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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TKL BRAF 456
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2L5 705
CMGC CDC2L6 20
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK8 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK2 220
TK CSK 195
CAMK DAPK3 13
CMGC DYRK2 222
TK EGFR 712
Other EIF2AK2 267
TK EPHA3 621
TK EPHB1 619
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
CMGC GSK3A 119
CMGC ICK 4
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
CMGC MAK 4
STE MAP2K4 102
STE MAP4K1 17
STE MAP4K2 16
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MELK 11
CAMK MYLK2 301
Other NEK1 4
Other NEK4 6
Other NEK5 4
Other NEK6 45
Other NEK9 52
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK PRKAA1 18
AGC PRKACA 44
AGC PRKACB 44
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKX 49
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
TK RET 724
TKL RIPK1 17
AGC RPS6KB1 91
CAMK SIK1 27
STE SLK 34
STE STK10 36
STE STK24 24
STE STK25 20
STE STK3 27
Other STK36 4
STE STK39 63
STE STK4 30
TK SYK 371
STE TAOK1 28
STE TAOK2 28
STE TAOK3 24
TK TEK 824
TK TIE1 839
TK TNK1 116
Other TTK 525
Other ULK1 16
Other ULK2 9
--YL--KGRLLGKGGFARCYEATD---T-------ETGS--AYAV-KVI---PQS-R-VAK---PH---QREKIL------------------------NEIELHRDL--Q------HRHIVRFSHHFE--D-----------------------------ADN--IY--IFLELCSRK--SLAHIWK---------ARH-------------------------TL--LEPEVRYYLRQILSGLKYLHQR-GILHRDLKLGNFFIT----E---NMEL---------KVGDFGLAARL-----------------EPPEQRK--------------KT---ICGTPNYVAPEV--LL-----------RQG----HGPEADVWSLGCVMYTLLC-GS-PP---------------FETA------------DLKETYRCIKQ----VH---YTLPASLS--------------------------------------------------------LPARQ-LLAAILRASPRDRPS-----ID-QILRHDFF--------
----ITMKHKLGGGQYGEVYEGVW---K-------KYSL--TVAV-KTL---K-E-D-TM----EV---EEFL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--R-----------------------------EPP--FY--IITEFMTYG--NLLDYLR----------EC----------------------NRQEV--NAVVLLYMATQISSAMEYLEKK-NFIHRDLAARNCLVG----E---NHLV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNK----FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---------DLSQVYELLEKDYR----ME---RPEGCP----------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------
----ITMKHKLGGGQYGEVYVGVW---K-------KYSL--TVAV-KTL---K-E-D-TM----EV---EEFL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--L-----------------------------EPP--FY--IVTEYMPYG--NLLDYLR----------EC----------------------NREEV--TAVVLLYMATQISSAMEYLEKK-NFIHRDLAARNCLVG----E---NHVV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNT----FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---------DLSQVYDLLEKGYR----ME---QPEGCP----------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F--------
---I-TLIRGLGHGAFGEVYEGQV---SG--MPNDPSPL--QVAV-KTL---P-E-V-CS----EQD-ELDFL-M-------------------------EALIISKF--N------HQNIVRCIGVSL--Q-----------------------------SLP--RF--ILLELMAGG--DLKSFLR----------ETRP-----------------RPSQPSSL--AMLDLLHVARDIACGCQYLEEN-HFIHRDIAARNCLLT----CPGPGRVA---------KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEA--FM-----------EGI----FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---------SNQEVLEFVTSGGR----MD---PPKNCP----------------------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I--------
----FEIGRPLGKGKFGNVYLARE---K-------QSKF--ILAL-KVL---FKA-QLEKA---GV---EHQLRR-------------------------EVEIQSHL--R------HPNILRLYGYFH--D-----------------------------ATR--VY--LILEYAPLG--TVYRELQ---------KLS-------------------------KF--DEQRTATYITELANALSYCHSK-RVIHRDIKPENLLLG----S---AGEL---------KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----------GRM----HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN------------TYQETYKRISR----VE---FTFPDFVT--------------------------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI--------
----FEIGRPLGKGKFGNVYLARE---K-------KSHF--IVAL-KVL---FKS-Q-IEK---EG---VEHQLR------------------------REIEIQAHL--H------HPNILRLYNYFY--D-----------------------------RRR--IY--LILEYAPRG--ELYKELQ---------KSC-------------------------TF--DEQRTATIMEELADALMYCHGK-KVIHRDIKPENLLLG----L---KGEL---------KIADFGWSV-------------------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRM----HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA------------SHNETYRRIVK----VD---LKFPASVP--------------------------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV--------
----FEIGRPLGKGKFGNVYLARL---K-------ESHF--IVAL-KVL---FKS-Q-IEK---EG---LEHQLR------------------------REIEIQAHL--Q------HPNILRLYNYFH--D-----------------------------ARR--VY--LILEYAPRG--ELYKELQ---------KSE-------------------------KL--DEQRTATIIEELADALTYCHDK-KVIHRDIKPENLLLG----F---RGEV---------KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRT----YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA------------SHSETYRRILK----VD---VRFPLSMP--------------------------------------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV--------
---L-RLVRKLGSGQFGEVWMGYY---K--------NNM--KVAI-KTL---K-E-G-TM----SP---EAFL-G-------------------------EANVMKAL--Q------HERLVRLYAVVT--------------------------------KEP--IY--IVTEYMARG--CLLDFLK----------TD----------------------EGSRL--SLPRLIDMSAQIAEGMAYIERM-NSIHRDLRAANILVS----E---ALCC---------KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH-----------FGV----FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---------SNPEVIRNLERGYR----MP---RPDTCP----------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------
----ITLLKELGSGQFGVVQLGKW---K--------GQY--DVAV-KMI---K-E-G-SM----SE---DEFF-Q-------------------------EAQTMMKL--S------HPKLVKFYGVCS--K-----------------------------EYP--IY--IVTEYISNG--CLLNYLR----------SH-----------------------GKGL--EPSQLLEMCYDVCEGMAFLESH-QFIHRDLAARNCLVD----R---DLCV---------KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH-----------YFK----YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---------DNSQVVLKVSQGHR----LY---RPHLAS----------------------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I--------
----ITVGQRIGSGSFGTVYKGKW---H----------G--DVAV-KML---N-VTA-PT----PQQ-LQAFK-N-------------------------EVGVLRKT--R------HVNILLFMGYST--------------------------------KPQ--LA--IVTQWCEGS--SLYHHLH----------II-----------------------ETKF--EMIKLIDIARQTAQGMDYLHAK-SIIHRDLKSNNIFLH----E---DLTV---------KIGDFGLATVK-------------S---R--WSGS--------------HQFEQLSGSILWMAPEV--IR-----------MQDK-NPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNI-N-------NRDQIIFMVGRGYLSPDLSK---VRSNCP----------------------------------------------------------KAMKR-LMAECLKKKRDERPL-----FP-QILA---SI-------
----YKLQSEIGKGAYGVVRLAYN---E-------SEDR--HYAM-KVL---SKK-K-LLK---QY---GFPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVNVVKLIEVLD--DP---------------------------AEDN--LY--LVFDLLRKG--PVMEVPC----------DK-------------------------PF--SEEQARLYLRDVILGLEYLHCQ-KIVHRDIKPSNLLLG----D---DGHV---------KIADFGVSNQF-----------------EGNDAQL--------------SS---TAGTPAFMAPEA--ISD--------SGQSF----SGKALDVWATGVTLYCFVY-GK-CP---------------FIDD------------FILALHRKIKN----EP---VVFPEEPEIS------------------------------------------------------EELKD-LILKMLDKNPETRIG-----VP-DIKLHPWV--------
