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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CLK1 161
CMGC CLK4 159
CMGC DYRK1A 150
CMGC DYRK1B 111
Other EIF2AK2 267
CMGC GSK3B 56
TK INSR 1023
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
TK MUSK 575
TK NTRK2 538
CMGC PCTK1 165
STE SLK 34
Other TTK 525
YL--KGRLLGKGGFARCYEATDT-----E-T-GS-AYAVKVIPQSRVAK---PH--QREKILNEIELHRDL-Q---HRH-----IVRFSHHFED-----------------------------ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMEL-------------------KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL-----------RQGHGPEADVWSLGCVMYTLLC-GS-PPFETA---DLKETYRCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF---
--ITMKHKLGGGQYGEVYEGVWK-----K-Y-SL-TVAVKTLK-EDTM----EV--EEFL-K-EAAVMKEI-K---HPN-----LVQLLGVCTR-----------------------------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV-------------------KVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQVYELLEKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
--YTKIEKIGEGTYGVVYKGRHK-----T-T-GQ-VVAMKKIRLESEEE---GV--PSTAIR-EISLLKEL-R---HPN-----IVSLQDVLMQ-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
--FQKVEKIGEGTYGVVYKARNK-----L-T-GE-VVALKKIRLDTETE---GV--PSTAIR-EISLLKEL-N---HPN-----IVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--FQKVEKIGEGTYGVVYKAKNR-----E-T-GQ-LVALKKIRLDLEME---GV--PSTAIR-EISLLKEL-K---HPN-----IVRLLDVVHN-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI-------------------KLADFGLARAF-----GVPLRTYTH---EVVTLWYRAPEILL----------GSKFYTTAVDIWSIGCIFAEMVT-RK-ALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF---
-Y-EPVAEIGVGAYGTVYKARDP-----H-S-GH-FVALKSVRVPNGGGGGGGL--PISTVR-EVALLRRL-EAFEHPN-----VVRLMDVCATSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV-------------------KLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RK-PLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---
--YEKLEKIGEGTYGTVFKAKNR-----E-T-HE-IVALKRVRLDDDDE---GV--PSSALR-EICLLKEL-K---HKN-----IVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF-----GIPVRCYSA---EVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGR-PLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF---
--YECVAEIGEGAYGKVFKARDL-----K-N-GGRFVALKRVRVQTGEE---GM--PLSTIR-EVAVLRHL-ETFEHPN-----VVRLFDVCTVSR------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNILVT--SSGQI-------------------KLADFGLARI------YSFQMALTS---VVVTLWYRAPEVLL-----------QSSYATPVDLWSVGCIFAEMFR-RK-PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF---
--YEKLAKIGQGTFGEVFKARHR-----K-T-GQ-KVALKKVLMENEKE---GF--PITALR-EIKILQLL-K---HEN-----VVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL-------------------KLADFGLARAFSL-AKNSQPNRYTN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF---
--YEIVDTLGEGAFGKVVECIDH-----K-AGGR-HVAVKIVKNVDRYC---EA--ARS----EIQVLEHL-NT-TDPNST-FRCVQMLEWFEH-----------------------------HGHIC--IVFELLGL---STYDFIK----ENG-------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA--------TYDDEHHST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GF-TVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF---
--YEIVDTLGEGAFGKVVECIDH-----GMD-GM-HVAVKIVKNVGRYR---EA--ARS----EIQVLEHL-NS-TDPNSV-FRCVQMLEWFDH-----------------------------HGHVC--IVFELLGL---STYDFIK----ENS-------------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHHST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GF-TVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF---
--YEIDSLIGKGSFGQVVKAYDR-----V-E-QE-WVAIKIIKNKKAFL---NQ--AQI----EVRLLELMNK---HDTEMKYYIVHLKRHFMF-----------------------------RNHLC--LVFEMLSY---NLYDLLR-----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ--------LGQRIYQ---YIQSRFYRSPEVLL-----------GMPYDLAIDMWSLGCILVEMHT-GE-PLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF---
--YEIDSLIGKGSFGQVVKAYDH-----Q-T-QE-LVAIKIIKNKKAFL---NQ--AQI----ELRLLELMNQ---HDTEMKYYIVHLKRHFMF-----------------------------RNHLC--LVFELLSY---NLYDLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ--------LGQRIYQ---YIQSRFYRSPEVLL-----------GTPYDLAIDMWSLGCILVEMHT-GE-PLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF---
