|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TK BLK 241
TKL BRAF 456
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB6 670
TK ERBB2 720
TK FES 561
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK1 212
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CMGC MAPK14 24
TK MUSK 575
Other NEK2 8
Other NEK3 4
CMGC NLK 126
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
Other PLK1 53
Other PLK2 82
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
TK SRC 270
STE STK10 36
TK SYK 371
TK TNK1 116
TK TNK2 150
TK YES1 277
--YL--KGRLLGKGGFARC---YEATDT----------------ETGS---AYAVKVI---PQS--RVAKPH---Q-REKIL---NEIELHRDL-QHRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK----ARH----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFITE---NMEL----KVGDFGLAARL------------EPPEQRK--------------KT---ICGTPNYVAPEVLL-----RQG---HGPEADVWSLGCVMYTLLC-GS-PP---------------FETA------DLKETY----RC----IKQ----VHYTLPASLS-----------------------------------------LPARQ-LLAAILRASPRDRPS-----IDQILRHDFF----
----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAVKTL---K-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGE---NHLV----KVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR----MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F----
----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAVKTL---K-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGE---NHVV----KVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYDLL----EK----GYR----MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F----
---I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAVKTL---P-E--VCS-EQD-EL-DFL-M----EALIISKF-NHQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR-----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLTCPGPGRVA----KIGDFGMARDI------Y-----R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR----MDPPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I----
---L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAIKTL---K-E--GTM-SP---E-AFL-G----EANVMKAL-QHERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM-----NSIHRDLRAANILVSE---ALCC----KIADFGLARII---------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR----MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L----
----ITVGQRIGSGSFGTV---YKGKWH-------------------G---DVAVKML---N-V-TAPT-PQQ-LQ-AFK-N----EVGVLRKT-RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK-----SIIHRDLKSNNIFLHE---DLTV----KIGDFGLATVK------S-----R--WSGS--------------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNI-N-NRDQIIFMV----GR----GYLSPDLSKVRSNCP-------------------------------------------KAMKR-LMAECLKKKRDERPL-----FPQILA---SI---
----FQKVEKIGEGTYGVV---YKARNK----------------LTGE---VVALKKI---RLD--TETEGV---P-STAIR----EISLLKEL-NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA--SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINT---EGAI----KLADFGLARAF------------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD---SEIDQLFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF----
----YEKLEKIGEGTYGTV---FKAKNR----------------ETHE---IVALKRV---RLD--DDDEGV---P-SSALR----EICLLKEL-KHKNIVRLHDVLH--S------DKKLTLVFEFCDQ-DLKKYFD---SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLINR---NGEL----KLADFGLARAF------------GIPVRCY--------------SA---EVVTLWYRPPDVLF----GAKL---YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN---DVDDQLKRI----FR----LLG----TPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AEEALQHPYF----
---W-DLVQTLGEGAYGEV---QLAVNR----------------VTEE---AVAVKIV---DMK--RAVDCP---E-NI-KK----EICINKML-NHENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE----PDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLDE---RDNL----KISDFGLATVFR----------YNNRERLL--------------NK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GE-LP---------------WDQP-----SDSCQEY----SD----WKE----KKTYLNPWKKI--D-------------------------------------SAPLA-LLHKILVENPSARIT-----IPDIKKDRW-Y---
----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAVKML---K-S--TAH-ADE-KE-ALM-S----ELKIMSHLGQHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK-----NCIHRDVAARNVLLTN---GHVA----KIGDFGLARDI------M-----N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT-----FQQICSFL------
----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAVKCI---K-N--DAT-AQ-----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR-----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN-----NFVHRDLAARNVLVSE---DNVA----KVSDFGLTKEA------------------S--------------STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---PLKDVVPRV----EK----GYK----MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL------
