG--RRN--LKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGTK-----R---YIHRDLATRNILVEN-----EN-RVKIGDFGLTKVL----PQ-----D--KEYY--------------KVKEPGESPIFWYAPESLT--ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KNNGR---LPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--SGP-DQ-QR-DFQ-R----EIQILKAL-HSDFIVKYRGVSYGPG--RQS--LRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGSR-----R---CVHRDLAARNILVES-----EA-HVKIADFGLAKLL----PL-----D--KDYY--------------VVREPGQSPIFWYAPESLS--DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EEGQR---LPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----
----LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML---K-E--GAT-HSEHR-ALM-S----ELKILIHIGHHLNVVNLLGACT-KP--GGP--LMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFLTLEHLICYSFQVAKGMEFLASR-----K---CIHRDLAARNILLSE-----KN-VVKICDFGLARDI-----Y-----K--DPDY--------------VRKGDARLPLKWMAPETIF--DRVYTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K-IDEEFCRRL----KEGTR---MRAPDYTT-------------------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL-------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQDEL-DFL-M----EALIISKF-RHQNIVRCVGLSL--R--ATP--RLILLELMSGGDMKSFLR-----HSRP--------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEEN-----H---FIHRDIAARNCLLSCA--GPSR-VAKIGDFGMARDI-----Y-----R--ASYY--------------RRGDRALLPVKWMPPEAFL--EGIFTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VGGGR---MDPPRGCP-------------------------------------------GPVYRIMTQCWQHEPELRPSFASILERL-------
----IEVEEVVGRGAFGVVCKAKWR------------------AKDVAIKQI---E------S-ESERK-AFI-V----ELRQLSRV-NHPNIVKLYGACL------NP--VCLVMEYAEGGSLYNVLH-----GA-------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSM-----QPKALIHRDLKPPNLLLVA-----GGTVLKICDFGTACDI-----------------Q--------------THMTNNKGSAAWMAPEVFE--GSNYSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HNGTR---PPLIKNLP-------------------------------------------KPIESLMTRCWSKDPSQRPSMEEIVKI--M-----
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--EAS-ADMQA-DFQ-R----EAALMAEF-DNPNIVKLLGVCA--V--GKP--MCLLFEYMAYGDLNEFLR-----SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSER-----K---FVHRDLATRNCLVGE-----NM-VVKIADFGLSRNI-----Y-----S--ADYY--------------KANENDAIPIRWMPPESIF--YNRYTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RDGNI---LSCPENCP-------------------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL-------
----YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVWKEL---DYG--SMTEAE--K-QMLVS----EVNLLREL-KHPNIVRYYDRII--DRTNTT--LYIVMEYCEGGDLASVITKGTKERQ-----------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHT---VLHRDLKPANVFLDG-----KQ-NVKLGDFGLARIL-----------NHDTSFA--------------KT---FVGTPYYMSPEQMN--RMSYNEKSDIWSLGCLLYELCA-LM-PP---------------FTAF------SQKELA----GKIRE---GKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I----
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--ASD-NA-RK-DFH-R----EAELLTNL-QHEHIVKFYGVCV--E--GDP--LIMVFEYMKHGDLNKFLR-----AHGPDAV--------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLASQ-----H---FVHRDLATRNCLVGE-----NL-LVKIGDFGMSRDV-----Y-----S--TDYY--------------RVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQGRV---LQRPRTCP-------------------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-----
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA-RK-DFQ-R----EAELLTNL-QHEHIVKFYGVCG--D--GDP--LIMVFEYMKHGDLNKFLR-----AHGPDAMIL-----------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLASQ-----H---FVHRDLATRNCLVGA-----NL-LVKIGDFGMSRDV-----Y-----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM--YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQGRV---LERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-------
---Y-IKLEKLGEGTYATVYKGRSK----------------LTENLVALKEI---RLE--HEEGAP--C--TAIR----EVSLLKDL-KHANIVTLHDIVH--T--DKS--LTLVFEYLDK-DLKQYMD---DCGN-----------------------------------------------------------------------IMSMHNVKLFLYQILRGLAYCHRR-----K---VLHRDLKPQNLLINE-----KG-ELKLADFGLARAK-----------SVPTKTY--------------SN---EVVTLWYRPPDVLL-GSSEYSTQIDMWGVGCIFFEMAS-GR-PL---------------FPGS---TVEDELHLI----FRLLG---TPSQETWPGISSNEEFKNYNFPKYK--------------PQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF-----
