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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
Other AURKA 133
CMGC CDK2 4
CMGC CDK7 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
TK EGFR 712
Other EIF2AK2 267
TK EPHA3 621
TK FGFR2 481
AGC GRK6 186
CMGC GSK3B 56
TKL IRAK4 186
CMGC MAPK10 64
CMGC MAPK12 27
CAMK MAPKAPK2 64
Other NEK2 8
STE OXSR1 17
CAMK PIM1 38
Other PLK1 53
Other PLK4 12
AGC PRKCI 245
TK RET 724
AGC RPS6KA1 62
CAMK STK11 49
STE STK24 24
Other TTK 525
--F-KFGKILGEGSFSTV---VLAREL-------ATSREYAIKILEKRH-IIKEN--K-VPYVTR------ERDVMSRL--D-HPF--FVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR--------KIG-------------------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS----PESKQARA-NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
---ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-ED-TM-EV--E-E-FL-K------EAAVMKEI--K-HPN--LVQLLGVCTR-----------------------------EPPFY--IITEFMTYG--NLLDYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVG-ENHLV----KVADFGLSRLM------T--GDTY-TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYP-GI------DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS------FAEIHQA--F-----------
---FEIGRPLGKGKFGNV---YLAREK-------QSKFILALKVLFKAQLEKAGV--E-H-QLRR------EVEIQSHL--R-HPN--ILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV--------HAPSSRR-TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
---FQKVEKIGEGTYGVV---YKARNK-------LTGEVVALKKIRLDT-ETEGV--P-S-TAIR------EISLLKEL--N-HPN--IVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF------GVPVRTY-TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
---YEKLDFLGEGQFATV---YKARDK-------NTNQIVAIKKIKLGH-RSEAK--D-G-INRTA---LREIKLLQEL--S-HPN--IIGLLDAFGH-----------------------------KSNIS--LVFDFMET---DLEVIIK-------DNSL-------------------------VLTPSHIKAYMLMTLQGLEYLHQH-----WILHRDLKPNNLLLD-ENGVL----KLADFGLAKSF------GSPNRAY-TH---QVVTRWYRAPELLF----------GARMYGVGVDMWAVGCILAELLL-RV-PFLP-GD------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG--------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------ATQALKMKYF-----------
-YI--MSKTLGSGACGEV---KLAFER-------KTCKKVAIKIISKRK-FAIGS--A-R-EADPALNVETEIEILKKL--N-HPC--IIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV--------GNK-------------------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-------LGETSLM-RT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
---YQLVRKLGRGKYSEV---FEAINI-------TNNEKVVVKILKPVK-KKKIK--R-------------EIKILENL-RG-GPN--IITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-----------Q-------------------------TLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-------YHPGQEY-NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF-----------
---YDTGEELGSGQFAVV---KKCREK-------STGLQYAAKFIKKRR-TKSSR--R-G-VSREDI--EREVSILKEI--Q-HPN--VITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA--------EKE-------------------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-------IDFGNEF-KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SPFL-GD---------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
--F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANK-E-IL-D------EAYVMASV--D-NPH--VCRLLGICL------------------------------TSTVQ--LITQLMPFG--CLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVK-TPQHV----KITDFGLAKLL--G---A--EEKE-YHAEGGKVPIKWMALESIL-----------HRIYTHQSDVWSYGVTVWELMTFGS-KPYD-GI------PASEISSILEKGERLPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF---------
--F-KEIELIGSGGFGQV---FKAKHR-------IDGKTYVIKRVKYNN-EKAER----------------EVKALAKL--D-HVN--IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK------RRGE-------------------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-------LKNDGKR-TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFE-T-------------SKFFTDLRDGIISDIFDK----------------------------------------KEKTLLQKLLSKKPEDRPN------TSEILR----TLT--------
--I-SIDKVVGAGEFGEV---CSGRLK----LPSKKEISVAIKTLK-VG-YT-EKQRR-D-FL-G------EASIMGQF--D-HPN--IIRLEGVVTK-----------------------------SKPVM--IVTEYMENG--SLDSFLR---------KH-----------------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILIN-SNLVC----KVSDFGLSRVL--E---D--DPEAAYTTRGGKIPIRWTSPEAIA-----------YRKFTSASDVWSYGIVLWEVMSYGE-RPYW-EM------SNQDVIKAVDEGYRLPPPMDCP-----------------------------------------AALYQLMLDCWQKDRNNRPK------FEQIVSIL-------------
---LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLS-D-LV-S------EMEMMKMIG-K-HKN--IINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLREYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVT-ENNVM----KIADFGLARDI--N---N--IDYY-KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SPYP-GI------PVEELFKLLKEGHRMDKPANCT-----------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
--F-RQYRVLGKGGFGEV---CACQVR-------ATGKMYACKKLEKKR-IKKRK--G-E-AMAL-----NEKQILEKV--N-SRF--VVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLKFHIYH------MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH-------VPEGQTI-KG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR------KKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
---YTDTKVIGNGSFGVV---YQAKLC-------DSGELVAIKKVLQDK-RFKNR----------------ELQIMRKL--D-HCN--IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY----SRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-------LVRGEPN-VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
VGG----NKMGEGGFGVV---YKGYVN-------NTT--VAVKKLAAMV-DITTE--ELK-QQFD-----QEIKVMAKC--Q-HEN--LVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-----LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE----KFAQTVMT-SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PAVD-EH------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ--------
