|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
AGC AKT3 148
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDKL2 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK FGFR1 478
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC ICK 4
TK JAK3 822
TK LCK 245
CAMK MARK2 53
CAMK NUAK1 55
CAMK NUAK2 97
CMGC PCTK1 165
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCQ 380
CAMK PRKD2 551
STE SLK 34
TK SRC 270
CAMK STK17A 61
STE STK24 24
---F-NFIKVLGKGSFGKVMLAELK-------GKDEVYAVKVLKKDV-ILQDD--DVDCTM------TEKRILALA-RK-----HPY-----LTQLYCCFQ--T----KDRLF--FVMEY-VNGG--DLMFQIQ----RSR-----------------KF---DEPRSRFYAAEVTSALMFLHQ--HGVIYRDLKLDNILLD--AEGHC----KLADFGMCKEG----ILNGVTTTT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQPP-------------FEAD-----NEDDLFESILHDDVLYPVWLS---------------------------------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
--FD--YLKLLGKGTFGKVILVREK-------ASGKYYAMKILKKEV-IIAKD--EVAHTL------TESRVLKNT--R-----HPF-----LTSLKYSFQ--T----KDRLC--FVMEY-VNGG--ELFFHLS----RER-----------------VF---SEDRTRFYGAEIVSALDYLHS--GKIVYRDLKLENLMLD--KDGHI----KITDFGLCKEG----ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ-----DHEKLFELILMEDIKFPRTLS---------------------------------------------------------------------SDAKSLLSGLLIKDPNKRLGGG--PDDAK-EIMRHSFF--------------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR-------EVEIQSHL--R-----HPN-----ILRLYGYFH--D----ATRVY--LILEY-APLG--TVYRELQ----KLS-----------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN-----TYQETYKRISRVEFTFPDFVT---------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-------LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG--VEHQLR------REIEIQAHL--H-----HPN-----ILRLYNYFY--D----RRRIY--LILEY-APRG--ELYKELQ----KSC-----------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL----KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GNPP-------------FESA-----SHNETYRRIVKVDLKFPASVP---------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-------LA-QVSAHPWV--------------
----FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKSQ-IEKEG--LEHQLR------REIEIQAHL--Q-----HPN-----ILRLYNYFH--D----ARRVY--LILEY-APRG--ELYKELQ----KSE-----------------KL---DEQRTATIIEELADALTYCHD--KKVIHRDIKPENLLLG--FRGEV----KIADFGWSV------HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FESA-----SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------LGARDLISRLLRYQPLERLP-------LA-QILKHPWV--------------
--YL--NLEKLGEGSYATVYKGISR-------INGQLVALKVISMNA-EEGVP---FTAIR-------EASLLKGL--K-----HAN-----IVLLHDIIH--T----KETLT--FVFEY-MHT---DLAQYMS---QHPG-----------------GL---HPHNVRLFMFQLLRGLAYIHH--QHVLHRDLKPQNLLIS--HLGEL----KLADFGLARAK----SIPSQTYSS---EVVTLWYRPPDALL-----GATEYSSELDIWGAGCIFIEMFQ-GQPL-------------FPGV-SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS-------AQ-EALVHDYF--------------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--PSTAIR-------EISLLKEL--N-----HPN-----IVKLLDVIH--T----ENKLY--LVFEF-LHQ---DLKKFMDA--SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
----FQKVEKIGEGTYGVVYKAKNR-------ETGQLVALKKIRLDL-EMEGV--PSTAIR-------EISLLKEL--K-----HPN-----IVRLLDVVH--N----ERKLY--LVFEF-LSQ---DLKKYMDS--TPGS-----------------EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI----KLADFGLARAF----GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RKAL-------------FPGD--SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
----YENLGLVGEGSYGMVMKCRNK-------DTGRIVAIKKFLESD-DDKMV--KKIAMR-------EIKLLKQL--R-----HEN-----LVNLLEVCK--K----KKRWY--LVFEF-VDHT--ILDDLEL----FPN-----------------GL---DYQVVQKYLFQIINGIGFCHS--HNIIHRDIKPENILVS--QSGVV----KLCDFGFARTL----AAPGEVYTD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GEPL-------------FPGD--SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------
