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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CAMK DAPK1 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TK JAK2 849
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK15 13
CMGC MAPK3 42
CMGC MAPK8 26
TK MUSK 575
CMGC PCTK1 165
Other PLK1 53
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
Other TTK 525
TK TXK 271
TK YES1 277
YL--KGRLLGKGGFARC---YEATDT-----E-T-GS---AYAVKVIPQSR-VAK---PH--QREKIL-----NEIELHRDL-Q-----HRH-----IVRFSHHFE--D--------ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMEL-------------------KVGDFGLAARL-------EPPEQRKKT---ICGTPNYVAPEVLL-----------RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA--------------DLKETYRCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF---------
--ITMKHKLGGGQYGEV---YEGVWK-----K-Y-SL---TVAVKTLK-ED-TM----EV--EEFL-K------EAAVMKEI-K-----HPN-----LVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV-------------------KVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYELLEKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---------
--ITMKHKLGGGQYGEV---YVGVWK-----K-Y-SL---TVAVKTLK-ED-TM----EV--EEFL-K------EAAVMKEI-K-----HPN-----LVQLLGVCT--L--------EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHVV-------------------KVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA-----------YNTFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYDLLEKGYRMEQPEGCP---------------------------------------------------------------PKVYELMRACWKWSPADRPS-----FAETHQA--F---------
--FEIGRPLGKGKFGNV---YLAREK-----Q-S-KF---ILALKVLFKAQLEKA---GV--EHQLRR------EVEIQSHL-R-----HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGEL-------------------KIADFGWSV---------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN--------------TYQETYKRISRVEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI---------
--FEIGRPLGKGKFGNV---YLAREK-----K-S-HF---IVALKVLFKSQ-IEK---EG--VEHQLR-----REIEIQAHL-H-----HPN-----ILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL-------------------KIADFGWSV---------HAPSLRRKT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA--------------SHNETYRRIVKVDLKFPASVP-------------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV---------
--YTKIEKIGEGTYGVV---YKGRHK-----T-T-GQ---VVAMKKIRLES-EEE---GV--PSTAIR------EISLLKEL-R-----HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF-------GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF---------
--FQKVEKIGEGTYGVV---YKARNK-----L-T-GE---VVALKKIRLDT-ETE---GV--PSTAIR------EISLLKEL-N-----HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---------
--FQKVEKIGEGTYGVV---YKAKNR-----E-T-GQ---LVALKKIRLDL-EME---GV--PSTAIR------EISLLKEL-K-----HPN-----IVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI-------------------KLADFGLARAF-------GVPLRTYTH---EVVTLWYRAPEILL----------GSKFYTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD-----------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF---------
-Y-EPVAEIGVGAYGTV---YKARDP-----H-S-GH---FVALKSVRVPN-GGGGGGGL--PISTVR------EVALLRRL-EA--FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV-------------------KLADFGLARI--------YSYQMALTP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL---------
--YEKLEKIGEGTYGTV---FKAKNR-----E-T-HE---IVALKRVRLDD-DDE---GV--PSSALR------EICLLKEL-K-----HKN-----IVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF-------GIPVRCYSA---EVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF---------
--YECVAEIGEGAYGKV---FKARDL-----K-N-GG--RFVALKRVRVQT-GEE---GM--PLSTIR------EVAVLRHL-ET--FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNILVT--SSGQI-------------------KLADFGLARI--------YSFQMALTS---VVVTLWYRAPEVLL-----------QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FRGS-----------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF---------
--YEKLAKIGQGTFGEV---FKARHR-----K-T-GQ---KVALKKVLMEN-EKE---GF--PITALR------EIKILQLL-K-----HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL-------------------KLADFGLARAFSL---AKNSQPNRYTN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN-----------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---------
