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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK1 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC DMPK 81
Other EIF2AK2 267
AGC GRK7 191
CMGC GSK3B 56
TK HCK 241
CAMK HUNK 61
TK INSR 1023
TKL IRAK4 186
CMGC MAPK14 24
CAMK MGC42105 74
Other NEK2 8
Other NEK3 4
CAMK PHKG1 20
CAMK PHKG2 24
Other PLK2 82
Other PLK3 62
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
STE SLK 34
STE STK10 36
TK TNK1 116
-YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIV---PKSL-LLKPH--Q-REKMS------------------------MEISIHRSL-AHQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK-----------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-------KKG--HSFEVDVWSIGCIMYTLLV-GK-PPFETS----CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT---INELLNDEFF------
---FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVL---FKAQLEKAGV--E-HQLRR-------------------------EVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-------GRM--HDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM---LREVLEHPWI------
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVL---FKSQ-IEKEG--V-EHQLR------------------------REIEIQAHL-HHPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------TFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG-LKGEL----KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-------GRM--HNEKVDLWCIGVLCYELLV-GN-PPFESA----SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP---LAQVSAHPWV------
---YQLYEDIGKGAFSVVRRCVKL-----CTGHEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL-KHSNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------YYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KEA--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT---AHEALKHPWV------
---YQLFEELGKGAFSVVRRCMKI-----PTGQEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL-KHPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------YYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDMWACGVILYILLV-GY-PPFWDE----DQHRLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKDLINKMLTINPAKRIT---ASEALKHPWI------
---YQLFEELGKGAFSVVRRCVKK-----TSTQEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL-KHPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------YYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV----QGEQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT---ADQALKHPWV------
---YKLQSEIGKGAYGVVRLAYNE-----SEDRHYAMKVL---SKKK-LLKQY--G-FPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL-DHVNVVKLIEVLDDP---------------------------AEDNLY--LVFDLLRKG--PVMEVPC-----DK-----------PFSEEQARLYLRDVILGLEYLHCQ-----KIVHRDIKPSNLLLG-DDGHV----KIADFGVSNQF----EGNDAQLSS---TAGTPAFMAPEAISD----SGQSF--SGKALDVWATGVTLYCFVY-GK-CPFIDD----FILALHRKIKNEPVVFPEEPEIS---------------------------EELKDLILKMLDKNPETRIG---VPDIKLHPWV------
---YTLKDEIGKGSYGVVKLAYNE-----NDNTYYAMKVL---SKKK-LIRQA--G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDP---------------------------NEDHLY--MVFELVNQG--PVMEVPT-----LK-----------PLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEF----KGSDALLSN---TVGTPAFMAPESLS------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CPFMDE----RIMCLHSKIKSQALEFPDQPDIA---------------------------EDLKDLITRMLDKNPESRIV---VPEIKLHPWV------
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKI---RLDT-ETEGV--P-STAIR-------------------------EISLLKEL-NHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL------GCKY--YSTAVDIWSLGCIFAEMVT-RR-ALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTS-MPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS---AKAALAHPFF------
