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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
AGC GRK1 190
AGC GRK4 187
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC ICK 4
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
CMGC MAK 4
STE MAP2K1 68
STE MAP2K2 72
STE MAP2K4 102
STE MAP2K5 166
TKL MAP3K10 98
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K7 36
TKL MAP3K9 144
Other PBK 32
AGC PKN1 615
AGC PRKCA 339
TK RET 724
CAMK STK17A 61
STE STK24 24
TK TEC 370
TKL TESK1 57
TKL TNNI3K 463
TK ZAP70 338
----F-NFIKVLGKGSFGKVMLAELK-----GKDE---VYAVKVL---KKD--VILQ---DD-----D-VDCTM--TEKRILALARK---HPYLTQLYCCFQ--T--------KDRLF--FVMEYVNGG--DLMFQIQ-----RSR--------------------------KFDEPRSRFYAAEVTSALMFLHQ--H---G---VIYRDLKLDNILLD-A--------EG-HC--------KLADFGMCKEG------ILNGVTTTT---FCGTPDYIAPEILQ----ELE-YGPSVDWWALGVLMYEMMA-GQPP---------------FEAD---------------NEDDLF-ESILHDDVLYPVWLS----------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------------------------------------------------
-----ITMKHKLGGGQYGEVYEGVWK-----KYSL---TVAVKTL---K-E--DTM----EV-----E-EFL-K---EAAVMKEI-K---HPNLVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR------EC----------------------NR-QEVNAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG-E--------NH-LV--------KVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA----YNK-FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI------------DLSQVYELL-EKDYRMERPEGCP------------------------------------------------EKVYELMRACWQWNPSDRPS-------FAEIHQA--F--------------------------------------------------------
-----YTKIEKIGEGTYGVVYKGRHK-----TTGQ---VVAMKKI---RLE--SEEE---GV-----P-STAIR---EISLLKEL-R---HPNIVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS--IPPGQ--------------------------YMDSSLVKSYLYQILQGIVFCHS--R---R---VLHRDLKPQNLLID-D--------KG-TI--------KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL---GSAR-YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD------------SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GKMALNHPYF--------------------------------------------------------
-----FQKVEKIGEGTYGVVYKARNK-----LTGE---VVALKKI---RLD--TETE---GV-----P-STAIR---EISLLKEL-N---HPNIVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA---SALT--------------------------GIPLPLIKSYLFQLLQGLAFCHS--H---R---VLHRDLKPQNLLIN-T--------EG-AI--------KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL---GCKY-YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD------------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AKAALAHPFF--------------------------------------------------------
-----FQKVEKIGEGTYGVVYKAKNR-----ETGQ---LVALKKI---RLD--LEME---GV-----P-STAIR---EISLLKEL-K---HPNIVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS---TPGS--------------------------ELPLHLIKSYLFQLLQGVSFCHS--H---R---VIHRDLKPQNLLIN-E--------LG-AI--------KLADFGLARAF------GVPLRTYTH---EVVTLWYRAPEILL---GSKF-YTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD------------SEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR--------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AKTALAHPYF--------------------------------------------------------
