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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
AGC AKT1 150
AGC AKT3 148
Other AURKC 43
TKL BRAF 456
CAMK CAMK2D 14
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
AGC CIT 97
CAMK DAPK2 23
CAMK DAPK3 13
AGC GRK4 187
AGC GRK7 191
CMGC GSK3A 119
CMGC ICK 4
TK JAK3 822
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
AGC PRKACA 44
AGC PRKACB 44
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCQ 380
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
TK RET 724
AGC ROCK1 76
CAMK STK17A 61
CAMK STK17B 33
--F-NFIKVLGKGSFGKVMLAELK-----GKDEVYAVKVLKKD-VILQDD--DVDCTM------TEKRILALARK----HPY--LTQLYCCFQ--T----------KDRLF--FVMEYVNGG--DLMFQIQ--RSR-------------------------KFDEPRSRFYAAEVTSALMFLHQ-HGVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG------ILNGVTTTT---FCGTPDYIAPEILQ------ELE---YGPSVDWWALGVLMYEMMA-GQPP-------------FEAD-----NEDDLFESILH----DDVLYPVWLS-----------------------------KEAVSILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF------------
--F-EYLKLLGKGTFGKVILVKEK-----ATGRYYAMKILKKE-VIVAKD--EVAHTL------TENRVLQNS-R----HPF--LTALKYSFQ--T----------HDRLC--FVMEYANGG--ELFFHLS--RER-------------------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI----KITDFGLCKEG------IKDGATMKT---FCGTPEYLAPEVLE------DND---YGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ-----DHEKLFELILM----EEIRFPRTLG-----------------------------PEAKSLLSGLLKKDPKQ--RLGGG--SEDAK-EIMQHRFF--------------
-FD--YLKLLGKGTFGKVILVREK-----ASGKYYAMKILKKE-VIIAKD--EVAHTL------TESRVLKNT-R----HPF--LTSLKYSFQ--T----------KDRLC--FVMEYVNGG--ELFFHLS--RER-------------------------VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG------ITDAATMKT---FCGTPEYLAPEVLE------DND---YGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ-----DHEKLFELILM----EDIKFPRTLS-----------------------------SDAKSLLSGLLIKDPNK--RLGGG--PDDAK-EIMRHSFF--------------
---FEIGRPLGKGKFGNVYLARLK-----ESHFIVALKVLFKS-QIEKEG--LEHQLR------REIEIQAHL-Q----HPN--ILRLYNYFH--D----------ARRVY--LILEYAPRG--ELYKELQ--KSE-------------------------KLDEQRTATIIEELADALTYCHD-KKVIHRDIKPENLLLG-FRGEV----KIADFGWSV--------HTPSLRRKT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GYPP-------------FESA-----SHSETYRRILK----VDVRFPLSMP-----------------------------LGARDLISRLLRYQPLE--RLP-------LA-QILKHPWV--------------
---ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTAPT-PQQLQAFK-N-------EVGVLRKT-R----HVN--ILLFMGYST-------------KPQLA--IVTQWCEGS--SLYHHLH---II-----------------------ETKFEMIKLIDIARQTAQGMDYLHA-KSIIHRDLKSNNIFLH-EDLTV----KIGDFGLATVK---S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQLP-------------YSNIN-NRDQIIFMVGRGYLSPDLSKVRSNCP-------------------------------KAMKRLMAECLKKKRDE--RPL-------FP-QILA---SI-------------
---YQLFEELGKGAFSVVRRCMKI-----PTGQEYAAKIINTK-KLSARD--HQKLER-------EARICRLL-K----HPN--IVRLHDSIS--E----------EGFHY--LVFDLVTGG--ELFEDIV--ARE-------------------------YYSEADASHCIQQILESVNHCHL-NGIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV------QGDQQAWFG---FAGTPGYLSPEVLR------KDP---YGKPVDMWACGVILYILLV-GYPP-------------FWDE-----DQHRLYQQIKA----GAYDFPSPEWDTVT-------------------------PEAKDLINKMLTINPAK--RIT-------AS-EALKHPWI--------------