---YEKLEKIGEGTYGTVFKAKNR-----ETHEIVALKRV---RLDD-DDEGV--P-SSALR-------------------------EICLLKEL-KHKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------DLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF------GAKL--YSTSIDMWSAGCIFAELANAGR-PLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTK-LPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS---AEEALQHPYF------
-YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKII---SKRK-FAIGS--A-READPALN-------------------VETEIEILKKL-NHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS----VGTAG--YNRAVDCWSLGVILFICLS-GY-PPFSEH---RTQVSLKDQITSGKYNFIPEVWAE-VS------------------------EKALDLVKKLLVVDPKARFT---TEEALRHPWL------
---YDTGEELGSGQFAVVKKCREK-----STGLQYAAKFI---KKRR-TKSSR--R-GVSREDI---------------------EREVSILKEI-QHPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKE-----------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANVSAVNYEFEDEYFSN-TS------------------------ALAKDFIRRLLVKDPKKRMT---IQDSLQHPWI------
---YDIGEELGSGQFAIVKKCREK-----STGLEYAAKFI---KKRQ-SRASR--R-GVSREEI---------------------EREVSILRQV-LHHNVITLHDVYEN-----------------------------RTDVV--LILELVSGG--ELFDFLA----QKE-----------SLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANITAVSYDFDEEFFSQ-TS------------------------ELAKDFIRKLLVKETRKRLT---IQEALRHPWI------
---YEMGEELGSGQFAIVRKCRQK-----GTGKEYAAKFI---KKRR-LSSSR--R-GVSREEI---------------------EREVNILREI-RHPNIITLHDIFEN-----------------------------KTDVV--LILELVSGG--ELFDFLA----EKE-----------SLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGE----TKQETLTNISAVNYDFDEEYFSN-TS------------------------ELAKDFIRRLLVKDPKRRMT---IAQSLEHSWI------
---FEILKVIGRGAFSEVAVVKMK-----QTGQVYAMKIM---NKWD-MLKRG--E-VSCFR------------------------EERDVLVNG-DRRWITQLHFAFQD-----------------------------ENYLY--LVMEYYVGG--DLLTLLS---KFGE-----------RIPAEMARFYLAEIVMAIDSVHRL-----GYVHRDIKPDNILLD-RCGHI----RLADFGSCLKL---RADGTVRSLV---AVGTPDYLSPEILQAVGGGPGTGS--YGPECDWWALGVFAYEMFY-GQ-TPFYAD-STAETYGKIVHYKE---HLSLPLVDEGVP------------------------EEARDFIQRLLCPP-ETRLGRGGAGDFRTHPFF------
--F-KEIELIGSGGFGQVFKAKHR-----IDGKTYVIKRV---KYNN-EKAER----------------------------------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-----LKNDGKRTR---SKGTLRYMSPEQIS-------SQD--YGKEVDLYALGLILAELLH-VCDTAFET--------SKFFTDLRDGIISDIFDK------------------------------KEKTLLQKLLSKKPEDRPN---TSEILR----TLT---
--F-TEFRVLGKGGFGEVCAVQVK-----NTGKMYACKKL---DKKR-LKKKG--G-EKMAL------------------------LEKEILEKV-SSPFIVSLAYAFES-----------------------------KTHLC--LVMSLMNGG--DLKFHIYN--VGTR-----------GLDMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF----T------------------------EEAKDICRLFLAKKPEQRLG---SRE-------KSDDPR
---YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKV---LQDK-RFKNR----------------------------------ELQIMRKL-DHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFPGD-SGVDQLVEIIKVLGTPTREQIREMNP-NYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLT---PLEACAHSFF------
---LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTM---K-PG-SM-SV--E-AFL-A-------------------------EANVMKTL-QHDKLVKLHAVVT------------------------------KEPIY--IITEFMAKG--SLLDFLK-----SD--------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVS-ASLVC----KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-------FGS--FTIKSDVWSFGILLMEIVTYGR-IPYPGM-SNPEVIRALERGYRMPRPENCP-------------------------------EELYNIMMRCWKNRPEERPT---FEYIQSV--L------