-F-KEIELIGSGGFGQVFKAKHR-----I-D-GK-TYVIKRVKYNNEKA---ER---------EVKALAKL-D---HVN-----IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-------------------------KL---DKVLALELFEQITKGVDYIHS--KKLIHRDLKPSNIFLV--DTKQV-------------------KIGDFGLVTS------LKNDGKRTR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK--------------------------------------------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT
--YTDTKVIGNGSFGVVYQAKLC-----D-S-GE-LVAIKKVLQDKRFK---NR---------ELQIMRKL-D---HCN-----IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL-------------------KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---
--ITLLRELGQGSFGMVYEGNARDIIKGE-A-ET-RVAVKTVN-ESAS----LRERIEFL-N-EASVMKGF-T---CHH-----VVRLLGVVSK-----------------------------GQPTL--VVMELMAHG--DLKSYLR-----SLRPEA--------------ENNPGRPPP---TLQEMIQMAAEIADGMAYLNA--KKFVHRDLAARNCMVA--HDFTV-------------------KIGDFGMTRDI--Y--E--TDYYRKGGKGLLPVRWMAPESLK-----------DGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNEQVLKFVMDGGYLDQPDNCP---------------------------------------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
--YTNLSYIGEGAYGMVCSAYDN-----V-N-KV-RVAIKKISPFEHQT---YC--QRT-LR-EIKILLRF-R---HEN-----IIGINDIIRAPT------------------------IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDL-------------------KICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIML----------NSKGYTKSIDIWSVGCILAEMLS-NR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL---
--YQNLKPIGSGAQGIVCAAYDA-----V-L-DR-NVAIKKLSRPFQNQ---TH--AKRAYR-ELVLMKCV-N---HKN-----IISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-ILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---
--YQNLSPVGSGAYGSVCAAFDT-----K-T-GL-RVAVKKLSRPFQSI---IH--AKRTYR-ELRLLKHM-K---HEN-----VIGLLDVFTPARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL-------------------KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML----------NWMHYNQTVDIWSVGCIMAELLT-GR-TLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---
-I-EYVRDIGEGAFGRVFQARAPGLLPYE-P-FT-MVAVKMLK-EEAS----ADMQADFQ-R-EAALMAEF-D---NPN-----IVKLLGVCAV-----------------------------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVG--ENMVV-------------------KIADFGLSRNI--Y--S--ADYYKANENDAIPIRWMPPESIF-----------YNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHEEVIYYVRDGNILSCPENCP---------------------------------------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL-----
-I-VLKRELGEGAFGKVFLAECYNLCPEQ-D-KI-LVAVKTLK-DASD----NA-RKDFH-R-EAELLTNL-Q---HEH-----IVKFYGVCVE-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVG--ENLLV-------------------KIGDFGMSRDV--Y--S--TDYYRVGGHTMLPIRWMPPESIM-----------YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNNEVIECITQGRVLQRPRTCP---------------------------------------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L---
-Y-IKLDKLGEGTYATVYKGKSK-----L-T-DN-LVALKEIRLEHEEG---AP--C-TAIR-EVSLLKDL-K---HAN-----IVTLHDIIHT-----------------------------EKSLT--LVFEYLDK---DLKQYLD---DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL-------------------KLADFGLARAK-----SIPTKTYSN---EVVTLWYRPPDILL----------GSTDYSTQIDMWGVGCIFYEMAT-GR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF---
--WEIIGELGDGAFGKVYKAQNK-----E-T-SV-LAAAKVIDTKSEEE---LE--DYM--V-EIDILASC-D---HPN-----IVKLLDAFYY-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI-------------------KLADFGVSAKN-----TRTIQRRDS---FIGTPYWMAPEVVMCE------TSKDRPYDYKADVWSLGITLIEMAE-IE-PPHHELNPMRVLLKIAKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV---
--YSILKQIGSGGSSKVFQVLNE-----K-K-Q--IYAIKYVNLEEADN---QT--LDSYRN-EIAYLNKLQQ--HSDK-----IIRLYDYEIT-----------------------------DQYIY--MVMECGNI---DLNSWLK----KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML-------------------KLIDFGIANQMQ---PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQQI--INQISKLHAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV---
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