---YQNLKPIGSGAQGIV---CAAYDA-------VLDRNVAIKKLSRPF-QNQTH--A-K-RAYR------ELVLMKCV--N-HKN--IISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ----------M-------------------------ELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL----KILDFGLART-------AGTSFMM-TP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-ILFP-GR------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS------VDDALQHPYI-----------
---YRDLQPVGSGAYGAV---CSAVDG-------RTGAKVAIKKLYRPF-QSELF--A-K-RAYR------ELRLLKHM--R-HEN--VIGLLDVFTPDET-----------------------LDDFTDFY--LVMPFMGT---DLGKLMK---------HE-------------------------KLGEDRIQFLVYQMLKGLRYIHAA-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR---------QADSEM-TG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFK-GS------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AGEALAHPYF-----------
KVT---SQVLGLGINGKV---LQIFNK-------RTQEKFALKMLQDCP-KAR-----------R------EVELHWRA-SQ-CPH--IVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD------RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE-------TTSHNSL-TT---PCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLC-GY-PPFY-SN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
---YEVLYTIGTGSYGRC---QKIRRK-------SDGKILVWKELDYGS-MTEAE--K-Q-MLVS------EVNLLREL--K-HPN--IVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLASVITKG----TKERQ-------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL------NHDTSFA-KT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LM-PPFT-AF---------SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
---YELQEVIGSGATAVV---QAAYCA-------PKKEKVAIKRINLEK-CQTSM--D-E--LLK------EIQAMSQC--H-HPN--IVSYYTSFVV-----------------------------KDELW--LVMKLLSGG--SVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLG-EDGSV----QIADFGVSAFLAT-GGDITRNKVR-KT---FVGTPCWMAPEVME----------QVRGYDFKADIWSFGITAIELAT-GA-APYH-KY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK------------------------------KYGKSFRKMISLCLQKDPEKRPT------AAELLRHKFF-----------
---YQVGPLLGSGGFGSV---YSGIRV-------SDNLPVAIKHVEKDR-ISDWG--E-L-PNGTRV--PMEVVLLKKV--S-SGFSGVIRLLDWFER-----------------------------PDSFV--LILERPEPV-QDLFDFIT--------ERG-------------------------ALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA--------LLKDTVY-TD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GD-IPFE-HD---------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM-----------
-YV--RGRFLGKGGFAKC---FEISDA-------DTKEVFAGKIVPKSL-LLKPH--Q-R-EKMS-----MEISIHRSL--A-HQH--VVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK--------RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV------EYDGERK-KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PPFE-TS---------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
--F-KVGNLLGKGSFAGV---YRAESI-------HTGLEVAIKMIDKKA-MYKAG--M-V-QRVQ-----NEVKIHCQL--K-HPS--ILELYNYFED-----------------------------SNYVY--LVLEMCHNG--EMNRYLK-------NRVK-------------------------PFSENEARHFMHQIITGMLYLHSH-----GILHRDLTLSNLLLT-RNMNI----KIADFGLATQL------KMPHEKH-YT---LCGTPNYISPEIAT-----------RSAHGLESDVWSLGCMFYTLLI-GR-PPFD-TD---------TVKNTLNKVVLADYEMPSFLS---------------------------------------IEAKDLIHQLLRRNPADRLS------LSSVLDHPFM-----------
--F-DLLRVIGRGSYAKV---LLVRLK-------KTDRIYAMKVVKKEL-VNDDE--D-I-DWVQ-----TEKHVFEQA-SN-HPF--LVGLHSCFQT-----------------------------ESRLF--FVIEYVNGG--DLMFHMQ--------RQR-------------------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG------LRPGDTT-ST---FCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMA-GR-SPFD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS---------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
--L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-EN-AS-PSELR-D-LL-S------EFNVLKQV--N-HPH--VIKLYGACSQ-----------------------------DGPLL--LIVEYAKYG--SLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVA-EGRKM----KISDFGLSRDV--Y---E--EDSY-VKRSQGRIPVKWMAIESLF-----------DHIYTTQSDVWSFGVLLWEIVTLGG-NPYP-GI------PPERLFNLLKTGHRMERPDNCS-----------------------------------------EEMYRLMLQCWKQEPDKRPV------FADISKDL-------------
---FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKAT-LKVRD--R-V-RTKM------ERDILADV--N-HPF--VVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS--------KEV-------------------------MFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA------IDHEKKA-YS---FCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLT-GS-LPFQ-GK---------DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAEEIKRHV--FY---------
YLM---GDLLGEGSYGKV---KEVLDS-------ETLCRRAVKILKKKK-LRRIP--N-G-EANVK----KEIQLLRRL--R-HKN--VIQLVDVLYNE---------------------------EKQKMY--MVMEYCVCGMQEMLDSVP---------EK-------------------------RFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALH----PFAADDTC-RT---SQGSPAFQPPEIAN---------GLDTFSGFKVDIWSAGVTLYNITT-GL-YPFE-GD---------NIYKLFENIGKGSYAIPGDCG---------------------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF-----------
---FTKLEKIGKGSFGEV---FKGIDN-------RTQKVVAIKIIDLEE-AEDEI--E-D-IQ-Q------EITVLSQC--D-SPY--VTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SALDLLE---------PG-------------------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL------TDTQIKR-NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PPHS-EL------HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI-----------
---YSILKQIGSGGSSKV---FQVLNE-------KKQ-IYAIKYVNLEE-ADNQT--L-D-SYRN------EIAYLNKL-QQHSDK--IIRLYDYEIT-----------------------------DQYIY--MVMECGNI---DLNSWLK--------KKK-------------------------SIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ----PDTTSVVK-DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQ-QI--------INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRIS------IPELLAHPYV-----------
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