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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK BLK 241
TKL BRAF 456
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
TK CSK 195
TK EGFR 712
TK EPHB4 615
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FGR 263
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK JAK2 849
TK KIT 589
TK LCK 245
TK LYN 247
CMGC MAPK14 24
Other NEK2 8
AGC PRKCA 339
TK PTK6 191
TKL RAF1 349
TK RET 724
TK SRC 270
TK SRMS 230
TK SYK 371
TK TEC 370
TKL TGFBR1 205
TK TNK2 150
TK YES1 277
TK ZAP70 338
--YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQS--R-VAKPH---Q-REKILNEIELHRDL--QHRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK----ARH-----------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR--------GILHRDLKLGNFFITE---NMELKVGDFGLAARL-------EPPEQRK-KT---ICGTPNYVAPEVLL------RQG---HGPEADVWSLGCVMYTLLC-GS----------PP---------------FETA--------DLKETY-RCIKQ----VHYTLPASLS----------------------------LPARQ-LLAAILRASPRDRPSIDQILRHDFF--------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV---E-EFL-K-EAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-----EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELL-EKDYR----MERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--------------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQD-EL-DFL-M-EALIISKF--NHQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR-----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI----Y--R--ASYY-RKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFV-TSGGR----MDPPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--------------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---E-HQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ----KLS-----------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS---AGELKIADFGWSV---------HAPSSRR-TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETY-KRISR----VEFTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--------------
---L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTLK-E--G-TM-SP---E-AFL-G-EANVMKAL--QHERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK-----TD--------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSE---ALCCKIADFGLARII----------DSEY-TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEVIRNL-ERGYR----MPRPDTCP------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--------------
----ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-V-TA-PT-PQQ-LQ-AFK-N-EVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH-----II---------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK----S--R--WSGS-HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMV-GRGYLSPDLSKVRSNCP------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI-------------
----LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E--G-SM-SE---D-EFI-E-EAKVMMNL--SHEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR-----EM---------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-------L--DDEY-TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----TNSETAEHI-AQGLR----LYRPHLAS------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE--S-EEEGV---P-STAIR-EISLLKEL--RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDS-IPPGQ-----------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDD---KGTIKLADFGLARAF-------GIPIRVY-TH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----SEIDQLFRI-FRALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLD-LLSKMLIYDPAKRISGKMALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV---P-STAIR-EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA--SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINT---EGAIKLADFGLARAF-------GVPVRTY-TH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF--------------
----LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCIK-N--D-AT-AQ-----AFL-A-EASVMTQL--RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR-----SR--------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA-------------S-STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI-----PLKDVVPRV-EKGYK----MDAPDGCP------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----------------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NK-EIL-D-EAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL----G--A--EEKE-YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSIL-EKGER----LPQPPICT------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF------------
---V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLK-G--G-YT-ERQ-RR-EFL-S-EASIMGQF--EHPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR-----LN---------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-ENS--S--DPTY-TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI-EQDYR----LPPPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL----------------
---L-KRVKVLGSGAFGTVYKGIWVP---EGETVKIPVAIKILN-E--T-TG-PKA-NV-EFM-D-EALIMASM--DHPHLVRLLGVCL---------SPTIQLVTQLMPHGCLLEYVH-----EH---------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVKS---PNHVKITDFGLARLL----E--G--DEKE-YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG----------KP---------------YDGI-----PTREIPDLL-EKGER----LPQPPICT------------------------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F--------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LS-DLI-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE---DNVMKIADFGLARDI----H--H--IDYY-KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLL-KEGHR----MDKPSNCT------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKD-LS-DLV-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR-----ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTE---NNVMKIADFGLARDI----N--N--IDYY-KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI-----PVEELFKLL-KEGHR----MDKPANCT------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----------------
----ITLERRLGTGCFGDVWLGTWN--------GSTKVAVKTLK-P--G-TM-SP---K-AFL-E-EAQVMKLL--RHDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK-----NP--------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGE---RLACKIADFGLARLI-------K--DDEY-NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR----------IP---------------YPGM-----NKREVLEQV-EQGYH----MPCPPGCP------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----------------
----LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--G-TM-SP---E-SFL-E-EAQIMKKL--KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-----DG--------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGN---GLICKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM-----NNREVLEQV-ERGYR----MPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----------------
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV---E-AFL-A-EANVMKTL--QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEVIRAL-ERGYR----MPRPENCP------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--------------
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRE-RI-EFL-N-EASVMKEF--NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR-----SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI----Y--E--TDYY-RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFV-MEGGL----LDKPDNCP------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I--------------