----YDTGEELGSGQFAVV---KKCREK----------------STGL---QYAAKFI---KKR--RTKSSR---R-GVSREDIEREVSILKEI-QHPNVITLHEVYE--N------KTDVILILELVAGGELFDFLA----EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLD---RNVPKPRIKIIDFGLAHK-------------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FLGD------TKQETL----AN----VSA----VNYEFEDEYFSNTS-------------------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI----
----YEMGEELGSGQFAIV---RKCRQK----------------GTGK---EYAAKFI---KKR--RLSSSR---R-GVSREEIEREVNILREI-RHPNIITLHDIFE--N------KTDVVLILELVSGGELFDFLA----EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLLD---KNVPNPRIKLIDFGIAHK-------------IEAGNEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FLGE------TKQETL----TN----ISA----VNYDFDEEYFSNTS-------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI----
----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKIL---R-P--DAT-KNA-RN-DFL-K----EVKIMSRL-KDPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL-----NFVHRDLATRNCLVGE---NFTI----KIADFGMSRNL------Y-----A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL------
----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAVKML---R-A--DAN-KNA-RN-DFL-K----EIKIMSRL-KDPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL-----NFVHRDLATRNCLVGK---NYTI----KIADFGMSRNL------Y-----S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL---
---F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAIKEL---R-E--ATS-PKA-NK-EIL-D----EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKT---PQHV----KITDFGLAKLL------G-----A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF--
----IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAIKAL---K-A--GYT-ERQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR-----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL-----GYVHRDLAARNVLVDS---NLVC----KVSDFGLSRVL------E-----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM---TNRDVISSV----EE----GYR----LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR-----FSQIVSVL------
---V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAIKTL---K-A--GYS-EKQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR-----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM-----NYVHRDLAARNILVNS---NLVC----KVSDFGLSRYLQ---DDT-----S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL------
---V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAIKTL---K-S--GYT-EKQ-RR-DFL-S----EASIMGQF-DHPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR-----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM-----NYVHRDLAARNILVNS---NLVC----KVSDFGLSRFLE---DDT-----S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---TNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL------
----IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAIQAL---W-A--GGA-ESL-QM-TFL-G----RAAVLGQF-QHPNILRLEGVVT--K------SRPLMVLTEFMELGPLDSFLR-----QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF-----AFVHRSLSAHSVLVNS---HLVC----KVARLGHSPQG--------------------------------------PSCLLRWAAPEVIA-----HGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR----LPPPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF---
---L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAIKVL---R-E--NTS-PKA-NK-EIL-D----EAYVMAGV-GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR-----EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV-----RLVHRDLAARNVLVKS---PNHV----KITDFGLARLL------D-----I--DETE--------------YHADGGKVPIKWMALESIL-----RRR---FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI---PAREIPDLL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPR-----FRELVSE--F----
---L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAVKSC---R-E--TLP-PDL-KA-KFL-Q----EARILKQY-SHPNIVRLIGVCT--Q------KQPIYIVMELVQGGDFLTFLR-----TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK-----CCIHRDLAARNCLVTE---KNVL----KISDFGMSREE------A-----D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR----LPCPELCP-------------------------------------------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL------
----IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAVKTL---K-P--GSM-DP---N-DFL-R----EAQIMKNL-RHPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR-----NYIHRDLAARNVLVGE---HNIY----KVADFGLARVFK----VD-----N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----SNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM---TGAQVIQML----AQ----NYR----LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L----
----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAIKTL---K-P--GTM-SP---E-SFL-E----EAQIMKKL-KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM-----NYIHRDLRSANILVGN---GLIC----KIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL------
