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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CAMK DAPK1 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
TKL MAP3K11 117
TKL MAP3K9 144
CMGC MAPK1 13
CMGC MAPK14 24
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CMGC PCTK1 165
Other PLK1 53
AGC ROCK2 92
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
CAMK STK33 116
TK TNK2 150
Other TTK 525
TK YES1 277
TK ZAP70 338
--YL--KGRLLGKGGFARC---YEATDT-----E-T-GS---AYAVKVIPQS--R-VAK---PH-----QREKIL------------------------NEIELHRDL-Q-----HRH-----IVRFSHHFE--D--------ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R---G---ILHRDLKLGNFFIT--E--------NMEL-------------------KVGDFGLAARL------EPPEQRK--------------KT---ICGTPNYVAPEVLL-----------RQG--HGPEADVWSLGCVMYTLLC-GSPP---------------FETA--------------DLKETY-RCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRD--RPS-----IDQILRHDFF---------
----ITMKHKLGGGQYGEV---YEGVWK-----K-Y-SL---TVAVKTLK-E--D-TM----EV-----EEFL-K-------------------------EAAVMKEI-K-----HPN-----LVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--E--------NHLV-------------------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F---------
----ITMKHKLGGGQYGEV---YVGVWK-----K-Y-SL---TVAVKTLK-E--D-TM----EV-----EEFL-K-------------------------EAAVMKEI-K-----HPN-----LVQLLGVCT--L--------EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--E--------NHVV-------------------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNT--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYDLL-EKGYRMEQPEGCP---------------------------------------------------------------PKVYELMRACWKWSPAD--RPS-----FAETHQA--F---------
----FEIGRPLGKGKFGNV---YLAREK-----Q-S-KF---ILALKVLFKA--QLEKA---GV-----EHQLRR-------------------------EVEIQSHL-R-----HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KF---DEQRTATYITELANALSYCHS--K---R---VIHRDIKPENLLLG--S--------AGEL-------------------KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----------GRM--HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN--------------TYQETY-KRISRVEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI---------
----FEIGRPLGKGKFGNV---YLAREK-----K-S-HF---IVALKVLFKS--Q-IEK---EG-----VEHQLR------------------------REIEIQAHL-H-----HPN-----ILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG--K---K---VIHRDIKPENLLLG--L--------KGEL-------------------KIADFGWSV--------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRM--HNEKVDLWCIGVLCYELLV-GNPP---------------FESA--------------SHNETY-RRIVKVDLKFPASVP-------------------------------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---------
----YTLKDEIGKGSYGVV---KLAYNE-----N-D-NT---YYAMKVLSKK--K-LIR---QA-----GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D-----HPN-----VVKLVEVLD--DP------NEDHLY--MVFELVNQG--PVMEVPT-----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q---K---IIHRDIKPSNLLVG--E--------DGHI-------------------KIADFGVSNEF------KGSDALL--------------SN---TVGTPAFMAPESLS----------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP---------------FMDE--------------RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKDLITRMLDKNPES--RIV-----VPEIKLHPWV---------
----YTKIEKIGEGTYGVV---YKGRHK-----T-T-GQ---VVAMKKIRLE--S-EEE---GV-----PSTAIR-------------------------EISLLKEL-R-----HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--R---R---VLHRDLKPQNLLID--D--------KGTI-------------------KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-----------SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF---------
----FQKVEKIGEGTYGVV---YKARNK-----L-T-GE---VVALKKIRLD--T-ETE---GV-----PSTAIR-------------------------EISLLKEL-N-----HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H---R---VLHRDLKPQNLLIN--T--------EGAI-------------------KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---------