----YTLKDEIGKGSYGVVKLAYN---E-------NDNT--YYAM-KVL---SKK-K-LIR---QA---GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPNVVKLVEVLD--DP---------------------------NEDH--LY--MVFELVNQG--PVMEVPT----------LK-------------------------PL--SEDQARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVG----E---DGHI---------KIADFGVSNEF-----------------KGSDALL--------------SN---TVGTPAFMAPES--LS----------ETRKIF--SGKALDVWAMGVTLYCFVF-GQ-CP---------------FMDE------------RIMCLHSKIKS----QA---LEFPDQPDIA------------------------------------------------------EDLKD-LITRMLDKNPESRIV-----VP-EIKLHPWV--------
---F-DIIGIIGEGTYGQVYKARD---K-------DTGE--MVAL-KKV---RLD-N-EKE---GF---PITAIR-------------------------EIKILRQL--T------HQSIINMKEIVT--DKEDAL-------------------DFKKDKGA--FY--LVFEYMDH---DLMGLLE--------SGLV-------------------------HF--NENHIKSFMRQLMEGLDYCHKK-NFLHRDIKCSNILLN----N---RGQI---------KLADFGLARLY----------------SSEESRPY--------------TN---KVITLWYRPPEL--LL----------GEER----YTPAIDVWSCGCILGELFT-KK-PI---------------FQAN---------QELAQLELISRICG----SP---CPAVWPDVIKLPYFNTMKPKKQY-----------------------------RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-----AE-QALQCEF-L-------
-EGC-----KVGRGTYGHVYKARR---K-------DGKDEKEYAL-KQI---EGT-G-ISM---SA---C----R-------------------------EIALLREL--K------HPNVIALQKVFL--SH---------------------------SDRK--VW--LLFDYAEH---DLWHIIKFHR--ASKANKK-------------------------PMQLPRSMVKSLLYQILDGIHYLHAN-WVLHRDLKPANILVMGEGPE---RGRV---------KIADMGFARLFN--------------SPLKPLADL--------------DP---VVVTFWYRAPEL--LL----------GARH----YTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDIKTSNPFHHDQLDRIFSVMG----FP---ADKDWEDIRKMPEYPTLQKDFRRTTYA---------------------NSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDPTKRIT-----SE-QALQDPYF--------
----FQCLNRIEEGTYGVVYRAKD---K-------KTDE--IVAL-KRL---KME-K-EKE---GF---PITSLR-------------------------EINTILKA--Q------HPNIVTVREIVV--GS---------------------------NMDK--IY--IVMNYVEH---DLKSLME--------TMKQ-------------------------PF--LPGEVKTLMIQLLRGVKHLHDN-WILHRDLKTSNLLLS----H---AGIL---------KVGDFGLAREY-----------------GSPLKAY--------------TP---VVVTLWYRAPEL--LL----------GAKE----YSTAVDMWSVGCIFGELLT-QK-PL---------------FPGK---------SEIDQINKVFKDLG----TP---SEKIWPGYSELPAVKKMTFSEHPY----------------------------NNLRKRFGALLSDQGFD-LMNKFLTYFPGRRIS-----AE-DGLKHEYF--------
----FQKVEKIGEGTYGVVYKARN---K-------LTGE--VVAL-KKI---RLD-T-ETE---GV---PSTAIR-------------------------EISLLKEL--N------HPNIVKLLDVIH--T-----------------------------ENK--LY--LVFEFLHQ---DLKKFMDA-------SALT-------------------------GI--PLPLIKSYLFQLLQGLAFCHSH-RVLHRDLKPQNLLIN----T---EGAI---------KLADFGLARAF-----------------GVPVRTY--------------TH---EVVTLWYRAPEI--LL----------GCKY----YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD---------SEIDQLFRIFRTLG----TP---DEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF--------
----FQKVEKIGEGTYGVVYKAKN---R-------ETGQ--LVAL-KKI---RLD-L-EME---GV---PSTAIR-------------------------EISLLKEL--K------HPNIVRLLDVVH--N-----------------------------ERK--LY--LVFEFLSQ---DLKKYMDS-------TPGS-------------------------EL--PLHLIKSYLFQLLQGVSFCHSH-RVIHRDLKPQNLLIN----E---LGAI---------KLADFGLARAF-----------------GVPLRTY--------------TH---EVVTLWYRAPEI--LL----------GSKF----YTTAVDIWSIGCIFAEMVT-RK-AL---------------FPGD---------SEIDQLFRIFRMLG----TP---SEDTWPGVTQLPDYKGSFPKWTR------------------------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-----AK-TALAHPYF--------
---Y-EPVAEIGVGAYGTVYKARD---P-------HSGH--FVAL-KSV---RVP-N-GGGGGGGL---PISTVR-------------------------EVALLRRL--EA---FEHPNVVRLMDVCA--TSR------------------------TDREIK--VT--LVFEHVDQ---DLRTYLDK-------APPP-------------------------GL--PAETIKDLMRQFLRGLDFLHAN-CIVHRDLKPENILVT----S---GGTV---------KLADFGLARI------------------YSYQMAL--------------TP---VVVTLWYRAPEV--LL-----------QST----YATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN---------SEADQLGKIFDLIG----LP---PEDDWPRDVSLPRGAFPPRGPR--------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AF-RALQHSYL--------
----YEKLEKIGEGTYGTVFKAKN---R-------ETHE--IVAL-KRV---RLD-D-DDE---GV---PSSALR-------------------------EICLLKEL--K------HKNIVRLHDVLH--S-----------------------------DKK--LT--LVFEFCDQ---DLKKYFD--------SCNG-------------------------DL--DPEIVKSFLFQLLKGLGFCHSR-NVLHRDLKPQNLLIN----R---NGEL---------KLADFGLARAF-----------------GIPVRCY--------------SA---EVVTLWYRPPDV--LF----------GAKL----YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN---------DVDDQLKRIFRLLG----TP---TEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF--------
-EGC-----KVGRGTYGHVYKAKR---K-------DGKDDKDYAL-KQI---EGT-G-ISM---SA---C----R-------------------------EIALLREL--K------HPNVISLQKVFL--SH---------------------------ADRK--VW--LLFDYAEH---DLWHIIKFHRASKANKKPV-------------------------QL--PRGMVKSLLYQILDGIHYLHAN-WVLHRDLKPANILVMGEGPE---RGRV---------KIADMGFARLFN--------------SPLKPLADL--------------DP---VVVTFWYRAPEL--LL----------GARH----YTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDIKTSNPYHHDQLDRIFNVMG----FP---ADKDWEDIKKMPEHSTLMKDFRRNTYT---------------------NCSLIKYMEKHKVKPDSKAFH-LLQKLLTMDPIKRIT-----SE-QAMQDPYF--------
----YEKLAKIGQGTFGEVFKARH---R-------KTGQ--KVAL-KKV---LME-N-EKE---GF---PITALR-------------------------EIKILQLL--K------HENVVNLIEICR--TKASP---------------------YNRCKGS--IY--LVFDFCEH---DLAGLLS--------NVLV-------------------------KF--TLSEIKRVMQMLLNGLYYIHRN-KILHRDMKAANVLIT----R---DGVL---------KLADFGLARAFSL-------------AKNSQPNRY--------------TN---RVVTLWYRPPEL--LL----------GERD----YGPPIDLWGAGCIMAEMWT-RS-PI---------------MQGN---------TEQHQLALISQLCG----SI---TPEVWPNVDNYELYEKLELVKGQK---------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-----SD-DALNHDFF--------
----YEKIGKIGEGSYGVVFKCRN---R-------DTGQ--IVAI-KKF---LES-E-DDP---VI---KKIALR-------------------------EIRMLKQL--K------HPNLVNLLEVFR--R-----------------------------KRR--LH--LVFEYCDHT--VLHELDR---------YQR-------------------------GV--PEHLVKSITWQTLQAVNFCHKH-NCIHRDVKPENILIT----K---HSVI---------KLCDFGFARLL-----------------AGPSDYY--------------TD---YVATRWYRSPEL--LV----------GDTQ----YGPPVDVWAIGCVFAELLS-GV-PL---------------WPGK---------SDVDQLYLIRKTLG----DL---IPRHQQVFSTNQYFSGVKIPDPED----------------------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT-----CE-QLLHHPYF--------
----YENLGLVGEGSYGMVMKCRN---K-------DTGR--IVAI-KKF---LES-D-DDK---MV---KKIAMR-------------------------EIKLLKQL--R------HENLVNLLEVCK--K-----------------------------KKR--WY--LVFEFVDHT--ILDDLEL---------FPN-------------------------GL--DYQVVQKYLFQIINGIGFCHSH-NIIHRDIKPENILVS----Q---SGVV---------KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPEL--LV----------GDVK----YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD---------SDIDQLYHIMMCLG----NL---IPRHQELFNKNPVFAGVRLPEIKE----------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF--------
