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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCQ 203
TK ABL1 261
TK ABL2 288
AGC AKT3 148
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
CAMK CAMK2A 13
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CAMK CASK 12
CMGC CDC2 4
CMGC CDC2L5 705
AGC CDC42BPA 77
AGC CDC42BPB 76
AGC CDC42BPG 71
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
AGC CIT 97
TK CSK 195
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC DMPK 81
Other DSTYK 651
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
CMGC DYRK3 209
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC ICK 4
TK ITK 363
TK JAK2 849
TK JAK3 822
CMGC MAK 4
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK8 26
CAMK MAPKAPK2 64
CAMK MAPKAPK5 22
AGC MAST1 374
TK MATK 235
CAMK MKNK2 84
CMGC NLK 126
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM2 132
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK6 191
TKL RAF1 349
TK RET 724
AGC ROCK1 76
AGC ROCK2 92
Other SBK1 53
STE SLK 34
TK SRC 270
TK SRMS 230
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
Other STK36 4
AGC STK38 89
AGC STK38L 90
TK SYK 371
TK TEC 370
TK TEK 824
TK TIE1 839
Other TLK2 440
TK TNK2 150
TK TXK 271
TK TYRO3 518
TK YES1 277
TK ZAP70 338
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQ-FFAIKALKKD--V-VL-MDD---DV-ECTM------------------------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T----------KEN------LF--FVMEY-LNGG--DLM-YHIQ----SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS--K--GIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN-----------------------------------MLGDA-KT--------------NT---FCGTPDYIAPEILL------------------GQK----YNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ---------------DE-EELF-HSIRM----DNPFYPRWLE----------------------------------------------------------------KEAKD-LLVKLFVREPEK--RLG-------VRGDIRQHPLF------------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSL-TVAVKTLK-E--D-TM--EV---EE-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--R----------EPP------FY--IITEF-MTYG--NLL-DYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K--NFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM-----------------------------------T--GD-TY--------------TAHAGAKFPIKWTAPESLA------------------YNK----FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI------------DLSQV-YELL-EKDYR----MERPEGCP------------------------------------------------------------------EKVYE-LMRACWQWNPSD--RPS-------FA-EIHQA--F------------------
----ITMKHKLGGGQYGEVYVGVWK-------KYSL-TVAVKTLK-E--D-TM--EV---EE-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--L----------EPP------FY--IVTEY-MPYG--NLL-DYLR-----EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--K--NFIHRDLAARNCLVG--ENHVV----KVADFGLSRLM-----------------------------------T--GD-TY--------------TAHAGAKFPIKWTAPESLA------------------YNT----FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI------------DLSQV-YDLL-EKGYR----MEQPEGCP------------------------------------------------------------------PKVYE-LMRACWKWSPAD--RPS-------FA-ETHQA--F------------------
--FD--YLKLLGKGTFGKVILVREK-------ASGK-YYAMKILKKE--V-II-AKD---EV-AHTL------------------------TESRVLKNT--R------HPF-----LTSLKYSFQ--T----------KDR------LC--FVMEY-VNGG--ELF-FHLS----RER-------------------------VF---SEDRTRFYGAEIVSALDYLHS--G--KIVYRDLKLENLMLD--KDGHI----KITDFGLCKEG-----------------------------------ITDAA-TM--------------KT---FCGTPEYLAPEVLE------------------DND----YGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ---------------DH-EKLF-ELILM----EDIKFPRTLS----------------------------------------------------------------SDAKS-LLSGLLIKDPNK--RLGGG--PDDAK-EIMRHSFF------------------
----FEIGRPLGKGKFGNVYLAREK-------QSKF-ILALKVLFKA--QLEK-AGV---EH-QLRR-------------------------EVEIQSHL--R------HPN-----ILRLYGYFH--D----------ATR------VY--LILEY-APLG--TVY-RELQ----KLS-------------------------KF---DEQRTATYITELANALSYCHS--K--RVIHRDIKPENLLLG--SAGEL----KIADFGWSV-------------------------------------HAPSS-RR--------------TT---LCGTLDYLPPEMIE------------------GRM----HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN---------------TY-QETY-KRISR----VEFTFPDFVT----------------------------------------------------------------EGARD-LISRLLKHNPSQ--RPM-------LR-EVLEHPWI------------------
----FEIGRPLGKGKFGNVYLAREK-------KSHF-IVALKVLFKS--Q-IE-KEG---VE-HQLR------------------------REIEIQAHL--H------HPN-----ILRLYNYFY--D----------RRR------IY--LILEY-APRG--ELY-KELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG--K--KVIHRDIKPENLLLG--LKGEL----KIADFGWSV-------------------------------------HAPSL-RR--------------KT---MCGTLDYLPPEMIE------------------GRM----HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA---------------SH-NETY-RRIVK----VDLKFPASVP----------------------------------------------------------------MGAQD-LISKLLRHNPSE--RLP-------LA-QVSAHPWV------------------
----FEIGRPLGKGKFGNVYLARLK-------ESHF-IVALKVLFKS--Q-IE-KEG---LE-HQLR------------------------REIEIQAHL--Q------HPN-----ILRLYNYFH--D----------ARR------VY--LILEY-APRG--ELY-KELQ----KSE-------------------------KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--FRGEV----KIADFGWSV-------------------------------------HTPSL-RR--------------KT---MCGTLDYLPPEMIE------------------GRT----YDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA---------------SH-SETY-RRILK----VDVRFPLSMP----------------------------------------------------------------LGARD-LISRLLRYQPLE--RLP-------LA-QILKHPWV------------------
---V-ALGKTLGEGEFGAVMEGQLN-----QDDSIL-KVAVKTMK-I-AI-CT--RSE-LED-FL-S-------------------------EAVCMKEF--D------HPN-----VMRLIGVCF--Q----------GSERESFPAPV--VILPF-MKHG--DLH-SFLL-----YSRL------------------GDQPVYL---PTQMLVKFMADIASGMEYLST--K--RFIHRDLAARNCMLN--ENMSV----CVADFGLSKKI-------------Y---------------------N--GD-YY--------------RQGRIAKMPVKWIAIESLA------------------DRV----YTSKSDVWSFGVTMWEIATRGQTP---------------YP-GV------------ENSEI-YDYL-RQGNR----LKQPADCL------------------------------------------------------------------DGLYA-LMSRCWELNPQD--RPS-------FT-ELREDL--------------------
---L-RLVRKLGSGQFGEVWMGYYK--------NNM-KVAIKTLK-E--G-TM--SP---EA-FL-G-------------------------EANVMKAL--Q------HER-----LVRLYAVVT-------------KEP------IY--IVTEY-MARG--CLL-DFLK-----TD----------------------EGSRL---SLPRLIDMSAQIAEGMAYIER--M--NSIHRDLRAANILVS--EALCC----KIADFGLARII--------------------------------------DS-EY--------------TAQEGAKFPIKWTAPEAIH------------------FGV----FTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM------------SNPEV-IRNL-ERGYR----MPRPDTCP------------------------------------------------------------------PELYRGVIAECWRSRPEE--RPT-------FE-FLQSV--L------------------
----YQLFEELGKGAFSVVRRCVKV-------LAGQ-EYAAKIINTK--K-LS-ARD---HQ-KLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E----------EGH------HY--LIFDL-VTGG--ELF-EDIV----ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLLLA--SKLKGA-AVKLADFGLAIEV-----------------------------------EGEQQ-AW--------------FG---FAGTPGYLSPEVLR------------------KDP----YGKPVDLWACGVILYILLV-GYPP---------------FW-DE---------------DQ-HRLY-QQIKA----GAYDFPSPEW-D-T-VT---------------------------------------------------------PEAKD-LINKMLTINPSK--RIT-------AA-EALKHPWI------------------
----YQLFEELGKGAFSVVRRCMKI-------PTGQ-EYAAKIINTK--K-LS-ARD---HQ-KLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E----------EGF------HY--LVFDL-VTGG--ELF-EDIV----ARE-------------------------YY---SEADASHCIQQILESVNHCHL--N--GIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV-----------------------------------QGDQQ-AW--------------FG---FAGTPGYLSPEVLR------------------KDP----YGKPVDMWACGVILYILLV-GYPP---------------FW-DE---------------DQ-HRLY-QQIKA----GAYDFPSPEW-D-T-VT---------------------------------------------------------PEAKD-LINKMLTINPAK--RIT-------AS-EALKHPWI------------------
----YQLFEELGKGAFSVVRRCVKK-------TSTQ-EYAAKIINTK--K-LS-ARD---HQ-KLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E----------EGF------HY--LVFDL-VTGG--ELF-EDIV----ARE-------------------------YY---SEADASHCIHQILESVNHIHQ--H--DIVHRDLKPENLLLA--SKCKGA-AVKLADFGLAIEV-----------------------------------QGEQQ-AW--------------FG---FAGTPGYLSPEVLR------------------KDP----YGKPVDIWACGVILYILLV-GYPP---------------FW-DE---------------DQ-HKLY-QQIKA----GAYDFPSPEW-D-T-VT---------------------------------------------------------PEAKN-LINQMLTINPAK--RIT-------AD-QALKHPWV------------------