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--CTS-DSVRE-KFL-Q----EALTMRQF-DHPHIVKLIGVIT-----ENP--VWIIMELCTLGELRSFLQ-----VR--------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLESK-----R---FVHRDIAARNVLVSS-----ND-CVKLGDFGLSRYM-----------E--DSTY--------------YKASKGKLPIKWMAPESIN--FRRFTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----ENGER---LPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--NAS-PSELR-DLL-S----EFNVLKQV-NHPHVIKLYGACS--Q--DGP--LLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEM-----K---LVHRDLAARNILVAE-----GR-KMKISDFGLSRDV-----Y-----E--EDSY--------------VKRSQGRIPVKWMAIESLF--DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KTGHR---MERPDNCS-------------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-------
FTGW----EKVGSGGFGQVYKVRHV----------------HWKTWLAIKCS---PSL--HVDDRE--R-MELLE----EAKKMEMA-KFRYILPVYGIC------REP--VGLVMEYMETGSLEKLLA-----SE-----------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHCMA---PP---LLHLDLKPANILLDA-----HY-HVKISDFGLAKCNG--------LSHSHDLSM--------------DG---LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE--KNILHIMVKV----VKGHR---PELPPVCRARPRAC-------------------------------------SHLIRLMQRCWQGDPRVRPTFQ--------GNGLN
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--GST-DQEKI-EFL-K----EAHLMSKF-NHPNILKQLGVCL--L--NEP--QYIILELMEGGDLLTYLR-----KARM--------------------------------------------------------------ATFYG-PLLTLVDLVDLCVDISKGCVYLERM-----H---FIHRDLAARNCLVSVKDYTSPR-IVKIGDFGLARDI-----Y-----K--NDYY--------------RKRGEGLLPVRWMAPESLM--DGIFTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QTGGR---LEPPRNCP-------------------------------------------DDLWNLMTQCWAQEPDQRPTFHRIQDQL-------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKII---DLE--EAEDEI--E-DIQ-Q----EITVLSQC-DSPYVTKYYGSYL--K--DTK--LWIIMEYLGGGSALDLLE-----PG-----------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE-----K---KIHRDIKAANVLLSE-----HG-EVKLADFGVAGQL-----------TDTQIKR--------------NT---FVGTPFWMAPEVIK--QSAYDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PKNNP---PTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----
---F-TKLDRIGKGSFGEVYKGIDN----------------HTKEVVAIKII---DLE--EAEDEI--E-DIQ-Q----EITVLSQC-DSPYITRYFGSYL--K--STK--LWIIMEYLGGGSALDLLK-----PG-----------------------------------------------------------------------PLEETYIATILREILKGLDYLHSE-----R---KIHRDIKAANVLLSE-----QG-DVKLADFGVAGQL-----------TDTQIKR--------------NT---FVGTPFWMAPEVIK--QSAYDFKADIWSLGITAIELAK-GE-PP---------------NSDL---HPMRVLFLI----PKNSP---PTLEGQHS-------------------------------------------KPFKEFVEACLNKDPRFRPTAKELLKHKFI-----
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTELG-DFL-R----EVSVMMNL-EHPHVLRLHGLVL-----GQP--LQMVMELAPLGSLHARLT-----AP------------------------------------------------------------------APT-PPLLVALLCLFLRQLAGAMAYLGAR-----G---LVHRDLATRNLLLAS-----PR-TIKVADFGLVRPL----GG-----A--RGRY--------------VMGGPRPIPYAWCAPESLR--HGAFSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----EDRAR---LPRPPLCS-------------------------------------------RALYSLALRCWAPHPADRPSFSHLE----GLL---
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVLSQ-PEAMD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL-----TPP--MKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLESK-----R---FIHRDLAARNLLLAT-----RD-LVKIGDFGLMRAL----PQ-----N--DDHY--------------VMQEHRKVPFAWCAPESLK--TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKEGER---LPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----
----WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAVKQV---ALD--TSNKLA--A-EKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--Q--ENT--VSIFMEFVPGGSISSIIN----RFG-----------------------------------------------------------------------PLPEMVFCKYTKQILQGVAYLHEN-----C---VVHRDIKGNNVMLMP-----TG-IIKLIDFGCARRLAWA-----GLNGTHSDML--------------KS---MHGTPYWMAPEVIN--ESGYGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM-----DRMAAMF----YIGAH---RGLMPPLPDHFS---------------------------------------ENAADFVRMCLTRDQHERPSALQLLKHSFL-----
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