----Y-EPVAEIGVGAYGTVYKARDP-----HSGH---FVALKSV---RVP--NGGGGGGGL-----P-ISTVR---EVALLRRL-EAFEHPNVVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK---APPP--------------------------GLPAETIKDLMRQFLRGLDFLHA--N---C---IVHRDLKPENILVT-S--------GG-TV--------KLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL----QST-YATPVDMWSVGCIFAEMFR-RKPL---------------FCGN------------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-------AFRALQHSYL--------------------------------------------------------
-----YECVAEIGEGAYGKVFKARDL-----KNGG--RFVALKRV---RVQ--TGEE---GM-----P-LSTIR---EVAVLRHL-ETFEHPNVVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK---VPEP--------------------------GVPTETIKDMMFQLLRGLDFLHS--H---R---VVHRDLKPQNILVT-S--------SG-QI--------KLADFGLARI-------YSFQMALTS---VVVTLWYRAPEVLL----QSS-YATPVDLWSVGCIFAEMFR-RKPL---------------FRGS------------SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ----------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-------AYSALSHPYF--------------------------------------------------------
-----YEKLAKIGQGTFGEVFKARHR-----KTGQ---KVALKKV---LME--NEKE---GF-----P-ITALR---EIKILQLL-K---HENVVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS----NVLV--------------------------KFTLSEIKRVMQMLLNGLYYIHR--N---K---ILHRDMKAANVLIT-R--------DG-VL--------KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL---GERD-YGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN------------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK-----------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-------SDDALNHDFF--------------------------------------------------------
-----YEKIGKIGEGSYGVVFKCRNR-----DTGQ---IVAIKKF---LES--EDDP---VI-----K-KIALR---EIRMLKQL-K---HPNLVNLLEVFR--R--------KRRLH--LVFEYCDHT--VLHELDR-----YQR--------------------------GVPEHLVKSITWQTLQAVNFCHK--H---N---CIHRDVKPENILIT-K--------HS-VI--------KLCDFGFARLL------AGPSDYYTD---YVATRWYRSPELLV---GDTQ-YGPPVDVWAIGCVFAELLS-GVPL---------------WPGK------------SDVDQLYLI-RKTLGDLIPRHQQVFSTNQYFSGVKIPDPED------------------MEPLELKFPNISYPALGLLKGCLHMDPTQRLT-------CEQLLHHPYF--------------------------------------------------------
-----YENLGLVGEGSYGMVMKCRNK-----DTGR---IVAIKKF---LES--DDDK---MV-----K-KIAMR---EIKLLKQL-R---HENLVNLLEVCK--K--------KKRWY--LVFEFVDHT--ILDDLEL-----FPN--------------------------GLDYQVVQKYLFQIINGIGFCHS--H---N---IIHRDIKPENILVS-Q--------SG-VV--------KLCDFGFARTL------AAPGEVYTD---YVATRWYRAPELLV---GDVK-YGKAVDVWAIGCLVTEMFM-GEPL---------------FPGD------------SDIDQLYHI-MMCLGNLIPRHQELFNKNPVFAGVRLPEIKE------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CAELLHHDFF--------------------------------------------------------
-FLDF----RVLGKGGFGEVSACQMK-----ATGK---LYACKKL---NKK--RLKK---RK-----G-YQGAM--VEKKILMKV-H---SRFIVSLAYAFE--T--------KADLC--LVMTIMNGG--DIRYHIYNV-NEENP--------------------------GFPEPRALFYTAQIICGLEHLHQ--R---R---IVYRDLKPENVLLD-N--------DG-NV--------RISDLGLAVEL------LDGQSKTKG---YAGTPGFMAPELLQ----GEE-YDFSVDYFALGVTLYEMIA-ARGP---------------FRAR-----------GEKVENKELK-HRIISEPVKYPDKFS----------------------------------------------QASKDFCEALLEKDPEKRLG-------FRD-------ETCDKLRAHPLF--------------------------------------------
