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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CSNK2A1 39
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
STE MAP2K1 68
CMGC MAPK11 24
CMGC MAPK14 24
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
TK SRC 270
TK TNK2 150
-YL--KGRLLGKGGFARCYEATDT----ETGS-AYAVKVIPQS--R-VAK---PH--QR-EKILNEIELHRDL-Q---HRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK---ARH---TLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMELKVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA----DLKETY-RCIKQVHYTLPASLS-----------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-----------
---FEIGRPLGKGKFGNVYLAREK----QSKF-ILALKVLFKA--QLEKA---GV--EH-QLRR-EVEIQSHL-R---HPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN----TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---YTKIEKIGEGTYGVVYKGRHK----TTGQ-VVAMKKIRLE--S-EEE---GV--PS-TAIR-EISLLKEL-R---HPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
---FQKVEKIGEGTYGVVYKARNK----LTGE-VVALKKIRLD--T-ETE---GV--PS-TAIR-EISLLKEL-N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
--Y-EPVAEIGVGAYGTVYKARDP----HSGH-FVALKSVRVP--N-GGGGGGGL--PI-STVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
---YECVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQ--T-GEE---GM--PL-STIR-EVAVLRHL-ETFEHPNVVRLFDVCT--VSR-TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP---GVPTETIKDMMFQLLRGLDFLHS-HRVVHRDLKPQNILVT-SSGQIKLADFGLARI-----YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FR-GS-SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-----------
---YQLVRKLGRGKYSEVFEAINI----TNNE-KVVVKILKPV--K-KKK---IK--R-------EIKILENLRG---GPNIITLADIVK--DP----VSRTPALVFEHVNNTDFKQLY------Q---TLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF-----------
---LTFVQEIGSGQFGLVHLGYWL-----NKD-KVAIKTIR-E--G-AM----SE--ED-FI-E-EAEVMMKL-S---HPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR----TQ-RGLFAAETLLGMCLDVCEGMAYLEE-ACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR-SNSEVVEDI-STGFRLYKPRLAS-------------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL-------------
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ-H--S-TE-----EHLRD-FE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH-KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDPLGDNTGA-LVAVKQLQ-H--S-GP----DQ-QRD-FQ-R-EIQILKAL-H---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH-RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DVPALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
---LKLVERLGAGQFGEVWMGYYN-----GHT-KVAVKSLK-Q--G-SM----SP--DA-FL-A-EANLMKQL-Q---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---FEKISELGAGNGGVVFKVSHK----PSGL--VMARKLIHL--E-IKP---AI--RN-QIIR-ELQVLHEC-N---SPYIVGFYGAFY--S------DGEISICMEHMDGGSLDQVLK---KAG---RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSG------QLIDSMANS---FVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAV-GRYP---------------IP-PP-DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-----------
LQG---LRPVGSGAYGSVCSAYDA----RLRQ-KVAVKKLSRP--F-QSL---IH--AR-RTYR-ELRLLKHL-K---HENVIGLLDVFT--PATSIEDFSEVYLVTTLMGA-DLNNIVK----CQ---ALSDEHVQFLVYQLLRGLKYIHS-AGIIHRDLKPSNVAVN-EDCELRILDFGLAR-------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKAL---------------FP-GS-DYIDQLKRI-MEVVGTPSPEVLAKISSEHARTYIQSLPPMP-------------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-----------
---YQNLSPVGSGAYGSVCAAFDT----KTGL-RVAVKKLSRP--F-QSI---IH--AK-RTYR-ELRLLKHM-K---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ---KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
--F-KFGKILGEGSFSTVVLAREL----ATSR-EYAIKILEKR--H-IIK---EN--KVPYVTR-ERDVMSRL-D---HPFFVKLYFTFQ--D------DEKLYFGLSYAKNGELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG----NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA----DTKE-VFAGKIVPKS--L-LLK---PH--QR-EKMSMEISIHRSL-A---HQHVVGFHGFFE--D------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS----CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL----TNNK-VYAAKIIPHS--R-VAK---PH--QR-EKIDKEIELHRIL-H---HKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK---ARK---VLTEPEVRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFIN-EAMELKVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FE-TT----NLKETY-RCIREARYTMPSSLL-----------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-----------
--L-RLEVKLGQGCFGEVWMGTWN-----GTT-RVAIKTLK-P--G-TM----SP--EA-FL-Q-EAQVMKKL-R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
--L-RLLEKLGDGSFGVVRRGEWD-APSGKTV-SVAVKCLK-PDVL-SQ----PEAMDD-FI-R-EVNAMHSL-D---HRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR----KH-QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLA-TRDLVKIGDFGLMRAL-PQ-N--DDHYVMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL-NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
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