----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAVKTM---K-P--GSM-SV---E-AFL-A----EANVMKTL-QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSA---SLVC----KIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR----MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L----
----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAIKTV---N-E--AAS-MRE-RI-EFL-N----EASVMKEF-NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR-----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAE---DFTV----KIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL---SNEQVLRFV----ME----GGL----LDKPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I----
----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAVKTV---N-E--SAS-LRE-RI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR-----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAH---DFTV----KIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MD----GGY----LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL------
FSEE----LKIGEGGFGCV---YRAVMR----------------NTV-----YAVKRL---KEN--ADLEWT---A-VKQSFL--TEVEQLSRF-RHPNIVDFAGYCA--Q------NGFYCLVYGFLPNGSLEDRLHCQTQACP----------------------------------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS---PSLIHGDIKSSNVLLDE---RLTP----KLGDFGLARFSRFAG---SSPSQSSMVART--------------QT---VRGTLAYLPEEYIK-----TGR---LAVDTDTFSFGVVVLETLA-GQ-RA---------------VKTHG-AR-TKYLKDL----VE----EEA----EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQ-LACCCLHRRAKRRPP-----MTQVYE----RL--
-VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAVKKL---AAM--VDITTE---ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSC-LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLDE---AFTA----KISDFGLARASE----------KFAQTVMT--------------SR---IVGTTAYMAPEALR------GE---ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH---REPQLLLDI----KE----EIE----DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ-
----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAIKTI---R-E--GAM-SE---E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR-----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA-----CVIHRDLAARNCLVGE---NQVI----KVSDFGMTRFV------------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR----LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL------
----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAVKKL---Q-H--STE--EH-LR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK-----RYIHRDLATRNILVEN---ENRV----KIGDFGLTKVL-----PQ-----D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV--
---L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAVKQL---Q-H--SGP-DQ--QR-DFQ-R----EIQILKAL-HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR-----RCVHRDLAARNILVES---EAHV----KIADFGLAKLL-----PL-----D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EE----GQR----LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL---
----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAVKML---K-P--SAH-LTE-RE-ALM-S----ELKVLSYLGNHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK-----NCIHRDLAARNILLTH---GRIT----KICDFGLARDI------K-----N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P-VDSKFYKMI----KE----GFR----MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I----
----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAVKSL---K-Q--GSM-SP---D-AFL-A----EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSD---TLSC----KIADFGLARLI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR----MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L----
---V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAIKTL---P-E--LCS-PQD-EL-DFL-M----EALIISKF-RHQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR-----HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN-----HFIHRDIAARNCLLSCAGPSRVA----KIGDFGMARDI------Y-----R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR----MDPPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPS-----FASILERL------
----IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAVKTL---K-P--GTM-SV---Q-AFL-E----EANLMKTL-QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK-----NYIHRDLRAANVLVSE---SLMC----KIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR---TNADVMTAL----SQ----GYR----MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L----
----YQNLSPVGSGAYGSV---CAAFDT----------------KTGL---RVAVKKL---SRP--FQSIIH---A-KRTYR----ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVNE---DCEL----KILDFGLAR---------------HTDDEM--------------TG---YVATRWYRAPEIML----NWMH---YNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT---DHIDQLKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF----