----YETLGKVGEGSYGTVMKCKH---K-------NTGQ--IVAI-KIF---YER-P-EQS---VN---K-IAMR-------------------------EIKFLKQF--H------HENLVNLIEVFR--Q-----------------------------KKK--IH--LVFEFIDHT--VLDELQH---------YCH-------------------------GL--ESKRLRKYLFQILRAIDYLHSN-NIIHRDIKPENILVS----Q---SGIT---------KLCDFGFARTL-----------------AAPGDIY--------------TD---YVATRWYRAPEL--VL----------KDTS----YGKPVDIWALGCMIIEMAT-GN-PY---------------LPSS---------SDLDLLHKIVLKVG----N----LSPHLQNIFSKSPIFAGVVLPQVQ---------------------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-----SS-DLLHHEYF--------
----FEILGVVGEGAYGVVLKCRH---K-------ETHE--IVAI-KKF---KDS-E-ENE---EV---KETTLR-------------------------ELKMLRTL--K------QENIVELKEAFR--R-----------------------------RGK--LY--LVFEYVEK---NMLELLE--------EMPN-------------------------GV--PPEKVKSYIYQLIKAIHWCHKN-DIVHRDIKPENLLIS----H---NDVL---------KLCDFGFARNL----------------SEGNNANY--------------TE---YVATRWYRSPEL--LL-----------GAP----YGKSVDMWSVGCILGELSD-GQ-PL---------------FPGE---------SEIDQLFTIQKVLG----PL---PSEQMKLFYSNPRFHGLRFPAVNH---------------------------PQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-----TE-QCLNHPTF--------
--YI--MSKTLGSGACGEVKLAFE---R-------KTCK--KVAI-KII---SKR-K-FAI---GS---AREADPALN-------------------VETEIEILKKL--N------HPCIIKIKNFF---D-----------------------------AED--YY--IVLELMEGG--ELFDKVV---------GNK-------------------------RL--KEATCKLYFYQMLLAVQYLHEN-GIIHRDLKPENVLLS----S---QEEDC------LIKITDFGHSKI------------------LGETSLM--------------RT---LCGTPTYLAPEV--LVS--------VGTAG----YNRAVDCWSLGVILFICLS-GY-PP---------------FSEH-----------RTQVSLKDQITS----GK---YNFIPEVWAEVS----------------------------------------------------EKALD-LVKKLLVVDPKARFT-----TE-EALRHPWL--------
----LKLLQTIGKGEFGDVMLGDY---R---------GN--KVAV-KCI---K-N-D-AT----AQ----AFL-A-------------------------EASVMTQL--R------HSNLVQLLGVIV-EE-----------------------------KGG--LY--IVTEYMAKG--SLVDYLR----------SR----------------------GRSVL--GGDCLLKFSLDVCEAMEYLEGN-NFVHRDLAARNVLVS----E---DNVA---------KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEA--LR-----------EKK----FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---------PLKDVVPRVEKGYK----MD---APDGCP----------------------------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL----------
----YEMGEELGSGQFAIVRKCRQ---K-------GTGK--EYAA-KFI---KKR-R-LSS---SR---RGVSREEI---------------------EREVNILREI--R------HPNIITLHDIFE--N-----------------------------KTD--VV--LILELVSGG--ELFDFLA---------EKE-------------------------SL--TEDEATQFLKQILDGVHYLHSK-RIAHFDLKPENIMLL----D---KNVPNP-----RIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GA-SP---------------FLGE------------TKQETLTNISA----VN---YDFDEEYFSNTS----------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IA-QSLEHSWI--------
----YEVLKVIGKGSFGQVVKAYD---H-------KVHQ--HVAL-KMV---RNE-K-RFH---RQ---AAE----------------------------EIRILEHL--RKQDKDNTMNVIHMLENFT--F-----------------------------RNH--IC--MTFELLSM---NLYELIKK-------NKFQ-------------------------GF--SLPLVRKFAHSILQCLDALHKN-RIIHCDLKPENILLK----Q---QGRSG-------IKVIDFGSSC--------------------YEHQRV--------------YT---YIQSRFYRAPEV--IL-----------GAR----YGMPIDMWSLGCILAELLT-GY-PL---------------LPGE---------DEGDQLACMIELLG----MP---SQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAVRMT-----PG-QALRHPWL--------
---F-KKIKVLGSGAFGTVYKGLW---IP---EGEKVKI--PVAI-KEL---R-E-A-TS----PKA-NKEIL-D-------------------------EAYVMASV--D------NPHVCRLLGICL--------------------------------TST--VQ--LITQLMPFG--CLLDYVR----------EH-----------------------KDNI--GSQYLLNWCVQIAKGMNYLEDR-RLVHRDLAARNVLVK----T---PQHV---------KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALES--IL-----------HRI----YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---------PASEISSILEKGER----LP---QPPICT----------------------------------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF------
---F-KEIELIGSGGFGQVFKAKH---R-------IDGK--TYVI-KRV---KYN-N-EKA---ER----------------------------------EVKALAKL--D------HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC--LF--IQMEFCDKG--TLEQWIEK-------RRGE-------------------------KL--DKVLALELFEQITKGVDYIHSK-KLIHRDLKPSNIFLV----D---TKQV---------KIGDFGLVTS------------------LKNDGKR--------------TR---SKGTLRYMSPEQ--IS-----------SQD----YGKEVDLYALGLILAELLH-VCDTA---------------FET----------------SKFFTDLR----DG---IISDIFDK---------------------------------------------------------KEKT-LLQKLLSKKPEDRPN-----TS-EILR----TLT-----
---I-SIDKVVGAGEFGEVCSGRL---K----LPSKKEI--SVAI-KTL---K-V-G-YT----EKQ-RRDFL-G-------------------------EASIMGQF--D------HPNIIRLEGVVT--K-----------------------------SKP--VM--IVTEYMENG--SLDSFLR----------KH-----------------------DAQF--TVIQLVGMLRGIASGMKYLSDM-GYVHRDLAARNILIN----S---NLVC---------KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEA--IA-----------YRK----FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM---------SNQDVIKAVDEGYR----LP---PPMDCP----------------------------------------------------------AALYQ-LMLDCWQKDRNNRPK-----FE-QIVSIL----------
---V-KIEEVIGAGEFGEVYKGRL---K----LPGKREI--YVAI-KTL---K-A-G-YS----EKQ-RRDFL-S-------------------------EASIMGQF--D------HPNIIRLEGVVT--K-----------------------------SRP--VM--IITEFMENG--ALDSFLR----------QN-----------------------DGQF--TVIQLVGMLRGIAAGMKYLAEM-NYVHRDLAARNILVN----S---NLVC---------KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEA--IA-----------YRK----FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---------SNQDVINAIEQDYR----LP---PPMDCP----------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL----------
--VI--LGELLGKGNFGEVYKGTL---K--------DKT--SVAV-KTC---K-E-D-LP----QEL-KIKFL-Q-------------------------EAKILKQY--D------HPNIVKLIGVCT--Q-----------------------------RQP--VY--IIMELVSGG--DFLTFLR----------RK-----------------------KDEL--KLKQLVKFSLDAAAGMLYLESK-NCIHRDLAARNCLVG----E---NNVL---------KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---------TNQQAREQVERGYR----MS---APQHCP----------------------------------------------------------EDISK-IMMKCWDYKPENRPK-----FS-ELQKEL----------
---L-VLGEQIGRGNFGEVFSGRL---R-------ADNT--LVAV-KSC---R-E-T-LP----PDL-KAKFL-Q-------------------------EARILKQY--S------HPNIVRLIGVCT--Q-----------------------------KQP--IY--IVMELVQGG--DFLTFLR----------TE-----------------------GARL--RVKTLLQMVGDAAAGMEYLESK-CCIHRDLAARNCLVT----E---KNVL---------KISDFGMSREE-------------A---D--GVYA--------------ASGGLRQVPVKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---------SNQQTREFVEKGGR----LP---CPELCP----------------------------------------------------------DAVFR-LMEQCWAYEPGQRPS-----FS-TIYQEL----------
---L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVT--KVAV-KML---K-S-D-AT----EKD-LSDLI-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------DGP--LY--VIVEYASKG--NLREYLQ----------ARRPPGLEY--------CYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVT----E---DNVM---------KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRI----YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---------PVEELFKLLKEGHR----MD---KPSNCT----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------
----LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAV--TVAV-KML---K-D-D-AT----EKD-LSDLV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------DGP--LY--VIVEYASKG--NLREYLR----------ARRPPGMEY--------SYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLVT----E---NNVM---------KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---------PVEELFKLLKEGHR----MD---KPANCT----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------
----LTLGKPLGEGCFGQVVMAEA---IGIDKDRAAKPV--TVAV-KML---K-D-D-AT----DKD-LSDLV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------GGP--LY--VLVEYAAKG--NLREFLR----------ARRPPGLDY--------SFDTCKPPEEQL--TFKDLVSCAYQVARGMEYLASQ-KCIHRDLAARNVLVT----E---DNVM---------KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---------PVEELFKLLKEGHR----MD---KPANCT----------------------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL----------
---L-VLGKPLGEGCFGQVVRAEA---FGMDPARPDQAS--TVAV-KML---K-D-N-AS----DKD-LADLV-S-------------------------EMEVMKLIG-R------HKNIINLLGVCT--Q-----------------------------EGP--LY--VIVECAAKG--NLREFLR----------ARRPPGPDL--------SPDGPRSSEGPL--SFPVLVSCAYQVARGMQYLESR-KCIHRDLAARNVLVT----E---DNVM---------KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---------PVEELFSLLREGHR----MD---RPPHCP----------------------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL----------
----YTDIKVIGNGSFGVVYQARL---A-------ETRE--LVAI-KKV---LQD-K-RFK---NR----------------------------------ELQIMRKL--D------HCNIVRLRYFFY--SSG-------------------------EKKDE--LYLNLVLEYVPETVYRVARHFT--------KAKL-------------------------TI--PILYVKVYMYQLFRSLAYIHSQ-GVCHRDIKPQNLLVD---PD---TAVL---------KLCDFGSAKQ------------------LVRGEPN--------------VS---YICSRYYRAPEL--IF----------GATD----YTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD---------SGVDQLVEIIKVLG----TP---TREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-----PL-EACAHSFF--------
----YTTIRQLGDGTYGSVLLGRS---I-------ESGE--LIAI-KKM---KRK-F-YSW---EE---C-MNLR-------------------------EVKSLKKL--N------HANVVKLKEVIR--E-----------------------------NDH--LY--FIFEYMKE---NLYQLIK--------ERNK-------------------------LF--PESAIRNIMYQILQGLAFIHKH-GFFHRDLKPENLLCM----G---PELV---------KIADFGLARE------------------IRSKPPY--------------TD---YVSTRWYRAPEV--LL----------RSTN----YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA---------SEIDTIFKICQVLG----TP---KKTDWPEGYQLSSAMNFRWPQCV-----------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----AS-QALRYPYF--------
----LTFVQEIGSGQFGLVHLGYW---L--------NKD--KVAI-KTI---R-E-G-AM----SE---EDFI-E-------------------------EAEVMMKL--S------HPKLVQLYGVCL--E-----------------------------QAP--IC--LVFEFMEHG--CLSDYLR----------TQ-----------------------RGLF--AAETLLGMCLDVCEGMAYLEEA-CVIHRDLAARNCLVG----E---NQVI---------KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEV--FS-----------FSR----YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---------SNSEVVEDISTGFR----LY---KPRLAS----------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL----------
---L-KRIRDLGEGHFGKVELCRY---DP---EGDNTGE--QVAV-KSL---K-P-E-SG----GNH-IADLK-K-------------------------EIEILRNL--Y------HENIVKYKGICT-ED------------------------------GGNGIK--LIMEFLPSG--SLKEYLP----------KN-----------------------KNKI--NLKQQLKYAVQICKGMDYLGSR-QYVHRDLAARNVLVE----S---EHQV---------KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPEC--LM-----------QSK----FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---------TVTRLVNTLKEGKR----LP---CPPNCP----------------------------------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQ-NLIE---GF-------
----LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGE--VVAV-KKL---Q-H-S-TE-----EH-LRDFE-R-------------------------EIEILKSL--Q------HDNIVKYKGVCYSAG-----------------------------RRN--LK--LIMEYLPYG--SLRDYLQ----------KH-----------------------KERI--DHIKLLQYTSQICKGMEYLGTK-RYIHRDLATRNILVE----N---ENRV---------KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPES--LT-----------ESK----FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---------IVFHLIELLKNNGR----LP---RPDGCP----------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------
---L-KYISQLGKGNFGSVELCRY---DP---LGDNTGA--LVAV-KQL---Q-H-S-GP----DQ--QRDFQ-R-------------------------EIQILKAL--H------SDFIVKYRGVSYGPG-----------------------------RQS--LR--LVMEYLPSG--CLRDFLQ----------RH-----------------------RARL--DASRLLLYSSQICKGMEYLGSR-RCVHRDLAARNILVE----S---EAHV---------KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPES--LS-----------DNI----FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-------ALCRLLELLEEGQR----LP---APPACP----------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------
----LKLVERLGAGQFGEVWMGYY---N--------GHT--KVAV-KSL---K-Q-G-SM----SP---DAFL-A-------------------------EANLMKQL--Q------HQRLVRLYAVVT--------------------------------QEP--IY--IITEYMENG--SLVDFLK----------TP----------------------SGIKL--TINKLLDMAAQIAEGMAFIEER-NYIHRDLRAANILVS----D---TLSC---------KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----------YGT----FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---------TNPEVIQNLERGYR----MV---RPDNCP----------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------
--LI--HGEVLGKGCFGQAIKVTH---R-------ETGE--VMVM-KEL---I---R-FD----EET-QRTFL-K-------------------------EVKVMRCL--E------HPNVLKFIGVLY--K-----------------------------DKR--LN--FITEYIKGG--TLRGIIK----------SM-----------------------DSQY--PWSQRVSFAKDIASGMAYLHSM-NIIHRDLNSHNCLVR----E---NKNV---------VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM--IN-----------GRS----YDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYL-P-------RTMDFGLNVRGFLD----RY---CPPNCP----------------------------------------------------------PSFFP-ITVRCCDLDPEKRPS-----FV-KLEH---WL-------
--LI--HGEVLGKGFFGQAIKVTH---K--------ATG--KVMVMKEL-----I-R-CD----EET-QKTFL-T-------------------------EVKVMRSL--D------HPNVLKFIGVLY--K-----------------------------DKK--LN--LLTEYIEGG--TLKDFLR----------SM------------------------DPF--PWQQKVRFAKGIASGMAYLHSM-CIIHRDLNSHNCLIK----L---DKTV---------VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM--LN-----------GKS----YDETVDIFSFGIVLCEIIGQVY-AD---------------PDCL-P-------RTLDFGLNVKLFWE----KF---VPTDCP----------------------------------------------------------PAFFP-LAAICCRLEPESRPA-----FS-KLED---SF-------
----YTTMRQLGDGTYGSVLMGKS---N-------ESGE--LVAI-KRM---KRK-F-YSW---DE---CM-NLR-------------------------EVKSLKKL--N------HANVIKLKEVIR--E-----------------------------NDH--LY--FIFEYMKE---NLYQLMK--------DRNK-------------------------LF--PESVIRNIMYQILQGLAFIHKH-GFFHRDMKPENLLCM----G---PELV---------KIADFGLARE------------------LRSQPPY--------------TD---YVSTRWYRAPEV--LL----------RSSV----YSSPIDVWAVGSIMAELYM-LR-PL---------------FPGT---------SEVDEIFKICQVLG----TP---KKSDWPEGYQLASSMNFRFPQCV-----------------------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-----AS-QALKHPYF--------