--F-DIIGIIGEGTYGQVYKARDK-----DTGEMVALKKVRLD-NEKEGF--PITAIR-------EIKILRQL-T----HQS--IINMKEIVT--DKEDALDFKKDKGAFY--LVFEYMDH---DLMGLLE-SGLV-------------------------HFNENHIKSFMRQLMEGLDYCHK-KNFLHRDIKCSNILLN-NRGQI----KLADFGLARLY-----SSEESRPYTN---KVITLWYRPPELLL-----GEER---YTPAIDVWSCGCILGELFT-KKPI-------------FQAN--QELAQLELISRICG----SPCPAVWPDVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALDLFDYMLALDPSK--RCT-------AE-QALQCEF-L-------------
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLD-TETEGV--PSTAIR-------EISLLKEL-N----HPN--IVKLLDVIH--T----------ENKLY--LVFEFLHQ---DLKKFMDASALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD--SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-------AK-AALAHPFF--------------
---FQKVEKIGEGTYGVVYKAKNR-----ETGQLVALKKIRLD-LEMEGV--PSTAIR-------EISLLKEL-K----HPN--IVRLLDVVH--N----------ERKLY--LVFEFLSQ---DLKKYMDSTPGS-------------------------ELPLHLIKSYLFQLLQGVSFCHS-HRVIHRDLKPQNLLIN-ELGAI----KLADFGLARAF------GVPLRTYTH---EVVTLWYRAPEILL-----GSKF---YTTAVDIWSIGCIFAEMVT-RKAL-------------FPGD--SEIDQLFRIFRMLG----TPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-------AK-TALAHPYF--------------
---YEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLME-NEKEGF--PITALR-------EIKILQLL-K----HEN--VVNLIEICR--TKASP--YNRCKGSIY--LVFDFCEH---DLAGLLS-NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL-----GERD---YGPPIDLWGAGCIMAEMWT-RSPI-------------MQGN--TEQHQLALISQLCG----SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-------SD-DALNHDFF--------------
---YENLGLVGEGSYGMVMKCRNK-----DTGRIVAIKKFLES-DDDKMV--KKIAMR-------EIKLLKQL-R----HEN--LVNLLEVCK--K----------KKRWY--LVFEFVDHT--ILDDLEL--FPN-------------------------GLDYQVVQKYLFQIINGIGFCHS-HNIIHRDIKPENILVS-QSGVV----KLCDFGFARTL------AAPGEVYTD---YVATRWYRAPELLV-----GDVK---YGKAVDVWAIGCLVTEMFM-GEPL-------------FPGD--SDIDQLYHIMMCLG----NLIPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVIDLAKKCLHIDPDK--RPF-------CA-ELLHHDFF--------------
---YETLGKVGEGSYGTVMKCKHK-----NTGQIVAIKIFYER-PEQSVN--K-IAMR-------EIKFLKQF-H----HEN--LVNLIEVFR--Q----------KKKIH--LVFEFIDHT--VLDELQH--YCH-------------------------GLESKRLRKYLFQILRAIDYLHS-NNIIHRDIKPENILVS-QSGIT----KLCDFGFARTL------AAPGDIYTD---YVATRWYRAPELVL-----KDTS---YGKPVDIWALGCMIIEMAT-GNPY-------------LPSS--SDLDLLHKIVLKVG----N-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPAD--RIS-------SS-DLLHHEYF--------------
---FEILGVVGEGAYGVVLKCRHK-----ETHEIVAIKKFKDS-EENEEV--KETTLR-------ELKMLRTL-K----QEN--IVELKEAFR--R----------RGKLY--LVFEYVEK---NMLELLE-EMPN-------------------------GVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL-----SEGNNANYTE---YVATRWYRSPELLL------GAP---YGKSVDMWSVGCILGELSD-GQPL-------------FPGE--SEIDQLFTIQKVLG----PLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPAD--RYL-------TE-QCLNHPTF--------------
--W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMK-RAVDCP--ENI-KK-------EICINKML-N----HEN--VVKFYGHRR--E----------GNIQY--LFLEYCSGG--ELFDRIE--PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR----YNNRERLLNK---MCGTLPYVAPELLK-----RREF---HAEPVDVWSCGIVLTAMLA-GELP-------------WDQP----SDSCQEYSDWKE----KKTYLNPWKKI--D-------------------------SAPLALLHKILVENPSA--RIT-------IP-DIKKDRW-Y-------------
-YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKR-KFAIGS--AREADPALN-VETEIEILKKL-N----HPC--IIKIKNFF---D----------AEDYY--IVLELMEGG--ELFDKVV--GNK-------------------------RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAG---YNRAVDCWSLGVILFICLS-GYPP-------------FSEH----RTQVSLKDQITS----GKYNFIPEVWAEVS-------------------------EKALDLVKKLLVVDPKA--RFT-------TE-EALRHPWL--------------
--F-EVRSLVGCGHFAEVQVVREK-----ATGDIYAMKVMKKK-ALLAQE--QVSFFE------EERNILSRS-T----SPW--IPQLQYAFQ--D----------KNHLY--LVMEYQPGG--DLLSLLN-RYED-------------------------QLDENLIQFYLAELILAVHSVHL-MGYVHRDIKPENILVD-RTGHI----KLVDFGSAAKM-----NSNKMVNAKL---PIGTPDYMAPEVLTVMNGDGKGT---YGLDCDWWSVGVIAYEMIY-GRSP-------------FAEG-----TSARTFNNIMN----FQRFLKFPDDPKVS-------------------------SDFLDLIQSLLCG-QKE--RLK-------FE-GLCCHPFF--------------
---YDIGEELGSGQFAIVKKCREK-----STGLEYAAKFIKKR-QSRASR--RGVSREEI---EREVSILRQV-L----HHN--VITLHDVYE--N----------RTDVV--LILELVSGG--ELFDFLA--QKE-------------------------SLSEEEATSFIKQILDGVNYLHT-KKIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE-------IEDGVEFKN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GASP-------------FLGD-----TKQETLANITA----VSYDFDEEFFSQTS-------------------------ELAKDFIRKLLVKETRK--RLT-------IQ-EALRHPWI--------------
---YEMGEELGSGQFAIVRKCRQK-----GTGKEYAAKFIKKR-RLSSSR--RGVSREEI---EREVNILREI-R----HPN--IITLHDIFE--N----------KTDVV--LILELVSGG--ELFDFLA--EKE-------------------------SLTEDEATQFLKQILDGVHYLHS-KRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK-------IEAGNEFKN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GASP-------------FLGE-----TKQETLTNISA----VNYDFDEEYFSNTS-------------------------ELAKDFIRRLLVKDPKR--RMT-------IA-QSLEHSWI--------------
-FR--HYRVLGKGGFGEVCACQVR-----ATGKMYACKKLQKK-RIKKRK--GEAMAL------NEKRILEKV-Q----SRF--VVSLAYAYE--T----------KDALC--LVLTIMNGG--DLKFHIYNLGNP-------------------------GFDEQRAVFYAAELCCGLEDLQR-ERIVYRDLKPENILLD-DRGHI----RISDLGLATE-------IPEGQRVRG---RVGTVGYMAPEVVN------NEK---YTFSPDWWGLGCLIYEMIQ-GHSP-------------FKKY--KEKVKWEEVDQRIK----NDTEEYSE---KFS-------------------------EDAKSICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F-------------
--F-TEFRVLGKGGFGEVCAVQVK-----NTGKMYACKKLDKK-RLKKKG--GEKMAL------LEKEILEKV-S----SPF--IVSLAYAFE--S----------KTHLC--LVMSLMNGG--DLKFHIYNVGTR-------------------------GLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE-------MKGGKPITQ---RAGTNGYMAPEILM-----EKVS---YSYPVDWFAMGCSIYEMVA-GRTP-------------FKDY-KEKVSKEDLKQRTLQ----DEVKFQHDNF---T-------------------------EEAKDICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR--------
---YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKVLQD-KRFKNR---------------ELQIMRKL-D----HCN--IVRLRYFFY--SSG------EKKDELYLNLVLEYVPETVYRVARHFT-KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF-----GATD---YTSSIDVWSAGCVLAELLL-GQPI-------------FPGD--SGVDQLVEIIKVLG----TPTREQIREMNPNYTEFKFPQIKAH---PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-------PL-EACAHSFF--------------