----YKLQSEIGKGAYGVVRLAYNE-------SEDR-HYAMKVLSKK--K-LL-KQY---GF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVN-----VVKLIEVLD--DP--------AEDN------LY--LVFDL-LRKG--PVM-EVPC-----DK-------------------------PF---SEEQARLYLRDVILGLEYLHC--Q--KIVHRDIKPSNLLLG--DDGHV----KIADFGVSNQF-----------------------------------EGNDA-QL--------------SS---TAGTPAFMAPEAISD---------------SGQSF----SGKALDVWATGVTLYCFVY-GKCP---------------FI-DD---------------FI-LALH-RKIKN----EPVVFPEEPE-I-S------------------------------------------------------------EELKD-LILKMLDKNPET--RIG-------VP-DIKLHPWV------------------
----YTLKDEIGKGSYGVVKLAYNE-------NDNT-YYAMKVLSKK--K-LI-RQA---GF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN-----VVKLVEVLD--DP--------NEDH------LY--MVFEL-VNQG--PVM-EVPT-----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q--KIIHRDIKPSNLLVG--EDGHI----KIADFGVSNEF-----------------------------------KGSDA-LL--------------SN---TVGTPAFMAPESLS-----------------ETRKIF--SGKALDVWAMGVTLYCFVF-GQCP---------------FM-DE---------------RI-MCLH-SKIKS----QALEFPDQPD-I-A------------------------------------------------------------EDLKD-LITRMLDKNPES--RIV-------VP-EIKLHPWV------------------
----YELCEVIGKGPFSVVRRCINR-------ETGQ-QFAVKIVDVA--K-FT-SSP---GL-STEDL----------------------KREASICHML--K------HPH-----IVELLETYS--S----------DGM------LY--MVFEF-MDGA--DLCFEIVKR-ADAGF-------------------------VY---SEAVASHYMRQILEALRYCHD--N--NIIHRDVKPHCVLLA--SKENSA-PVKLGGFGVAIQL-----------------------------------GESGL-VA--------------GG---RVGTPHFMAPEVVK------------------REP----YGKPVDVWGCGVILFILLS-GCLP---------------FY-GT----------------K-ERLF-EGIIK----GKYKMNPRQW-S-H-IS---------------------------------------------------------ESAKD-LVRRMLMLDPAE--RIT-------VY-EALNHPWL------------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQ-VVAMKKIRLE--S-EE-EGV---PS-TAIR-------------------------EISLLKEL--R------HPN-----IVSLQDVLM--Q----------DSR------LY--LIFEF-LSM---DLK-KYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--R--RVLHRDLKPQNLLID--DKGTI----KLADFGLARAF-----------------------------------GIPIR-VY--------------TH---EVVTLWYRSPEVLL-----------------GSAR----YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD------------SEIDQ-LFRI-FRALG----TPNNEVWPEV-E-S-LQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAK--RIS-------GK-MALNHPYF------------------
---F-DIIGIIGEGTYGQVYKARDK-------DTGE-MVALKKVRLD--N-EK-EGF---PI-TAIR-------------------------EIKILRQL--T------HQS-----IINMKEIVT--DKEDALDFKKDKGA------FY--LVFEY-MDH---DLM-GLLE---SGLV-------------------------HF---NENHIKSFMRQLMEGLDYCHK--K--NFLHRDIKCSNILLN--NRGQI----KLADFGLARLY----------------------------------SSEESR-PY--------------TN---KVITLWYRPPELLL-----------------GEER----YTPAIDVWSCGCILGELFT-KKPI---------------FQ-AN------------QELAQ-LELI-SRICG----SPCPAVWPDV-I-K-LPYFNTMKPKKQY----------------------------------RRKLREEFVFIPAAALD-LFDYMLALDPSK--RCT-------AE-QALQCEF-L-----------------
----FEILKVIGRGAFGEVAVVKLK-------NADK-VFAMKILNKW--E-ML-KRA---ET-ACFR------------------------EERDVLVNG--D------NKW-----ITTLHYAFQ--D----------DNN------LY--LVMDY-YVGG--DLL-TLLS---KFED-------------------------RL---PEDMARFYLAEMVIAIDSVHQ--L--HYVHRDIKPDNILMD--MNGHI----RLADFGSCLKL----------------------------------MEDGTV-QS--------------SV---AVGTPDYISPEILQAM-------------EDGKGR----YGPECDWWSLGVCMYEMLY-GETP---------------FY-AE------------SLV----ETY-GKIMN----HKERFQFPAQVT-D-VS---------------------------------------------------------ENAKD-LIRRLICSREHR---LGQ----NGIE-DFKKHPFF------------------
----FEIIKVIGRGAFGEVAVVKMK-------NTER-IYAMKILNKW--E-ML-KRA---ET-ACFR------------------------EERDVLVNG--D------CQW-----ITALHYAFQ--D----------ENH------LY--LVMDY-YVGG--DLL-TLLS---KFED-------------------------KL---PEDMARFYIGEMVLAIDSIHQ--L--HYVHRDIKPDNVLLD--VNGHI----RLADFGSCLKM-----------------------------------NDDGTVQS--------------SV---AVGTPDYISPEILQAM-------------EDGMGK----YGPECDWWSLGVCMYEMLY-GETP---------------FY-AE---------------SL-VETY-GKIMN----HEERFQFPSHVT-D-VS---------------------------------------------------------EEAKD-LIQRLICSRE-R--RLGQ----NGIE-DFKKHAF-F-----------------
----FEILKVIGRGAFGEVTVVRQR-------DTGQ-IFAMKMLHKW--E-ML-KRA---ET-ACFR------------------------EERDVLVKG--D------SRW-----VTTLHYAFQ--D----------EEY------LY--LVMDY-YAGG--DLL-TLLS---RFED-------------------------RL---PPELAQFYLAEMVLAIHSLHQ--L--GYVHRDVKPDNVLLD--VNGHI----RLADFGSCLRL-----------------------------------NTNGMVDS--------------SV---AVGTPDYISPEILQAM-------------EEGKGH----YGPQCDWWSLGVCAYELLF-GETP---------------FY-AE------------SLVET-YGKI-M---N----HEDHLQFPPD-VPD-VP---------------------------------------------------------ASAQD-LIRQLLCRQEERLGRGG-------LD-DFRNHPFF------------------
----FQKVEKIGEGTYGVVYKARNK-------LTGE-VVALKKIRLD--T-ET-EGV---PS-TAIR-------------------------EISLLKEL--N------HPN-----IVKLLDVIH--T----------ENK------LY--LVFEF-LHQ---DLK-KFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF-----------------------------------GVPVR-TY--------------TH---EVVTLWYRAPEILL-----------------GCKY----YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD------------SEIDQ-LFRI-FRTLG----TPDEVVWPGV-T-S-MPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-------AK-AALAHPFF------------------
----FQKVEKIGEGTYGVVYKAKNR-------ETGQ-LVALKKIRLD--L-EM-EGV---PS-TAIR-------------------------EISLLKEL--K------HPN-----IVRLLDVVH--N----------ERK------LY--LVFEF-LSQ---DLK-KYMDS--TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H--RVIHRDLKPQNLLIN--ELGAI----KLADFGLARAF-----------------------------------GVPLR-TY--------------TH---EVVTLWYRAPEILL-----------------GSKF----YTTAVDIWSIGCIFAEMVT-RKAL---------------FP-GD------------SEIDQ-LFRI-FRMLG----TPSEDTWPGV-T-Q-LPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQ--RIT-------AK-TALAHPYF------------------
----YEKLEKIGEGTYGTVFKAKNR-------ETHE-IVALKRVRLD--D-DD-EGV---PS-SALR-------------------------EICLLKEL--K------HKN-----IVRLHDVLH--S----------DKK------LT--LVFEF-CDQ---DLK-KYFD---SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R--NVLHRDLKPQNLLIN--RNGEL----KLADFGLARAF-----------------------------------GIPVR-CY--------------SA---EVVTLWYRPPDVLF-----------------GAKL----YSTSIDMWSAGCIFAELANAGRPL---------------FP-GN------------DVDDQ-LKRI-FRLLG----TPTEEQWPSM-T-K-LPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQ--RIS-------AE-EALQHPYF------------------
----YECVAEIGEGAYGKVFKARDL-------KNGGRFVALKRVRVQ--T-GE-EGM---PL-STIR-------------------------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSR-----TDRETK------LT--LVFEH-VDQ---DLT-TYLDK--VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--H--RVVHRDLKPQNILVT--SSGQI----KLADFGLARI------------------------------------YSFQM-AL--------------TS---VVVTLWYRAPEVLL------------------QSS----YATPVDLWSVGCIFAEMFR-RKPL---------------FR-GS------------SDVDQ-LGKI-LDVIG----LPGEEDWPRD-V-A-LPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAK--RIS-------AY-SALSHPYF------------------
----YEKLAKIGQGTFGEVFKARHR-------KTGQ-KVALKKVLME--N-EK-EGF---PI-TALR-------------------------EIKILQLL--K------HEN-----VVNLIEICR--TKASP--YNRCKGS------IY--LVFDF-CEH---DLA-GLLS---NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--N--KILHRDMKAANVLIT--RDGVL----KLADFGLARAFSL-------------------------------AKNSQPN-RY--------------TN---RVVTLWYRPPELLL-----------------GERD----YGPPIDLWGAGCIMAEMWT-RSPI---------------MQ-GN------------TEQHQ-LALI-SQLCG----SITPEVWPNV-D-N-YELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQ--RID-------SD-DALNHDFF------------------
----YEKIGKIGEGSYGVVFKCRNR-------DTGQ-IVAIKKFLES--E-DD-PVI---KK-IALR-------------------------EIRMLKQL--K------HPN-----LVNLLEVFR--R----------KRR------LH--LVFEY-CDHT--VLH-ELDR----YQR-------------------------GV---PEHLVKSITWQTLQAVNFCHK--H--NCIHRDVKPENILIT--KHSVI----KLCDFGFARLL-----------------------------------AGPSD-YY--------------TD---YVATRWYRSPELLV-----------------GDTQ----YGPPVDVWAIGCVFAELLS-GVPL---------------WP-GK------------SDVDQ-LYLI-RKTLG----DLIPRHQQVF-S-T-NQYFSGVKIPDPED---------------------------------MEPLELKFPNISYPALG-LLKGCLHMDPTQ--RLT-------CE-QLLHHPYF------------------
