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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
TK DDR2 563
TK FLT4 845
TK IGF1R 999
TK INSRR 979
TK KDR 834
STE MYO3A 21
TK NTRK1 510
TK PTK2B 425
--VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLN-RITD-IGEVSQFLTEGIIMKDF--SHPNVLSLLGICLRS-----EGSPLVVLPYMKHGDLRNFIR-----NE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-----TQKFTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYLLQ----GRR---LLQPEYCP--DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
--LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-ADAN-KNARNDFLKEIKIMSRL--KDPNIIHLLAVCI-T-----DDPLCMITEYMENGDLNQFLS-----RHEPPN--------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS--GDYY--RIQGRAVLPIRWMSWESIL-----LGKFTTASDVWAFGVTLWETFTFCQEQPYSQL-SDEQVIENTGEFFRDQGRQTYLPQPAICP--DSVYKLMLSCWRRDTKNRPSFQEIHL---LL
--LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLK-EGAT-ASEHRALMSELKILIHIG-NHLNVVNLLGACTKP-----QGPLMVIVEFCKYGNLSNFLR-----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR--PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYK--DPDY--VRKGSARLPLKWMAPESIF-----DKVYTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRLRD----GTR---MRAPELAT--PAIRRIMLNCWSGDPKARPAFSELVEIL---
--ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTVN-EAAS-MRERIEFLNEASVMKEF--NCHHVVRLLGVVS-Q-----GQPTLVIMELMTRGDLKSYLR-----SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE--TDYY--RKGGKGLLPVRWMSPESLK-----DGVFTTYSDVWSFGVVLWEIATLAE-QPYQGL-SNEQVLRFVME----GGL---LDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I-
-I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTVN-ELAS-PRECIEFLKEASVMKAF--KCHHVVRLLGVVS-Q-----GQPTLVIMELMTRGDLKSHLR-----SLRPEA--------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE--TDYY--RKGGKGLLPVRWMAPESLK-----DGIFTTHSDVWSFGVVLWEIVTLAE-QPYQGL-SNEQVLKFVMD----GGV---LEELEGCP--LQLQELMSRCWQPNPRLRPSFTHILD---SI
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLK-EGAT-HSEHRALMSELKILIHIG-HHLNVVNLLGACTKP-----GGPLMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDY--VRKGDARLPLKWMAPETIF-----DRVYTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRLKE----GTR---MRAPDYTT--PEMYQTMLDCWHGEPSQRPTFSELVEHL---
--WEITETIGKGTYGKVFKVLNK----------------KNGQKAAVKILDPIHDIDEE--IEA--EYNILKAL-SDHPNVVRFYGIYF-KKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGE-------------------------------------------------------------------RMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL-TSTRHRR--NT---SVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGD-GD-PPLADL-HPMRALFKIPR----NPP---PKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI-
IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKALK-EASE-SA-RQDFQREAELLTML--QHQHIVRFFGVCT-E-----GRPLLMVFEYMRHGDLNRFLR-----SHGPDAKL---------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS--TDYY--RVGGRTMLPIRWMPPESIL-----YRKFTTESDVWSFGVVLWEIFTYGK-QPWYQL-SNTEAIDCITQ----GRE---LERPRACP--PEVYAIMRGCWQREPQQRHSIKDVHARL---
-V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTCK-KDCT-LDNKEKFMSEAVIMKNL--DHPHIVKLIGIIE-------EEPTWIIMELYPYGELGHYLE-----RN-----------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-E--DEDY--YKASVTRLPIKWMSPESIN-----FRRFTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVLEK----GDR---LPKPDLCP--PVLYTLMTRCWDYDPSDRPRFTELVCS--L-
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