---FR--HYRVLGKGGFGEVCACQVR-----ATGK---MYACKKL---QKK--RIKK---RK-----G-EAMAL--NEKRILEKV-Q---SRFVVSLAYAYE--T--------KDALC--LVLTIMNGG--DLKFHIYN---LGNP--------------------------GFDEQRAVFYAAELCCGLEDLQR--E---R---IVYRDLKPENILLD-D--------RG-HI--------RISDLGLATE-------IPEGQRVRG---RVGTVGYMAPEVVN----NEK-YTFSPDWWGLGCLIYEMIQ-GHSP---------------FKKY------------KEKVKWEEV-DQRIKNDTEEYSE---KFS------------------------------------------EDAKSICRMLLTKNPSKRLGCR--GEGAAGVKQHPV-F-------------------------------------------------------
----F-RQYRVLGKGGFGEVCACQVR-----ATGK---MYACKKL---EKK--RIKK---RK-----G-EAMAL--NEKQILEKV-N---SRFVVSLAYAYE--T--------KDALC--LVLTLMNGG--DLKFHIYH---MGQA--------------------------GFPEARAVFYAAEICCGLEDLHR--E---R---IVYRDLKPENILLD-D--------HG-HI--------RISDLGLAVH-------VPEGQTIKG---RVGTVGYMAPEVVK----NER-YTFSPDWWALGCLLYEMIA-GQSP---------------FQQR------------KKKIKREEV-ERLVK-EVPEEYSER--FS------------------------------------------PQARSLCSQLLCKDPAERLGCR--GGSAREVKEHPLF--------------------------------------------------------
----F-TEFRVLGKGGFGEVCAVQVK-----NTGK---MYACKKL---DKK--RLKK---KG-----G-EKMAL--LEKEILEKV-S---SPFIVSLAYAFE--S--------KTHLC--LVMSLMNGG--DLKFHIYN---VGTR--------------------------GLDMSRVIFYSAQIACGMLHLHE--L---G---IVYRDMKPENVLLD-D--------LG-NC--------RLSDLGLAVE-------MKGGKPITQ---RAGTNGYMAPEILM---EKVS-YSYPVDWFAMGCSIYEMVA-GRTP---------------FKDY-----------KEKVSKEDLK-QRTLQDEVKFQHDNF---T------------------------------------------EEAKDICRLFLAKKPEQRLG-------SRE-------KSDDPR--------------------------------------------------
-----YTDIKVIGNGSFGVVYQARLA-----ETRE---LVAIKKV---LQD--KRFK---NR---------------ELQIMRKL-D---HCNIVRLRYFFY--SSG----EKKDELYLNLVLEYVPETVYRVARHFT----KAKL--------------------------TIPILYVKVYMYQLFRSLAYIHS--Q---G---VCHRDIKPQNLLVDPD--------TA-VL--------KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF---GATD-YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD------------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH--------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-------PLEACAHSFF--------------------------------------------------------
-----YTDTKVIGNGSFGVVYQAKLC-----DSGE---LVAIKKV---LQD--KRFK---NR---------------ELQIMRKL-D---HCNIVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHY-SRAKQ--------------------------TLPVIYVKLYMYQLFRSLAYIHS--F---G---ICHRDIKPQNLLLDPD--------TA-VL--------KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF---GATD-YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD------------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH--------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-------PLEACAHSFF--------------------------------------------------------
-----YTTIRQLGDGTYGSVLLGRSI-----ESGE---LIAIKKM---KRK--FYSW---EE-----C--MNLR---EVKSLKKL-N---HANVVKLKEVIR--E--------NDHLY--FIFEYMKE---NLYQLIK----ERNK--------------------------LFPESAIRNIMYQILQGLAFIHK--H---G---FFHRDLKPENLLCM-G--------PE-LV--------KIADFGLARE-------IRSKPPYTD---YVSTRWYRAPEVLL---RSTN-YSSPIDVWAVGCIMAEVYT-LRPL---------------FPGA------------SEIDTIFKI-CQVLGTPKKTDWPEGYQLSSAMNFRWPQCV-------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------ASQALRYPYF--------------------------------------------------------