IGS----RKLGEGSFAKVREGLHV-----LTGEKVAIKVI---DKKR-AKKDT--Y-VTKNLR-----------------------REGQIQQMI-RHPNITQLLDILET-----------------------------ENSYY--LVMELCPGG--NLMHKIY----EKK-----------RLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD-EDNNI----KLIDFGLSNCAG--ILGYSDPFST---QCGSPAYAAPELLA-------RKK--YGPKIDVWSIGVNMYAMLT-GT-LPFTVE--PFSLRALYQKMVD-KEMNPLPTQ---LS------------------------TGAISFLRSLLEPDPVKRPN---IQQALANRWL------
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV---N-ES-AS-LRERI-EFL-N-------------------------EASVMKGF-TCHHVVRLLGVVSK-----------------------------GQPTL--VVMELMAHG--DLKSYLR-----SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVA-HDFTV----KIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMAPESLK-------DGV--FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFVMDGGYLDQPDNCP-------------------------------ERVTDLMRMCWQFNPKMRPT---FLEIVNLL--------
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKL---AAMV-DITTE--ELKQQFD------------------------QEIKVMAKC-QHENLVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--------GE--ITPKSDIYSFGVVLLEIIT-GL-PAVDEH-REPQLLLDIKEEIEDEEKTIEDYIDK-KMNDAD----------------STSVEAMYSVASQCLHEKKNKRPD---IKKVQQ----LLQ---
---YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKL---SRPF-QSIIH--A-KRTYR-------------------------ELRLLKHM-KHENVIGLLDVFTPARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVN-EDCEL----KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML------NWMH--YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLILRLVGTPGAELLKKISS-ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT---AAQALAHAYF------
---YRIRGEIGSGNFSQVKLGIHS-----LTKEKVAIKIL---DKTK-LDQKT--Q-RLLSR-------------------------EISSMEKL-HHPNIIRLYEVVET-----------------------------LSKLH--LVMEYAGGG--ELFGKIS----TEG-----------KLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT-SNTCV----KVGDFGFSTV-----SKKGEMLNT---FCGSPPYAAPELFR------DEHY--IGIYVDIWALGVLLYFMVT-GT-MPFRAE----TVAKLKKSILEGTYSVPPHV-----S------------------------EPCHRLIRGVLQQIPTERYG---IDCIMNDEWM------
---YEVLYTIGTGSYGRCQKIRRK-----SDGKILVWKEL---DYGS-MTEAE--K-QMLVS-------------------------EVNLLREL-KHPNIVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLASVITKGTKERQ-----------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL----NHDTSFAKT---FVGTPYYMSPEQMN-------RMS--YNEKSDIWSLGCLLYELCA-LM-PPFTAF----SQKELAGKIREGKFRRIPYRY----S------------------------DELNEIITRMLNLKDYHRPS---VEEILENPL-I-----
--Y-MVLRMIGEGSFGRALLVQHE-----SSNQMFAMKEI---RLPK-SFSNT--Q-N-SRK-------------------------EAVLLAKM-KHPNIVAFKESFEA-----------------------------EGHLY--IVMEYCDGG--DLMQKIKQ--QKGK-----------LFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLT-QNGKV----KLGDFGSARLL----SNPMAFACT---YVGTPYYVPPEIWE-------NLP--YNNKSDIWSLGCILYELCT-LK-HPFQAN-SWKNLILKVCQGCISPLPSHYS-------------------------------YELQFLVKQMFKRNPSHRPS---ATTLLS----RGIV--
---YEPKEILGRGVSSVVRRCIHK-----PTSQEYAVKVI---DVTG-GGSFS--P-EEVRELRE------------------ATLKEVDILRKVSGHPNIIQLKDTYET-----------------------------NTFFF--LVFDLMKRG--ELFDYLT----EKV-----------TLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ-----LEPGERLRE---VCGTPSYLAPEIIECS-MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PPFWHR----KQMLMLRMIMSGNYQFGSPEWDD-YS------------------------DTVKDLVSRFLVVQPQNRYT---AEEALAHPFF------
YDP---KDVIGRGVSSVVRRCVHR-----ATGHEFAVKIM---EVTA-ERLSP--E-QLEEVREA-------------------TRRETHILRQVAGHPHIITLIDSYES-----------------------------SSFMF--LVFDLMRKG--ELFDYLT----EKV-----------ALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD-DNMQI----RLSDFGFSCH-----LEPGEKLRE---LCGTPGYLAPEILKCS-MDETHPG--YGKEVDLWACGVILFTLLA-GS-PPFWHR----RQILMLRMIMEGQYQFSSPEWDD-RS------------------------STVKDLISRLLQVDPEARLT---AEQALQHPFF------