----FEILGVVGEGAYGVVLKCRHK-------ETHEIVAIKKFKDSE-ENEEV--KETTLR-------ELKMLRTL--K-----QEN-----IVELKEAFR--R----RGKLY--LVFEY-VEK---NMLELLE---EMPN-----------------GV---PPEKVKSYIYQLIKAIHWCHK--NDIVHRDIKPENLLIS--HNDVL----KLCDFGFARNL---SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQPL-------------FPGE--SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TE-QCLNHPTF--------------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKR-AVDCP--ENI-KK-------EICINKML--N-----HEN-----VVKFYGHRR--E----GNIQY--LFLEY-CSGG--ELFDRIE----PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL----KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELP-------------WDQP----SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------SAPLALLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKRK-FAIGS--AREADPALN-VETEIEILKKL--N-----HPC-----IIKIKNFF---D----AEDYY--IVLEL-MEGG--ELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPP-------------FSEH----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------EKALDLVKKLLVVDPKARFT-------TE-EALRHPWL--------------
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKRR-TKSSR--RGVSREDI---EREVSILKEI--Q-----HPN-----VITLHEVYE--N----KTDVI--LILEL-VAGG--ELFDFLA----EKE-----------------SL---TEEEATEFLKQILNGVYYLHS--LQIAHFDLKPENIMLL--DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGD-----TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-------IQ-DSLQHPWI--------------
----YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFIKKRQ-SRASR--RGVSREEI---EREVSILRQV--L-----HHN-----VITLHDVYE--N----RTDVV--LILEL-VSGG--ELFDFLA----QKE-----------------SL---SEEEATSFIKQILDGVNYLHT--KKIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGD-----TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-------IQ-EALRHPWI--------------
----YEMGEELGSGQFAIVRKCRQK-------GTGKEYAAKFIKKRR-LSSSR--RGVSREEI---EREVNILREI--R-----HPN-----IITLHDIFE--N----KTDVV--LILEL-VSGG--ELFDFLA----EKE-----------------SL---TEDEATQFLKQILDGVHYLHS--KRIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGE-----TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------
----YEIDSLIGKGSFGQVVKAYDR-------VEQEWVAIKIIKNKK-AFLNQ--AQI----------EVRLLELM-NK-----HDTEMKYYIVHLKRHFM--F----RNHLC--LVFEM-LSY---NLYDLLR-----NT-----------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ-------LGQRIYQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GEPL-------------FSGA--NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-------PY-YALQHSFF--------------
----YEIDSLIGKGSFGQVVKAYDH-------QTQELVAIKIIKNKK-AFLNQ--AQI----------ELRLLELM-NQ-----HDTEMKYYIVHLKRHFM--F----RNHLC--LVFEL-LSY---NLYDLLR-----NT-----------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ-------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GEPL-------------FSGS--NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-------PL-GALQHGFF--------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLSDLI-S-------EMEMMKMIG-K-----HKN-----IINLLGACT--Q----DGPLY--VIVEY-ASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--KKCIHRDLAARNVLVT--EDNVM----KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGGSP-------------YPGV--PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-------FK-QLVEDL----------------
FLDF----RVLGKGGFGEVSACQMK-------ATGKLYACKKLNKKR-LKKRK--GYQGAM------VEKKILMKV--H-----SRF-----IVSLAYAFE--T----KADLC--LVMTI-MNGG--DIRYHIYNVNEENP-----------------GF---PEPRALFYTAQIICGLEHLHQ--RRIVYRDLKPENVLLD--NDGNV----RISDLGLAVEL----LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGP-------------FRAR-GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEVCACQVR-------ATGKMYACKKLQKKR-IKKRK--GEAMAL------NEKRILEKV--Q-----SRF-----VVSLAYAYE--T----KDALC--LVLTI-MNGG--DLKFHIYN--LGNP-----------------GF---DEQRAVFYAAELCCGLEDLQR--ERIVYRDLKPENILLD--DRGHI----RISDLGLATE-----IPEGQRVRG---RVGTVGYMAPEVVN------NEKYTFSPDWWGLGCLIYEMIQ-GHSP-------------FKKY--KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR--GEGAA-GVKQHPV-F-------------