--VGG----NKMGEGGFGVVYKGYVN-----NTT-----VAVKKL---AAM--VDIT---TE-----ELKQQFD--QEIKVMAKC-Q---HENLVELLGFSS--D--------GDDLC--LVYVYMPNG--SLLDRLSC--LDGTP--------------------------PLSWHMRCKIAQGAANGINFLHE--N---H---HIHRDIKSANILLD-E--------AF-TA--------KISDFGLARASE----KFAQTVMTSR---IVGTTAYMAPEALR-----GE-ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH------------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD----------------------------------STSVEAMYSVASQCLHEKKNKRPD-------IKKVQQ----LLQ-----------------------------------------------------
-----LTFVQEIGSGQFGLVHLGYWL------NKD---KVAIKTI---R-E--GAM----SE-----E-DFI-E---EAEVMMKL-S---HPKLVQLYGVCL--E--------QAPIC--LVFEFMEHG--CLSDYLR------TQ-----------------------R-GLFAAETLLGMCLDVCEGMAYLEE--A---C---VIHRDLAARNCLVG-E--------NQ-VI--------KVSDFGMTRFV------L--DDQYTSSTGTKFPVKWASPEVFS----FSR-YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR------------SNSEVVEDI-STGFRLYKPRLAS------------------------------------------------THVYQIMNHCWKERPEDRPA-------FSRLLRQL----------------------------------------------------------
-----LKFLQQLGKGNFGSVEMCRYDP-LQDNTGE---VVAVKKL---Q-H--STE-----EH---LR-DFE-R---EIEILKSL-Q---HDNIVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ------KH-----------------------K-ERIDHIKLLQYTSQICKGMEYLGT--K---R---YIHRDLATRNILVE-N--------EN-RV--------KIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT----ESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM------------IVFHLIELL-KNNGRLPRPDGCP------------------------------------------------DEIYMIMTECWNNNVNQRPS-------FRDLA----LRV------------------------------------------------------
----L-KYISQLGKGNFGSVELCRYDP-LGDNTGA---LVAVKQL---Q-H--SGP----DQ----QR-DFQ-R---EIQILKAL-H---SDFIVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ------RH-----------------------R-ARLDASRLLLYSSQICKGMEYLGS--R---R---CVHRDLAARNILVE-S--------EA-HV--------KIADFGLAKLL--PL--D--KDYYVVREPGQSPIFWYAPESLS----DNI-FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P----------ALCRLLELL-EEGQRLPAPPACP------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FSALGP---QL-------------------------------------------------------
-----YTTMRQLGDGTYGSVLMGKSN-----ESGE---LVAIKRM---KRK--FYSW---DE-----C-M-NLR---EVKSLKKL-N---HANVIKLKEVIR--E--------NDHLY--FIFEYMKE---NLYQLMK----DRNK--------------------------LFPESVIRNIMYQILQGLAFIHK--H---G---FFHRDMKPENLLCM-G--------PE-LV--------KIADFGLARE-------LRSQPPYTD---YVSTRWYRAPEVLL---RSSV-YSSPIDVWAVGSIMAELYM-LRPL---------------FPGT------------SEVDEIFKI-CQVLGTPKKSDWPEGYQLASSMNFRFPQCV-------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-------ASQALKHPYF--------------------------------------------------------
-----FEKISELGAGNGGVVFKVSHK-----PSGL----VMARKL---IHL--EIKP---AI-----R-NQIIR---ELQVLHEC-N---SPYIVGFYGAFY--S--------DGEIS--ICMEHMDGG--SLDQVLK-----KAG--------------------------RIPEQILGKVSIAVIKGLTYLRE-KH---K---IMHRDVKPSNILVN-S--------RG-EI--------KLCDFGVSG--------QLIDSMANS---FVGTRSYMSPERLQ----GTH-YSVQSDIWSMGLSLVEMAV-GRYP---------------IPPP------------DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-------LKQLMVHAFI--------------------------------------------------------