--LK--DLGEIGRGAYGSVNKMVH---K-------PSGQ--IMAV-KRI---RST-V-DEK---EQ---KQL-LM-------------------------DLDVVMRS-SD------CPYIVQFYGALF--R-----------------------------EGD--CW--ICMELMSTSFDKFYKYVYS-------VLDD-------------------------VI--PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLD----R---SGNI---------KLCDFGISGQ------------------LVDSIAK--------------TR---DAGCRPYMAPER--IDP-------SASRQG----YDVRSDVWSLGITLYELAT-GR-FP---------------YPKW----------NSVFDQLTQVVKG----DP---PQLSNSEEREFS----------------------------------------------------PSFIN-FVNLCLTKDESKRPK-----YK-ELLKHPFI--------
----YDLLQRLGGGTYGEVFKARD---K-------VSGD--LVAL-KMV---KME-P-DDD---VS---T--LQK-------------------------EILILKTC--R------HANIVAYHGSYL--W-----------------------------LQK--LW--ICMEFCGAG--SLQDIYQ---------VTG-------------------------SL--SELQISYVCREVLQGLAYLHSQ-KKIHRDIKGANILIN----D---AGEV---------RLADFGISAQI-----------------GATLARR--------------LS---FIGTPYWMAPEVAAVA----------LKGG----YNELCDIWSLGITAIELAE-LQ-PP---------------LFDV---------HPLRVLFLMTKSGY----QP---PRLKEKGKWS------------------------------------------------------AAFHN-FIKVTLTKSPKKRPS-----AT-KMLSHQL-V-------
----FELLQRVGAGTYGDVYKARD---T-------VTSE--LAAV-KIV---KLD-P-GDD---IS---SL--QQ-------------------------EITILREC--R------HPNVVAYIGSYL--R-----------------------------NDR--LW--ICMEFCGGG--SLQEIYH---------ATG-------------------------PL--EERQIAYVCREALKGLHHLHSQ-GKIHRDIKGANLLLT----L---QGDV---------KLADFGVSGEL-----------------TASVAKR--------------RS---FIGTPYWMAPEVAAVE----------RKGG----YNELCDVWALGITAIELGE-LQ-PP---------------LFHL---------HPMRALMLMSKSSF----QP---PKLRDKTR--WT----------------------------------------------------QNFHH-FLKLALTKNPKKRPT-----AE-KLLQHPF-T-------
----YQNLKPIGSGAQGIVCAAYD---A-------VLDR--NVAI-KKL---SRP-F-QNQ---TH---AKRAYR-------------------------ELVLMKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQD--VY--LVMELMDA---NLCQVIQ-----------M-------------------------EL--DHERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK----S---DCTL---------KILDFGLART------------------AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----------GMG----YKENVDIWSVGCIMGEMVR-HK-IL---------------FPGR---------DYIDQWNKVIEQLG----TP---CPEFMKKLQPTVRNYVENRPKYAGLTFPK-----------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VD-DALQHPYI--------
----YRDLQPVGSGAYGAVCSAVD---G-------RTGA--KVAI-KKL---YRP-F-QSE---LF---AKRAYR-------------------------ELRLLKHM--R------HENVIGLLDVFT--PDET-----------------------LDDFTD--FY--LVMPFMGT---DLGKLMK----------HE-------------------------KL--GEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVN----E---DCEL---------KILDFGLAR--------------------QADSEM--------------TG---YVVTRWYRAPEV--IL----------NWMR----YTQTVDIWSVGCIMAEMIT-GK-TL---------------FKGS---------DHLDQLKEIMKVTG----TP---PAEFVQRLQSDEAKNYMKGLPELE----------------------------KKDFASILTNASPLAVN-LLEKMLVLDAEQRVT-----AG-EALAHPYF--------
YVSP----THVGSGAYGSVCSAID---K-------RSGE--KVAI-KKL---SRP-F-QSE---IF---AKRAYR-------------------------ELLLLKHM--Q------HENVIGLLDVFT--PASS-----------------------LRNFYD--FY--LVMPFMQT---DLQKIM-----------GM-------------------------EF--SEEKIQYLVYQMLKGLKYIHSA-GVVHRDLKPGNLAVN----E---DCEL---------KILDFGLAR--------------------HADAEM--------------TG---YVVTRWYRAPEV--IL----------SWMH----YNQTVDIWSVGCIMAEMLT-GK-TL---------------FKGK---------DYLDQLTQILKVTG----VP---GTEFVQKLNDKAAKSYIQSLPQTP----------------------------RKDFTQLFPRASPQAAD-LLEKMLELDVDKRLT-----AA-QALTHPFF--------
----YQNLKPIGSGAQGIVCAAYD---A-------ILER--NVAI-KKL---SRP-F-QNQ---TH---AKRAYR-------------------------ELVLMKCV--N------HKNIIGLLNVFT--PQKS-----------------------LEEFQD--VY--IVMELMDA---NLCQVIQ-----------M-------------------------EL--DHERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK----S---DCTL---------KILDFGLART------------------AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----------GMG----YKENVDLWSVGCIMGEMVC-HK-IL---------------FPGR---------DYIDQWNKVIEQLG----TP---CPEFMKKLQPTVRTYVENRPKYAGYSFEK-----------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VD-EALQHPYI--------
----YQQLKPIGSGAQGIVCAAFD---T-------VLGI--NVAV-KKL---SRP-F-QNQ---TH---AKRAYR-------------------------ELVLLKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQD--VY--LVMELMDA---NLCQVIH-----------M-------------------------EL--DHERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK----S---DCTL---------KILDFGLART------------------ACTNFMM--------------TP---YVVTRYYRAPEV--IL-----------GMG----YKENVDIWSVGCIMGELVK-GC-VI---------------FQGT---------DHIDQWNKVIEQLG----TP---SAEFMKKLQPTVRNYVENRPKYPGIKFEE-----------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VD-EALRHPYI--------
----YELHETIGTGGFAKVKLACH---I-------LTGE--MVAI-KIM---DKN-T-LGS---DL---PRIKT--------------------------EIEALKNL--R------HQHICQLYHVLE--T-----------------------------ANK--IF--MVLEYCPGG--ELFDYII---------SQD-------------------------RL--SEEETRVVFRQIVSAVAYVHSQ-GYAHRDLKPENLLFD----E---YHKL---------KLIDFGLCAKP----------------KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ----------GKSY----LGSEADVWSMGILLYVLMC-GF-LP---------------FDDD------------NVMALYKKIMR----GK---YDVPKWLS--------------------------------------------------------PSSIL-LLQQMLQVDPKKRIS-----MK-NLLNHPWI--------
--MN--SKEALGGGKFGAVCTCME---K-------ATGL--KLAA-KVI---KKQ-T-PKD---KE---M--VLL-------------------------EIEVMNQL--N------HRNLIQLYAAIE--T-----------------------------PHE--IV--LFMEYIEGG--ELFERIV--------DEDY-------------------------HL--TEVDTMVFVRQICDGILFMHKM-RVLHLDLKPENILCV---NT---TGHL--------VKIIDFGLARR------------------YNPNEKL--------------KV---NFGTPEFLSPEV--VN-----------YDQ----ISDKTDMWSMGVITYMLLS-GL-SP---------------FLGD------------DDTETLNNVLS----GN---WYFDEETFEAVS----------------------------------------------------DEAKD-FVSNLIVKDQRARMN-----AA-QCLAHPWL--------
---Y-VRLQKIGEGSFGKAILVKS---T-------EDGR--QYVI-KEI---NIS-R-MSS---KE---REESRR-------------------------EVAVLANM--K------HPNIVQYRESFE--E-----------------------------NGS--LY--IVMDYCEGG--DLFKRINA-------QKGV-------------------------LF--QEDQILDWFVQICLALKHVHDR-KILHRDIKSQNIFLT----K---DGTV---------QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEI--CE-----------NKP----YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG------------SMKNLVLKIIS----GS---FPPVSLHYS-------------------------------------------------------YDLRS-LVSQLFKRNPRDRPS-----VN-SILEKGF-I-------
---Y-CYLRVVGKGSYGEVTLVKH---R-------RDGK--QYVI-KKL---NLR-N-ASS---RE---RRAAEQ-------------------------EAQLLSQL--K------HPNIVTYKESWE--G----------------------------GDGL--LY--IVMGFCEGG--DLYRKLKE-------QKGQ-------------------------LL--PENQVVEWFVQIAMALQYLHEK-HILHRDLKTQNVFLT----R---TNII---------KVGDLGIARVL-----------------ENHCDMA--------------ST---LIGTPYYMSPEL--FS-----------NKP----YNYKSDVWALGCCVYEMAT-LK-HA---------------FNAK------------DMNSLVYRIIE----GK---LPPMPRDY---S----------------------------------------------------PELAE-LIRTMLSKRPEERPS-----VR-SILRQPYI--------
----YDVIKAIGQGAFGKAYLAKG---K-------SDSK--HCVI-KEI---NFE-K-MPI---QE---KEASKK-------------------------EVILLEKM--K------HPNIVAFFNSFQ--E-----------------------------NGR--LF--IVMEYCDGG--DLMKRINR-------QRGV-------------------------LF--SEDQILGWFVQISLGLKHIHDR-KILHRDIKAQNIFLS----K---NGMV--------AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEI--CQ-----------NKP----YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN------------NLQQLVLKICQ----AH---FAPISPGF---S----------------------------------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL--------
