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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
AGC AKT1 150
AGC AKT3 148
Other AURKA 133
CMGC CDK2 4
CMGC CDK4 6
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
CMGC MAPK1 13
CMGC MAPK14 24
CMGC MAPK8 26
CAMK MAPKAPK2 64
AGC PDPK1 82
CAMK PIM2 132
Other PLK1 53
Other PLK2 82
Other TTK 525
-YL--KGRLLGKGGFARCYEATDT----ETGSAYAVKVIPQSR-VAK---PH--QR-EKIL---NEIELHRDL-Q----HRHIVRFSHHFE--D------ADNIY--IFLEL-CSRK--SLAHIWK----ARH--TLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMEL---KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL-----------RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA-----DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
--F-EYLKLLGKGTFGKVILVKEK----ATGRYYAMKILKKEV-IVA---KD--EV-AHTL---TENRVLQNS-R----HPFLTALKYSFQ--T------HDRLC--FVMEY-ANGG--ELFFHLS----RER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI---KITDFGLCKEG-----IKDGATMKT---FCGTPEYLAPEVLE-----------DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ-----DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----------
-FD--YLKLLGKGTFGKVILVREK----ASGKYYAMKILKKEV-IIA---KD--EV-AHTL---TESRVLKNT-R----HPFLTSLKYSFQ--T------KDRLC--FVMEY-VNGG--ELFFHLS----RER--VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHI---KITDFGLCKEG-----ITDAATMKT---FCGTPEYLAPEVLE-----------DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ-----DHEKLFELILMEDIKFPRTLS---------------------------------------SDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF-----------
---FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKA---GV--EH-QLRR----EVEIQSHL-R----HPNILRLYGYFH--D------ATRVY--LILEY-APLG--TVYRELQ----KLS--KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGEL---KIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETE---GV--PS-TAIR----EISLLKEL-N----HPNIVKLLDVIH--T------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPN-GGGGGGGL--PI-STVR----EVALLRRL-EA-FEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEH-VDQ---DLRTYLDK--APPP--GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTV---KLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN--SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL-----------
---YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDK-RFK---NR-------------ELQIMRKL-D----HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE-----EHLRD-FE-R----EIEILKSL-Q----HDNIVKYKGVCYSAG------RRNLK--LIMEY-LPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE-NENRV---KIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM--IVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP----DQ-QRD-FQ-R----EIQILKAL-H----SDFIVKYRGVSYGPG------RQSLR--LVMEY-LPSG--CLRDFLQ-----RHRARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE-SEAHV---KIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVP-ALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL----------
---YTNLSYIGEGAYGMVCSAYDN----VNKVRVAIKKISPFE-HQT---YC--QR-T-LR----EIKILLRF-R----HENIIGINDIIR--APT-IEQMKDVY--IVQDL-MET---DLYKLLK-----TQ--HLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIML----------NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK--HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL-----------
---YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPF-QSI---IH--AK-RTYR----ELRLLKHM-K----HENVIGLLDVFT--PARSLEEFNDVY--LVTHL-MGA---DLNNIVK-----CQ--KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML----------NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT--DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
---YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPF-QNQ---TH--AK-RAYR----ELVLMKCV-N----HKNIIGLLNVFT--PQKSLEEFQDVY--IVMEL-MDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTL---KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR--DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI-----------
KVT---SQVLGLGINGKVLQIFNK----RTQEKFALKMLQDCP-KAR-------------R----EVELHWRASQ----CPHIVRIVDVYE--NLY--AGRKCLL--IVMEC-LDGG--ELFSRIQD--RGDQ--AFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE------TTSHNSLTT---PCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FYSN-HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-----------
--F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-IIK---EN--KVPYVTR----ERDVMSRL-D----HPFFVKLYFTFQ--D------DEKLY--FGLSY-AKNG--ELLKYIR----KIG--SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG-----NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---YRLGPLLGKGGFGTVFAGHRL----TDRLQVAIKVIPRNR-VLG---WS--PL-SDSVTCPLEVALLWKV-GAGGGHPGVIRLLDWFE--T------QEGFM--LVLERPLPAQ--DLFDYIT----EKG--PLGEGPSRCFFGQVVAAIQHCHS-RGVVHRDIKDENILIDLRRGCA---KLIDFGSGA-------LLHDEPYTD---FDGTRVYSPPEWIS----------RHQYHALPATVWSLGILLYDMVC-GDIP---------------FERD-----------QEILEAELHFPAHVS---------------------------------------PDCCALIRRCLAPKPSSRPS-----LEEILLDPWM-----------
-YV--RGRFLGKGGFAKCFEISDA----DTKEVFAGKIVPKSL-LLK---PH--QR-EKMS---MEISIHRSL-A----HQHVVGFHGFFE--D------NDFVF--VVLEL-CRRR--SLLELHK----RRK--ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS-----CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL----TNNKVYAAKIIPHSR-VAK---PH--QR-EKID---KEIELHRIL-H----HKHVVQFYHYFE--D------KENIY--ILLEY-CSRR--SMAHILK----ARK--VLTEPEVRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFIN-EAMEL---KVGDFGLAARL-----EPLEHRRRT---ICGTPNYLSPEVLN-----------KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT-----NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF-----------
---YSILKQIGSGGSSKVFQVLNE----KKQ-IYAIKYVNLEE-ADN---QT--LD-SYRN----EIAYLNKLQQ---HSDKIIRLYDYEI--T------DQYIY--MVMEC-GNI---DLNSWLK----KKK--SIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV--DGML---KLIDFGIANQMQ---PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTP---------------FQQI----INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV-----------
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