----F-ERISELGAGNGGVVTKVQHR-----PSGL---IMARKLI---HLE--IKPA----I-----R-NQIIR---ELQVLHEC-N---SPYIVGFYGAFY--S--------DGEIS--ICMEHMDGG--SLDQVLK-----EAK--------------------------RIPEEILGKVSIAVLRGLAYLRE-KH---Q---IMHRDVKPSNILVN-S--------RG-EI--------KLCDFGVSG--------QLIDSMANS---FVGTRSYMAPERLQ----GTH-YSVQSDIWSMGLSLVELAV-GRYP---------------IPPP------------DAKE-LEAI-FGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERAD-------LKMLTNHTFI--------------------------------------------------------
---LK--DLGEIGRGAYGSVNKMVHK-----PSGQ---IMAVKRI---RST--VDEK---EQ-----K-QL-LM---DLDVVMRSSD---CPYIVQFYGALF--R--------EGDCW--ICMELMSTSFDKFYKYVYS---VLDD--------------------------VIPEEILGKITLATVKALNHLKE--N--LK---IIHRDIKPSNILLD-R--------SG-NI--------KLCDFGISGQ-------LVDSIAKTR---DAGCRPYMAPERIDPSASRQG-YDVRSDVWSLGITLYELAT-GRFP---------------YPKW-------------NSVFDQLT-QVVKGDPPQLSNSEEREFS------------------------------------------PSFINFVNLCLTKDESKRPK-------YKELLKHPFI--------------------------------------------------------
--IRY---RDTLGHGNGGTVYKAYHV-----PSGK---ILAVKVI---LLD--ITLE---LQ-----K-QI-MS---ELEILYKC-D---SSYIIGFYGAFF--V--------ENRIS--ICTEFMDGG--SLD---------VYR--------------------------KMPEHVLGRIAVAVVKGLTYLWS--L---K---ILHRDVKPSNMLVN-T--------RG-QV--------KLCDFGVST--------QLVNSIAKT---YVGTNAYMAPERIS----GEQ-YGIHSDVWSLGISFMELAL-GRFP---------------YPQI------------QKNQGSLMP-LQLLQCIVDEDSPVLPVGEF----------------------------------------SEPFVHFITQCMRKQPKERPA-------PEELMGHPFI--------------------------------------------------------
-----LQLEEIIGVGGFGKVYRALWR-------GE---EVAVKAARLDP-E--KDP----AVT---AE-QVC-Q---EARLFGAL-Q---HPNIIALRGACL--N--------PPHLC--LVMEYARGG--ALSRVLA------GR--------------------------RVPPHVLVNWAVQVARGMNYLHN--D---APVPIIHRDLKSINILIL-EAIENHNLADT-VL--------KITDFGLAREW-----------HKTTKMSAAGTYAWMAPEVIR----LSL-FSKSSDVWSFGVLLWELLT-GEVP---------------YREI------------DALAVAYGVAMNKLTLPIPSTCP------------------------------------------------EPFARLLEECWDPDPHGRPD-------FGSILKRL----------------------------------------------------------
-----LRLEEVIGIGGFGKVYRGSWR-------GE---LVAVKAA---R-Q--DPD----EDISVTAE-SVR-Q---EARLFAML-A---HPNIIALKAVCL--E--------EPNLC--LVMEYAAGG--PLSRALA------GR--------------------------RVPPHVLVNWAVQIARGMHYLHC--E---ALVPVIHRDLKSNNILLL-QPIESDDMEHK-TL--------KITDFGLAREW-----------HKTTQMSAAGTYAWMAPEVIK----AST-FSKGSDVWSFGVLLWELLT-GEVP---------------YRGI------------DCLAVAYGVAVNKLTLPIPSTCP------------------------------------------------EPFAQLMADCWAQDPHRRPD-------FASILQQL----------------------------------------------------------
LDLQW------VGSGAQGAVFLGRFH-------GE---EVAVKKV---R-D--LKE----T----------------DIKHLRKL-K---HPNIITFKGVCT--Q--------APCYC--ILMEFCAQG--QLYEVLR------AG-------------------------RPVTPSLLVDWSMGIAGGMNYLHL--H---K---IIHRDLKSPNMLIT-Y--------DD-VV--------KISDFGTSKEL----------SDKSTKMSFAGTVAWMAPEVIR----NEP-VSEKVDIWSFGVVLWELLT-GEIP---------------YKDV------------DSSAIIWGVGSNSLHLPVPSSCP------------------------------------------------DGFKILLRQCWNSKPRNRPS-------FRQILLH--L--------------------------------------------------------
-ISEL----QWLGSGAQGAVFLGKFR-------AE---EVAIKKV---R-E--QNE----TD----------------IKHLRKL-K---HPNIIAFKGVCT--Q--------APCYC--IIMEYCAHG--QLYEVLR------AG-------------------------RKITPRLLVDWSTGIASGMNYLHL--H---K---IIHRDLKSPNVLVT-H--------TD-AV--------KISDFGTSKEL----------SDKSTKMSFAGTVAWMAPEVIR----NEP-VSEKVDIWSFGVVLWELLT-GEIP---------------YKDV------------DSSAIIWGVGSNSLHLPVPSTCP------------------------------------------------DGFKILMKQTWQSKPRNRPS-------FRQTLMH--L--------------------------------------------------------