----YENLGLVGEGSYGMVMKCRNK-------DTGR-IVAIKKFLES--D-DD-KMV---KK-IAMR-------------------------EIKLLKQL--R------HEN-----LVNLLEVCK--K----------KKR------WY--LVFEF-VDHT--ILD-DLEL----FPN-------------------------GL---DYQVVQKYLFQIINGIGFCHS--H--NIIHRDIKPENILVS--QSGVV----KLCDFGFARTL-----------------------------------AAPGE-VY--------------TD---YVATRWYRAPELLV-----------------GDVK----YGKAVDVWAIGCLVTEMFM-GEPL---------------FP-GD------------SDIDQ-LYHI-MMCLG----NLIPRHQELF-N-K-NPVFAGVRLPEIKE---------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDK--RPF-------CA-ELLHHDFF------------------
----YETLGKVGEGSYGTVMKCKHK-------NTGQ-IVAIKIFYER--P-EQ-SVN---K--IAMR-------------------------EIKFLKQF--H------HEN-----LVNLIEVFR--Q----------KKK------IH--LVFEF-IDHT--VLD-ELQH----YCH-------------------------GL---ESKRLRKYLFQILRAIDYLHS--N--NIIHRDIKPENILVS--QSGIT----KLCDFGFARTL-----------------------------------AAPGD-IY--------------TD---YVATRWYRAPELVL-----------------KDTS----YGKPVDIWALGCMIIEMAT-GNPY---------------LP-SS------------SDLDL-LHKI-VLKVG----N-LSPHLQNI-F-S-KSPIFAGVVLPQVQ--------------------------------HPKNARKKYPKLNGLLAD-IVHACLQIDPAD--RIS-------SS-DLLHHEYF------------------
----FEILGVVGEGAYGVVLKCRHK-------ETHE-IVAIKKFKDS--E-EN-EEV---KE-TTLR-------------------------ELKMLRTL--K------QEN-----IVELKEAFR--R----------RGK------LY--LVFEY-VEK---NML-ELLE---EMPN-------------------------GV---PPEKVKSYIYQLIKAIHWCHK--N--DIVHRDIKPENLLIS--HNDVL----KLCDFGFARNL----------------------------------SEGNNA-NY--------------TE---YVATRWYRSPELLL------------------GAP----YGKSVDMWSVGCILGELSD-GQPL---------------FP-GE------------SEIDQ-LFTI-QKVLG----PLPSEQMKLF-Y-S-NPRFHGLRFPAVNH--------------------------------PQSLERRYLGILNSVLLD-LMKNLLKLDPAD--RYL-------TE-QCLNHPTF------------------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEE-AVAVKIVDMK--R-AV-DCP---EN-I-KK-------------------------EICINKML--N------HEN-----VVKFYGHRR--E----------GNI------QY--LFLEY-CSGG--ELF-DRIE----PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I--GITHRDIKPENLLLD--ERDNL----KISDFGLATVFR---------------------------------YNNRER-LL--------------NK---MCGTLPYVAPELLK-----------------RREF----HAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP--------------SDS-CQEY-SDWKE----KKTYLNPWKK-I----D---------------------------------------------------------SAPLA-LLHKILVENPSA--RIT-------IP-DIKKDRW-Y-----------------
--YI--MSKTLGSGACGEVKLAFER-------KTCK-KVAIKIISKR--K-FA-IGS---AR-EADPALN-------------------VETEIEILKKL--N------HPC-----IIKIKNFF---D----------AED------YY--IVLEL-MEGG--ELF-DKVV----GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI------------------------------------LGETS-LM--------------RT---LCGTPTYLAPEVLVS---------------VGTAG----YNRAVDCWSLGVILFICLS-GYPP---------------FS-EH--------------RTQ-VSLK-DQITS----GKYNFIPEVW-A-E-VS---------------------------------------------------------EKALD-LVKKLLVVDPKA--RFT-------TE-EALRHPWL------------------
---F-EVRSLVGCGHFAEVQVVREK-------ATGD-IYAMKVMKKK--A-LL-AQE---QV-SFFE------------------------EERNILSRS--T------SPW-----IPQLQYAFQ--D----------KNH------LY--LVMEY-QPGG--DLL-SLLN---RYED-------------------------QL---DENLIQFYLAELILAVHSVHL--M--GYVHRDIKPENILVD--RTGHI----KLVDFGSAAKM----------------------------------NSNKMV-NA--------------KL---PIGTPDYMAPEVLTVM------------NGDGKGT----YGLDCDWWSVGVIAYEMIY-GRSP---------------FA-EG---------------TS-ARTF-NNIMN----FQRFLKFPDD-P-K-VS---------------------------------------------------------SDFLD-LIQSLLCG-QKE--RLK-------FE-GLCCHPFF------------------
----LKLLQTIGKGEFGDVMLGDYR---------GN-KVAVKCIK-N--D-AT--AQ----A-FL-A-------------------------EASVMTQL--R------HSN-----LVQLLGVIV-EE----------KGG------LY--IVTEY-MAKG--SLV-DYLR-----SR----------------------GRSVL---GGDCLLKFSLDVCEAMEYLEG--N--NFVHRDLAARNVLVS--EDNVA----KVSDFGLTKEA------------------------------------------S--------------STQDTGKLPVKWTAPEALR------------------EKK----FSTKSDVWSFGILLWEIYSFGRVP---------------YP-RI------------PLKDV-VPRV-EKGYK----MDAPDGCP------------------------------------------------------------------PAVYE-VMKNCWHLDAAM--RPS-------FL-QLREQL--------------------
----YQLVRKLGRGKYSEVFEAINI-------TNNE-RVVVKILKPV--K-KK-KIK---R-------------------------------EVKILENL-RG------GTN-----IIKLIDTVK--DP--------VSKT------PA--LVFEY-INNT--DFK-QLY-------Q-------------------------IL---TDFDIRFYMYELLKALDYCHS--K--GIMHRDVKPHNVMID-HQQKKL----RLIDWGLAEF------------------------------------YHPAQ-EY--------------NV---RVASRYFKGPELLV-----------------DYQM----YDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ------------DNYDQ-LVRI-AKVLG----TEELYGYLKK-Y-H-IDLDPHFNDILGQHSRK---------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQ--RLT-------AK-EAMEHPYF------------------
----YDTGEELGSGQFAVVKKCREK-------STGL-QYAAKFIKKR--R-TK-SSR---RG-VSREDI---------------------EREVSILKEI--Q------HPN-----VITLHEVYE--N----------KTD------VI--LILEL-VAGG--ELF-DFLA----EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--L--QIAHFDLKPENIMLL--DRNVPKPRIKIIDFGLAHK------------------------------------IDFGN-EF--------------KN---IFGTPEFVAPEIVN------------------YEP----LGLEADMWSIGVITYILLS-GASP---------------FL-GD---------------TK-QETL-ANVSA----VNYEFEDEYF-S-N-TS---------------------------------------------------------ALAKD-FIRRLLVKDPKK--RMT-------IQ-DSLQHPWI------------------
----YDIGEELGSGQFAIVKKCREK-------STGL-EYAAKFIKKR--Q-SR-ASR---RG-VSREEI---------------------EREVSILRQV--L------HHN-----VITLHDVYE--N----------RTD------VV--LILEL-VSGG--ELF-DFLA----QKE-------------------------SL---SEEEATSFIKQILDGVNYLHT--K--KIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE------------------------------------IEDGV-EF--------------KN---IFGTPEFVAPEIVN------------------YEP----LGLEADMWSIGVITYILLS-GASP---------------FL-GD---------------TK-QETL-ANITA----VSYDFDEEFF-S-Q-TS---------------------------------------------------------ELAKD-FIRKLLVKETRK--RLT-------IQ-EALRHPWI------------------
----YEMGEELGSGQFAIVRKCRQK-------GTGK-EYAAKFIKKR--R-LS-SSR---RG-VSREEI---------------------EREVNILREI--R------HPN-----IITLHDIFE--N----------KTD------VV--LILEL-VSGG--ELF-DFLA----EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK------------------------------------IEAGN-EF--------------KN---IFGTPEFVAPEIVN------------------YEP----LGLEADMWSIGVITYILLS-GASP---------------FL-GE---------------TK-QETL-TNISA----VNYDFDEEYF-S-N-TS---------------------------------------------------------ELAKD-FIRRLLVKDPKR--RMT-------IA-QSLEHSWI------------------
----FEILKVIGRGAFSEVAVVKMK-------QTGQ-VYAMKIMNKW--D-ML-KRG---EV-SCFR------------------------EERDVLVNG--D------RRW-----ITQLHFAFQ--D----------ENY------LY--LVMEY-YVGG--DLL-TLLS---KFGE-------------------------RI---PAEMARFYLAEIVMAIDSVHR--L--GYVHRDIKPDNILLD--RCGHI----RLADFGSCLKL----------------------------------RADGTV-RS--------------LV---AVGTPDYLSPEILQAVG-----------GGPGTGS----YGPECDWWALGVFAYEMFY-GQTP---------------FY-AD------------STAET-YGKI-VHYKE-------HLSLPLV-D-EGVP---------------------------------------------------------EEARD-FIQRLLCPP-ET--RLGR----GGAG-DFRTHPFF------------------
---K--LGQELGRGQYGVVYLCDNW-------GGHF-PCALKSVVPP--D-EK-HWN---D---LAL-------------------------EFHYMRSL-PK------HER-----LVDLHGSVI--DYNY---GGGSSIA------VL--LIMER-LHR---DLY-TGLK------A-------------------------GL---TLETRLQIALDVVEGIRFLHS--Q--GLVHRDIKLKNVLLD--KQNRA----KITDLGFCK--------------------------------------PEAM-MS--------------GS---IVGTPIHMAPELFT-------------------GK----YDNSVDVYAFGILFWYICS-GSVK---------------LP-EAF----------ERCASK-DHLW-NNVRR----GARPERLPVF------D---------------------------------------------------------EECWQ-LMEACWDGDPLK--RP-------------------LLGIVQPML---------
----YEIDSLIGKGSFGQVVKAYDR-------VEQE-WVAIKIIKNK--K-AF-LNQ---AQ-I----------------------------EVRLLELM-NK------HDTEMKYYIVHLKRHFM--F----------RNH------LC--LVFEM-LSY---NLY-DLLR-----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ--------------------------------------LGQ-RI--------------YQ---YIQSRFYRSPEVLL------------------GMP----YDLAIDMWSLGCILVEMHT-GEPL---------------FS-GA------------NEVDQ-MNKI-VEVLG----IPPAHILDQA-P-K-ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKT--RIQ-------PY-YALQHSFF------------------
----YEIDSLIGKGSFGQVVKAYDH-------QTQE-LVAIKIIKNK--K-AF-LNQ---AQ-I----------------------------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F----------RNH------LC--LVFEL-LSY---NLY-DLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ--------------------------------------LGQ-RI--------------YQ---YIQSRFYRSPEVLL------------------GTP----YDLAIDMWSLGCILVEMHT-GEPL---------------FS-GS------------NEVDQ-MNRI-VEVLG----IPPAAMLDQA-P-K-ARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAA--RIS-------PL-GALQHGFF------------------