---YTTIRQLGDGTYGSVLLGRSI-----ESGELIAIKKMKRK-FYSWEE--C-MNLR-------EVKSLKKL-N----HAN--VVKLKEVIR--E----------NDHLY--FIFEYMKE---NLYQLIK-ERNK-------------------------LFPESAIRNIMYQILQGLAFIHK-HGFFHRDLKPENLLCM-GPELV----KIADFGLARE-------IRSKPPYTD---YVSTRWYRAPEVLL-----RSTN---YSSPIDVWAVGCIMAEVYT-LRPL-------------FPGA--SEIDTIFKICQVLG----TPKKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQLLRDMLQWDPKK--RPT-------AS-QALRYPYF--------------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-H-SGP-DQ-QRDFQ-R-------EIQILKAL-H----SDF--IVKYRGVSYGPG----------RQSLR--LVMEYLPSG--CLRDFLQ---RH-----------------------RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE-SEAHV----KIADFGLAKLL--PL--D--KDYYVVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVP-ALCRLLELLEEGQR----LPAPPACP-------------------------------AEVHELMKLCWAPSPQD--RPS-------FS-ALGP---QL-------------
---YEPKEILGRGVSSVVRRCIHK-----PTSQEYAVKVIDVT-GGGSFS--PEEVRELREATLKEVDILRKVSG----HPN--IIQLKDTYE--T----------NTFFF--LVFDLMKRG--ELFDYLT--EKV-------------------------TLSEKETRKIMRALLEVICTLHK-LNIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ-------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPG---YGKEVDMWSTGVIMYTLLA-GSPP-------------FWHR-----KQMLMLRMIMS----GNYQFGSPEWDDYS-------------------------DTVKDLVSRFLVVQPQN--RYT-------AE-EALAHPFF--------------
YDP---KDVIGRGVSSVVRRCVHR-----ATGHEFAVKIMEVT-AERLSP--EQLEEVREA-TRRETHILRQVAG----HPH--IITLIDSYE--S----------SSFMF--LVFDLMRKG--ELFDYLT--EKV-------------------------ALSEKETRSIMRSLLEAVSFLHA-NNIVHRDLKPENILLD-DNMQI----RLSDFGFSCH-------LEPGEKLRE---LCGTPGYLAPEILKCSMDETHPG---YGKEVDLWACGVILFTLLA-GSPP-------------FWHR-----RQILMLRMIME----GQYQFSSPEWDDRS-------------------------STVKDLISRLLQVDPEA--RLT-------AE-QALQHPFF--------------
---YQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKD-RISDWG--ELPNGTRV---PMEVVLLKKV-S----SGFSGVIRLLDWFE--R----------PDSFV--LILERPEPV-QDLFDFIT--ERG-------------------------ALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGEL----KLIDFGSGA--------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRY---HGRSAAVWSLGILLYDMVC-GDIP-------------FEHD-----------EEIIR----GQVFFRQRVS-----------------------------SECQHLIRWCLALRPSD--RPT-------FE-EIQNHPWM--------------
---YQVGAVLGSGGFGTVYAGSRI-----ADGLPVAVKHVVKE-RVTEWG--SLGGATV----PLEVVLLRKV-GAAGGARG--VIRLLDWFE--R----------PDGFL--LVLERPEPA-QDLFDFIT--ERG-------------------------ALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA--------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRY---HGRSATVWSLGVLLYDMVC-GDIP-------------FEQD-----------EEILR----GRLLFRRRVS-----------------------------PECQQLIRWCLSLRPSE--RPS-------LD-QIAAHPWM--------------
--F-KFLAVLGRGHFGKVLLSEFR-----PSGELFAIKALKKG-DIVARD--EVESLM------CEKRILAAV-TS-AGHPF--LVNLFGCFQ--T----------PEHVC--FVMEYSAGG--DLMLHIH---SD-------------------------VFSEPRAIFYSACVVLGLQFLHE-HKIVYRDLKLDNLLLD-TEGYV----KIADFGLCKEG------MGYGDRTST---FCGTPEFLAPEVLT------DTS---YTRAVDWWGLGVLLYEMLV-GESP-------------FPGD-----DEEEVFDSIVN----DEVRYPRFLS-----------------------------AEAIGIMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF--------------
-FR--CCAVLGRGHFGKVLLAEYK-----NTNEMFAIKALKKG-DIVARD--EVDSLM------CEKRIFETV-NS-VRHPF--LVNLFACFQ--T----------KEHVC--FVMEYAAGG--DLMMHIH---TD-------------------------VFSEPRAVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLD-TEGFV----KIADFGLCKEG------MGYGDRTST---FCGTPEFLAPEVLT------ETS---YTRAVDWWGLGVLIYEMLV-GESP-------------FPGD-----DEEEVFDSIVN----DEVRYPRFLS-----------------------------TEAISIMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF--------------