----FQKVEKIGEGTYGVV---YKAKNR-----E-T-GQ---LVALKKIRLD--L-EME---GV-----PSTAIR-------------------------EISLLKEL-K-----HPN-----IVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H---R---VIHRDLKPQNLLIN--E--------LGAI-------------------KLADFGLARAF------GVPLRTY--------------TH---EVVTLWYRAPEILL----------GSKF--YTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD-----------SEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AKTALAHPYF---------
---Y-EPVAEIGVGAYGTV---YKARDP-----H-S-GH---FVALKSVRVP--N-GGGGGGGL-----PISTVR-------------------------EVALLRRL-EA--FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--N---C---IVHRDLKPENILVT--S--------GGTV-------------------KLADFGLARI-------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QST--YATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-----------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL---------
----YEKLEKIGEGTYGTV---FKAKNR-----E-T-HE---IVALKRVRLD--D-DDE---GV-----PSSALR-------------------------EICLLKEL-K-----HKN-----IVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R---N---VLHRDLKPQNLLIN--R--------NGEL-------------------KLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDVLF----------GAKL--YSTSIDMWSAGCIFAELANAGRPL---------------FPGN-----------DVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AEEALQHPYF---------
----YECVAEIGEGAYGKV---FKARDL-----K-N-GG--RFVALKRVRVQ--T-GEE---GM-----PLSTIR-------------------------EVAVLRHL-ET--FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--H---R---VVHRDLKPQNILVT--S--------SGQI-------------------KLADFGLARI-------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----------QSS--YATPVDLWSVGCIFAEMFR-RKPL---------------FRGS-----------SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RIS-----AYSALSHPYF---------
----YEKLAKIGQGTFGEV---FKARHR-----K-T-GQ---KVALKKVLME--N-EKE---GF-----PITALR-------------------------EIKILQLL-K-----HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--N---K---ILHRDMKAANVLIT--R--------DGVL-------------------KLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPELLL----------GERD--YGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN-----------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-----SDDALNHDFF---------
---W-DLVQTLGEGAYGEV---QLAVNR-----V-T-EE---AVAVKIVDMK--R-AVD---CP-----ENI-KK-------------------------EICINKML-N-----HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I---G---ITHRDIKPENLLLD--E--------RDNL-------------------KISDFGLATVFR----YNNRERLL--------------NK---MCGTLPYVAPELLK----------RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-------------SDSCQEY-SDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y--------
--YI--MSKTLGSGACGEV---KLAFER-----K-T-CK---KVAIKIISKR--K-FAI---GS-----AREADPALN-------------------VETEIEILKKL-N-----HPC-----IIKIKNFF---D--------AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--N---G---IIHRDLKPENVLLS--S--------QEEDC----------------LIKITDFGHSKI-------LGETSLM--------------RT---LCGTPTYLAPEVLVS--------VGTAG--YNRAVDCWSLGVILFICLS-GYPP---------------FSEH-------------RTQVSLK-DQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL---------
---W-EMRERLGTGGFGNV---CLYQHR-----E-L-DL---KIAIKSCRLE--L-STK---NR-----ER-WCH-------------------------EIQIMKKL-N-----HAN-----VVKACDVPE--ELN---ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-------------------------GL---KESQILSLLSDIGSGIRYLHE--N---K---IIHRDLKPENIVLQ--D--------VGGKI----------------IHKIIDLGYAKD-------VDQGSLC--------------TS---FVGTLQYLAPELFE-----------NKP--YTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQ--RG----------------GPVDLTLKQ
----YEIVDTLGEGAFGKV---VECIDH-----K-AGGR---HVAVKIVKNV--D-RYC---EA-----ARS----------------------------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG-------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--N---K---LTHTDLKPENILFV--Q--------SDYTEAYNPKIKRDERTLINPDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FPTH-----------DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAK--RIT-----LREALKHPFF---------