----FQIEKKIGRGQFSEVYKATC---L-------LDRK--TVAL-KKV---QIF-E-MMD---AK---ARQDCV------------------------KEIGLLKQL--N------HPNIIKYLDSFI--E-----------------------------DNE--LN--IVLELADAG--DLSQMIKYF-----KKQKR-------------------------LI--PERTVWKYFVQLCSAVEHMHSR-RVMHRDIKPANVFIT----A---TGVV---------KLGDLGLGRFF-----------------SSETTAA--------------HS---LVGTPYYMSPER--IH-----------ENG----YNFKSDIWSLGCLLYEMAA-LQ-SP---------------FYGD----------KMNLFSLCQKIEQ----CD---YPPLPGEHYS------------------------------------------------------EKLRE-LVSMCICPDPHQRPD-----IG-Y-------VHQVAKQM
-YIP---IRVLGRGAFGEATLYRR---T-------EDDS--LVVW-KEV---DLT-R-LSE---KE---RRDALN-------------------------EIVILALL--Q------HDNIIAYYNHFM--D-----------------------------NTT--LL--IELEYCNGG--NLYDKILR-------QKDK-------------------------LF--EEEMVVWYLFQIVSAVSCIHKA-GILHRDIKTLNIFLT----K---ANLI---------KLGDYGLAKKL-----------------NSEYSMA--------------ET---LVGTPYYMSPEL--CQ-----------GVK----YNFKSDIWAVGCVIFELLT-LK-RT---------------FDAT------------NPLNLCVKIVQ----GI---RAMEVDSS-QYS----------------------------------------------------LELIQ-MVHSCLDQDPEQRPT-----AD-ELLDRPL-L-------
--IV--LKWELGEGAFGKVFLAEC---HN--LLPEQDKM--LVAV-KAL---K-E-A-SE----SA--RQDFQ-R-------------------------EAELLTML--Q------HQHIVRFFGVCT--E-----------------------------GRP--LL--MVFEYMRHG--DLNRFLR----------SHGPDAKL---------LAGGEDVAPGPL--GLGQLLAVASQVAAGMVYLAGL-HFVHRDLATRNCLVG----Q---GLVV---------KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----------YRK----FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---------SNTEAIDCITQGRE----LE---RPRACP----------------------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL----------
---I-VLKRELGEGAFGKVFLAEC---YN--LCPEQDKI--LVAV-KTL---K-D-A-SD----NA--RKDFH-R-------------------------EAELLTNL--Q------HEHIVKFYGVCV--E-----------------------------GDP--LI--MVFEYMKHG--DLNKFLR----------AHGPDAV-----------LMAEGNPPTEL--TQSQMLHIAQQIAAGMVYLASQ-HFVHRDLATRNCLVG----E---NLLV---------KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---------SNNEVIECITQGRV----LQ---RPRTCP----------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L--------
---I-VLKRELGEGAFGKVFLAEC---YN--LSPTKDKM--LVAV-KAL---K-D-P-TL----AA--RKDFQ-R-------------------------EAELLTNL--Q------HEHIVKFYGVCG--D-----------------------------GDP--LI--MVFEYMKHG--DLNKFLR----------AHGPDAMIL--------VDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQ-HFVHRDLATRNCLVG----A---NLLV---------KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---------SNTEVIECITQGRV----LE---RPRVCP----------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL----------
---Y-ILGDTLGVGTFGKVKVGKH---E-------LTGH--KVAV-KIL---NRQ-K-IRS---LD---VVGKIR------------------------REIQNLKLF--R------HPHIIKLYQVIS--T-----------------------------PSD--IF--MVMEYVSGG--ELFDYIC---------KNG-------------------------RL--DEKESRRLFQQILSGVDYCHRH-MVVHRDLKPENVLLD----A---HMNA---------KIADFGLSNM------------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS----------GRLY----AGPEVDIWSSGVILYALLC-GT-LP---------------FDDD------------HVPTLFKKICD----GI---FYTPQYLN--------------------------------------------------------PSVIS-LLKHMLQVDPMKRAT-----IK-DIREHEWF--------
---F-ERIKTLGTGSFGRVMLVKH---K-------ETGN--HYAM-KIL---DKQ-K-VVK---LK---QIEHTL------------------------NEKRILQAV--N------FPFLVKLEFSFK--D-----------------------------NSN--LY--MVMEYVPGG--EMFSHLR---------RIG-------------------------RF--SEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLID----Q---QGYI---------QVTDFGFAK--------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL-----------SKG----YNKAVDWWALGVLIYEMAA-GY-PP---------------FFAD------------QPIQIYEKIVS----GK---VRFPSHFS--------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVN-DIKNHKWF--------
---F-ERKKTLGTGSFGRVMLVKH---K-------ATEQ--YYAM-KIL---DKQ-K-VVK---LK---QIEHTL------------------------NEKRILQAV--N------FPFLVRLEYAFK--D-----------------------------NSN--LY--MVMEYVPGG--EMFSHLR---------RIG-------------------------RF--SEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLID----H---QGYI---------QVTDFGFAK--------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL-----------SKG----YNKAVDWWALGVLIYEMAA-GY-PP---------------FFAD------------QPIQIYEKIVS----GK---VRFPSHFS--------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVS-DIKTHKWF--------
--FI--LHKMLGKGSFGKVFLAEF---K-------KTNQ--FFAI-KAL---KKD-V-VLM---DD---DVECTM------------------------VEKRVLSLA-WE------HPFLTHMFCTFQ--T-----------------------------KEN--LF--FVMEYLNGG--DLMYHIQ---------SCH-------------------------KF--DLSRATFYAAEIILGLQFLHSK-GIVYRDLKLDNILLD----K---DGHI---------KIADFGMCKEN-----------------MLGDAKT--------------NT---FCGTPDYIAPEI--LL-----------GQK----YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ------------DEEELFHSIRM----DN---PFYPRWLE--------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------
--PD----EVLGSGQFGIVYGGKH---R-------KTGR--DVAI-KII---DKL-R-FPT---KQ---ESQLRN-------------------------EVAILQNL--H------HPGVVNLECMFE--T-----------------------------PER--VF--VVMEKLHGD--MLEMILS--------SEKG-------------------------RL--PEHITKFLITQILVALRHLHFK-NIVHCDLKPENVLLA----S---ADPFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------NKG----YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED--------------EDIHDQIQN----AA---FMYPPNPWKEIS----------------------------------------------------HEAID-LINNLLQVKMRKRYS-----VD-KTLSHPWL--------
--PD----EVLGSGQFGVVYGGKH---R-------KTGR--DVAV-KVI---DKL-R-FPT---KQ---ESQLRN-------------------------EVAILQSL--R------HPGIVNLECMFE--T-----------------------------PEK--VF--VVMEKLHGD--MLEMILS--------SEKG-------------------------RL--PERLTKFLITQILVALRHLHFK-NIVHCDLKPENVLLA----S---ADPFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LL-----------NQG----YNRSLDMWSVGVIMYVSLS-GT-FP---------------FNED--------------EDINDQIQN----AA---FMYPASPWSHIS----------------------------------------------------AGAID-LINNLLQVKMRKRYS-----VD-KSLSHPWL--------
-FAD----EVLGSGQFGIVYGGKH---R-------KTGR--DVAI-KVI---DKM-R-FPT---KQ---ESQLRN-------------------------EVAILQNL--H------HPGIVNLECMFE--T-----------------------------PER--VF--VVMEKLHGD--MLEMILS--------SEKS-------------------------RL--PERITKFMVTQILVALRNLHFK-NIVHCDLKPENVLLA----S---AEPFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------SKG----YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED--------------EDINDQIQN----AA---FMYPPNPWREIS----------------------------------------------------GEAID-LINNLLQVKMRKRYS-----VD-KSLSHPWL--------
--FD--TLATVGTGTFGRVHLVKE---K-------TAKH--FFAL-KVM---SIP-D-VIR---LK---QEQHVH------------------------NEKSVLKEV--S------HPFLIRLFWTWH--D-----------------------------ERF--LY--MLMEYVPGG--ELFSYLR---------NRG-------------------------RF--SSTTGLFYSAEIICAIEYLHSK-EIVYRDLKPENILLD----R---DGHI---------KLTDFGFAKK--------------------LVDRT--------------WT---LCGTPEYLAPEV--IQ-----------SKG----HGRAVDWWALGILIFEMLS-GF-PP---------------FFDD------------NPFGIYQKILA----GK---IDFPRHLD--------------------------------------------------------FHVKD-LIKKLLVVDRTRRLGNMKNGAN-DVKHHRWF--------
