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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK1 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC DMPK 81
Other EIF2AK2 267
TK FGFR1 478
TK FGFR3 472
AGC GRK7 191
TK HCK 241
CAMK HUNK 61
TK INSR 1023
TKL IRAK4 186
CMGC MAPK14 24
CAMK MAPKAPK2 64
CAMK MGC42105 74
Other NEK2 8
Other NEK3 4
AGC PDPK1 82
CAMK PHKG2 24
Other PLK2 82
Other PLK3 62
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
STE SLK 34
STE STK10 36
TK TNK1 116
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIV---PKSL-LLKPH--Q-R-EKMS------------------------MEISIHRSL--AHQHVVGFHGFFED-----------------------------NDFVFVVLELCRRRSLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNEDLEV----KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-------KKG--HSFEVDVWSIGCIMYTLLV-GK-PPFETS----CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT---INELLNDEFF-----------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKAQLEKAGV--E-H-QLRR-------------------------EVEIQSHL--RHPNILRLYGYFHD-----------------------------ATRVYLILEYAPLGTVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-------GRM--HDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM---LREVLEHPWI-----------
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVL---FKSQ-IEKEG--V-E-HQLR------------------------REIEIQAHL--HHPNILRLYNYFYD-----------------------------RRRIYLILEYAPRGELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLGLKGEL----KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-------GRM--HNEKVDLWCIGVLCYELLV-GN-PPFESA----SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP---LAQVSAHPWV-----------
---YQLYEDIGKGAFSVVRRCVKL-------CTGHEYAAKII---NTKK-LSARD--H-Q-KLER-------------------------EARICRLL--KHSNIVRLHDSISE-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLASKCKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KEA--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT---AHEALKHPWV-----------
---YQLFEELGKGAFSVVRRCMKI-------PTGQEYAAKII---NTKK-LSARD--H-Q-KLER-------------------------EARICRLL--KHPNIVRLHDSISE-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLASKSKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDMWACGVILYILLV-GY-PPFWDE----DQHRLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKDLINKMLTINPAKRIT---ASEALKHPWI-----------
---YQLFEELGKGAFSVVRRCVKK-------TSTQEYAAKII---NTKK-LSARD--H-Q-KLER-------------------------EARICRLL--KHPNIVRLHDSISE-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLASKCKGA-AVKLADFGLAIEV----QGEQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT---ADQALKHPWV-----------
---YKLQSEIGKGAYGVVRLAYNE-------SEDRHYAMKVL---SKKK-LLKQY--G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--DHVNVVKLIEVLDDP---------------------------AEDNLYLVFDLLRKGPVMEVPC-----DK-----------------PFSEEQARLYLRDVILGLEYLHCQ-----KIVHRDIKPSNLLLGDDGHV----KIADFGVSNQF----EGNDAQLSS---TAGTPAFMAPEAISD----SGQSF--SGKALDVWATGVTLYCFVY-GK-CPFIDD----FILALHRKIKNEPVVFPEEPEIS---------------------------EELKDLILKMLDKNPETRIG---VPDIKLHPWV-----------
---YTLKDEIGKGSYGVVKLAYNE-------NDNTYYAMKVL---SKKK-LIRQA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--DHPNVVKLVEVLDDP---------------------------NEDHLYMVFELVNQGPVMEVPT-----LK-----------------PLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVGEDGHI----KIADFGVSNEF----KGSDALLSN---TVGTPAFMAPESLS------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CPFMDE----RIMCLHSKIKSQALEFPDQPDIA---------------------------EDLKDLITRMLDKNPESRIV---VPEIKLHPWV-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLDT-ETEGV--P-S-TAIR-------------------------EISLLKEL--NHPNIVKLLDVIHT-----------------------------ENKLYLVFEFLHQ-DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL------GCKY--YSTAVDIWSLGCIFAEMVT-RR-ALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTS-MPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS---AKAALAHPFF-----------
---YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRV---RLDD-DDEGV--P-S-SALR-------------------------EICLLKEL--KHKNIVRLHDVLHS-----------------------------DKKLTLVFEFCDQ-DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLINRNGEL----KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF------GAKL--YSTSIDMWSAGCIFAELANAGR-PLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTK-LPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS---AEEALQHPYF-----------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKII---SKRK-FAIGS--A-R-EADPALN-------------------VETEIEILKKL--NHPCIIKIKNFF-D-----------------------------AEDYYIVLELMEGGELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS----VGTAG--YNRAVDCWSLGVILFICLS-GY-PPFSEH---RTQVSLKDQITSGKYNFIPEVWAE-VS------------------------EKALDLVKKLLVVDPKARFT---TEEALRHPWL-----------
---YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFI---KKRR-TKSSR--R-G-VSREDI---------------------EREVSILKEI--QHPNVITLHEVYEN-----------------------------KTDVILILELVAGGELFDFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANVSAVNYEFEDEYFSN-TS------------------------ALAKDFIRRLLVKDPKKRMT---IQDSLQHPWI-----------
---YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFI---KKRQ-SRASR--R-G-VSREEI---------------------EREVSILRQV--LHHNVITLHDVYEN-----------------------------RTDVVLILELVSGGELFDFLA----QKE-----------------SLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANITAVSYDFDEEFFSQ-TS------------------------ELAKDFIRKLLVKETRKRLT---IQEALRHPWI-----------
---YEMGEELGSGQFAIVRKCRQK-------GTGKEYAAKFI---KKRR-LSSSR--R-G-VSREEI---------------------EREVNILREI--RHPNIITLHDIFEN-----------------------------KTDVVLILELVSGGELFDFLA----EKE-----------------SLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGE----TKQETLTNISAVNYDFDEEYFSN-TS------------------------ELAKDFIRRLLVKDPKRRMT---IAQSLEHSWI-----------
---FEILKVIGRGAFSEVAVVKMK-------QTGQVYAMKIM---NKWD-MLKRG--E-V-SCFR------------------------EERDVLVNG--DRRWITQLHFAFQD-----------------------------ENYLYLVMEYYVGGDLLTLLS---KFGE-----------------RIPAEMARFYLAEIVMAIDSVHRL-----GYVHRDIKPDNILLDRCGHI----RLADFGSCLKL---RADGTVRSLV---AVGTPDYLSPEILQAVGGGPGTGS--YGPECDWWALGVFAYEMFY-GQ-TPFYAD-STAETYGKIVHYKE---HLSLPLVDEGVP------------------------EEARDFIQRLLCPP-ETRLGRGGAGDFRTHPFF-----------
--F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRV---KYNN-EKAER-----------------------------------EVKALAKL--DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLVDTKQV----KIGDFGLVTS-----LKNDGKRTR---SKGTLRYMSPEQIS-------SQD--YGKEVDLYALGLILAELLH-VCDTAFET--------SKFFTDLRDGIISDIFDK------------------------------KEKTLLQKLLSKKPEDRPN---TSEILR----TLT--------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-SD-AT-EKDLS-D-LI-S-------------------------EMEMMKMIG-KHKNIINLLGACTQ-----------------------------DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVTEDNVM----KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF-------DRI--YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLLKEGHRMDKPSNCT-------------------------------NELYMMMRDCWHAVPSQRPT---FKQLVEDL-------------
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML---K-DD-AT-DKDLS-D-LV-S-------------------------EMEMMKMIG-KHKNIINLLGACTQ-----------------------------GGPLYVLVEYAAKGNLREFLR-----ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ-----KCIHRDLAARNVLVTEDNVM----KIADFGLARDV--H-N--LDYYKKTTNGRLPVKWMAPEALF-------DRV--YTHQSDVWSFGVLLWEIFTLGG-SPYPGI-PVEELFKLLKEGHRMDKPANCT-------------------------------HDLYMIMRECWHAAPSQRPT---FKQLVEDL-------------
--F-TEFRVLGKGGFGEVCAVQVK-------NTGKMYACKKL---DKKR-LKKKG--G-E-KMAL------------------------LEKEILEKV--SSPFIVSLAYAFES-----------------------------KTHLCLVMSLMNGGDLKFHIYN--VGTR-----------------GLDMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLDDLGNC----RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF----T------------------------EEAKDICRLFLAKKPEQRLG---SRE-------KSDDPR-----
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTM---K-PG-SM-SV--E-A-FL-A-------------------------EANVMKTL--QHDKLVKLHAVVT------------------------------KEPIYIITEFMAKGSLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSASLVC----KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-------FGS--FTIKSDVWSFGILLMEIVTYGR-IPYPGM-SNPEVIRALERGYRMPRPENCP-------------------------------EELYNIMMRCWKNRPEERPT---FEYIQSV--L-----------