--Y-CRGKVLGKGGFAKCYEMTDL-----TNNKVYAAKII---PHSR-VAKPH--Q-REKID------------------------KEIELHRIL-HHKHVVQFYHYFED-----------------------------KENIY--ILLEYCSRR--SMAHILK----ARK-----------VLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN-EAMEL----KVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-------KQG--HGCESDIWALGCVMYTMLL-GR-PPFETT----NLKETYRCIREARYTMPSSLL-----------------------------APAKHLIASMLSKNPEDRPS---LDDIIRHDFF------
-YL--KGRLLGKGGFARCYEATDT-----ETGSAYAVKVI---PQSR-VAKPH--Q-REKIL------------------------NEIELHRDL-QHRHIVRFSHHFED-----------------------------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------TLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-------RQG--HGPEADVWSLGCVMYTLLC-GS-PPFETA----DLKETYRCIKQVHYTLPASLS-----------------------------LPARQLLAAILRASPRDRPS---IDQILRHDFF------
-PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKII---DKLR-FPTKQ--E-SQLRN-------------------------EVAILQNL-HHPGVVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKG-----------RLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------NKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDIHDQIQNAAFMYPPNPWKE-IS------------------------HEAIDLINNLLQVKMRKRYS---VDKTLSHPWL------
-PD----EVLGSGQFGVVYGGKHR-----KTGRDVAVKVI---DKLR-FPTKQ--E-SQLRN-------------------------EVAILQSL-RHPGIVNLECMFET-----------------------------PEKVF--VVMEKLHGD--MLEMILS---SEKG-----------RLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLL-------NQG--YNRSLDMWSVGVIMYVSLS-GT-FPFNED------EDINDQIQNAAFMYPASPWSH-IS------------------------AGAIDLINNLLQVKMRKRYS---VDKSLSHPWL------
FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVI---DKMR-FPTKQ--E-SQLRN-------------------------EVAILQNL-HHPGIVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------RLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------SKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDINDQIQNAAFMYPPNPWRE-IS------------------------GEAIDLINNLLQVKMRKRYS---VDKSLSHPWL------
---IELGRCIGEGQFGDVHQGIYM--SPENPALAVAIKTC---K-NC-TS-DSVRE-KFL-Q-------------------------EALTMRQF-DHPHIVKLIGVIT------------------------------ENPVW--IIMELCTLG--ELRSFLQ-----VR---------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVS-SNDCV----KLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-------FRR--FTSASDVWMFGVCMWEILMHGV-KPFQGV-KNNDVIGRIENGERLPMPPNCP-------------------------------PTLYSLMTKCWAYDPSRRPR---FTELKAQL--------
---WEIIGELGDGAFGKVYKAQNK-----ETSVLAAAKVI---DTKS-EEELE--D-YM--V-------------------------EIDILASC-DHPNIVKLLDAFYY-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------PLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCE--TSKDRP--YDYKADVWSLGITLIEMAE-IE-PPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS-----------------------------SNFKDFLKKCLEKNVDARWT---TSQLLQHPFV------
---WEIVGELGDGAFGKVYKAKNK-----ETGALAAAKVI---ETKS-EEELE--D-YI--V-------------------------EIEILATC-DHPYIVKLLGAYYH-----------------------------DGKLW--IMIEFCPGG--AVDAIML---ELDR-----------GLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMT-LEGDI----RLADFGVSAKN----LKTLQKRDS---FIGTPYWMAPEVVMCE--TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PPHHEL-NPMRVLLKIAKSDPPTLLTPSKWS-----------------------------VEFRDFLKIALDKNPETRPS---AAQLLEHPFV------
VCR---GELLGSGCFGVVHRGLWT--LPSGKSVPVAVKSLRVGP-EG-PM-GTELG-DFL-R-------------------------EVSVMMNL-EHPHVLRLHGLVL------------------------------GQPLQ--MVMELAPLG--SLHARLT-----AP-------APTPPLLVALLCLFLRQLAGAMAYLGAR-----GLVHRDLATRNLLLA-SPRTI----KVADFGLVRPL-GG-A--RGRYVMGGPRPIPYAWCAPESLR-------HGA--FSSASDVWMFGVTLWEMFSGGE-EPWAGV-PPYLILQRLEDRARLPRPPLCS-------------------------------RALYSLALRCWAPHPADRPS---FSHLE----GLL----
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