---I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAVKML---K-E--EAS-ADM-QA-DFQ-R----EAALMAEF-DNPNIVKLLGVCA--V------GKPMCLLFEYMAYGDLNEFLR-----SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER-----KFVHRDLATRNCLVGE---NMVV----KIADFGLSRNI------Y-----S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RD----GNI----LSCPENCP-------------------------------------------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL------
----YEVLYTIGTGSYGRC---QKIRRK----------------SDGK---ILVWKEL---DYG--SMTEAE---K-QMLVS----EVNLLREL-KHPNIVRYYDRII--DR----TNTTLYIVMEYCEGGDLASVITKGTKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG---KQNV----KLGDFGLARIL------------NHDTSFA--------------KT---FVGTPYYMSPEQMN-----RMS---YNEKSDIWSLGCLLYELCA-LM-PP---------------FTAF------SQKELA----GK----IRE----GKFRRIPYRY---S-------------------------------------DELNE-IITRMLNLKDYHRPS-----VEEILENPL-I---
---Y-MVLRMIGEGSFGRA---LLVQHE----------------SSNQ---MFAMKEI---RLP--KSFSNT---Q-N-SRK----EAVLLAKM-KHPNIVAFKESFE--A------EGHLYIVMEYCDGGDLMQKIKQ--QKGK----------------------------------------------------------------------------------------------------LFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLTQ---NGKV----KLGDFGSARLL------------SNPMAFA--------------CT---YVGTPYYVPPEIWE-----NLP---YNNKSDIWSLGCILYELCT-LK-HP---------------FQAN---SWKNLILKV----CQ----GCI----SPLPSHYS-------------------------------------------YELQF-LVKQMFKRNPSHRPS-----ATTLLS----RGIV
-IEP---DRPIGYGAFGVV---WSVTDP----------------RDGK---RVALKKM---PNV--FQNLVS---C-KRVFR----ELKMLCFF-KHDNVLSALDILQ--PPH-IDYFEEIYVVTELMQS-DLHKIIV----SPQ----------------------------------------------------------------------------------------------------PLSSDHVKVFLYQILRGLKYLHSA-----GILHRDIKPGNLLVNS---NCVL----KICDFGLARVE-----------ELDESRHM--------------TQ---EVVTQYYRAPEILM----GSRH---YSNAIDIWSVGCIFAELLG-RR-IL---------------FQAQ---SPIQQLDLI----TD----LLG----TPSLEAMRTACEGAKAHILRGPHKQP------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSKRIS-----AKDALAHPYL----
--IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAVKAL---K-E--ASE-SA--RQ-DFQ-R----EAELLTML-QHQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR-----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL-----HFVHRDLATRNCLVGQ---GLVV----KIGDFGMSRDI------Y-----S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---SNTEAIDCI----TQ----GRE----LERPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL------
---I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAVKTL---K-D--ASD-NA--RK-DFH-R----EAELLTNL-QHEHIVKFYGVCV--E------GDPLIMVFEYMKHGDLNKFLR-----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ-----HFVHRDLATRNCLVGE---NLLV----KIGDFGMSRDV------Y-----S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV----LQRPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L----
---I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAVKAL---K-D--PTL-AA--RK-DFQ-R----EAELLTNL-QHEHIVKFYGVCG--D------GDPLIMVFEYMKHGDLNKFLR-----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ-----HFVHRDLATRNCLVGA---NLLV----KIGDFGMSRDV------Y-----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQ----GRV----LERPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL------
---L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAVKML---K-P--TAR-SSE-KQ-ALM-S----ELKIMTHLGPHLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK-----NCVHRDLAARNVLLAQ---GKIV----KICDFGLARDI------M-----H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M-VDSTFYNKI----KS----GYR----MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV---
---L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAVKML---K-S--TAR-SSE-KQ-ALM-S----ELKIMSHLGPHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK-----NCVHRDLAARNVLICE---GKLV----KICDFGLARDI------M-----R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P-MNEQFYNAI----KR----GYR----MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL---
--YV--RGRFLGKGGFAKC---FEISDA----------------DTKE---VFAGKIV---PKS--LLLKPH---Q-REKMS---MEISIHRSL-AHQHVVGFHGFFE--D------NDFVFVVLELCRRRSLLELHK----RRK----------------------------------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNE---DLEV----KIGDFGLATKV------------EYDGERK--------------KT---LCGTPNYIAPEVLS-----KKG---HSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS------CLKETY----LR----IKK----NEYSIPKHIN-----------------------------------------PVAAS-LIQKMLQTDPTARPT-----INELLNDEFF----
---Y-CRGKVLGKGGFAKC---YEMTDL----------------TNNK---VYAAKII---PHS--RVAKPH---Q-REKID---KEIELHRIL-HHKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK----ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFINE---AMEL----KVGDFGLAARL------------EPLEHRR--------------RT---ICGTPNYLSPEVLN-----KQG---HGCESDIWALGCVMYTMLL-GR-PP---------------FETT------NLKETY----RC----IRE----ARYTMPSSLL-----------------------------------------APAKH-LIASMLSKNPEDRPS-----LDDIIRHDFF----