IGS----RKLGEGSFAKVREGLHV-------LTGEKVAIKVI---DKKR-AKKDT--Y-V-TKNLR-----------------------REGQIQQMI--RHPNITQLLDILET-----------------------------ENSYYLVMELCPGGNLMHKIY----EKK-----------------RLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLDEDNNI----KLIDFGLSNCAG--ILGYSDPFST---QCGSPAYAAPELLA-------RKK--YGPKIDVWSIGVNMYAMLT-GT-LPFTVE--PFSLRALYQKMVD-KEMNPLPTQ---LS------------------------TGAISFLRSLLEPDPVKRPN---IQQALANRWL-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTV---N-ES-AS-LRERI-E-FL-N-------------------------EASVMKGF--TCHHVVRLLGVVSK-----------------------------GQPTLVVMELMAHGDLKSYLR-----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAHDFTV----KIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMAPESLK-------DGV--FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFVMDGGYLDQPDNCP-------------------------------ERVTDLMRMCWQFNPKMRPT---FLEIVNLL-------------
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKL---AAMV-DITTE--ELK-QQFD------------------------QEIKVMAKC--QHENLVELLGFSSD-----------------------------GDDLCLVYVYMPNGSLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLDEAFTA----KISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--------GE--ITPKSDIYSFGVVLLEIIT-GL-PAVDEH-REPQLLLDIKEEIEDEEKTIEDYIDK-KMNDAD----------------STSVEAMYSVASQCLHEKKNKRPD---IKKVQQ----LLQ--------
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKL---SRPF-QSIIH--A-K-RTYR-------------------------ELRLLKHM--KHENVIGLLDVFTPARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVNEDCEL----KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML------NWMH--YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLILRLVGTPGAELLKKISS-ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT---AAQALAHAYF-----------
KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKML---QDCP-KAR-----------R-------------------------EVELHWRA-SQCPHIVRIVDVYENLY-------------------------AGRKCLLIVMECLDGGELFSRIQD--RGDQ-----------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYTSKRPNA-ILKLTDFGFAKE-----TTSHNSLTT---PCYTPYYVAPEVLG-------PEK--YDKSCDMWSLGVIMYILLC-GY-PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE-VS------------------------EEVKMLIRNLLKTEPTQRMT---ITEFMNHPWI-----------
---YRIRGEIGSGNFSQVKLGIHS-------LTKEKVAIKIL---DKTK-LDQKT--Q-R-LLSR-------------------------EISSMEKL--HHPNIIRLYEVVET-----------------------------LSKLHLVMEYAGGGELFGKIS----TEG-----------------KLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYTSNTCV----KVGDFGFSTV-----SKKGEMLNT---FCGSPPYAAPELFR------DEHY--IGIYVDIWALGVLLYFMVT-GT-MPFRAE----TVAKLKKSILEGTYSVPPHV-----S------------------------EPCHRLIRGVLQQIPTERYG---IDCIMNDEWM-----------
---YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKEL---DYGS-MTEAE--K-Q-MLVS-------------------------EVNLLREL--KHPNIVRYYDRIIDR---------------------------TNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV----KLGDFGLARIL----NHDTSFAKT---FVGTPYYMSPEQMN-------RMS--YNEKSDIWSLGCLLYELCA-LM-PPFTAF----SQKELAGKIREGKFRRIPYRY----S------------------------DELNEIITRMLNLKDYHRPS---VEEILENPL-I----------
--Y-MVLRMIGEGSFGRALLVQHE-------SSNQMFAMKEI---RLPK-SFSNT--Q-N--SRK-------------------------EAVLLAKM--KHPNIVAFKESFEA-----------------------------EGHLYIVMEYCDGGDLMQKIKQ--QKGK-----------------LFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLTQNGKV----KLGDFGSARLL----SNPMAFACT---YVGTPYYVPPEIWE-------NLP--YNNKSDIWSLGCILYELCT-LK-HPFQAN-SWKNLILKVCQGCISPLPSHYS-------------------------------YELQFLVKQMFKRNPSHRPS---ATTLLS----RGIV-------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKIL---EKRH-IIKEN--K-VPYVTR-------------------------ERDVMSRL--DHPFFVKLYFTFQD-----------------------------DEKLYFGLSYAKNGELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLNEDMHI----QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-------EKS--ACKSSDLWALGCIIYQLVA-GL-PPFRAG----NEYLIFQKIIKLEYDFPEKFF-----------------------------PKARDLVEKLLVLDATKRLG---CEEM------EGYGPLKAHPF
