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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK8 26
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCD 349
AGC PRKCQ 380
-F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-IIK---EN--KVPYVTR-ERDVMSRL-D---HPF-----FVKLYFTFQ--D------DEKLY--FGLSYAKNG--ELLKYIR----KIG--SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHIQITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG----NEYLIFQKIIKLEYDFPEKFF-------------------------------------------------------------PKARDLVEKLLVLDATKRLG-CE-EM------EGYGPLKAHPF
--FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKA---GV--EH-QLRR-EVEIQSHL-R---HPN-----ILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS--KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGELKIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN----TYQETYKRISRVEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQRPM-LR-EVLEHPWI-----------
--FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETE---GV--PS-TAIR-EISLLKEL-N---HPN-----IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAIKLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-AK-AALAHPFF-----------
-Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPN-GGGGGGGL--PI-STVR-EVALLRRL-EAFEHPN-----VVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP--GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTVKLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-AF-RALQHSYL-----------
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKR-AVD---CP--EN-I-KK-EICINKML-N---HEN-----VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI--GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNLKISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSARIT-IP-DIKKDRW-Y----------
--YQLVRKLGRGKYSEVFEAINI----TNNEKVVVKILKPVK-KKK---IK--R-------EIKILENLRG---GPN-----IITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q--TL---TDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEF------YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK---------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-AR-EAMEHPYF-----------
--YEIDSLIGKGSFGQVVKAYDR----VEQEWVAIKIIKNKK-AFL---NQ--AQ-I----EVRLLELMNK---HDTEMKYYIVHLKRHFM--F------RNHLC--LVFEMLSY---NLYDLLR-----NT--NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ--------LGQRIYQ---YIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHT-GEPL---------------FS-GA-NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-PY-YALQHSFF-----------
--YEIDSLIGKGSFGQVVKAYDH----QTQELVAIKIIKNKK-AFL---NQ--AQ-I----ELRLLELMNQ---HDTEMKYYIVHLKRHFM--F------RNHLC--LVFELLSY---NLYDLLR-----NT--HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ--------LGQRIYQ---YIQSRFYRSPEVLL-GTPYDLAIDMWSLGCILVEMHT-GEPL---------------FS-GS-NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-PL-GALQHGFF-----------
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDK-RFK---NR----------ELQIMRKL-D---HCN-----IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PL-EACAHSFF-----------
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE-----EHLRD-FE-R-EIEILKSL-Q---HDN-----IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRVKIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-IVFHLIELLKNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-FR-DLA----LRV---------
-L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP----DQ-QRD-FQ-R-EIQILKAL-H---SDF-----IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RHRARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHVKIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DVPALCRLLELLEEGQRLPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-FS-ALGP---QL----------
--YTNLSYIGEGAYGMVCSAYDN----VNKVRVAIKKISPFE-HQT---YC--QR-T-LR-EIKILLRF-R---HEN-----IIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ--HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDLKICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FP-GK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-VE-QALAHPYL-----------
--YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPF-QNQ---TH--AK-RAYR-ELVLMKCV-N---HKN-----IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M--EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTLKILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-VD-DALQHPYI-----------
--YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPF-QSI---IH--AK-RTYR-ELRLLKHM-K---HEN-----VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ--KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCELKILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-AA-QALAHAYF-----------
--YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPF-QNQ---TH--AK-RAYR-ELVLMKCV-N---HKN-----IIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M--EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTLKILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-VD-EALQHPYI-----------
YV--RGRFLGKGGFAKCFEISDA----DTKEVFAGKIVPKSL-LLK---PH--QR-EKMSMEISIHRSL-A---HQH-----VVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK----RRK--AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN--EDLEVKIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS----CLKETYLRIKKNEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTARPT-IN-ELLNDEFF-----------
-Y-CRGKVLGKGGFAKCYEMTDL----TNNKVYAAKIIPHSR-VAK---PH--QR-EKIDKEIELHRIL-H---HKH-----VVQFYHYFE--D------KENIY--ILLEYCSRR--SMAHILK----ARK--VL---TEPEVRYYLRQIVSGLKYLHE--QEILHRDLKLGNFFIN--EAMELKVGDFGLAARL-----EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FE-TT----NLKETYRCIREARYTMPSSLL-------------------------------------------------------------APAKHLIASMLSKNPEDRPS-LD-DIIRHDFF-----------
YL--KGRLLGKGGFARCYEATDT----ETGSAYAVKVIPQSR-VAK---PH--QR-EKILNEIELHRDL-Q---HRH-----IVRFSHHFE--D------ADNIY--IFLELCSRK--SLAHIWK----ARH--TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMELKVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA----DLKETYRCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRDRPS-ID-QILRHDFF-----------
FI--FHKVLGKGSFGKVLLGELK----GRGEYFAIKALKKDV-VLI---DD--DV-ECTMVEKRVLTLAAE---NPF-----LTHLICTFQ--T------KDHLF--FVMEFLNGG--DLMYHIQ----DKG--RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVLLD--RDGHIKIADFGMCKEN-----IFGESRAST---FCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD----DEDELFESIRVDTPHYPRWIT-------------------------------------------------------------KESKDILEKLFEREPTKRLGVTG-NIKIHPFF-----------
FI--LHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKDV-VLM---DD--DV-ECTMVEKRVLSLAWE---HPF-----LTHMFCTFQ--T------KENLF--FVMEYLNGG--DLMYHIQ----SCH--KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHIKIADFGMCKEN-----MLGDAKTNT---FCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ----DEEELFHSIRMDNPFYPRWLE-------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-VRGDIRQHPLF-----------
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