----YEIVSTLGEGTFGRV---VQCVDH-----R-R-GG--ARVALKIIKNV--E-KYK---EA-----AR---L-------------------------EINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN-------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--N---K---LTHTDLKPENILFV--N--------SDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELG--WSQPCDVWSIGCIIFEYYV-GFTL---------------FQTH-----------DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLT-----LGEALQHPFF---------
----YEIVDTLGEGAFGKV---VECIDH-----GMD-GM---HVAVKIVKNV--G-RYR---EA-----ARS----------------------------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS-------------------------FLP-FQIDHIRQMAYQICQSINFLHH--N---K---LTHTDLKPENILFV--K--------SDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FQTH-----------DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF---------
----YDTGEELGSGQFAVV---KKCREK-----S-T-GL---QYAAKFIKKR--R-TKS---SR-----RGVSREDI---------------------EREVSILKEI-Q-----HPN-----VITLHEVYE--N--------KTDVI--LILELVAGG--ELFDFLA----EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--L---Q---IAHFDLKPENIMLL--D--------RNVPKP---------------RIKIIDFGLAHK-------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GASP---------------FLGD--------------TKQETL-ANVSAVNYEFEDEYFSNTS---------------------------------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQDSLQHPWI---------
----YEIDSLIGKGSFGQV---VKAYDR-----V-E-QE---WVAIKIIKNK--K-AFL---NQ-----AQI----------------------------EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL---S---IIHCDLKPENILLCNPK--------RSAI-------------------KIVDFGSSCQ---------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GMP--YDLAIDMWSLGCILVEMHT-GEPL---------------FSGA-----------NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKT--RIQ-----PYYALQHSFF---------
----YEIDSLIGKGSFGQV---VKAYDH-----Q-T-QE---LVAIKIIKNK--K-AFL---NQ-----AQI----------------------------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL---S---IIHCDLKPENILLCNPK--------RSAI-------------------KIVDFGSSCQ---------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GTP--YDLAIDMWSLGCILVEMHT-GEPL---------------FSGS-----------NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAA--RIS-----PLGALQHGFF---------
----ITLERRLGTGCFGDV---WLGTWN-------G-ST---KVAVKTLK-P--G-TM----SP-----KAFL-E-------------------------EAQVMKLL-R-----HDK-----LVQLYAVVS-----------EEPIY--IVTEFMCHG--SLLDFLK-----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M---N---YIHRDLRAANILVG--E--------RLAC-------------------KIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----------FGR--FTIKSDVWSFGILLTELITKGRIP---------------YPGM-----------NKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYEAMEQTWRLDPEE--RPT-----FEYLQSFL-----------
----LQLIKRLGNGQFGEV---WMGTWN-------G-NT---KVAIKTLK-P--G-TM----SP-----ESFL-E-------------------------EAQIMKKL-K-----HDK-----LVQLYAVVS-----------EEPIY--IVTEYMNKG--SLLDFLK-----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M---N---YIHRDLRSANILVG--N--------GLIC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-----------NNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHELMIHCWKKDPEE--RPT-----FEYLQSFL-----------
----YTDTKVIGNGSFGVV---YQAKLC-----D-S-GE---LVAIKKVLQD--K-RFK---NR------------------------------------ELQIMRKL-D-----HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F---G---ICHRDIKPQNLLLD-PD--------TAVL-------------------KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPELIF----------GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF---------
----LKLEKKLGAGQFGEV---WMATYN-------K-HT---KVAVKTMK-P--G-SM----SV-----EAFL-A-------------------------EANVMKTL-Q-----HDK-----LVKLHAVVT-----------KEPIY--IITEFMAKG--SLLDFLK-----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R---N---YIHRDLRAANILVS--A--------SLVC-------------------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGS--FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-----------SNPEVIRAL-ERGYRMPRPENCP---------------------------------------------------------------EELYNIMMRCWKNRPEE--RPT-----FEYIQSV--L---------