YDP---KDVIGRGVSSVVRRCVHR-------ATGHEFAVKIM---EVTA-ERLSP--E-Q-LEEVREA-------------------TRRETHILRQV-AGHPHIITLIDSYES-----------------------------SSFMFLVFDLMRKGELFDYLT----EKV-----------------ALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLDDNMQI----RLSDFGFSCH-----LEPGEKLRE---LCGTPGYLAPEILKCS-MDETHPG--YGKEVDLWACGVILFTLLA-GS-PPFWHR----RQILMLRMIMEGQYQFSSPEWDD-RS------------------------STVKDLISRLLQVDPEARLT---AEQALQHPFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKII---PHSR-VAKPH--Q-R-EKID------------------------KEIELHRIL--HHKHVVQFYHYFED-----------------------------KENIYILLEYCSRRSMAHILK----ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFINEAMEL----KVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-------KQG--HGCESDIWALGCVMYTMLL-GR-PPFETT----NLKETYRCIREARYTMPSSLL-----------------------------APAKHLIASMLSKNPEDRPS---LDDIIRHDFF-----------
-YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVI---PQSR-VAKPH--Q-R-EKIL------------------------NEIELHRDL--QHRHIVRFSHHFED-----------------------------ADNIYIFLELCSRKSLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFITENMEL----KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-------RQG--HGPEADVWSLGCVMYTLLC-GS-PPFETA----DLKETYRCIKQVHYTLPASLS-----------------------------LPARQLLAAILRASPRDRPS---IDQILRHDFF-----------
-PD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKII---DKLR-FPTKQ--E-S-QLRN-------------------------EVAILQNL--HHPGVVNLECMFET-----------------------------PERVFVVMEKLHGDMLEMILS---SEKG-----------------RLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLASADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------NKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDIHDQIQNAAFMYPPNPWKE-IS------------------------HEAIDLINNLLQVKMRKRYS---VDKTLSHPWL-----------
-PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVI---DKLR-FPTKQ--E-S-QLRN-------------------------EVAILQSL--RHPGIVNLECMFET-----------------------------PEKVFVVMEKLHGDMLEMILS---SEKG-----------------RLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLASADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLL-------NQG--YNRSLDMWSVGVIMYVSLS-GT-FPFNED------EDINDQIQNAAFMYPASPWSH-IS------------------------AGAIDLINNLLQVKMRKRYS---VDKSLSHPWL-----------
FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVI---DKMR-FPTKQ--E-S-QLRN-------------------------EVAILQNL--HHPGIVNLECMFET-----------------------------PERVFVVMEKLHGDMLEMILS---SEKS-----------------RLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLASAEPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------SKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDINDQIQNAAFMYPPNPWRE-IS------------------------GEAIDLINNLLQVKMRKRYS---VDKSLSHPWL-----------
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTC---K-NC-TS-DSVRE-K-FL-Q-------------------------EALTMRQF--DHPHIVKLIGVIT------------------------------ENPVWIIMELCTLGELRSFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSSNDCV----KLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-------FRR--FTSASDVWMFGVCMWEILMHGV-KPFQGV-KNNDVIGRIENGERLPMPPNCP-------------------------------PTLYSLMTKCWAYDPSRRPR---FTELKAQL-------------
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVI---DTKS-EEELE--D-Y-M--V-------------------------EIDILASC--DHPNIVKLLDAFYY-----------------------------ENNLWILIEFCAGGAVDAVML---ELER-----------------PLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFTLDGDI----KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCE--TSKDRP--YDYKADVWSLGITLIEMAE-IE-PPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS-----------------------------SNFKDFLKKCLEKNVDARWT---TSQLLQHPFV-----------
---WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVI---ETKS-EEELE--D-Y-I--V-------------------------EIEILATC--DHPYIVKLLGAYYH-----------------------------DGKLWIMIEFCPGGAVDAIML---ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMTLEGDI----RLADFGVSAKN----LKTLQKRDS---FIGTPYWMAPEVVMCE--TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PPHHEL-NPMRVLLKIAKSDPPTLLTPSKWS-----------------------------VEFRDFLKIALDKNPETRPS---AAQLLEHPFV-----------
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-EG-PM-GTELG-D-FL-R-------------------------EVSVMMNL--EHPHVLRLHGLVL------------------------------GQPLQMVMELAPLGSLHARLT-----AP-------------APTPPLLVALLCLFLRQLAGAMAYLGAR-----GLVHRDLATRNLLLASPRTI----KVADFGLVRPL-GG-A--RGRYVMGGPRPIPYAWCAPESLR-------HGA--FSSASDVWMFGVTLWEMFSGGE-EPWAGV-PPYLILQRLEDRARLPRPPLCS-------------------------------RALYSLALRCWAPHPADRPS---FSHLE----GLL---------
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