-W-DLVQTLGEGAYGEV---QLAVNR-----V-T-EE---AVAVKIVDMKR-AVD---CP--ENI-KK------EICINKML-N-----HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL-------------------KISDFGLATVFR-----YNNRERLLNK---MCGTLPYVAPELLK----------RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y--------
YI--MSKTLGSGACGEV---KLAFER-----K-T-CK---KVAIKIISKRK-FAI---GS--AREADPALNVETEIEILKKL-N-----HPC-----IIKIKNFF---D--------AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS--SQEEDC----------------LIKITDFGHSKI--------LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH-------------RTQVSLKDQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL---------
-W-EMRERLGTGGFGNV---CLYQHR-----E-L-DL---KIAIKSCRLEL-STK---NR--ER-WCH------EIQIMKKL-N-----HAN-----VVKACDVPE--ELN---ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-------------------------GL---KESQILSLLSDIGSGIRYLHE--NKIIHRDLKPENIVLQ--DVGGKI----------------IHKIIDLGYAKD--------VDQGSLCTS---FVGTLQYLAPELFE-----------NKPYTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ
--YEIVDTLGEGAFGKV---VECIDH-----K-AGGR---HVAVKIVKNVD-RYC---EA--ARS---------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG-------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA----------TYDDEHHST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FPTH-----------DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRIT-----LREALKHPFF---------
--YEIVSTLGEGTFGRV---VQCVDH-----R-R-GG--ARVALKIIKNVE-KYK---EA--AR---L------EINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN-------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT----------FDHEHHST---IVSTRHYRAPEVIL-----------ELGWSQPCDVWSIGCIIFEYYV-GFTL---------------FQTH-----------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF---------
--YEIVDTLGEGAFGKV---VECIDH-----GMD-GM---HVAVKIVKNVG-RYR---EA--ARS---------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS-------------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA----------TYDDEHHST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQTH-----------DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-----LDEALQHPFF---------
--YDTGEELGSGQFAVV---KKCREK-----S-T-GL---QYAAKFIKKRR-TKS---SR--RGVSREDI--EREVSILKEI-Q-----HPN-----VITLHEVYE--N--------KTDVI--LILELVAGG--ELFDFLA----EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--LQIAHFDLKPENIMLL--DRNVPKP---------------RIKIIDFGLAHK--------IDFGNEFKN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASP---------------FLGD--------------TKQETLANVSAVNYEFEDEYFSNTS---------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI---------
--YEIDSLIGKGSFGQV---VKAYDR-----V-E-QE---WVAIKIIKNKK-AFL---NQ--AQI---------EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ----------LGQRIYQ---YIQSRFYRSPEVLL-----------GMPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGA-----------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-----PYYALQHSFF---------
--YEIDSLIGKGSFGQV---VKAYDH-----Q-T-QE---LVAIKIIKNKK-AFL---NQ--AQI---------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ----------LGQRIYQ---YIQSRFYRSPEVLL-----------GTPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGS-----------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PLGALQHGFF---------
--ITLERRLGTGCFGDV---WLGTWN-------G-ST---KVAVKTLK-PG-TM----SP--KAFL-E------EAQVMKLL-R-----HDK-----LVQLYAVVS-----------EEPIY--IVTEFMCHG--SLLDFLK-----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG--ERLAC-------------------KIADFGLARLI-------K--DDEYNPCQGSKFPIKWTAPEAAL-----------FGRFTIKSDVWSFGILLTELITKGRIP---------------YPGM-----------NKREVLEQVEQGYHMPCPPGCP---------------------------------------------------------------ASLYEAMEQTWRLDPEERPT-----FEYLQSFL-----------
--LQLIKRLGNGQFGEV---WMGTWN-------G-NT---KVAIKTLK-PG-TM----SP--ESFL-E------EAQIMKKL-K-----HDK-----LVQLYAVVS-----------EEPIY--IVTEYMNKG--SLLDFLK-----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--MNYIHRDLRSANILVG--NGLIC-------------------KIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-----------NNREVLEQVERGYRMPCPQDCP---------------------------------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-----------