----YEVLKVIGKGSFGQVVKAYDH-------KVHQ-HVALKMVRNE--K-RF-HRQ---AA-E----------------------------EIRILEHL--RKQDKDNTMN-----VIHMLENFT--F----------RNH------IC--MTFEL-LSM---NLY-ELIKK--NKFQ-------------------------GF---SLPLVRKFAHSILQCLDALHK--N--RIIHCDLKPENILLK--QQGRSG--IKVIDFGSSC--------------------------------------YEHQ-RV--------------YT---YIQSRFYRAPEVIL------------------GAR----YGMPIDMWSLGCILAELLT-GYPL---------------LP-GE------------DEGDQ-LACM-IELLG----MPSQKLLDAS-K-R-AKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAV--RMT-------PG-QALRHPWL------------------
----YEVLKIIGKGSFGQVARVYDH-------KLRQ-YVALKMVRNE--K-RF-HRQ---AA-E----------------------------EIRILEHL--KKQDKTGSMN-----VIHMLESFT--F----------RNH------VC--MAFEL-LSI---DLY-ELIKK--NKFQ-------------------------GF---SVQLVRKFAQSILQSLDALHK--N--KIIHCDLKPENILLK--HHGRSS--TKVIDFGSSCF--------------------------------------EYQ-KL--------------YT---YIQSRFYRAPEIIL------------------GSR----YSTPIDIWSFGCILAELLT-GQPL---------------FP-GE------------DEGDQ-LACM-MELLG----MPPPKLLEQS-K-R-AKYFINSKGIPRYCSVTTQADGRVVLVG-----GRSRRGKKRGPPGSKDWGTALKGCDDYLFIE-FLKRCLHWDPSA--RLT-------PA-QALRHPWI------------------
--VI--LGELLGKGNFGEVYKGTLK--------DKT-SVAVKTCK-E--D-LP--QEL-KIK-FL-Q-------------------------EAKILKQY--D------HPN-----IVKLIGVCT--Q----------RQP------VY--IIMEL-VSGG--DFL-TFLR-----RK-----------------------KDEL---KLKQLVKFSLDAAAGMLYLES--K--NCIHRDLAARNCLVG--ENNVL----KISDFGMSRQE-----------------------------------D--GG-VY--------------SSSGLKQIPIKWTAPEALN------------------YGR----YSSESDVWSFGILLWETFSLGVCP---------------YP-GM------------TNQQA-REQV-ERGYR----MSAPQHCP------------------------------------------------------------------EDISK-IMMKCWDYKPEN--RPK-------FS-ELQKEL--------------------
---L-VLGEQIGRGNFGEVFSGRLR-------ADNT-LVAVKSCR-E--T-LP--PDL-KAK-FL-Q-------------------------EARILKQY--S------HPN-----IVRLIGVCT--Q----------KQP------IY--IVMEL-VQGG--DFL-TFLR-----TE-----------------------GARL---RVKTLLQMVGDAAAGMEYLES--K--CCIHRDLAARNCLVT--EKNVL----KISDFGMSREE-------------A---------------------D--GV-YA--------------ASGGLRQVPVKWTAPEALN------------------YGR----YSSESDVWSFGILLWETFSLGASP---------------YP-NL------------SNQQT-REFV-EKGGR----LPCPELCP------------------------------------------------------------------DAVFR-LMEQCWAYEPGQ--RPS-------FS-TIYQEL--------------------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV-TVAVKMLK-D--D-AT--EKD-LSD-LV-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q----------DGP------LY--VIVEY-ASKG--NLR-EYLR-----ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q--KCIHRDLAARNVLVT--ENNVM----KIADFGLARDI-------------N---------------------N--ID-YY--------------KKTTNGRLPVKWMAPEALF------------------DRV----YTHQSDVWSFGVLMWEIFTLGGSP---------------YP-GI------------PVEEL-FKLL-KEGHR----MDKPANCT------------------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-------FK-QLVEDL--------------------
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV-TVAVKMLK-D--D-AT--DKD-LSD-LV-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q----------GGP------LY--VLVEY-AAKG--NLR-EFLR-----ARRPPGLDY--------SFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--Q--KCIHRDLAARNVLVT--EDNVM----KIADFGLARDV-------------H---------------------N--LD-YY--------------KKTTNGRLPVKWMAPEALF------------------DRV----YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GI------------PVEEL-FKLL-KEGHR----MDKPANCT------------------------------------------------------------------HDLYM-IMRECWHAAPSQ--RPT-------FK-QLVEDL--------------------
---L-VLGKPLGEGCFGQVVRAEAFGMDPARPDQAS-TVAVKMLK-D--N-AS--DKD-LAD-LV-S-------------------------EMEVMKLIG-R------HKN-----IINLLGVCT--Q----------EGP------LY--VIVEC-AAKG--NLR-EFLR-----ARRPPGPDL--------SPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--R--KCIHRDLAARNVLVT--EDNVM----KIADFGLARGV-------------H---------------------H--ID-YY--------------KKTSNGRLPVKWMAPEALF------------------DRV----YTHQSDVWSFGILLWEIFTLGGSP---------------YP-GI------------PVEEL-FSLL-REGHR----MDRPPHCP------------------------------------------------------------------PELYG-LMRECWHAAPSQ--RPT-------FK-QLVEAL--------------------
----ITLERRLGTGCFGDVWLGTWN--------GST-KVAVKTLK-P--G-TM--SP---KA-FL-E-------------------------EAQVMKLL--R------HDK-----LVQLYAVVS-------------EEP------IY--IVTEF-MCHG--SLL-DFLK-----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M--NYIHRDLRAANILVG--ERLAC----KIADFGLARLI-----------------------------------K--DD-EY--------------NPCQGSKFPIKWTAPEAAL------------------FGR----FTIKSDVWSFGILLTELITKGRIP---------------YP-GM------------NKREV-LEQV-EQGYH----MPCPPGCP------------------------------------------------------------------ASLYE-AMEQTWRLDPEE--RPT-------FE-YLQSFL--------------------
----LQLIKRLGNGQFGEVWMGTWN--------GNT-KVAIKTLK-P--G-TM--SP---ES-FL-E-------------------------EAQIMKKL--K------HDK-----LVQLYAVVS-------------EEP------IY--IVTEY-MNKG--SLL-DFLK-----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M--NYIHRDLRSANILVG--NGLIC----KIADFGLARLI-----------------------------------E--DN-EY--------------TARQGAKFPIKWTAPEAAL------------------YGR----FTIKSDVWSFGILLTELVTKGRVP---------------YP-GM------------NNREV-LEQV-ERGYR----MPCPQDCP------------------------------------------------------------------ISLHE-LMIHCWKKDPEE--RPT-------FE-YLQSFL--------------------
FLDF----RVLGKGGFGEVSACQMK-------ATGK-LYACKKLNKK--R-LK-KRK---GY-QGAM------------------------VEKKILMKV--H------SRF-----IVSLAYAFE--T----------KAD------LC--LVMTI-MNGG--DIR-YHIYNVNEENP-------------------------GF---PEPRALFYTAQIICGLEHLHQ--R--RIVYRDLKPENVLLD--NDGNV----RISDLGLAVEL-----------------------------------LDGQS-KT--------------KG---YAGTPGFMAPELLQ------------------GEE----YDFSVDYFALGVTLYEMIA-ARGP---------------FR-AR-----------GEKVEN-KELK-HRIIS----EPVKYPDKFS----------------------------------------------------------------QASKD-FCEALLEKDPEK--RLG-------FR-D-------ETCDKLRAHPLF------
--FR--HYRVLGKGGFGEVCACQVR-------ATGK-MYACKKLQKK--R-IK-KRK---GE-AMAL------------------------NEKRILEKV--Q------SRF-----VVSLAYAYE--T----------KDA------LC--LVLTI-MNGG--DLK-FHIYN--LGNP-------------------------GF---DEQRAVFYAAELCCGLEDLQR--E--RIVYRDLKPENILLD--DRGHI----RISDLGLATE------------------------------------IPEGQ-RV--------------RG---RVGTVGYMAPEVVN------------------NEK----YTFSPDWWGLGCLIYEMIQ-GHSP---------------FK-KY------------KEKVK-WEEV-DQRIK----NDTEEYSE-----K-FS---------------------------------------------------------EDAKS-ICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F-----------------
---F-RQYRVLGKGGFGEVCACQVR-------ATGK-MYACKRLEKK--R-IK-KRK---GE-SMAL------------------------NEKQILEKV--N------SQF-----VVNLAYAYE--T----------KDA------LC--LVLTI-MNGG--DLK-FHIYN--MGNP-------------------------GF---EEERALFYAAEILCGLEDLHR--E--NTVYRDLKPENILLD--DYGHI----RISDLGLAVK------------------------------------IPEGD-LI--------------RG---RVGTVGYMAPEVLN------------------NQR----YGLSPDYWGLGCLIYEMIE-GQSP---------------FR-GR---------------KE-KVKR-EEVDR----RVLETEEVYS-H-K-FS---------------------------------------------------------EEAKS-ICKMLLTKDAKQ--RLGCQ--EEGAA-EVKRHPFF------------------
---F-RQYRVLGKGGFGEVCACQVR-------ATGK-MYACKKLEKK--R-IK-KRK---GE-AMAL------------------------NEKQILEKV--N------SRF-----VVSLAYAYE--T----------KDA------LC--LVLTL-MNGG--DLK-FHIYH--MGQA-------------------------GF---PEARAVFYAAEICCGLEDLHR--E--RIVYRDLKPENILLD--DHGHI----RISDLGLAVH------------------------------------VPEGQ-TI--------------KG---RVGTVGYMAPEVVK------------------NER----YTFSPDWWALGCLLYEMIA-GQSP---------------FQ-QR------------KKKIK-REEV-ERLVK-----EVPEEYSER-----FS---------------------------------------------------------PQARS-LCSQLLCKDPAE--RLGCR--GGSAR-EVKEHPLF------------------
---F-TEFRVLGKGGFGEVCAVQVK-------NTGK-MYACKKLDKK--R-LK-KKG---GE-KMAL------------------------LEKEILEKV--S------SPF-----IVSLAYAFE--S----------KTH------LC--LVMSL-MNGG--DLK-FHIYN--VGTR-------------------------GL---DMSRVIFYSAQIACGMLHLHE--L--GIVYRDMKPENVLLD--DLGNC----RLSDLGLAVE------------------------------------MKGGK-PI--------------TQ---RAGTNGYMAPEILM-----------------EKVS----YSYPVDWFAMGCSIYEMVA-GRTP---------------FK-DY-----------KEKVSK-EDLK-QRTLQ----DEVKFQHDNF------T---------------------------------------------------------EEAKD-ICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR------------