----IELGRCIGEGQFGDVHQGIY---M----SPENPAL--AVAI-KTC---K-N-C-TS----DSV-REKFL-Q-------------------------EALTMRQF--D------HPHIVKLIGVIT--------------------------------ENP--VW--IIMELCTLG--ELRSFLQ----------VR-----------------------KYSL--DLASLILYAYQLSTALAYLESK-RFVHRDIAARNVLVS----S---NDCV---------KLGDFGLSRYM-----------------E--DSTY--------------YKASKGKLPIKWMAPES--IN-----------FRR----FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---------KNNDVIGRIENGER----LP---MPPNCP----------------------------------------------------------PTLYS-LMTKCWAYDPSRRPR-----FT-ELKAQL----------
---V-VLNRILGEGFFGEVYEGVY---T----NHKGEKI--NVAV-KTC---K-K-D-CT----LDN-KEKFM-S-------------------------EAVIMKNL--D------HPHIVKLIGIIE--------------------------------EEP--TW--IIMELYPYG--ELGHYLE----------RN-----------------------KNSL--KVLTLVLYSLQICKAMAYLESI-NCVHRDIAVRNILVA----S---PECV---------KLGDFGLSRYI-----------------E--DEDY--------------YKASVTRLPIKWMSPES--IN-----------FRR----FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL---------ENKDVIGVLEKGDR----LP---KPDLCP----------------------------------------------------------PVLYT-LMTRCWDYDPSDRPR-----FT-ELVCS--L--------
--VM--LSTRIGSGSFGTVYKGKW---H----------G--DVAV-KIL---K-VVD-PT----PEQ-FQAFR-N-------------------------EVAVLRKT--R------HVNILLFMGYMT--------------------------------KDN--LA--IVTQWCEGS--SLYKHLH----------VQ-----------------------ETKF--QMFQLIDIARQTAQGMDYLHAK-NIIHRDMKSNNIFLH----E---GLTV---------KIGDFGLATVK-------------S---R--WSGS--------------QQVEQPTGSVLWMAPEV--IR-----------MQDN-NPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHI-N-------NRDQIIFMVGRGYASPDLSK---LYKNCP----------------------------------------------------------KAMKR-LVADCVKKVKEERPL-----FP-QILSS--I--------
---L-VLGKTLGEGEFGKVVKATA---FH--LKGRAGYT--TVAV-KML---K-E-N-AS----PSE-LRDLL-S-------------------------EFNVLKQV--N------HPHVIKLYGACS--Q-----------------------------DGP--LL--LIVEYAKYG--SLRGFLR----------ESRKVGPGYLGSGGSRNSSSLDHPDERAL--TMGDLISFAWQISQGMQYLAEM-KLVHRDLAARNILVA----E---GRKM---------KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----------DHI----YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---------PPERLFNLLKTGHR----ME---RPDNCS----------------------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL----------
-LES----AELDSGGFGKVSLCFH---R--------TQG--LMIM-KTV--YK-G-P-NC----IEH-NEALL-E-------------------------EAKMMNRL--R------HSRVVKLLGVII--E-----------------------------EGK--YS--LVMEYMEKG--NLMHVLK----------AE------------------------MST--PLSVKGRIILEIIEGMCYLHGK-GVIHKDLKPENILVD----N---DFHI---------KIADLGLASFKMWS------KLNNE-------EHNELR--------EVDGTAKKNGGTLYYMAPEH--LN-----------DVNA--KPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENA-I-------CEQQLIMCIKSGNR----PDVDDITEYCP----------------------------------------------------------REIIS-LMKLCWEANPEARPT-----FP-GIEEK--F--------
----FELLRVLGKGGYGKVFQVRKVTGA-------NTGK--IFAM-KVL---KKA-M-IVR---NA---KDTAHTK-----------------------AERNILEEV--K------HPFIVDLIYAFQ--T-----------------------------GGK--LY--LILEYLSGG--ELFMQLE---------REG-------------------------IF--MEDTACFYLAEISMALGHLHQK-GIIYRDLKPENIMLN----H---QGHV---------KLTDFGLCKES-----------------IHDGTVT--------------HT---FCGTIEYMAPEI--LM-----------RSG----HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE------------NRKKTIDKILK----CK---LNLPPYLT--------------------------------------------------------QEARD-LLKKLLKRNAASRLGAGPGDAG-EVQAHPFF--------
----YDIERTLGKGNFAVVKLARH---R-------VTKT--QVAI-KII---DKT-R-LDS---SN---LEKIYR-------------------------EVQLMKLL--N------HPHIIKLYQVME--T-----------------------------KDM--LY--IVTEFAKNG--EMFDYLT---------SNG-------------------------HL--SENEARKKFWQILSAVEYCHDH-HIVHRDLKTENLLLD----G---NMDI---------KLADFGFGNF------------------YKSGEPL--------------ST---WCGSPPYAAPEV--FE----------GKEY----EGPQLDIWSLGVVLYVLVC-GS-LP---------------FDGP------------NLPTLRQRVLE----GR---FRIPFFMS--------------------------------------------------------QDCES-LIRRMLVVDPARRIT-----IA-QIRQHRWM--------
----WEIIGELGDGAFGKVYKAQN---K-------ETSV--LAAA-KVI---DTK-S-EEE---LE---DYM--V-------------------------EIDILASC--D------HPNIVKLLDAFY--Y-----------------------------ENN--LW--ILIEFCAGG--AVDAVML--------ELER-------------------------PL--TESQIQVVCKQTLDALNYLHDN-KIIHRDLKAGNILFT----L---DGDI---------KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE------TSKDRP----YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---------NPMRVLLKIAKSEP----PT---LAQPSRWS--------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TS-QLLQHPFV--------
----WEIVGELGDGAFGKVYKAKN---K-------ETGA--LAAA-KVI---ETK-S-EEE---LE---DYI--V-------------------------EIEILATC--D------HPYIVKLLGAYY--H-----------------------------DGK--LW--IMIEFCPGG--AVDAIML--------ELDR-------------------------GL--TEPQIQVVCRQMLEALNFLHSK-RIIHRDLKAGNVLMT----L---EGDI---------RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE------TMKDTP----YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL---------NPMRVLLKIAKSDP----PT---LLTPSKWS--------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AA-QLLEHPFV--------
----FTKLEKIGKGSFGEVFKGID---N-------RTQK--VVAI-KII---DLE-E-AED---EI---EDIQ-Q-------------------------EITVLSQC--D------SPYVTKYYGSYL--K-----------------------------DTK--LW--IIMEYLGGG--SALDLLE----------PG-------------------------PL--DETQIATILREILKGLDYLHSE-KKIHRDIKAANVLLS----E---HGEV---------KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----------QSA----YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---------HPMKVLFLIPKNNP----PT---LEGNYS----------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI--------
---F-TKLDRIGKGSFGEVYKGID---N-------HTKE--VVAI-KII---DLE-E-AED---EI---EDIQ-Q-------------------------EITVLSQC--D------SPYITRYFGSYL--K-----------------------------STK--LW--IIMEYLGGG--SALDLLK----------PG-------------------------PL--EETYIATILREILKGLDYLHSE-RKIHRDIKAANVLLS----E---QGDV---------KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----------QSA----YDFKADIWSLGITAIELAK-GE-PP---------------NSDL---------HPMRVLFLIPKNSP----PT---LEGQHS----------------------------------------------------------KPFKE-FVEACLNKDPRFRPT-----AK-ELLKHKFI--------
---F-DVLEKLGEGSYGSVFKAIH---K-------ESGQ--VVAI-KQV---PVE-S-DLQ---EI-------IK-------------------------EISIMQQC--D------SPYVVKYYGSYF--K-----------------------------NTD--LW--IVMEYCGAG--SVSDIIR--------LRNK-------------------------TL--IEDEIATILKSTLKGLEYLHFM-RKIHRDIKAGNILLN----T---EGHA---------KLADFGVAGQL-----------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITSIEMAE-GK-PP---------------YADI---------HPMRAIFMIPTNPP----PT---FRKPELWS--------------------------------------------------------DDFTD-FVKKCLVKNPEQRAT-----AT-QLLQHPFI--------