----LKFLQQLGKGNFGSV---EMCRYDP-LQDN-T-GE---VVAVKKLQ-H--S-TE-----EH---LRDFE-R-------------------------EIEILKSL-Q-----HDN-----IVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--K---R---YIHRDLATRNILVE--N--------ENRV-------------------KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL-KNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV-------
---L-KYISQLGKGNFGSV---ELCRYDP-LGDN-T-GA---LVAVKQLQ-H--S-GP----DQ----QRDFQ-R-------------------------EIQILKAL-H-----SDF-----IVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--R---R---CVHRDLAARNILVE--S--------EAHV-------------------KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL--------
----LKLVERLGAGQFGEV---WMGYYN-------G-HT---KVAVKSLK-Q--G-SM----SP-----DAFL-A-------------------------EANLMKQL-Q-----HQR-----LVRLYAVVT-----------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKL---TINKLLDMAAQIAEGMAFIEE--R---N---YIHRDLRAANILVS--D--------TLSC-------------------KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGT--FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNL-ERGYRMVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L---------
----IKLVKRLGAGQFGEV---WMGYYN-------N-ST---KVAVKTLK-P--G-TM----SV-----QAFL-E-------------------------EANLMKTL-Q-----HDK-----LVRLYAVVT--R--------EEPIY--IITEYMAKG--SLLDFLK-----SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K---N---YIHRDLRAANVLVS--E--------SLMC-------------------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGC--FTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-----------TNADVMTAL-SQGYRMPRVENCP---------------------------------------------------------------DELYDIMKMCWKEKAEE--RPT-----FDYLQSV--L---------
----LRLEEVIGIGGFGKV---YRGSWR---------GE---LVAVKAAR-Q--D-PD----EDISVTAESVR-Q-------------------------EARLFAML-A-----HPN-----IIALKAVCL--E--------EPNLC--LVMEYAAGG--PLSRALA-----GR-------------------------RV---PPHVLVNWAVQIARGMHYLHC--E---ALVPVIHRDLKSNNILLL--QPIESDDMEHKTL-------------------KITDFGLAREW-----------HK--------------TTQMSAAGTYAWMAPEVIK-----------AST--FSKGSDVWSFGVLLWELLT-GEVP---------------YRGI-----------DCLAVAYGVAVNKLTLPIPSTCP---------------------------------------------------------------EPFAQLMADCWAQDPHR--RPD-----FASILQQL-----------
---L-TLEEIIGIGGFGKV---YRAFWI-----G-D-E-----VAVKAARHDP-D-EDI---SQ-----TIENVR------------------------QEAKLFAML-K-----HPN-----IIALRGVCL--K--------EPNLC--LVMEFARGG--PLNRVLS-----GK-------------------------RI---PPDILVNWAVQIARGMNYLHD--EAIVP---IIHRDLKSSNILIL--Q--------KVENGDLS-----------NKILKITDFGLAR--------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----------ASM--FSKGSDVWSYGVLLWELLT-GEVP---------------FRGI--------------DGLAVA-YGVAMNKLALPIPSTCP-----------------------------------------------------------EPFAKLMEDCWNPDPHS--RPS-----FTNILDQ---LT-------
----YTNLSYIGEGAYGMV---CSAYDN-----V-N-KV---RVAIKKISPF--E-HQT---YC-----QRT-LR-------------------------EIKILLRF-R-----HEN-----IIGINDIIR--APT---IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS--A---N---VLHRDLKPSNLLLN--T--------TCDL-------------------KICDFGLARVAD---PDHDHTGFL--------------TE---YVATRWYRAPEIML----------NSKG--YTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHI-LGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHK--RIE-----VEQALAHPYL---------
----YQNLSPVGSGAYGSV---CAAFDT-----K-T-GL---RVAVKKLSRP--F-QSI---IH-----AKRTYR-------------------------ELRLLKHM-K-----HEN-----VIGLLDVFT--PARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--A---D---IIHRDLKPSNLAVN--E--------DCEL-------------------KILDFGLAR---------HTDDEM--------------TG---YVATRWYRAPEIML----------NWMH--YNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF---------