--F-ERIKTLGTGSFGRVMLVKHK-----ETGNHYAMKILDKQ-KVVKLK--QIEHTL------NEKRILQAV-N----FPF--LVKLEFSFK--D----------NSNLY--MVMEYVPGG--EMFSHLR--RIG-------------------------RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-QQGYI----QVTDFGFAK---------RVKGRTWT---LCGTPEYLAPEIIL------SKG---YNKAVDWWALGVLIYEMAA-GYPP-------------FFAD-----QPIQIYEKIVS----GKVRFPSHFS-----------------------------SDLKDLLRNLLQVDLTK--RFGNL--KNGVN-DIKNHKWF--------------
--F-ERKKTLGTGSFGRVMLVKHK-----ATEQYYAMKILDKQ-KVVKLK--QIEHTL------NEKRILQAV-N----FPF--LVRLEYAFK--D----------NSNLY--MVMEYVPGG--EMFSHLR--RIG-------------------------RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-HQGYI----QVTDFGFAK---------RVKGRTWT---LCGTPEYLAPEIIL------SKG---YNKAVDWWALGVLIYEMAA-GYPP-------------FFAD-----QPIQIYEKIVS----GKVRFPSHFS-----------------------------SDLKDLLRNLLQVDLTK--RFGNL--KNGVS-DIKTHKWF--------------
--F-NFLMVLGKGSFGKVMLSERK-----GTDELYAVKILKKD-VVIQDD--DVECTM------VEKRVLALPGK----PPF--LTQLHSCFQ--T----------MDRLY--FVMEYVNGG--DLMYHIQ--QVG-------------------------RFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN------IWDGVTTKT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAFGVLLYEMLA-GQAP-------------FEGE-----DEDELFQSIME----HNVAYPKSMS-----------------------------KEAVAICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF
-FI--FHKVLGKGSFGKVLLGELK-----GRGEYFAIKALKKD-VVLIDD--DVECTM------VEKRVLTLAAE----NPF--LTHLICTFQ--T----------KDHLF--FVMEFLNGG--DLMYHIQ--DKG-------------------------RFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLD-RDGHI----KIADFGMCKEN------IFGESRAST---FCGTPDYIAPEILQ------GLK---YTFSVDWWSFGVLLYEMLI-GQSP-------------FHGD-----DEDELFESIRV----DTPHYPRWIT-----------------------------KESKDILEKLFEREPTK--RLG------VTG-NIKIHPFF--------------
---FEFIRVLGKGSFGKVMLARVK-----ETGDLYAVKVLKKD-VILQDD--DVECTM------TEKRILSLARN----HPF--LTQLFCCFQ--T----------PDRLF--FVMEFVNGG--DLMFHIQ--KSR-------------------------RFDEARARFYAAEIISALMFLHD-KGIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG------ICNGVTTAT---FCGTPDYIAPEILQ------EML---YGPAVDWWAMGVLLYEMLC-GHAP-------------FEAE-----NEDDLFEAILN----DEVVYPTWLH-----------------------------EDATGILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-------------
-FI--LHKMLGKGSFGKVFLAEFK-----KTNQFFAIKALKKD-VVLMDD--DVECTM------VEKRVLSLAWE----HPF--LTHMFCTFQ--T----------KENLF--FVMEYLNGG--DLMYHIQ--SCH-------------------------KFDLSRATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLD-KDGHI----KIADFGMCKEN------MLGDAKTNT---FCGTPDYIAPEILL------GQK---YNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ-----DEEELFHSIRM----DNPFYPRWLE-----------------------------KEAKDLLVKLFVREPEK--RLG-------VRGDIRQHPLF--------------
FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVIDKM-RFPTKQ--ESQLRN-------EVAILQNL-H----HPG--IVNLECMFE--T----------PERVF--VVMEKLHGD--MLEMILS-SEKS-------------------------RLPERITKFMVTQILVALRNLHF-KNIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI-------IGEKSFRRS---VVGTPAYLAPEVLR------SKG---YNRSLDMWSVGVIIYVSLS-GTFP-------------FNED-------EDINDQIQN----AAFMYPPNPWREIS-------------------------GEAIDLINNLLQVKMRK--RYS-------VD-KSLSHPWL--------------