-----IEVEEVVGRGAFGVVCKAKWR-------AK---DVAIKQI---E------S----ESE---RK-AFI-V---ELRQLSRV-N---HPNIVKLYGACL------------NPVC--LVMEYAEGG--SLYNVLH------GA----------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS--M---QPKALIHRDLKPPNLLLV-A--------GGTVL--------KICDFGTACDI------------QTHMTNNKGSAAWMAPEVFE----GSN-YSEKCDVFSWGIILWEVITR-RKP---------------FDEIGG----------PAFRIMWAV-HNGTRPPLIKNLP------------------------------------------------KPIESLMTRCWSKDPSQRPS-------MEEIVKI--M--------------------------------------------------------
----L-TLEEIIGIGGFGKVYRAFWI-----GDE-----VAVKAA---RHDP-DEDI---SQ-----T-IENVR--QEAKLFAML-K---HPNIIALRGVCL--K--------EPNLC--LVMEFARGG--PLNRVLS------GK--------------------------RIPPDILVNWAVQIARGMNYLHD--EAIVP---IIHRDLKSSNILIL-Q--------KV-ENGDLSNKILKITDFGLAR--------EWHRTTKMS---AAGTYAWMAPEVIR----ASM-FSKGSDVWSYGVLLWELLT-GEVP---------------FRGI---------------DGLAVA-YGVAMNKLALPIPSTCP--------------------------------------------EPFAKLMEDCWNPDPHSRPS-------FTNILDQ---LT------------------------------------------------------
---PF---MQKLGFGTGVNVYLMKRS-----PRGLSHSPWAVKKI---NPI--CNDH---YR-----S-VYQKRLMDEAKILKSL-H---HPNIVGYRAFTE--A-------NDGSLC--LAMEYGGEK--SLNDLIEERYKASQD--------------------------PFPAAIILKVALNMARGLKYLHQ-EK---K---LLHGDIKSSNVVIK-G--------DF-ET-------IKICDVGVSLPLD---ENMTVTDPEAC---YIGTEPWKPKEAVE---ENGV-ITDKADIFAFGLTLWEMMT-LSIP---------------HINLSNDDDDEDKTFDESDFDDEAY-YAALGTRPPINMEELDESY------------------------------------------QKVIELFSVCTNEDPKDRPS-------AAHIVE----AL------------------------------------------------------
----F-KFLAVLGRGHFGKVLLSEFR-----PSGE---LFAIKAL---KKG--DIVA---RD-----E-VESLM--CEKRILAAV-TSAGHPFLVNLFGCFQ--T--------PEHVC--FVMEYSAGG--DLMLHIH------SD--------------------------VFSEPRAIFYSACVVLGLQFLHE--H---K---IVYRDLKLDNLLLD-T--------EG-YV--------KIADFGLCKEG------MGYGDRTST---FCGTPEFLAPEVLT----DTS-YTRAVDWWGLGVLLYEMLV-GESP---------------FPGD---------------DEEEVF-DSIVNDEVRYPRFLS----------------------------------------------AEAIGIMRRLLRRNPERRLGSS--ERDAEDVKKQPFF--------------------------------------------------------
----F-NFLMVLGKGSFGKVMLADRK-----GTEE---LYAIKIL---KKD--VVIQ---DD-----D-VECTM--VEKRVLALLDK---PPFLTQLHSCFQ--T--------VDRLY--FVMEYVNGG--DLMYHIQ-----QVG--------------------------KFKEPQAVFYAAEISIGLFFLHK--R---G---IIYRDLKLDNVMLD-S--------EG-HI--------KIADFGMCKEH------MMDGVTTRT---FCGTPDYIAPEIIA----YQP-YGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE---------------DEDELF-QSIMEHNVSYPKSLS----------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF------------------------------------------
----L-VLGKTLGEGEFGKVVKATAFHLKGRAGYT---TVAVKML---K-E--NAS----PSE---LR-DLL-S---EFNVLKQV-N---HPHVIKLYGACS--Q--------DGPLL--LIVEYAKYG--SLRGFLR------ESRKVGPGYLGSGGSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAE--M---K---LVHRDLAARNILVA-E--------GR-KM--------KISDFGLSRDV---Y--E--EDSYVKRSQGRIPVKWMAIESLF----DHI-YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI------------PPERLFNLL-KTGHRMERPDNCS------------------------------------------------EEMYRLMLQCWKQEPDKRPV-------FADISKDL----------------------------------------------------------