--YTDTKVIGNGSFGVV---YQAKLC-----D-S-GE---LVAIKKVLQDK-RFK---NR--------------ELQIMRKL-D-----HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL-------------------KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---------
--LKLEKKLGAGQFGEV---WMATYN-------K-HT---KVAVKTMK-PG-SM----SV--EAFL-A------EANVMKTL-Q-----HDK-----LVKLHAVVT-----------KEPIY--IITEFMAKG--SLLDFLK-----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS--ASLVC-------------------KIADFGLARVI-------E--DNEYTAREGAKFPIKWTAPEAIN-----------FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-----------SNPEVIRALERGYRMPRPENCP---------------------------------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L---------
--LKFLQQLGKGNFGSV---EMCRYDP-LQDN-T-GE---VVAVKKLQ-HS-TE-----EHLRDFE-R------EIEILKSL-Q-----HDN-----IVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV-------------------KIGDFGLTKVL--PQ---D--KEYYKVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELLKNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV-------
--LKLVERLGAGQFGEV---WMGYYN-------G-HT---KVAVKSLK-QG-SM----SP--DAFL-A------EANLMKQL-Q-----HQR-----LVRLYAVVT-----------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS--DTLSC-------------------KIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNLERGYRMVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---------
--IKLVKRLGAGQFGEV---WMGYYN-------N-ST---KVAVKTLK-PG-TM----SV--QAFL-E------EANLMKTL-Q-----HDK-----LVRLYAVVT--R--------EEPIY--IITEYMAKG--SLLDFLK-----SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER--KNYIHRDLRAANVLVS--ESLMC-------------------KIADFGLARVI-------E--DNEYTAREGAKFPIKWTAPEAIN-----------FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-----------TNADVMTALSQGYRMPRVENCP---------------------------------------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L---------
--YTNLSYIGEGAYGMV---CSAYDN-----V-N-KV---RVAIKKISPFE-HQT---YC--QRT-LR------EIKILLRF-R-----HEN-----IIGINDIIR--APT---IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDL-------------------KICDFGLARVAD----PDHDHTGFLTE---YVATRWYRAPEIML----------NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL---------
--YQNLKPIGSGAQGIV---CAAYDA-----V-L-DR---NVAIKKLSRPF-QNQ---TH--AKRAYR------ELVLMKCV-N-----HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI---------
--YQNLSPVGSGAYGSV---CAAFDT-----K-T-GL---RVAVKKLSRPF-QSI---IH--AKRTYR------ELRLLKHM-K-----HEN-----VIGLLDVFT--PARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL-------------------KILDFGLAR----------HTDDEMTG---YVATRWYRAPEIML----------NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF---------
YL--LRRQLGQGAYGIV---WKAVDR-----R-T-GE---VVAIKKIFDAF-RDK---TD--AQRTFR------EITLLQEFGD-----HPN-----IISLLDVIR--AE------NDRDIY--LVFEFMDT---DLNAVIR----KGG-------------------------LL---QDVHVRSIFYQLLRATRFLHS--GHVVHRDQKPSNVLLD--ANCTV-------------------KLCDFGLARSLGD--LPEGPEDQAVTE---YVATRWYRAPEVLL----------SSHRYTLGVDMWSLGCILGEMLR-GRPL---------------FPGT-----------STLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRP--------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDKRLS-----ATQALQHPYV---------
--YTQLQYIGEGAYGMV---SSAYDH-----V-R-KT---RVAIKKISPFE-HQT---YC--QRT-LR------EIQILLRF-R-----HEN-----VIGIRDILR--AST---LEAMRDVY--IVQDLMET---DLYKLLK-----SQ-------------------------QL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLIN--TTCDL-------------------KICDFGLARIAD----PEHDHTGFLTE---YVATRWYRAPEIML----------NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKT---------------------------------KVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT-----VEEALAHPYL---------
--YQNLKPIGSGAQGIV---CAAYDA-----I-L-ER---NVAIKKLSRPF-QNQ---TH--AKRAYR------ELVLMKCV-N-----HKN-----IIGLLNVFT--PQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI---------
-I-EYVRDIGEGAFGRV---FQARAPGLLPYE-P-FT---MVAVKMLK-EE-AS----ADMQADFQ-R------EAALMAEF-D-----NPN-----IVKLLGVCA--V--------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVG--ENMVV-------------------KIADFGLSRNI---Y---S--ADYYKANENDAIPIRWMPPESIF-----------YNRYTTESDVWAYGVVLWEIFSYGLQP---------------YYGM-----------AHEEVIYYVRDGNILSCPENCP---------------------------------------------------------------VELYNLMRLCWSKLPADRPS-----FTSIHRIL-----------