---F-TEFRVLGKGGFGEVCAVQVK-------NTGKMYACKKLDKKR-LKKKG--GEKMAL------LEKEILEKV--S-----SPF-----IVSLAYAFE--S----KTHLC--LVMSL-MNGG--DLKFHIYN--VGTR-----------------GL---DMSRVIFYSAQIACGMLHLHE--LGIVYRDMKPENVLLD--DLGNC----RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTP-------------FKDY-KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-------SR-E-------KSDDPR--------
----YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDK-RFKNR---------------ELQIMRKL--D-----HCN-----IVRLRYFFY--SSGEKKDELYLNLVLEY-VPETVYRVARHFT---KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFKNR---------------ELQIMRKL--D-----HCN-----IVRLRYFFY--SSGEKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-------PL-EACAHSFF--------------
----YEVLEFLGRGTFGQVAKCWKR-------STKEIVAIKILKNHP-SYARQ--GQI----------EVSILSRL--S-----SENADEYNFVRSYECFQ--H----KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS-----------------PL---PLKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLV--DPVRQPYRVKVIDFGSAS------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YPGA--SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-------PL-KTLNHQFV--------------
----YEVLEFLGRGTFGQVVKCWKR-------GTNEIVAIKILKNHP-SYARQ--GQI----------EVSILARL--STESADDYN-----FVRAYECFQ--H----KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS-----------------PL---PLKYIRPVLQQVATALMKLKS--LGLIHADLKPENIMLV--DPSRQPYRVKVIDFGSAS------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YPGA--SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQVVKCWKR-------GTNEIVAIKILKNHP-SYARQ--GQI----------EVSILARL--S-----TENADEYNFVRAYECFQ--H----RNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS-----------------PL---PLKVIRPILQQVATALKKLKS--LGLIHADLKPENIMLV--DPVRQPYRVKVIDFGSAS------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YPGA--LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-------PA-ETLNHPFV--------------
----YTTIRQLGDGTYGSVLLGRSI-------ESGELIAIKKMKRKF-YSWEE--C-MNLR-------EVKSLKKL--N-----HAN-----VVKLKEVIR--E----NDHLY--FIFEY-MKE---NLYQLIK---ERNK-----------------LF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLLCM--GPELV----KIADFGLARE-----IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LRPL-------------FPGA--SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-------EIQILKAL--H-----SDF-----IVKYRGVSYGPG----RQSLR--LVMEY-LPSG--CLRDFLQ-----RH---------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV----KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVP-ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP--DAFL-A-------EANLMKQL--Q-----HQR-----LVRLYAVVT-------QEPIY--IITEY-MENG--SLVDFLK-----TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS--DTLSC----KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGRIP-------------YPGM--TNPEVIQNLERGYRMVRPDNCP-----------------------------------------------------------------------EELYQLMRLCWKERPEDRPT-------FD-YLRSV--L--------------
----YRLLKTIGKGNFAKVKLARHI-------LTGKEVAVKIIDKTQ-LNSSS--LQKLFR-------EVRIMKVL--N-----HPN-----IVKLFEVIE--T----EKTLY--LVMEY-ASGG--EVFDYLV----AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--KFIVHRDLKAENLLLD--ADMNI----KIADFGFSNE-----FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLP-------------FDGQ-----NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------TDCENLLKKFLILNPSKRGT-------LE-QIMKDRWM--------------
----YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKDK-IKDEQ--DMVHIR------REIEIMSSL--N-----HPH-----IISIYEVFE--N----KDKIV--IIMEY-ASKG--ELYDYIS----ERR-----------------RL---SERETRHFFRQIVSAVHYCHK--NGVVHRDLKLENILLD--DNCNI----KIADFGLSNL-----YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMP-------------FDGF-----DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT-------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKVKKARES-------SGR-LVAIKSIRKDK-IKDEQ--DLMHIR------REIEIMSSL--N-----HPH-----IIAIHEVFE--N----SSKIV--IVMEY-ASRG--DLYDYIS----ERQ-----------------QL---SEREARHFFRQIVSAVHYCHQ--NRVVHRDLKLENILLD--ANGNI----KIADFGLSNL-----YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMP-------------FDGH-----DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------SDACGLIRWLLMVNPTRRAT-------LE-DVASHWW-V-------------
---Y-IKLDKLGEGTYATVYKGKSK-------LTDNLVALKEIRLEH-EEGAP--C-TAIR-------EVSLLKDL--K-----HAN-----IVTLHDIIH--T----EKSLT--LVFEY-LDK---DLKQYLD---DCGN-----------------II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL----KLADFGLARAK----SIPTKTYSN---EVVTLWYRPPDILL-----GSTDYSTQIDMWGVGCIFYEMAT-GRPL-------------FPGS--TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AE-DAMKHPFF--------------
----YEKLEKLGEGSYATVYKGKSK-------VNGKLVALKVIRLQE-EEGTP--F-TAIR-------EASLLKGL--K-----HAN-----IVLLHDIIH--T----KETLT--LVFEY-VHT---DLCQYMD---KHPG-----------------GL---HPDNVKLFLFQLLRGLSYIHQ--RYILHRDLKPQNLLIS--DTGEL----KLADFGLARAK----SVPSHTYSN---EVVTLWYRPPDVLL-----GSTEYSTCLDMWGVGCIFVEMIQ-GVAA-------------FPGM-KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS-------AQ-AALSHEYF--------------
----YEPKEILGRGVSSVVRRCIHK-------PTSQEYAVKVIDVTG-GGSFS--PEEVRELREATLKEVDILRKV-SG-----HPN-----IIQLKDTYE--T----NTFFF--LVFDL-MKRG--ELFDYLT----EKV-----------------TL---SEKETRKIMRALLEVICTLHK--LNIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ-----LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPP-------------FWHR-----KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
----YQVGPLLGSGGFGSVYSGIRV-------SDNLPVAIKHVEKDR-ISDWG--ELPNGTRV---PMEVVLLKKV--S-----SGFS---GVIRLLDWFE--R----PDSFV--LILER-PEPV-QDLFDFIT----ERG-----------------AL---QEELARSFFWQVLEAVRHCHN--CGVLHRDIKDENILID-LNRGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GDIP-------------FEHD-----------EEIIRGQVFFRQRVS---------------------------------------------------------------------SECQHLIRWCLALRPSDRPT-------FE-EIQNHPWM--------------
----YRLGPLLGKGGFGTVFAGHRL-------TDRLQVAIKVIPRNR-VLGWS--PLSDSVTC---PLEVALLWKV--GAG-GGHPG-----VIRLLDWFE--T----QEGFM--LVLERPLPAQ--DLFDYIT----EKG-----------------PL---GEGPSRCFFGQVVAAIQHCHS--RGVVHRDIKDENILID-LRRGCA----KLIDFGSGA------LLHDEPYTD---FDGTRVYSPPEWIS-----RHQYHALPATVWSLGILLYDMVC-GDIP-------------FERD-----------QEILEAELHFPAHVS---------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS-------LE-EILLDPWM--------------
----YQVGAVLGSGGFGTVYAGSRI-------ADGLPVAVKHVVKER-VTEWG--SLGGATV----PLEVVLLRKV--GAA-GGARG-----VIRLLDWFE--R----PDGFL--LVLER-PEPA-QDLFDFIT----ERG-----------------AL---DEPLARRFFAQVLAAVRHCHS--CGVVHRDIKDENLLVD-LRSGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIP-------------FEQD-----------EEILRGRLLFRRRVS---------------------------------------------------------------------PECQQLIRWCLSLRPSERPS-------LD-QIAAHPWM--------------
---F-KFLAVLGRGHFGKVLLSEFR-------PSGELFAIKALKKGD-IVARD--EVESLM------CEKRILAAV--TS--AGHPF-----LVNLFGCFQ--T----PEHVC--FVMEY-SAGG--DLMLHIH-----SD-----------------VF---SEPRAIFYSACVVLGLQFLHE--HKIVYRDLKLDNLLLD--TEGYV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GESP-------------FPGD-----DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------AEAIGIMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEYK-------NTNEMFAIKALKKGD-IVARD--EVDSLM------CEKRIFETV--NS--VRHPF-----LVNLFACFQ--T----KEHVC--FVMEY-AAGG--DLMMHIH-----TD-----------------VF---SEPRAVFYAACVVLGLQYLHE--HKIVYRDLKLDNLLLD--TEGFV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESP-------------FPGD-----DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKILKKDV-VIQDD--DVECTM------VEKRVLALL-DK-----PPF-----LTQLHSCFQ--T----VDRLY--FVMEY-VNGG--DLMYHIQ----QVG-----------------KF---KEPQAVFYAAEISIGLFFLHK--RGIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEH----MMDGVTTRT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQPP-------------FDGE-----DEDELFQSIMEHNVSYPKSLS---------------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