--LCP---GRELGRGKFAVVRKCIKK-----DSGK---EFAAKFM---RKR--RKGQ---DC-----R-MEIIH---EIAVLELAQD---NPWVINLHEVYE--T--------ASEMI--LVLEYAAGG--EIFDQCVA---DREE--------------------------AFKEKDVQRLMRQILEGVHFLHT--R---D---VVHLDLKPQNILLT-S--------ES-PLG-----DIKIVDFGLSRI-------LKNSEELRE---IMGTPEYVAPEILS----YDP-ISMATDMWSIGVLTYVMLT-GISP---------------FLGN---------------DKQETF-LNISQMNLSYSEEEFDVLS------------------------------------------ESAVDFIRTLLVKKPEDRAT-------AEECLKHPWL--------------------------------------------------------
-----FTKLEKIGKGSFGEVFKGIDN-----RTQK---VVAIKII---DLE--EAED---EI-----E-DIQ-Q---EITVLSQC-D---SPYVTKYYGSYL--K--------DTKLW--IIMEYLGGG--SALDLLE------PG--------------------------PLDETQIATILREILKGLDYLHS--E---K---KIHRDIKAANVLLS-E--------HG-EV--------KLADFGVAGQL------TDTQIKRNT---FVGTPFWMAPEVIK----QSA-YDSKADIWSLGITAIELAR-GEPP---------------HSEL------------HPMKVLFLI-PKNNPPTLEGNYS------------------------------------------------KPLKEFVEACLNKEPSFRPT-------AKELLKHKFI--------------------------------------------------------
-----LTFMRELGSGLFGVVRLGKWR------AQY---KVAIKAI---R-E--GAM----CE-----E-DFI-E---EAKVMMKL-T---HPKLVQLYGVCT--Q--------QKPIY--IVTEFMERG--CLLNFLR------QR-----------------------Q-GHFSRDVLLSMCQDVCEGMEYLER--N---S---FIHRDLAARNCLVS-E--------AG-VV--------KVSDFGMARYV------L--DDQYTSSSGAKFPVKWCPPEVFN----YSR-FSSKSDVWSFGVLMWEVFTEGRMP---------------FEKY------------TNYEVVTMV-TRGHRLYQPKLAS------------------------------------------------NYVYEVMLRCWQEKPEGRPS-------FEDLLRT--I--------------------------------------------------------
----F-HCAEKIGAGFFSEVYKVRHR-----QSGQ---VMVLKMN---KLP--SNRG---NT----------LR---EVQLMNRL-R---HPNILRFMGVCV--H--------QGQLH--ALTEYMNGG--TLEQLLS-----SPE--------------------------PLSWPVRLHLALDIARGLRYLHS--K---G---VFHRDLTSKNCLVR-R--------ED-RGF-----TAVVGDFGLAEKIPV--YREGARKEPLA---VVGSPYWMAPEVLR----GEL-YDEKADVFAFGIVLCELIA-R-VP-------------------------------------------------------------------------------------------------------------------------------------------ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL
-----IEFHEIIGSGSFGKVYKGRCR-------NK---IVAIKRY---R-ANTYCS----KSD---VD-MFC-R---EVSILCQL-N---HPCVIQFVGACL-ND--------PSQFA--IVTQYISGG--SLFSLLH------EQ-----------------------K-RILDLQSKLIIAVDVAKGMEYLHNLTQ---P---IIHRDLNSHNILLY-E--------DG-HA--------VVADFGESRFL---Q--S--LD-EDNMTKQPGNLRWMAPEVFT----QCTRYTIKADVFSYALCLWEILT-GEIP---------------FAHL------------KPAAAAADMAYHHIRPPIGYSIP------------------------------------------------KPISSLLIRGWNACPEGRPE-------FSEVVMKL----------------------------------------------------------
-LIAD----IELGCGNFGSVRQGVYR---MRKKQI---DVAIKVL---K-Q--GTE----KAD---TE-EMM-R---EAQIMHQL-D---NPYIVRLIGVCQ-----------AEALM--LVMEMAGGG--PLHKFLV------GK-----------------------R-EEIPVSNVAELLHQVSMGMKYLEE--K---N---FVHRDLAARNVLLV-N--------RH-YA--------KISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN----FRK-FSSRSDVWSYGVTMWEALSYGQKP---------------YKKM------------KGPEVMAFI-EQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPD-------FLTVEQR--M--------------------------------------------------------
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