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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE PAK7 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
TK JAK2 849
TK JAK3 822
TK NTRK2 538
STE PAK4 321
CAMK PRKD3 576
TK TXK 271
ANFI-----KIGEGSTGIVCIATEK-----HTGKQVAVKKMDLRKQQR---RE--L--LFNEVVIMRDYH---HDNVVDMYSSYL--V-----GDELWVVMEFLEGGALTDIVT----HT--------------RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRI---KLSDFGFCAQV--SKEVPKRKS---LVGTPYWMAPEVIS-RLPYGTEVDIWSLGIMVIEMID-GEPP---------------YFNE-PPLQAMRRIRDSLPPRVKDLHK----VS----------------------SVLRGFLDLMLVREPSQRATAQELLGHPFL--
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEE---GV--PSTAIREISLLKELR---HPNIVSLQDVLM--Q-----DSRLYLIFEFLSM-DLKKYLDSIPPGQ--------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETE---GV--PSTAIREISLLKELN---HPNIVKLLDVIH--T-----ENKLYLVFEFLHQ-DLKKFMDA-SALT--------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
----FQKVEKIGEGTYGVVYKAKNR-----ETGQLVALKKIRLDLEME---GV--PSTAIREISLLKELK---HPNIVRLLDVVH--N-----ERKLYLVFEFLSQ-DLKKYMDS-TPGS--------------ELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAI---KLADFGLARAF--GVPLRTYTH---EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD-SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF--
---Y-EPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGL--PISTVREVALLRRLEAFEHPNVVRLMDVCA--TSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPP--------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
----LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-REIEILKSLQ---HDNIVKYKGVCYSAG-----RRNLKLIMEYLPYGSLRDYLQ----KH------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV---KIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
---L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HSGP----DQ-QRDFQ-REIQILKALH---SDFIVKYRGVSYGPG-----RQSLRLVMEYLPSGCLRDFLQ----RH------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV---KIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---I-VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASD----NA-RKDFH-REAELLTNLQ---HEHIVKFYGVCV--E-----GDPLIMVFEYMKHGDLNKFLR----AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV---KIGDFGMSRDV-YS--TDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-SNNEVIECITQGRVLQRPRTCP----------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L--
DNFI-----KIGEGSTGIVCIATVR-----SSGKLVAVKKMDLRKQQR---RE--L--LFNEVVIMRDYQ---HENVVEMYNSYL--V-----GDELWVVMEFLEGGALTDIVT----HT--------------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV---KLSDFGFCAQV--SKEVPRRKS---LVGTPYWMAPELIS-RLPYGPEVDIWSLGIMVIEMVD-GEPP---------------YFNE-PPLKAMKMIRDNLPPRLKNLHKVS--------------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL--
-FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVIDKMRFPT---KQ--ESQLRNEVAILQNLH---HPGIVNLECMFE--T-----PERVFVVMEKLHGDMLEMILS--SEKS--------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI---IGEKSFRRS---VVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLS-GTFP---------------FNED------EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL--
---L-AFIKEIGSGQFGVVHLGEWR------SHIQVAIKAIN-EGSM----SE--EDFI-EEAKVMMKLS---HSKLVQLYGVCI--Q-----RKPLYIVTEFMENGCLLNYLR----EN------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV---KISDFGMTRYV--L--DDEYVSSFGAKFPIKWSPPEVFL-FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-SNLQVVEAISEGFRLYRPHLAP----------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV-
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