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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
AGC ADRBK1 191
AGC ADRBK2 191
AGC AKT1 150
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
AGC PKN2 657
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCZ 252
AGC ROCK2 92
---F-NFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARK---HPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQ----RSRKFDEPRSRFYAAEVTSALMFLHQ-HGVIYRDLKLDNILLDAEGHCKLADFGMCKEG-ILNGVTTTTFCGTPDYIAPEILQ----ELEYGPSVDWWALGVLMYEMMAGQPPFEAD-------NEDDLFESILHDDVLYPVWLS----KEAVSILKAFMTKNPHK--RLGCVASQNGEDAIKQHP--FF------------
---F-SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS----QHGVFSEADMRFYAAEIILGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQ---KGVAYDSSADWFSLGCMLFKLLRGHSPFRQH----KTKDKHEIDRMTLTMAVELPDSFS----PELRSLLEGLLQRDVNR--RLGCL--GRGAQEVKESPFF--------------
---F-SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLS----QHGVFSEKEMRFYATEIILGLEHMHN-RFVVYRDLKPANILLDEHGHARISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQ---KGTAYDSSADWFSLGCMLFKLLRGHSPFRQH----KTKDKHEIDRMTLTVNVELPDTFS----PELKSLLEGLLQRDVSK--RLGCH--GGGSQEVKEHSFF--------------
---F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-R---HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ-------DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGG--SEDAKEIMQHRFF--------------
FLDF----RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKV-H---SRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQ-RRIVYRDLKPENVLLDNDGNVRISDLGLAVEL-LDGQSKTKGYAGTPGFMAPELLQ----GEEYDFSVDYFALGVTLYEMIAARGPFRAR---GEKVENKELKHRIISEPVKYPDKFS----QASKDFCEALLEKDPEK--RLG-------FRD-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-Q---SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYN--LGNPGFDEQRAVFYAAELCCGLEDLQR-ERIVYRDLKPENILLDDRGHIRISDLGLATE--IPEGQRVRGRVGTVGYMAPEVVN----NEKYTFSPDWWGLGCLIYEMIQGHSPFKKY----KEKVKWEEVDQRIKNDTEEYSE---KFSEDAKSICRMLLTKNPSK--RLGCR--GEGAAGVKQHPV-F-------------
---F-RQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYN--MGNPGFEEERALFYAAEILCGLEDLHR-ENTVYRDLKPENILLDDYGHIRISDLGLAVK--IPEGDLIRGRVGTVGYMAPEVLN----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGR-------KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ--RLGCQ--EEGAAEVKRHPFF--------------
---F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-N---SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLDDHGHIRISDLGLAVH--VPEGQTIKGRVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIAGQSPFQQR----KKKIKREEVERLVK-EVPEEYSER--FSPQARSLCSQLLCKDPAE--RLGCR--GGSAREVKEHPLF--------------
---F-TEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKV-S---SPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYN--VGTRGLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE--MKGGKPITQRAGTNGYMAPEILM---EKVSYSYPVDWFAMGCSIYEMVAGRTPFKDY---KEKVSKEDLKQRTLQDEVKFQHDNF---TEEAKDICRLFLAKKPEQ--RLG-------SRE-------KSDDPR--------
--FR--CCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV-NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-----TDVFSEPRAVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----ETSYTRAVDWWGLGVLIYEMLVGESPFPGD-------DEEEVFDSIVNDEVRYPRFLS----TEAISIMRRLLRRNPER--RLGAS--EKDAEDVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK---PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEH-MMDGVTTRTFCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLAGQPPFDGE-------DEDELFQSIMEHNVSYPKSLS----KEAVSVCKGLMTKHPAK--RLG-------C---------GPEGERDVREHAFF
---F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK---PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN-IWDGVTTKTFCGTPDYIAPEIIA----YQPYGKSVDWWAFGVLLYEMLAGQAPFEGE-------DEDELFQSIMEHNVAYPKSMS----KEAVAICKGLMTKHPGK--RLG-------C---------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE---NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN-IFGESRASTFCGTPDYIAPEILQ----GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD-------DEDELFESIRVDTPHYPRWIT----KESKDILEKLFEREPTK--RLG------VTGNIKIHPFF--------------
----FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN---HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQ----KSRRFDEARARFYAAEIISALMFLHD-KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQ----EMLYGPAVDWWAMGVLLYEMLCGHAPFEAE-------NEDDLFEAILNDEVVYPTWLH----EDATGILKSFMTKNPTM--RLGSLT-QGGEHAILRHPF-F-------------
---F-DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS---NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQ----RQRKLPEEHARFYAAEICIALNFLHE-RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEG-LGPGDTTSTFCGTPNYIAPEILR----GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLS----VKASHVLKGFLNKDPKE--RLGCRP-QTGF---------SDIKSHAFF-----
----YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-N---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD-------SLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-------VEEIRQHPFF--------------
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