--F-NIIDTLGVGGFGRVELVQLKS----EESKTFAMKILKKR-HIVDTR--QQEHIR------SEKQIMQGA-H----SDF--IVRLYRTFK--D----------SKYLY--MLMEACLGG--ELWTILR--DRG-------------------------SFEDSTTRFYTACVVEAFAYLHS-KGIIYRDLKPENLILD-HRGYA----KLVDFGFAKK-------IGFGKKTWT---FCGTPEYVAPEIIL------NKG---HDISADYWSLGILMYELLT-GSPP-------------FSGP-----DPMKTYNIILR----GIDMIEFPKKIA---------------------------KNAANLIKKLCRDNPSE--RLGNL--KNGVK-DIQKHKWF--------------
--L-EIIATLGVGGFGRVELVKVK-----NENVAFAMKCIRKK-HIVDTK--QQEHVY------SEKRILEEL-C----SPF--IVKLYRTFK--D----------NKYVY--MLLEACLGG--ELWSILR--DRG-------------------------SFDEPTSKFCVACVTEAFDYLHR-LGIIYRDLKPENLILD-AEGYL----KLVDFGFAKK-------IGSGQKTWT---FCGTPEYVAPEVIL------NKG---HDFSVDFWSLGILVYELLT-GNPP-------------FSGV-----DQMMTYNLILK----GIEKMDFPRKIT---------------------------RRPEDLIRRLCRQNPTE--RLGNL--KNGIN-DIKKHRWL--------------
-FD--TLATVGTGTFGRVHLVKEK-----TAKHFFALKVMSIP-DVIRLK--QEQHVH------NEKSVLKEV-S----HPF--LIRLFWTWH--D----------ERFLY--MLMEYVPGG--ELFSYLR--NRG-------------------------RFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD-RDGHI----KLTDFGFAKK---------LVDRTWT---LCGTPEYLAPEVIQ------SKG---HGRAVDWWALGILIFEMLS-GFPP-------------FFDD-----NPFGIYQKILA----GKIDFPRHLD-----------------------------FHVKDLIKKLLVVDRTR--RLGNM--KNGAN-DVKHHRWF--------------
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-E-NAS-PSELRDLL-S-------EFNVLKQV-N----HPH--VIKLYGACS--Q----------DGPLL--LIVEYAKYG--SLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVA-EGRKM----KISDFGLSRDV---Y--E--EDSYVKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGGNP-------------YPGI--PPERLFNLLKTGHR----MERPDNCS-------------------------------EEMYRLMLQCWKQEPDK--RPV-------FA-DISKDL----------------
---YEVVKVIGRGAFGEVQLVRHK-----STRKVYAMKLLSKF-EMIKRS--DSAFFW------EERDIMAFA-N----SPW--VVQLFYAFQ--D----------DRYLY--MVMEYMPGG--DLVNLMS---NY-------------------------DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHL----KLADFGTCMKM-----NKEGMVRCDT---AVGTPDYISPEVLKS--QGGDGY---YGRECDWWSVGVFLYEMLV-GDTP-------------FYAD-----SLVGTYSKIMN----HKNSLTFPDDNDIS-------------------------KEAKNLICAFLTDREVRLGRNG-------VE-EIKRHLFF--------------
LCP---GRELGRGKFAVVRKCIKK-----DSGKEFAAKFMRKR-RKGQDC--RMEIIH-------EIAVLELAQD----NPW--VINLHEVYE--T----------ASEMI--LVLEYAAGG--EIFDQCVADREE-------------------------AFKEKDVQRLMRQILEGVHFLHT-RDVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI-------LKNSEELRE---IMGTPEYVAPEILS------YDP---ISMATDMWSIGVLTYVMLT-GISP-------------FLGN-----DKQETFLNISQ----MNLSYSEEEFDVLS-------------------------ESAVDFIRTLLVKKPED--RAT-------AE-ECLKHPWL--------------
ILT---SKELGRGKFAVVRQCISK-----STGQEYAAKFLKKR-RRGQDC--RAEILH-------EIAVLELAKS----CPR--VINLHEVYE--N----------TSEII--LILEYAAGG--EIFSLCLPELAE-------------------------MVSENDVIRLIKQILEGVYYLHQ-NNIVHLDLKPQNILLS-SIYPLG-DIKIVDFGMSRK-------IGHACELRE---IMGTPEYLAPEILN------YDP---ITTATDMWNIGIIAYMLLT-HTSP-------------FVGE-----DNQETYLNISQ----VNVDYSEETFSSVS-------------------------QLATDFIQSLLVKNPEK--RPT-------AE-ICLSHSWL--------------
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