----YTDIKVIGNGSFGVVYQARLA-------ETRE-LVAIKKVLQD--K-RF-KNR-----------------------------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG------EKKDE------LYLNLVLEY-VPETVYRVA-RHFT---KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q--GVCHRDIKPQNLLVD-PDTAVL----KLCDFGSAKQ------------------------------------LVRGE-PN--------------VS---YICSRYYRAPELIF-----------------GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD------------SGVDQ-LVEI-IKVLG----TPTREQIREM-N-P-NYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSS--RLS-------PL-EACAHSFF------------------
----YTDTKVIGNGSFGVVYQAKLC-------DSGE-LVAIKKVLQD--K-RF-KNR-----------------------------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG------EKKDE------VYLNLVLDY-VPETVYRVA----RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F--GICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ------------------------------------LVRGE-PN--------------VS---YICSRYYRAPELIF-----------------GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD------------SGVDQ-LVEI-IKVLG----TPTREQIREM-N-P-NYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTA--RLT-------PL-EACAHSFF------------------
----LKLEKKLGAGQFGEVWMATYN--------KHT-KVAVKTMK-P--G-SM--SV---EA-FL-A-------------------------EANVMKTL--Q------HDK-----LVKLHAVVT-------------KEP------IY--IITEF-MAKG--SLL-DFLK-----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R--NYIHRDLRAANILVS--ASLVC----KIADFGLARVI-----------------------------------E--DN-EY--------------TAREGAKFPIKWTAPEAIN------------------FGS----FTIKSDVWSFGILLMEIVTYGRIP---------------YP-GM------------SNPEV-IRAL-ERGYR----MPRPENCP------------------------------------------------------------------EELYN-IMMRCWKNRPEE--RPT-------FE-YIQSV--L------------------
----YTTIRQLGDGTYGSVLLGRSI-------ESGE-LIAIKKMKRK--F-YS-WEE---C--MNLR-------------------------EVKSLKKL--N------HAN-----VVKLKEVIR--E----------NDH------LY--FIFEY-MKE---NLY-QLIK---ERNK-------------------------LF---PESAIRNIMYQILQGLAFIHK--H--GFFHRDLKPENLLCM--GPELV----KIADFGLARE------------------------------------IRSKP-PY--------------TD---YVSTRWYRAPEVLL-----------------RSTN----YSSPIDVWAVGCIMAEVYT-LRPL---------------FP-GA------------SEIDT-IFKI-CQVLG----TPKKTDWPEG-Y-Q-LSSAMNFRWPQCV----------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKK--RPT-------AS-QALRYPYF------------------
----LTFVQEIGSGQFGLVHLGYWL--------NKD-KVAIKTIR-E--G-AM--SE---ED-FI-E-------------------------EAEVMMKL--S------HPK-----LVQLYGVCL--E----------QAP------IC--LVFEF-MEHG--CLS-DYLR-----TQ-----------------------RGLF---AAETLLGMCLDVCEGMAYLEE--A--CVIHRDLAARNCLVG--ENQVI----KVSDFGMTRFV-----------------------------------L--DD-QY--------------TSSTGTKFPVKWASPEVFS------------------FSR----YSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR------------SNSEV-VEDI-STGFR----LYKPRLAS------------------------------------------------------------------THVYQ-IMNHCWKERPED--RPA-------FS-RLLRQL--------------------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGE-VVAVKKLQ-H--S-TE---EH-LRD-FE-R-------------------------EIEILKSL--Q------HDN-----IVKYKGVCYSAG----------RRN------LK--LIMEY-LPYG--SLR-DYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--K--RYIHRDLATRNILVE--NENRV----KIGDFGLTKVL------------PQ---------------------D--KE-YY--------------KVKEPGESPIFWYAPESLT------------------ESK----FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM------------IVFHL-IELL-KNNGR----LPRPDGCP------------------------------------------------------------------DEIYM-IMTECWNNNVNQ--RPS-------FR-DLA----LRV----------------
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGA-LVAVKQLQ-H--S-GP--DQ--QRD-FQ-R-------------------------EIQILKAL--H------SDF-----IVKYRGVSYGPG----------RQS------LR--LVMEY-LPSG--CLR-DFLQ-----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--R--RCVHRDLAARNILVE--SEAHV----KIADFGLAKLL------------PL---------------------D--KD-YY--------------VVREPGQSPIFWYAPESLS------------------DNI----FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P----------ALCRL-LELL-EEGQR----LPAPPACP------------------------------------------------------------------AEVHE-LMKLCWAPSPQD--RPS-------FS-ALGP---QL-----------------
----YTTMRQLGDGTYGSVLMGKSN-------ESGE-LVAIKRMKRK--F-YS-WDE---CM--NLR-------------------------EVKSLKKL--N------HAN-----VIKLKEVIR--E----------NDH------LY--FIFEY-MKE---NLY-QLMK---DRNK-------------------------LF---PESVIRNIMYQILQGLAFIHK--H--GFFHRDMKPENLLCM--GPELV----KIADFGLARE------------------------------------LRSQP-PY--------------TD---YVSTRWYRAPEVLL-----------------RSSV----YSSPIDVWAVGSIMAELYM-LRPL---------------FP-GT------------SEVDE-IFKI-CQVLG----TPKKSDWPEG-Y-Q-LASSMNFRFPQCV----------------------------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKK--RPT-------AS-QALKHPYF------------------
----YQNLKPIGSGAQGIVCAAYDA-------VLDR-NVAIKKLSRP--F-QN-QTH---AK-RAYR-------------------------ELVLMKCV--N------HKN-----IISLLNVFT--PQKT----LEEFQD------VY--LVMEL-MDA---NLC-QVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART------------------------------------AGTSF-MM--------------TP---YVVTRYYRAPEVIL------------------GMG----YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR------------DYIDQ-WNKV-IEQLG----TPCPEFMKKL-Q-P-TVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RIS-------VD-DALQHPYI------------------
----YRDLQPVGSGAYGAVCSAVDG-------RTGA-KVAIKKLYRP--F-QS-ELF---AK-RAYR-------------------------ELRLLKHM--R------HEN-----VIGLLDVFT--PDET----LDDFTD------FY--LVMPF-MGT---DLG-KLMK-----HE-------------------------KL---GEDRIQFLVYQMLKGLRYIHA--A--GIIHRDLKPGNLAVN--EDCEL----KILDFGLAR--------------------------------------QADS-EM--------------TG---YVVTRWYRAPEVIL-----------------NWMR----YTQTVDIWSVGCIMAEMIT-GKTL---------------FK-GS------------DHLDQ-LKEI-MKVTG----TPPAEFVQRL-Q-S-DEAKNYMKGLPELE---------------------------------KKDFASILTNASPLAVN-LLEKMLVLDAEQ--RVT-------AG-EALAHPYF------------------
----YQNLKPIGSGAQGIVCAAYDA-------ILER-NVAIKKLSRP--F-QN-QTH---AK-RAYR-------------------------ELVLMKCV--N------HKN-----IIGLLNVFT--PQKS----LEEFQD------VY--IVMEL-MDA---NLC-QVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART------------------------------------AGTSF-MM--------------TP---YVVTRYYRAPEVIL------------------GMG----YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR------------DYIDQ-WNKV-IEQLG----TPCPEFMKKL-Q-P-TVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASK--RIS-------VD-EALQHPYI------------------
-KVT---SQVLGLGINGKVLQIFNK-------RTQE-KFALKMLQDC--P-KA-R-----------R-------------------------EVELHWRA-SQ------CPH-----IVRIVDVYE--NLY------AGRKC------LL--IVMEC-LDGG--ELF-SRIQD--RGDQ-------------------------AF---TEREASEIMKSIGEAIQYLHS--I--NIAHRDVKPENLLYT--SKRPNA-ILKLTDFGFAKE------------------------------------TTSHN-SL--------------TT---PCYTPYYVAPEVLG------------------PEK----YDKSCDMWSLGVIMYILLC-GYPP---------------FY-SN-----------HGLAIS-PGMK-TRIRM----GQYEFPNPEW-S-E-VS---------------------------------------------------------EEVKM-LIRNLLKTEPTQ--RMT-------IT-EFMNHPWI------------------
-INW---TQKLGAGISGPVRVCVKK-------STQE-RFALKILLDR--P-KA-R-----------N-------------------------EVRLHMMC-AT------HPN-----IVQIIEVFA--NSVQFPHESSPRAR------LL--IVMEM-MEGG--ELF-HRIS----QHR-------------------------HF---TEKQASQVTKQIALALRHCHL--L--NIAHRDLKPENLLFK--DNS-LDAPVKLCDFGFAK--------------------------------------IDQG-DL--------------MT---PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT----YNKSCDLWSLGVIIYVMLC-GYPP---------------FY-SKH----------HSRTIP-KDMR-RKIMT----GSFEFPEEEW-S-Q-IS---------------------------------------------------------EMAKD-VVRKLLKVKPEE--RLT-------IE-GVLDHPWL------------------
--FD--TIKLISNGAYGAVYLVRHR-------DTRQ-RFAMKKINKQ--N-LILRNQ---IQ-QAFV-------------------------ERDILTFA--E------NPF-----VVGMFCSFE--T----------RRH------LC--MVMEY-VEGG--DCA-TLLK----NIG-------------------------AL---PVEMARMYFAETVLALEYLHN--Y--GIVHRDLKPDNLLIT--SMGHI----KLTDFGLSKMGLMSLTTN--------------------LYEGHIEKDAREF-LD--------------KQ---VCGTPEYIAPEVIL------------------RQG----YGKPVDWWAMGIILYEFLV-GCVP---------------FF-GD---------------TP-EELF-GQVIS----DDILWPEGDE---A-LP---------------------------------------------------------TEAQL-LISSLLQTNPLV--RLGA----GGAF-EVKQHSFF------------------