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRE-RI-EFL-N-EASVMKGF--TCHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR-----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI----Y--E--TDYY-RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFV-MDGGY----LDQPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----------------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE---ELKQQFDQEIKVMAKC--QHENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSC-LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE---AFTAKISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH-----REPQLLLDI-KEEIE----DEEKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPDIKKVQQ----LLQ-----------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE--EH-LR-DFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-----KH---------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN---ENRVKIGDFGLTKVL---PQ--D--KEYY-KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL-KNNGR----LPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV------------
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTE-RE-ALM-S-ELKVLSYLG-NHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH---GRITKICDFGLARDI----K--N--DSNY-VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---VDSKFYKMI-KEGFR----MLSPEHAP------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--------------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---D-AFL-A-EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNL-ERGYR----MVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--------------
----IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-P--G-TM-SV---Q-AFL-E-EANLMKTL--QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK-----SD--------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE---SLMCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTAL-SQGYR----MPRVENCP------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--------------
----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP--F-QSIIH---A-KRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ-----------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE---DCELKILDFGLAR----------HTDDEM-TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQLKLI-LRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF--------------
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYG--S-MTEAE---K-QMLVS-EVNLLREL--KHPNIVRYYDRII--DR----TNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLDG---KQNVKLGDFGLARIL-------NHDTSFA-KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM----------PP---------------FTAF--------SQKELA-GKIRE----GKFRRIPYRY---S------------------------DELNE-IITRMLNLKDYHRPSVEEILENPL-I-------------
---F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKILKKD--V-VIQDD---D-VECTMVEKRVLALL-DKPPFLTQLHSCFQ--T------VDRLYFVMEYVNGGDLMYHIQ----QVG-----------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLDS---EGHIKIADFGMCKEH-------MMDGVTT-RT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE--------DEDELF-QSIME----HNVSYPKSLS----------------------------KEAVS-VCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
---F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-R--D-NL-LH--QQ-MLQ-S-EIQAMKKL--RHKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR-----DS--------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGE---NTLCKVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ----------VP---------------YPGM-----SNHEAFLRV-DAGYR----MPCPLECP------------------------------PSVHK-LMLTCWCRDPEQRPCFKALRERL----------------
--VM--LSTRIGSGSFGTVYKGKWH----------GDVAVKILK-V-VD-PT-PEQ-FQ-AFR-N-EVAVLRKT--RHVNILLFMGYMT---------KDNLAIVTQWCEGSSLYKHLH-----VQ---------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHE---GLTVKIGDFGLATVK----S--R--WSGS-QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LP---------------YSHI-N---NRDQIIFMV-GRGYASPDLSKLYKNCP------------------------------KAMKR-LVADCVKKVKEERPLFPQILSS--I--------------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSE-LR-DLL-S-EFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE---GRKMKISDFGLSRDV----Y--E--EDSY-VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----PPERLFNLL-KTGHR----MERPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL----------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---E-AFL-Q-EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-----GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQV-ERGYR----MPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLWL--------GSLPVAIKVIK-S--A-NM-K---LT-DLA-K-EIQTLKGL--RHERLIRLHAVCS--G------GEPVYIVTELMRKGNLQAFLG-----TP--------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVDD---GLACKVADFGLARLL-------K--DDIY-SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ----------CP---------------YEGM-----TNHETLQQI-MRGYR----LPRPAACP------------------------------AEVYV-LMLECWRSSPEERPSFATLREKL----------------
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKD-ELL-A-EANVMQQL--DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-----QN----------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT---QHYAKISDFGLSKAL----R--A--DENYYKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEVTAML-EKGER----MGCPAGCP------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL------------
----LTFMRELGSGLFGVVRLGKWR--------AQYKVAIKAIR-E--G-AM-CE---E-DFI-E-EAKVMMKL--THPKLVQLYGVCT--Q------QKPIYIVTEFMERGCLLNFLR-----QR---------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVSE---AGVVKVSDFGMARYV-------L--DDQY-TSSSGAKFPVKWCPPEVFN------YSR---FSSKSDVWSFGVLMWEVFTEGR----------MP---------------FEKY-----TNYEVVTMV-TRGHR----LYQPKLAS------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I--------------
--IV--LQESIGKGRFGEVWRGKWR-------GEE--VAVKIFSSR--E-ERSWF---R-EA----EIYQTVML--RHENILGFIAADN--KDN--GTWTQLWLVSDYHEHGSLFDYLN-----RY-----------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK---NGTCCIADLGLAVRHDS---ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVV-CEQKL----RPNIPNRWQSCEAL------------------------RVMAK-IMRECWYANGAARLTALRIKK----TL------------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MD-DFI-R-EVNAMHSL--DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL---PQ--N--DDHY-VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----NGSQILHKIDKEGER----LPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-P--G-TM-MP---E-AFL-Q-EAQIMKKL--RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK-----EG--------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE---NLVCKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREVLEQV-ERGYR----MPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KAD-TE-EMM-R-EAQIMHQL--DNPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV-----GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLVN---RHYAKISDFGLSKAL---GA--D--DSYY-TARSAGKWPLKWYAPECIN------FRK---FSSRSDVWSYGVTMWEALSYGQ----------KP---------------YKKM-----KGPEVMAFI-EQGKR----MECPPECP------------------------------PELYA-LMSDCWIYKWEDRPDFLTVEQR--M--------------
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