----YHVLEMIGEGSFGRVYKGRR---K-------YSAQ--VVAL-KFI---PKL-G-RSE---KE---LRNLQR-------------------------EIEIMRGL--R------HPNIVHMLDSFE--T-----------------------------DKE--VV--VVTDYAEG---ELFQILE---------DDG-------------------------KL--PEDQVQAIAAQLVSALYYLHSH-RILHRDMKPQNILLA----K---GGGI---------KLCDFGFARAM-----------------STNTMVL--------------TS---IKGTPLYMSPEL--VE-----------ERP----YDHTADLWSVGCILYELAV-GT-PP---------------FYAT------------SIFQLVSLILK----DP---VRWPSTIS--------------------------------------------------------PCFKN-FLQGLLTKDPRQRLS-----WP-DLLYHPFI--------
----YELQEVIGSGATAVVQAALC---K-------PRQE--RVAI-KRI---NLE-K-CQT---SM---DE-LLK-------------------------EIQAMSQC--S------HPNVVTYYTSFV--V-----------------------------KDE--LW--LVMKLLSGG--SMLDIIKYIVN-RGEHKNG-------------------------VL--EEAIIATILKEVLEGLDYLHRN-GQIHRDLKAGNILLG----E---DGSV---------QIADFGVSAFLAT------------GGDVTRNKVR--------------KT---FVGTPCWMAPEV--ME----------QVRG----YDFKADMWSFGITAIELAT-GA-AP---------------YHKY---------PPMKVLMLTLQNDP----PT---LETGVEDKE--MMK-----------------------------------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AA-ELLKCKFF--------
---F-DVLEKLGEGSYGSVYKAIH---K-------ETGQ--IVAI-KQV---PVE-S-DLQ---EI-------IK-------------------------EISIMQQC--D------SPHVVKYYGSYF--K-----------------------------NTD--LW--IVMEYCGAG--SVSDIIR--------LRNK-------------------------TL--TEDEIATILQSTLKGLEYLHFM-RKIHRDIKAGNILLN----T---EGHA---------KLADFGVAGQL-----------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITAIEMAE-GK-PP---------------YADI---------HPMRAIFMIPTNPP----PT---FRKPELWS--------------------------------------------------------DNFTD-FVKQCLVKSPEQRAT-----AT-QLLQHPFV--------
-TLE---DKELGSGNFGTVKKGYY---Q-----MKKVVK--TVAV-KIL---K-N-E-AN----DPALKDELL-A-------------------------EANVMQQL--D------NPYIVRMIGICE--------------------------------AES--WM--LVMEMAELG--PLNKYLQ----------QN------------------------RHV--KDKNIIELVHQVSMGMKYLEES-NFVHRDLAARNVLLV----T---QHYA---------KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPEC--IN-----------YYK----FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---------KGSEVTAMLEKGER----MG---CPAGCP----------------------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL------
---F-TDLREIGHGSFGAVYFARD---V-------RTNE--VVAI-KKM---SYS-G-KQS---TE---KWQDII------------------------KEVKFLQRI--K------HPNSIEYKGCYL--R-----------------------------EHT--AW--LVMEYCLG---SASDLLE--------VHKK-------------------------PL--QEVEIAAITHGALQGLAYLHSH-TMIHRDIKAGNILLT----E---PGQV---------KLADFGSASM---------------------ASPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDVWSLGITCIELAE-RK-PP---------------LFNM---------NAMSALYHIAQNES----PT---LQSNEWS---------------------------------------------------------DYFRN-FVDSCLQKIPQDRPT-----SE-ELLKHIF-V-------
--FS--DLREIGHGSFGAVYFARD---V-------RNSE--VVAI-KKM---SYS-G-KQS---NE---KWQDII------------------------KEVRFLQKL--R------HPNTIQYRGCYL--R-----------------------------EHT--AW--LVMEYCLG---SASDLLE--------VHKK-------------------------PL--QEVEIAAVTHGALQGLAYLHSH-NMIHRDVKAGNILLS----E---PGLV---------KLGDFGSASI---------------------MAPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDVWSLGITCIELAE-RK-PP---------------LFNM---------NAMSALYHIAQNES----PV---LQSGHWS---------------------------------------------------------EYFRN-FVDSCLQKIPQDRPT-----SE-VLLKHRFV--------
FIGL----HEIGHGSFGAVYFATN---A-------HTSE--VVAI-KKM---SYS-G-KQT---HE---KWQDIL------------------------KEVKFLRQL--K------HPNTIEYKGCYL--K-----------------------------EHT--AW--LVMEYCLG---SASDLLE--------VHKK-------------------------PL--QEVEIAAITHGALHGLAYLHSH-ALIHRDIKAGNILLT----E---PGQV---------KLADFGSASM---------------------ASPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDIWSLGITCIELAE-RK-PP---------------LFNM---------NAMSALYHIAQNDS----PT---LQSNEWTD---------------------------------------------------------SFRR-FVDYCLQKIPQERPT-----SA-ELLRHDFV--------
----IKFQDVIGEGNFGQVLKARI---K-----KDGLRM--DAAI-KRM---K-E-Y-AS----KDD-HRDFA-G-------------------------ELEVLCKLG-H------HPNIINLLGACE--H-----------------------------RGY--LY--LAIEYAPHG--NLLDFLR----------KSRVLETDP--------AFAIANSTASTL--SSQQLLHFAADVARGMDYLSQK-QFIHRDLAARNILVG----E---NYVA---------KIADFGLSRGQ---------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---------TCAELYEKLPQGYR----LE---KPLNCD----------------------------------------------------------DEVYD-LMRQCWREKPYERPS-----FA-QILV---SL-------
----ITFEDLIGEGNFGQVIRAMI---K-----KDGLKM--NAAI-KML---K-E-Y-AS----END-HRDFA-G-------------------------ELEVLCKLG-H------HPNIINLLGACK--N-----------------------------RGY--LY--IAIEYAPYG--NLLDFLR----------KSRVLETDP--------AFAREHGTASTL--SSRQLLRFASDAANGMQYLSEK-QFIHRDLAARNVLVG----E---NLAS---------KIADFGLSRGE---------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---------TCAELYEKLPQGYR----ME---QPRNCD----------------------------------------------------------DEVYE-LMRQCWRDRPYERPP-----FA-QIALQ--L--------
-VCR---GELLGSGCFGVVHRGLW---T----LPSGKSV--PVAV-KSLRVGP-E-G-PM----GTE-LGDFL-R-------------------------EVSVMMNL--E------HPHVLRLHGLVL--------------------------------GQP--LQ--MVMELAPLG--SLHARLT----------AP---------------------APTPPL--LVALLCLFLRQLAGAMAYLGAR-GLVHRDLATRNLLLA----S---PRTI---------KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPES--LR-----------HGA----FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---------PPYLILQRLEDRAR----LP---RPPLCS----------------------------------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL------
----YSILKQIGSGGSSKVFQVLN---E-------KKQ---IYAI-KYV---NLE-E-ADN---QT---LDSYRN-------------------------EIAYLNKL-QQ-----HSDKIIRLYDYEI--T-----------------------------DQY--IY--MVMECGNI---DLNSWLK---------KKK-------------------------SI--DPWERKSYWKNMLEAVHTIHQH-GIVHSDLKPANFLIV--------DGML---------KLIDFGIANQMQ---------------PDTTSVVK--------------DS---QVGTVNYMPPEA--IKDMSSSRENGKSKSK----ISPKSDVWSLGCILYYMTY-GK-TP---------------FQQI-----------INQISKLHAIID----PN---HEIEFPDIPE------------------------------------------------------KDLQD-VLKCCLKRDPKQRIS-----IP-ELLAHPYV--------
--FS--RKDLIGHGAFAVVFKGRH---R-------EKHD-LEVAV-KCI---NKK-N-LAK---SQ---T-LLGK-------------------------EIKILKEL--K------HENIVALYDFQE--M-----------------------------ANS--VY--LVMEYCNGG--DLADYLH---------AMR-------------------------TL--SEDTIRLFLQQIAGAMRLLHSK-GIIHRDLKPQNILLS----N---PAGRRANPNSIRVKIADFGFARY------------------LQSNMMA--------------AT---LCGSPMYMAPEV--IM-----------SQH----YDGKADLWSIGTIVYQCLT-GK-AP---------------FQAS---------SPQDLRLFYEKNKT----LV---PTIPRETS--------------------------------------------------------APLRQ-LLLALLQRNHKDRMD-----FD-EFFHHPFL--------
---Y-SKRDLVGHGAFAVVFRGRH---R-------QKTD-WEVAI-KSI---NKK-N-LSK---SQ----ILLGK-------------------------EIKILKEL--Q------HENIVALYDVQE--L-----------------------------PNS--VF--LVMEYCNGG--DLADYLQ---------AKG-------------------------TL--SEDTIRVFLHQIAAAMRILHSK-GIIHRDLKPQNILLS----Y---ANRRKSSVSGIRIKIADFGFARY------------------LHSNMMA--------------AT---LCGSPMYMAPEV--IM-----------SQH----YDAKADLWSIGTVIYQCLV-GK-PP---------------FQAN---------SPQDLRMFYEKNRS---------LMPSIPRETS------------------------------------------------------PYLAN-LLLGLLQRNQKDRMD-----FE-AFFSHPFL--------
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