-Y-IKLDKLGEGTYATV---YKGKSK-----L-T-DN---LVALKEIRLEH-EEG---AP--C-TAIR------EVSLLKDL-K-----HAN-----IVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL-------------------KLADFGLARAK-------SIPTKTYSN---EVVTLWYRPPDILL----------GSTDYSTQIDMWGVGCIFYEMAT-GRPL---------------FPGS-----------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AEDAMKHPFF---------
YV--RGRFLGKGGFAKC---FEISDA-----D-T-KE---VFAGKIVPKSL-LLK---PH--QREKMS-----MEISIHRSL-A-----HQH-----VVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK----RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN--EDLEV-------------------KIGDFGLATKV-------EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS--------------CLKETYLRIKKNEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF---------
--FELLKVLGQGSFGKVFLVRKVTRP-----D-S-GH---LYAMKVLKKAT-LKV---RD--RVRTKM------ERDILADV-N-----HPF-----VVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MF---TEEDVKFYLAELALGLDHLHS--LGIIYRDLKPENILLD--EEGHI-------------------KLTDFGLSKEA-------IDHEKKAYS---FCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK--------------DRKETMTLILKAKLGMPQFLS-------------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY-------
--FELLKVLGQGSYGKV---FLVRKV-----K-G-SDAGQLYAMKVLKKAT-LKV---RD--RVRSKM------ERDILAEV-N-----HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD--EEGHI-------------------KITDFGLSKEA-------IDHDKRAYS---FCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GSLP---------------FQGK--------------DRKETMALILKAKLGMPQFLS-------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF---------
--FELLKVLGQGSFGKV---FLVRKK-----T-G-PDAGQLYAMKVLKKAS-LKV---RD--RVRTKM------ERDILVEV-N-----HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DVFTRLS----KEV-------------------------LF---TEEDVKFYLAELALALDHLHQ--LGIVYRDLKPENILLD--EIGHI-------------------KLTDFGLSKES-------VDQEKKAYS---FCGTVEYMAPEVVN-----------RRGHSQSADWWSYGVLMFEMLT-GTLP---------------FQGK--------------DRNETMNMILKAKLGMPQFLS-------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF---------
--WEIIGELGDGAFGKV---YKAQNK-----E-T-SV---LAAAKVIDTKS-EEE---LE--DYM--V------EIDILASC-D-----HPN-----IVKLLDAFY--Y--------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI-------------------KLADFGVSAKN-------TRTIQRRDS---FIGTPYWMAPEVVMCE------TSKDRPYDYKADVWSLGITLIEMAE-IEPP---------------HHEL-----------NPMRVLLKIAKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV---------
-L-RLEVKLGQGCFGEV---WMGTWN-------G-TT---RVAIKTLK-PG-TM----SP--EAFL-Q------EAQVMKKL-R-----HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC-------------------KVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-----------VNREVLDQVERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---------
--YSILKQIGSGGSSKV---FQVLNE-----K-K-Q----IYAIKYVNLEE-ADN---QT--LDSYRN------EIAYLNKLQQ----HSDK-----IIRLYDYEI--T--------DQYIY--MVMECGNI---DLNSWLK----KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML-------------------KLIDFGIANQMQ-----PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTP---------------FQQI-------------INQISKLHAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV---------
-L-AFIKEIGSGQFGVV---HLGEWR-------S-HI---QVAIKAIN-EG-SM----SE--EDFI-E------EAKVMMKL-S-----HSK-----LVQLYGVCI--Q--------RKPLY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER--NGYIHRDLAARNCLVS--STCIV-------------------KISDFGMTRYV-------L--DDEYVSSFGAKFPIKWSPPEVFL-----------FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-----------SNLQVVEAISEGFRLYRPHLAP---------------------------------------------------------------MSIYEVMYSCWHEKPEGRPT-----FAELLR---AV--------
-L-RLEVKLGQGCFGEV---WMGTWN-------G-TT---KVAIKTLK-PG-TM----MP--EAFL-Q------EAQIMKKL-R-----HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC-------------------KIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-----------VNREVLEQVERGYRMPCPQGCP---------------------------------------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL-----------
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