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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK7 203
Other AURKA 133
CMGC CDK2 4
TK EGFR 712
TK EPHA3 621
TK FGFR2 481
AGC GRK6 186
CAMK MAPKAPK2 64
TK MST1R 1082
Other NEK2 8
STE OXSR1 17
AGC PRKCI 245
TK SRC 270
---FRIEKKIGRGQFSEVYRAACL-------LDGVPVALKKVQIFD-LMDAK--ARADCIKEIDLLKQL--NHPNVIKYYASFI-E----DNELNIVLELADAGDLSRMIKHF----KKQKR-----------------LIPERTVWKYFVQLCSALEHMHSR-----RVMHRDIKPANVFITATGVV---KLGDLGLGRFF------SSKTTAA--HS---LVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD-------KMNLYSLCKKIEQCDYPPLPSDHYS------------------------EELRQLVNMCINPDPEKRPD------VTYV------YDVA
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL--RHPNILRLYGYFH-D----ATRVYLILEYAPLGTVYRELQ--------KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGEL---KIADFGWSV--------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI----
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL--NHPNIVKLLDVIH-T----ENKLYLVFEFLHQ-DLKKFMDA------SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI---KLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF----
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D-EAYVMASV--DNPHVCRLLGICL------TSTVQLITQLMPFGCLLDYVR---------EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKTPQHV---KITDFGLAKLL--G---A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI------PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF--
--I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-VG-YT-EKQRRDFL-G-EASIMGQF--DHPNIIRLEGVVT-K----SKPVMIVTEYMENGSLDSFLR---------KH---------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILINSNLVC---KVSDFGLSRVL--E---D--DPEA-AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM------SNQDVIKAVDEGYRLPPPMDCP----------------------------AALYQLMLDCWQKDRNNRPK------FEQIVSIL------
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSDLV-S-EMEMMKMIG-KHKNIINLLGACT-Q----DGPLYVIVEYASKGNLREYLR---------ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVTENNVM---KIADFGLARDI--N---N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI------PVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL------
--F-RQYRVLGKGGFGEVCACQVR-------ATGKMYACKKLEKKR-IKKRK--GEAMALNEKQILEKV--NSRFVVSLAYAYE-T----KDALCLVLTLMNGGDLKFHIYH------MGQA-----------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLDDHGHI---RISDLGLAVH-------VPEGQTI--KG---RVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIA-GQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF----
KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDCP-KAR---------R-EVELHWRA-SQCPHIVRIVDVYE-NLYAGRKCLLIVMECLDGGELFSRIQD------RGDQ-----------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-------TTSHNSL--TT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI----
THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-RI-TE-MQQVEAFL-R-EGLLMRGL--NHPNVLALIGIMLPP----EGLPHVLLPYMCHGDLLQFIR---------SP---------------QRNPTVKDLISFGLQVARSMEYLAEQ-----KFVHRDLAARNCMLDESFTV---KVADFGLARDI--L---D--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHI------DPFDLTHFLAQGRRLPQPEYCP----------------------------DSLYQVMQQCWEADPAVRPT------FRVLV----GEV--
---YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYGS-MTEAE--KQMLVS-EVNLLREL--KHPNIVRYYDRII-DR--TNTTLYIVMEYCEGGDLASVITKG----TKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARIL------NHDTSFA--KT---FVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---------SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I---
---YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLEK-CQTSM--DE-LLK-EIQAMSQC--HHPNIVSYYTSFV-V----KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------VLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLGEDGSV---QIADFGVSAFLAT-GGDITRNKVR--KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK-----------------KYGKSFRKMISLCLQKDPEKRPT------AAELLRHKFF----
--F-DLLRVIGRGSYAKVLLVRLK-------KTDRIYAMKVVKKEL-VNDDE--DIDWVQTEKHVFEQA-SNHPFLVGLHSCFQ-T----ESRLFFVIEYVNGGDLMFHMQ--------RQR-----------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLDSEGHI---KLTDYGMCKEG------LRPGDTT--ST---FCGTPNYIAPEILR-GEDYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F---
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLK---------GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGENLVC---KVADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM------VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPT------FEYLQAF--L----
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