---I-EYVRDIGEGAFGRV---FQARAPGLLPYE-P-FT---MVAVKMLK-E--E-AS----ADM---QADFQ-R-------------------------EAALMAEF-D-----NPN-----IVKLLGVCA--V--------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--R---K---FVHRDLATRNCLVG--E--------NMVV-------------------KIADFGLSRNI---Y--S--ADYY--------------KANENDAIPIRWMPPESIF-----------YNR--YTTESDVWAYGVVLWEIFSYGLQP---------------YYGM-----------AHEEVIYYV-RDGNILSCPENCP---------------------------------------------------------------VELYNLMRLCWSKLPAD--RPS-----FTSIHRIL-----------
---I-VLKRELGEGAFGKV---FLAECYNLCPEQ-D-KI---LVAVKTLK-D--A-SD----NA----RKDFH-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCV--E--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--Q---H---FVHRDLATRNCLVG--E--------NLLV-------------------KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-----------SNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYELMLGCWQREPHM--RKN-----IKGIHTL--L---------
---I-VLKRELGEGAFGKV---FLAECYNLSPTK-D-KM---LVAVKALK-D--P-TL----AA----RKDFQ-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCG--D--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--Q---H---FVHRDLATRNCLVG--A--------NLLV-------------------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSFGVILWEIFTYGKQP---------------WFQL-----------SNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYDVMLGCWQREPQQ--RLN-----IKEIYKIL-----------
---Y-IKLDKLGEGTYATV---YKGKSK-----L-T-DN---LVALKEIRLE--H-EEG---AP-----C-TAIR-------------------------EVSLLKDL-K-----HAN-----IVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--Q---K---VLHRDLKPQNLLIN--E--------RGEL-------------------KLADFGLARAK------SIPTKTY--------------SN---EVVTLWYRPPDILL----------GSTD--YSTQIDMWGVGCIFYEMAT-GRPL---------------FPGS-----------TVEEQLHFI-FRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRN--RIS-----AEDAMKHPFF---------
--YV--RGRFLGKGGFAKC---FEISDA-----D-T-KE---VFAGKIVPKS--L-LLK---PH-----QREKMS------------------------MEISIHRSL-A-----HQH-----VVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK----RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--N---R---VIHRDLKLGNLFLN--E--------DLEV-------------------KIGDFGLATKV------EYDGERK--------------KT---LCGTPNYIAPEVLS-----------KKG--HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS--------------CLKETY-LRIKKNEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF---------
----YDVVKVIGRGAFGEV---QLVRHK-----A-S-QK---VYAMKLLSKF--E-MIK---RS-----DSAFFW------------------------EERDIMAFA-N-----SPW-----VVQLFYAFQ--D--------DRYLY--MVMEYMPGG--DLVNLMS-----NY-------------------------DV---PEKWAKFYTAEVVLALDAIHS--M---G---LIHRDVKPDNMLLD--K--------HGHL-------------------KLADFGTCMKM-----DETGMVHC--------------DT---AVGTPDYISPEVLKS-------QGGDGF--YGRECDWWSVGVFLYEMLV-GDTP---------------FYAD--------------SLVGTY-SKIMDHKNSLCFPEDAEIS---------------------------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---------
----FELLKVLGQGSFGKVFLVRKVTRP-----D-S-GH---LYAMKVLKKA--T-LKV---RD-----RVRTKM-------------------------ERDILADV-N-----HPF-----VVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MF---TEEDVKFYLAELALGLDHLHS--L---G---IIYRDLKPENILLD--E--------EGHI-------------------KLTDFGLSKEA------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RQG--HSHSADWWSYGVLMFEMLT-GSLP---------------FQGK--------------DRKETM-TLILKAKLGMPQFLS-------------------------------------------------------------TEAQSLLRALFKRNPAN--RLGSGPDGAEEIKRHV--FY-------
----FELLKVLGQGSYGKV---FLVRKV-----K-G-SDAGQLYAMKVLKKA--T-LKV---RD-----RVRSKM-------------------------ERDILAEV-N-----HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L---G---IIYRDLKPENILLD--E--------EGHI-------------------KITDFGLSKEA------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----------RRG--HTQSADWWSFGVLMFEMLT-GSLP---------------FQGK--------------DRKETM-ALILKAKLGMPQFLS-------------------------------------------------------------GEAQSLLRALFKRNPCN--RLGAGIDGVEEIKRHPFF---------