---F-NFLMVLGKGSFGKVMLSERK-------GTDELYAVKILKKDV-VIQDD--DVECTM------VEKRVLALP-GK-----PPF-----LTQLHSCFQ--T----MDRLY--FVMEY-VNGG--DLMYHIQ----QVG-----------------RF---KEPHAVFYAAEIAIGLFFLQS--KGIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEN----IWDGVTTKT---FCGTPDYIAPEIIA------YQPYGKSVDWWAFGVLLYEMLA-GQAP-------------FEGE-----DEDELFQSIMEHNVAYPKSMS---------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKALKKDV-VLIDD--DVECTM------VEKRVLTLA-AE-----NPF-----LTHLICTFQ--T----KDHLF--FVMEF-LNGG--DLMYHIQ----DKG-----------------RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVLLD--RDGHI----KIADFGMCKEN----IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSP-------------FHGD-----DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
----FEFIRVLGKGSFGKVMLARVK-------ETGDLYAVKVLKKDV-ILQDD--DVECTM------TEKRILSLA-RN-----HPF-----LTQLFCCFQ--T----PDRLF--FVMEF-VNGG--DLMFHIQ----KSR-----------------RF---DEARARFYAAEIISALMFLHD--KGIIYRDLKLDNVLLD--HEGHC----KLADFGMCKEG----ICNGVTTAT---FCGTPDYIAPEILQ------EMLYGPAVDWWAMGVLLYEMLC-GHAP-------------FEAE-----NEDDLFEAILNDEVVYPTWLH---------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F-------------
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKALKKDV-VLMDD--DVECTM------VEKRVLSLA-WE-----HPF-----LTHMFCTFQ--T----KENLF--FVMEY-LNGG--DLMYHIQ----SCH-----------------KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN----MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ-----DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
--PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVIDKLR-FPTKQ--ESQLRN-------EVAILQSL--R-----HPG-----IVNLECMFE--T----PEKVF--VVMEK-LHGD--MLEMILS---SEKG-----------------RL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFP-------------FNED-------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
----WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTKS-EEELE--DYM--V-------EIDILASC--D-----HPN-----IVKLLDAFY--Y----ENNLW--ILIEF-CAGG--AVDAVML---ELER-----------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPP-------------HHEL--NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-------TS-QLLQHPFV--------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-Q-------EAQVMKKL--R-----HEK-----LVQLYAVVS-------EEPIY--IVTEY-MSKG--SLLDFLK-----GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC----KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGRVP-------------YPGM--VNREVLDQVERGYRMPCPPECP-----------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-------FE-YLQAF--L--------------
-LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFMRKRR-KGQDC--RMEIIH-------EIAVLELA-QD-----NPW-----VINLHEVYE--T----ASEMI--LVLEY-AAGG--EIFDQCVA--DREE-----------------AF---KEKDVQRLMRQILEGVHFLHT--RDVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI-----LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISP-------------FLGN-----DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLEE-AEDEI--EDIQ-Q-------EITVLSQC--D-----SPY-----VTKYYGSYL--K----DTKLW--IIMEY-LGGG--SALDLLE-----PG-----------------PL---DETQIATILREILKGLDYLHS--EKKIHRDIKAANVLLS--EHGEV----KLADFGVAGQL----TDTQIKRNT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GEPP-------------HSEL--HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
|