----LTLGAQIGEGEFGAVLQGEYL---------GQ-KVAVKNIK-C--D-VT--AQ----A-FL-D-------------------------ETAVMTKM--Q------HEN-----LVRLLGVIL-------------HQG------LY--IVMEH-VSKG--NLV-NFLR-----TR----------------------GRALV---NTAQLLQFSLHVAEGMEYLES--K--KLVHRDLAARNILVS--EDLVA----KVSDFGLAKAE------------------------------------------R--------------KGLDSSRLPVKWTAPEALK------------------HGK----FTSKSDVWSFGVLLWEVFSYGRAP---------------YP-KM------------SLKEV-SEAV-EKGYR----MEPPEGCP------------------------------------------------------------------GPVHV-LMSSCWEAEPAR--RPP-------FR-KLAEKL--------------------
QLQE----DVLGEGAHARVQTCINL-------ITSQ-EYAVKIIEKQ--P-GH-IRS---R---VFR-------------------------EVEMLYQC-QG------HRN-----VLELIEFFE--E----------EDR------FY--LVFEK-MRGG--SIL-SHIH----KRR-------------------------HF---NELEASVVVQDVASALDFLHN--K--GIAHRDLKPENILCE--HPNQVS-PVKICDFDLGSGIKLN----------------------------GDCSPISTP-EL--------------LT---PCGSAEYMAPEVVEAF-------------SEEASI----YDKRCDLWSLGVILYILLS-GYPP---------------FV-GRCGSDCGWDRGEACPACQ-NMLF-ESIQE----GKYEFPDKDW-A-H-IS---------------------------------------------------------CAAKD-LISKLLVRDAKQ--RLS-------AA-QVLQHPWV------------------
-IEP---DRPIGYGAFGVVWSVTDP-------RDGK-RVALKKMPNV--F-QN-LVS---CK-RVFR-------------------------ELKMLCFF--K------HDN-----VLSALDILQ--PPH-----IDYFEE------IY--VVTEL-MQS---DLH-KIIV----SPQ-------------------------PL---SSDHVKVFLYQILRGLKYLHS--A--GILHRDIKPGNLLVN--SNCVL----KICDFGLARVE----------------------------------ELDESR-HM--------------TQ---EVVTQYYRAPEILM-----------------GSRH----YSNAIDIWSVGCIFAELLG-RRIL---------------FQ-AQ------------SPIQQ-LDLI-TDLLG----TPSLEAMRTA-C-E-GAKAHILRGPHKQP--------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSK--RIS-------AK-DALAHPYL------------------
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKM-LVAVKALK-E--A-SE--SA--RQD-FQ-R-------------------------EAELLTML--Q------HQH-----IVRFFGVCT--E----------GRP------LL--MVFEY-MRHG--DLN-RFLR-----SHGPDAKL---------LAGGEDVAPGPL---GLGQLLAVASQVAAGMVYLAG--L--HFVHRDLATRNCLVG--QGLVV----KIGDFGMSRDI-------------Y---------------------S--TD-YY--------------RVGGRTMLPIRWMPPESIL------------------YRK----FTTESDVWSFGVVLWEIFTYGKQP---------------WY-QL------------SNTEA-IDCI-TQGRE----LERPRACP------------------------------------------------------------------PEVYA-IMRGCWQREPQQ--RHS-------IK-DVHARL--------------------
---I-VLKRELGEGAFGKVFLAECYN--LCPEQDKI-LVAVKTLK-D--A-SD--NA--RKD-FH-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCV--E----------GDP------LI--MVFEY-MKHG--DLN-KFLR-----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--Q--HFVHRDLATRNCLVG--ENLLV----KIGDFGMSRDV-------------Y---------------------S--TD-YY--------------RVGGHTMLPIRWMPPESIM------------------YRK----FTTESDVWSLGVVLWEIFTYGKQP---------------WY-QL------------SNNEV-IECI-TQGRV----LQRPRTCP------------------------------------------------------------------QEVYE-LMLGCWQREPHM--RKN-------IK-GIHTL--L------------------
---I-VLKRELGEGAFGKVFLAECYN--LSPTKDKM-LVAVKALK-D--P-TL--AA--RKD-FQ-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCG--D----------GDP------LI--MVFEY-MKHG--DLN-KFLR-----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--Q--HFVHRDLATRNCLVG--ANLLV----KIGDFGMSRDV-------------Y---------------------S--TD-YYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------------------YRK----FTTESDVWSFGVILWEIFTYGKQP---------------WF-QL------------SNTEV-IECI-TQGRV----LERPRVCP------------------------------------------------------------------KEVYD-VMLGCWQREPQQ--RLN-------IK-EIYKIL--------------------
---F-KFGKILGEGSFSTVVLAREL-------ATSR-EYAIKILEKR--H-II-KEN---KVPYVTR-------------------------ERDVMSRL--D------HPF-----FVKLYFTFQ--D----------DEK------LY--FGLSY-AKNG--ELL-KYIR----KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG--K--GIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS---------------------------------PESKQA-RA--------------NS---FVGTAQYVSPELLT------------------EKS----ACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG---------------NE-YLIF-QKIIK----LEYDFPEKFF----------------------------------------------------------------PKARD-LVEKLLVLDATK--RLG-------CE-EM------EGYGPLKAHPF-------
----YEPKEILGRGVSSVVRRCIHK-------PTSQ-EYAVKVIDVT--G-GG-SFS---PE-EVRELRE------------------ATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T----------NTF------FF--LVFDL-MKRG--ELF-DYLT----EKV-------------------------TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ------------------------------------LEPGE-RL--------------RE---VCGTPSYLAPEIIECS------------MNEDHPG----YGKEVDMWSTGVIMYTLLA-GSPP---------------FW-HR---------------KQ-MLML-RMIMS----GNYQFGSPEW-D-D-YS---------------------------------------------------------DTVKD-LVSRFLVVQPQN--RYT-------AE-EALAHPFF------------------
-YDP---KDVIGRGVSSVVRRCVHR-------ATGH-EFAVKIMEVT--A-ER-LSP---EQ-LEEVREA-------------------TRRETHILRQV-AG------HPH-----IITLIDSYE--S----------SSF------MF--LVFDL-MRKG--ELF-DYLT----EKV-------------------------AL---SEKETRSIMRSLLEAVSFLHA--N--NIVHRDLKPENILLD--DNMQI----RLSDFGFSCH------------------------------------LEPGE-KL--------------RE---LCGTPGYLAPEILKCS------------MDETHPG----YGKEVDLWACGVILFTLLA-GSPP---------------FW-HR---------------RQ-ILML-RMIME----GQYQFSSPEW-D-D-RS---------------------------------------------------------STVKD-LISRLLQVDPEA--RLT-------AE-QALQHPFF------------------
----YRLGPLLGKGGFGTVFAGHRL-------TDRL-QVAIKVIPRN--R-VL-GWS---PL-SDSVTC---------------------PLEVALLWKV--GAG--GGHPG-----VIRLLDWFE--T----------QEG------FM--LVLERPLPAQ--DLF-DYIT----EKG-------------------------PL---GEGPSRCFFGQVVAAIQHCHS--R--GVVHRDIKDENILID-LRRGCA----KLIDFGSGA-------------------------------------LLHDE-PY--------------TD---FDGTRVYSPPEWIS-----------------RHQY----HALPATVWSLGILLYDMVC-GDIP---------------FE-RD-----------------------QEILE----AELHFPAHVS----------------------------------------------------------------PDCCA-LIRRCLAPKPSS--RPS-------LE-EILLDPWM------------------
----YQVGAVLGSGGFGTVYAGSRI-------ADGL-PVAVKHVVKE--R-VT-EWG---SL-GGATV----------------------PLEVVLLRKV--GAA--GGARG-----VIRLLDWFE--R----------PDG------FL--LVLER-PEPA-QDLF-DFIT----ERG-------------------------AL---DEPLARRFFAQVLAAVRHCHS--C--GVVHRDIKDENLLVD-LRSGEL----KLIDFGSGA-------------------------------------LLKDT-VY--------------TD---FDGTRVYSPPEWIR-----------------YHRY----HGRSATVWSLGVLLYDMVC-GDIP---------------FE-QD-----------------------EEILR----GRLLFRRRVS----------------------------------------------------------------PECQQ-LIRWCLSLRPSE--RPS-------LD-QIAAHPWM------------------
---F-KFLAVLGRGHFGKVLLSEFR-------PSGE-LFAIKALKKG--D-IV-ARD---EV-ESLM------------------------CEKRILAAV--TS---AGHPF-----LVNLFGCFQ--T----------PEH------VC--FVMEY-SAGG--DLM-LHIH-----SD-------------------------VF---SEPRAIFYSACVVLGLQFLHE--H--KIVYRDLKLDNLLLD--TEGYV----KIADFGLCKEG-----------------------------------MGYGD-RT--------------ST---FCGTPEFLAPEVLT------------------DTS----YTRAVDWWGLGVLLYEMLV-GESP---------------FP-GD---------------DE-EEVF-DSIVN----DEVRYPRFLS----------------------------------------------------------------AEAIG-IMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF------------------
--FR--CCAVLGRGHFGKVLLAEYK-------NTNE-MFAIKALKKG--D-IV-ARD---EV-DSLM------------------------CEKRIFETV--NS---VRHPF-----LVNLFACFQ--T----------KEH------VC--FVMEY-AAGG--DLM-MHIH-----TD-------------------------VF---SEPRAVFYAACVVLGLQYLHE--H--KIVYRDLKLDNLLLD--TEGFV----KIADFGLCKEG-----------------------------------MGYGD-RT--------------ST---FCGTPEFLAPEVLT------------------ETS----YTRAVDWWGLGVLIYEMLV-GESP---------------FP-GD---------------DE-EEVF-DSIVN----DEVRYPRFLS----------------------------------------------------------------TEAIS-IMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF------------------
--YV--RGRFLGKGGFAKCFEISDA-------DTKE-VFAGKIVPKS--L-LL-KPH---QR-EKMS------------------------MEISIHRSL--A------HQH-----VVGFHGFFE--D----------NDF------VF--VVLEL-CRRR--SLL-ELHK----RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--N--RVIHRDLKLGNLFLN--EDLEV----KIGDFGLATKV-----------------------------------EYDGE-RK--------------KT---LCGTPNYIAPEVLS------------------KKG----HSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS---------------CL-KETY-LRIKK----NEYSIPKHIN----------------------------------------------------------------PVAAS-LIQKMLQTDPTA--RPT-------IN-ELLNDEFF------------------