----IELGRCIGEGQFGDV---HQGIYM-------------SPENPAL---AVAIKTC---K-N--CTS-DSV-RE-KFL-Q----EALTMRQF-DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ-----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSS---NDCV----KLGDFGLSRYM------------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----EN----GER----LPMPPNCP-------------------------------------------PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL------
---V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAVKTC---K-K--DCT-LDN-KE-KFM-S----EAVIMKNL-DHPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE-----RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVAS---PECV----KLGDFGLSRYI------------E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRR---FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL---ENKDVIGVL----EK----GDR----LPKPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L----
--VM--LSTRIGSGSFGTV---YKGKWH-------------------G---DVAVKIL---K-V-VDPT-PEQ-FQ-AFR-N----EVAVLRKT-RHVNILLFMGYMT---------KDNLAIVTQWCEGSSLYKHLH-----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK-----NIIHRDMKSNNIFLHE---GLTV----KIGDFGLATVK------S-----R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHI-N-NRDQIIFMV----GR----GYASPDLSKLYKNCP-------------------------------------------KAMKR-LVADCVKKVKEERPL-----FPQILSS--I----
---L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAVKML---K-E--NAS-PSE-LR-DLL-S----EFNVLKQV-NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVAE---GRKM----KISDFGLSRDV------Y-----E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR----MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL------
----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAMKVL---KKA--TLKVRD---R-VRTKM----ERDILADV-NHPFVVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS----KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLDE---EGHI----KLTDFGLSKEA------------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RQG---HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK------DRKETM----TL----ILK----AKLGMPQFLS-----------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAMKVL---KKA--TLKVRD---R-VRSKM----ERDILAEV-NHPFIVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS----KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLDE---EGHI----KITDFGLSKEA------------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----RRG---HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK------DRKETM----AL----ILK----AKLGMPQFLS-----------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF----
----FELLKVLGQGSFGKV---FLVRKK----------------TGPDAGQLYAMKVL---KKA--SLKVRD---R-VRTKM----ERDILVEV-NHPFIVKLHYAFQ--T------EGKLYLILDFLRGGDVFTRLS----KEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLDE---IGHI----KLTDFGLSKES------------VDQEKKA--------------YS---FCGTVEYMAPEVVN-----RRG---HSQSADWWSYGVLMFEMLT-GT-LP---------------FQGK------DRNETM----NM----ILK----AKLGMPQFLS-----------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAIKTL---K-P--GTM-SP---E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGE---NLVC----KVADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR----MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L----
----WEIVGELGDGAFGKV---YKAKNK----------------ETGA---LAAAKVI---ETK--SEEELE---D-YI--V----EIEILATC-DHPYIVKLLGAYY--H------DGKLWIMIEFCPGGAVDAIML---ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMTL---EGDI----RLADFGVSAKN------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL---NPMRVLLKI----AK----SDP----PTLLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV----
-TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAVKIL---K-N--EAN-DPALKD-ELL-A----EANVMQQL-DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES-----NFVHRDLAARNVLLVT---QHYA----KISDFGLSKAL------R-----A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EK----GER----MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL--
-VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAVKSLRVGP-E--GPM-GTE-LG-DFL-R----EVSVMMNL-EHPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT-----AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR-----GLVHRDLATRNLLLAS---PRTI----KVADFGLVRPL-----GG-----A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----ED----RAR----LPRPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL--
---L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAVKCL---K-PDVLSQ-PEA-MD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLAT---RDLV----KIGDFGLMRAL-----PQ-----N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER----LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAIKTL---K-P--GTM-MP---E-AFL-Q----EAQIMKKL-RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM-----NYIHRDLRAANILVGE---NLVC----KIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL------
|