----FELLKVLGQGSFGKV---FLVRKK-----T-G-PDAGQLYAMKVLKKA--S-LKV---RD-----RVRTKM-------------------------ERDILVEV-N-----HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DVFTRLS----KEV-------------------------LF---TEEDVKFYLAELALALDHLHQ--L---G---IVYRDLKPENILLD--E--------IGHI-------------------KLTDFGLSKES------VDQEKKA--------------YS---FCGTVEYMAPEVVN-----------RRG--HSQSADWWSYGVLMFEMLT-GTLP---------------FQGK--------------DRNETM-NMILKAKLGMPQFLS-------------------------------------------------------------AEAQSLLRMLFKRNPAN--RLGS--EGVEEIKRHLFF---------
----WEIIGELGDGAFGKV---YKAQNK-----E-T-SV---LAAAKVIDTK--S-EEE---LE-----DYM--V-------------------------EIDILASC-D-----HPN-----IVKLLDAFY--Y--------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--N---K---IIHRDLKAGNILFT--L--------DGDI-------------------KLADFGVSAKN------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE------TSKDRP--YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-----------NPMRVLLKI-AKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TSQLLQHPFV---------
---L-RLEVKLGQGCFGEV---WMGTWN-------G-TT---RVAIKTLK-P--G-TM----SP-----EAFL-Q-------------------------EAQVMKKL-R-----HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--M---N---YVHRDLRAANILVG--E--------NLVC-------------------KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-----------VNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L---------
----YTFGRILGKGSFGIV---IEATDK-----E-T-ET---KWAIKKVNKE--K-AGS---SA-----VKLLER-------------------------EVNILKSV-K-----HEH-----IIHLEQVFE--T--------PKKMY--LVMELCEDG--ELKEILD----RKG-------------------------HF---SENETRWIIQSLASAIAYLHN--N---D---IVHRDLKLENIMVK--S--------SLIDDNNE----------INLNIKVTDFGLAVKK-----QSRSEAML--------------QA---TCGTPIYMAPEVIS-----------AHD--YSQQCDIWSIGVVMYMLLR-GEPP---------------FLAS--------------SEEKLF-ELIRKGELHFENAVWNSIS---------------------------------------------------------DCAKSVLKQLMKVDPAH--RIT-----AKELLDNQWL---------
---L-RLLEKLGDGSFGVV---RRGEWD--APSG-K-TV---SVAVKCLK-PDVL-SQ----PEA---MDDFI-R-------------------------EVNAMHSL-D-----HRN-----LIRLYGVVL-----------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHF---LLGTLSRYAVQVAEGMGYLES--K---R---FIHRDLAARNLLLA--T--------RDLV-------------------KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRT--FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-----------NGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYNVMVQCWAHKPED--RPT-----FVALRDF--L---------
----YSILKQIGSGGSSKV---FQVLNE-----K-K-Q----IYAIKYVNLE--E-ADN---QT-----LDSYRN-------------------------EIAYLNKLQQ----HSDK-----IIRLYDYEI--T--------DQYIY--MVMECGNI---DLNSWLK----KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--H---G---IVHSDLKPANFLIV-----------DGML-------------------KLIDFGIANQMQ----PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTP---------------FQQI-------------INQISKL-HAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IPELLAHPYV---------
---L-RLEVKLGQGCFGEV---WMGTWN-------G-TT---KVAIKTLK-P--G-TM----MP-----EAFL-Q-------------------------EAQIMKKL-R-----HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--M---N---YIHRDLRAANILVG--E--------NLVC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILQTELVTKGRVP---------------YPGM-----------VNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FEYIQSFL-----------
LIAD----IELGCGNFGSV---RQGVYR---MRK-K-QI---DVAIKVLK-Q--G-TE----KAD---TEEMM-R-------------------------EAQIMHQL-D-----NPY-----IVRLIGVCQ-----------AEALM--LVMEMAGGG--PLHKFLV-----GK-----------------------REEI---PVSNVAELLHQVSMGMKYLEE--K---N---FVHRDLAARNVLLV--N--------RHYA-------------------KISDFGLSKAL--GA--D--DSYY--------------TARSAGKWPLKWYAPECIN-----------FRK--FSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-----------KGPEVMAFI-EQGKRMECPPECP---------------------------------------------------------------PELYALMSDCWIYKWED--RPD-----FLTVEQR--M---------
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