---Y-CRGKVLGKGGFAKCYEMTDL-------TNNK-VYAAKIIPHS--R-VA-KPH---QR-EKID------------------------KEIELHRIL--H------HKH-----VVQFYHYFE--D----------KEN------IY--ILLEY-CSRR--SMA-HILK----ARK-------------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q--EILHRDLKLGNFFIN--EAMEL----KVGDFGLAARL-----------------------------------EPLEH-RR--------------RT---ICGTPNYLSPEVLN------------------KQG----HGCESDIWALGCVMYTMLL-GRPP---------------FE-TT---------------NL-KETY-RCIRE----ARYTMPSSLL----------------------------------------------------------------APAKH-LIASMLSKNPED--RPS-------LD-DIIRHDFF------------------
--YL--KGRLLGKGGFARCYEATDT-------ETGS-AYAVKVIPQS--R-VA-KPH---QR-EKIL------------------------NEIELHRDL--Q------HRH-----IVRFSHHFE--D----------ADN------IY--IFLEL-CSRK--SLA-HIWK----ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R--GILHRDLKLGNFFIT--ENMEL----KVGDFGLAARL-----------------------------------EPPEQ-RK--------------KT---ICGTPNYVAPEVLL------------------RQG----HGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA---------------DL-KETY-RCIKQ----VHYTLPASLS----------------------------------------------------------------LPARQ-LLAAILRASPRD--RPS-------ID-QILRHDFF------------------
---F-NFLMVLGKGSFGKVMLADRK-------GTEE-LYAIKILKKD--V-VI-QDD---DV-ECTM------------------------VEKRVLALL-DK------PPF-----LTQLHSCFQ--T----------VDR------LY--FVMEY-VNGG--DLM-YHIQ----QVG-------------------------KF---KEPQAVFYAAEISIGLFFLHK--R--GIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEH-----------------------------------MMDGV-TT--------------RT---FCGTPDYIAPEIIA------------------YQP----YGKSVDWWAYGVLLYEMLA-GQPP---------------FD-GE---------------DE-DELF-QSIME----HNVSYPKSLS----------------------------------------------------------------KEAVS-VCKGLMTKHPAK--RLG-------C----------GPEGERDVREHAFF----
---F-NFLMVLGKGSFGKVMLSERK-------GTDE-LYAVKILKKD--V-VI-QDD---DV-ECTM------------------------VEKRVLALP-GK------PPF-----LTQLHSCFQ--T----------MDR------LY--FVMEY-VNGG--DLM-YHIQ----QVG-------------------------RF---KEPHAVFYAAEIAIGLFFLQS--K--GIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEN-----------------------------------IWDGV-TT--------------KT---FCGTPDYIAPEIIA------------------YQP----YGKSVDWWAFGVLLYEMLA-GQAP---------------FE-GE---------------DE-DELF-QSIME----HNVAYPKSMS----------------------------------------------------------------KEAVA-ICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF----
--FI--FHKVLGKGSFGKVLLGELK-------GRGE-YFAIKALKKD--V-VL-IDD---DV-ECTM------------------------VEKRVLTLA-AE------NPF-----LTHLICTFQ--T----------KDH------LF--FVMEF-LNGG--DLM-YHIQ----DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS--K--GIIYRDLKLDNVLLD--RDGHI----KIADFGMCKEN-----------------------------------IFGES-RA--------------ST---FCGTPDYIAPEILQ------------------GLK----YTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD---------------DE-DELF-ESIRV----DTPHYPRWIT----------------------------------------------------------------KESKD-ILEKLFEREPTK--RLG------VTG-NIKIHPFF------------------
---F-NFIKVLGKGSFGKVMLAELK-------GKDE-VYAVKVLKKD--V-IL-QDD---DV-DCTM------------------------TEKRILALA-RK------HPY-----LTQLYCCFQ--T----------KDR------LF--FVMEY-VNGG--DLM-FQIQ----RSR-------------------------KF---DEPRSRFYAAEVTSALMFLHQ--H--GVIYRDLKLDNILLD--AEGHC----KLADFGMCKEG-----------------------------------ILNGV-TT--------------TT---FCGTPDYIAPEILQ------------------ELE----YGPSVDWWALGVLMYEMMA-GQPP---------------FE-AD---------------NE-DDLF-ESILH----DDVLYPVWLS----------------------------------------------------------------KEAVS-ILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF----------------
----FEFIRVLGKGSFGKVMLARVK-------ETGD-LYAVKVLKKD--V-IL-QDD---DV-ECTM------------------------TEKRILSLA-RN------HPF-----LTQLFCCFQ--T----------PDR------LF--FVMEF-VNGG--DLM-FHIQ----KSR-------------------------RF---DEARARFYAAEIISALMFLHD--K--GIIYRDLKLDNVLLD--HEGHC----KLADFGMCKEG-----------------------------------ICNGV-TT--------------AT---FCGTPDYIAPEILQ------------------EML----YGPAVDWWAMGVLLYEMLC-GHAP---------------FE-AE---------------NE-DDLF-EAILN----DEVVYPTWLH----------------------------------------------------------------EDATG-ILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-----------------
--PD----EVLGSGQFGIVYGGKHR-------KTGR-DVAIKIIDKL--R-FP-TKQ---ES-QLRN-------------------------EVAILQNL--H------HPG-----VVNLECMFE--T----------PER------VF--VVMEK-LHGD--MLE-MILS---SEKG-------------------------RL---PEHITKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEVLR------------------NKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED------------------EDIH-DQIQN----AAFMYPPNPW-K-E-IS---------------------------------------------------------HEAID-LINNLLQVKMRK--RYS-------VD-KTLSHPWL------------------
--PD----EVLGSGQFGVVYGGKHR-------KTGR-DVAVKVIDKL--R-FP-TKQ---ES-QLRN-------------------------EVAILQSL--R------HPG-----IVNLECMFE--T----------PEK------VF--VVMEK-LHGD--MLE-MILS---SEKG-------------------------RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEVLL------------------NQG----YNRSLDMWSVGVIMYVSLS-GTFP---------------FN-ED------------------EDIN-DQIQN----AAFMYPASPW-S-H-IS---------------------------------------------------------AGAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL------------------
-FAD----EVLGSGQFGIVYGGKHR-------KTGR-DVAIKVIDKM--R-FP-TKQ---ES-QLRN-------------------------EVAILQNL--H------HPG-----IVNLECMFE--T----------PER------VF--VVMEK-LHGD--MLE-MILS---SEKS-------------------------RL---PERITKFMVTQILVALRNLHF--K--NIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEVLR------------------SKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED------------------EDIN-DQIQN----AAFMYPPNPW-R-E-IS---------------------------------------------------------GEAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL------------------
---F-TLCRKLGSGYFGEVFEGLWK--------DRV-QVAIKVIS-R--D-NL--LH--QQM-LQ-S-------------------------EIQAMKKL--R------HKH-----ILALYAVVS--V----------GDP------VY--IITEL-MAKG--SLL-ELLR-----DS----------------------DEKVL---PVSELLDIAWQVAEGMCYLES--Q--NYIHRDLAARNILVG--ENTLC----KVGDFGLARLI--------------------------------------KE-DV--------------YLSHDHNIPYKWTAPEALS------------------RGH----YSTKSDVWSFGILLHEMFSRGQVP---------------YP-GM------------SNHEA-FLRV-DAGYR----MPCPLECP------------------------------------------------------------------PSVHK-LMLTCWCRDPEQ--RPC-------FK-ALRERL--------------------
--VM--LSTRIGSGSFGTVYKGKWH----------G-DVAVKILK-V-VD-PT--PEQ-FQA-FR-N-------------------------EVAVLRKT--R------HVN-----ILLFMGYMT-------------KDN------LA--IVTQW-CEGS--SLY-KHLH-----VQ-----------------------ETKF---QMFQLIDIARQTAQGMDYLHA--K--NIIHRDMKSNNIFLH--EGLTV----KIGDFGLATVK-------------S---------------------R--WS-GS--------------QQVEQPTGSVLWMAPEVIR------------------MQDN-NPFSFQSDVYSYGIVLYELMT-GELP---------------YS-HI-N----------NRDQI-IFMV-GRGYASPDLSKLYKNCP------------------------------------------------------------------KAMKR-LVADCVKKVKEE--RPL-------FP-QILSS--I------------------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYT-TVAVKMLK-E--N-AS--PSE-LRD-LL-S-------------------------EFNVLKQV--N------HPH-----VIKLYGACS--Q----------DGP------LL--LIVEY-AKYG--SLR-GFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M--KLVHRDLAARNILVA--EGRKM----KISDFGLSRDV-------------Y---------------------E--ED-SY--------------VKRSQGRIPVKWMAIESLF------------------DHI----YTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI------------PPERL-FNLL-KTGHR----MERPDNCS------------------------------------------------------------------EEMYR-LMLQCWKQEPDK--RPV-------FA-DISKDL--------------------
----YEVVKVIGRGAFGEVQLVRHK-------STRK-VYAMKLLSKF--E-MI-KRS---DS-AFFW------------------------EERDIMAFA--N------SPW-----VVQLFYAFQ--D----------DRY------LY--MVMEY-MPGG--DLV-NLMS-----NY-------------------------DV---PEKWARFYTAEVVLALDAIHS--M--GFIHRDVKPDNMLLD--KSGHL----KLADFGTCMKM----------------------------------NKEGMV-RC--------------DT---AVGTPDYISPEVLKS--------------QGGDGY----YGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD---------------SL-VGTY-SKIMN----HKNSLTFPDD-N-D-IS---------------------------------------------------------KEAKN-LICAFLTDREVRLGRNG-------VE-EIKRHLFF------------------
----YDVVKVIGRGAFGEVQLVRHK-------ASQK-VYAMKLLSKF--E-MI-KRS---DS-AFFW------------------------EERDIMAFA--N------SPW-----VVQLFYAFQ--D----------DRY------LY--MVMEY-MPGG--DLV-NLMS-----NY-------------------------DV---PEKWAKFYTAEVVLALDAIHS--M--GLIHRDVKPDNMLLD--KHGHL----KLADFGTCMKM----------------------------------DETGMV-HC--------------DT---AVGTPDYISPEVLKS--------------QGGDGF----YGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD---------------SL-VGTY-SKIMD----HKNSLCFPED-A-E-IS---------------------------------------------------------KHAKN-LICAFLTDREVRLGRNG-------VE-EIRQHPFF------------------
----YELVRELGKGTYGKVDLVVYK-------GTGT-KMALKFVNKS--K-TK-LKN---F----LR-------------------------EVSITNSL-SS------SPF-----IIKVFDVVF--E---------TEDC------YV--FAQEY-APAG--DLF-DIIP----PQV-------------------------GL---PEDTVKRCVQQLGLALDFMHG--R--QLVHRDIKPENVLLFDRECRRV----KLADFGMTR--------------------------------------RVGC-RV--------------KR---VSGTIPYTAPEVCQAG-------------RADGLA----VDTGVDVWAFGVLIFCVLT-GNFP---------------WE-AA------------SGADAFFEEF-VRWQR----GRLPGLPSQW-R-R-FT---------------------------------------------------------EPALR-MFQRLLALEPER--RGP-------AK-EVF-----RFLKH-------------
----WEIIGELGDGAFGKVYKAQNK-------ETSV-LAAAKVIDTK--S-EE-ELE---DY-M--V-------------------------EIDILASC--D------HPN-----IVKLLDAFY--Y----------ENN------LW--ILIEF-CAGG--AVD-AVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN-----------------------------------TRTIQ-RR--------------DS---FIGTPYWMAPEVVMCE-------------TSKDRP----YDYKADVWSLGITLIEMAE-IEPP---------------HH-EL------------NPMRV-LLKI-AKSEP----PTLAQPSRWS----------------------------------------------------------------SNFKD-FLKKCLEKNVDA--RWT-------TS-QLLQHPFV------------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTT-RVAIKTLK-P--G-TM--SP---EA-FL-Q-------------------------EAQVMKKL--R------HEK-----LVQLYAVVS-------------EEP------IY--IVTEY-MSKG--SLL-DFLK-----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--M--NYVHRDLRAANILVG--ENLVC----KVADFGLARLI-----------------------------------E--DN-EY--------------TARQGAKFPIKWTAPEAAL------------------YGR----FTIKSDVWSFGILLTELTTKGRVP---------------YP-GM------------VNREV-LDQV-ERGYR----MPCPPECP------------------------------------------------------------------ESLHD-LMCQCWRKEPEE--RPT-------FE-YLQAF--L------------------
--FA--LGRKLGEGYFGEVWEGLWL--------GSL-PVAIKVIK-S--A-NM--K---LTD-LA-K-------------------------EIQTLKGL--R------HER-----LIRLHAVCS--G----------GEP------VY--IVTEL-MRKG--NLQ-AFLG-----TP----------------------EGRAL---RLPPLLGFACQVAEGMSYLEE--Q--RVVHRDLAARNVLVD--DGLAC----KVADFGLARLL-----------------------------------K--DD-IY--------------SPSSSSKIPVKWTAPEAAN------------------YRV----FSQKSDVWSFGVLLHEVFTYGQCP---------------YE-GM------------TNHET-LQQI-MRGYR----LPRPAACP------------------------------------------------------------------AEVYV-LMLECWRSSPEE--RPS-------FA-TLREKL--------------------
-LCP---GRELGRGKFAVVRKCIKK-------DSGK-EFAAKFMRKR--R-KG-QDC---RM-EIIH-------------------------EIAVLELA-QD------NPW-----VINLHEVYE--T----------ASE------MI--LVLEY-AAGG--EIF-DQCVA--DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI------------------------------------LKNSE-EL--------------RE---IMGTPEYVAPEILS------------------YDP----ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN---------------DK-QETF-LNISQ----MNLSYSEEEF-D-V-LS---------------------------------------------------------ESAVD-FIRTLLVKKPED--RAT-------AE-ECLKHPWL------------------
-ILT---SKELGRGKFAVVRQCISK-------STGQ-EYAAKFLKKR--R-RG-QDC---RA-EILH-------------------------EIAVLELA-KS------CPR-----VINLHEVYE--N----------TSE------II--LILEY-AAGG--EIF-SLCLP--ELAE-------------------------MV---SENDVIRLIKQILEGVYYLHQ--N--NIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK------------------------------------IGHAC-EL--------------RE---IMGTPEYLAPEILN------------------YDP----ITTATDMWNIGIIAYMLLT-HTSP---------------FV-GE---------------DN-QETY-LNISQ----VNVDYSEETF-S-S-VS---------------------------------------------------------QLATD-FIQSLLVKNPEK--RPT-------AE-ICLSHSWL------------------
----FTKLEKIGKGSFGEVFKGIDN-------RTQK-VVAIKIIDLE--E-AE-DEI---ED-IQ-Q-------------------------EITVLSQC--D------SPY-----VTKYYGSYL--K----------DTK------LW--IIMEY-LGGG--SAL-DLLE-----PG-------------------------PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVLLS--EHGEV----KLADFGVAGQL-----------------------------------TDTQI-KR--------------NT---FVGTPFWMAPEVIK------------------QSA----YDSKADIWSLGITAIELAR-GEPP---------------HS-EL------------HPMKV-LFLI-PKNNP----PTLEGNYS------------------------------------------------------------------KPLKE-FVEACLNKEPSF--RPT-------AK-ELLKHKFI------------------
---F-TKLDRIGKGSFGEVYKGIDN-------HTKE-VVAIKIIDLE--E-AE-DEI---ED-IQ-Q-------------------------EITVLSQC--D------SPY-----ITRYFGSYL--K----------STK------LW--IIMEY-LGGG--SAL-DLLK-----PG-------------------------PL---EETYIATILREILKGLDYLHS--E--RKIHRDIKAANVLLS--EQGDV----KLADFGVAGQL-----------------------------------TDTQI-KR--------------NT---FVGTPFWMAPEVIK------------------QSA----YDFKADIWSLGITAIELAK-GEPP---------------NS-DL------------HPMRV-LFLI-PKNSP----PTLEGQHS------------------------------------------------------------------KPFKE-FVEACLNKDPRF--RPT-------AK-ELLKHKFI------------------
----YHVLEMIGEGSFGRVYKGRRK-------YSAQ-VVALKFIPKL--G-RS-EKE---LR-NLQR-------------------------EIEIMRGL--R------HPN-----IVHMLDSFE--T----------DKE------VV--VVTDY-AEG---ELF-QILE----DDG-------------------------KL---PEDQVQAIAAQLVSALYYLHS--H--RILHRDMKPQNILLA--KGGGI----KLCDFGFARAM-----------------------------------STNTM-VL--------------TS---IKGTPLYMSPELVE------------------ERP----YDHTADLWSVGCILYELAV-GTPP---------------FY-AT---------------SI-FQLV-SLILK----DPVRWPSTIS----------------------------------------------------------------PCFKN-FLQGLLTKDPRQ--RLS-------WP-DLLYHPFI------------------
---F-ESLKVIGRGAFGEVRLVQKK-------DTGH-VYAMKILRKA--D-ML-EKE---QV-GHIR------------------------AERDILVEA--D------SLW-----VVKMFYSFQ--D----------KLN------LY--LIMEF-LPGG--DMM-TLLM----KKD-------------------------TL---TEEETQFYIAETVLAIDSIHQ--L--GFIHRDIKPDNLLLD--SKGHV----KLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQ-LA--------------FS---TVGTPDYIAPEVFM------------------QTG----YNKLCDWWSLGVIMYEMLI-GYPP---------------FC-SE---------------TP-QETY-KKVMN----WKETLTFPPE-V-P-IS---------------------------------------------------------EKAKD-LILRFCCEW--------------------------EHRIGAPGVEEIKSNSFF
---F-ESLKVIGRGAFGEVRLVQKK-------DTGH-IYAMKILRKS--D-ML-EKE---QV-AHIR------------------------AERDILVEA--D------GAW-----VVKMFYSFQ--D----------KRN------LY--LIMEF-LPGG--DMM-TLLM----KKD-------------------------TL---TEEETQFYISETVLAIDAIHQ--L--GFIHRDIKPDNLLLD--AKGHV----KLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQ-LA--------------YS---TVGTPDYIAPEVFM------------------QTG----YNKLCDWWSLGVIMYEMLI-GYPP---------------FC-SE---------------TP-QETY-RKVMN----WKETLVFPPE-V-P-IS---------------------------------------------------------EKAKD-LILRFCI-DSEN--RIGN----SGVE-EIKGHPFF------------------
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVK-TVAVKILK-N--E-AN--DPALKDE-LL-A-------------------------EANVMQQL--D------NPY-----IVRMIGICE-------------AES------WM--LVMEM-AELG--PLN-KYLQ-----QN------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--NFVHRDLAARNVLLV--TQHYA----KISDFGLSKAL-------------R---------------------A--DE-NY-------------YKAQTHGKWPVKWYAPECIN------------------YYK----FSSKSDVWSFGVLMWEAFSYGQKP---------------YR-GM------------KGSEV-TAML-EKGER----MGCPAGCP------------------------------------------------------------------REMYD-LMNLCWTYDVEN--RPG-------FA-AVE----LRL----------------
----LTFMRELGSGLFGVVRLGKWR--------AQY-KVAIKAIR-E--G-AM--CE---ED-FI-E-------------------------EAKVMMKL--T------HPK-----LVQLYGVCT--Q----------QKP------IY--IVTEF-MERG--CLL-NFLR-----QR-----------------------QGHF---SRDVLLSMCQDVCEGMEYLER--N--SFIHRDLAARNCLVS--EAGVV----KVSDFGMARYV-----------------------------------L--DD-QY--------------TSSSGAKFPVKWCPPEVFN------------------YSR----FSSKSDVWSFGVLMWEVFTEGRMP---------------FE-KY------------TNYEV-VTMV-TRGHR----LYQPKLAS------------------------------------------------------------------NYVYE-VMLRCWQEKPEG--RPS-------FE-DLLRT--I------------------
----IKFQDVIGEGNFGQVLKARIK-----KDGLRM-DAAIKRMK-E--Y-AS--KDD-HRD-FA-G-------------------------ELEVLCKLG-H------HPN-----IINLLGACE--H----------RGY------LY--LAIEY-APHG--NLL-DFLR-----KSRVLETDP--------AFAIANSTASTL---SSQQLLHFAADVARGMDYLSQ--K--QFIHRDLAARNILVG--ENYVA----KIADFGLSRGQ---------------------------------------E-VY--------------VKKTMGRLPVRWMAIESLN------------------YSV----YTTNSDVWSYGVLLWEIVSLGGTP---------------YC-GM------------TCAEL-YEKL-PQGYR----LEKPLNCD------------------------------------------------------------------DEVYD-LMRQCWREKPYE--RPS-------FA-QILV---SL-----------------
----ITFEDLIGEGNFGQVIRAMIK-----KDGLKM-NAAIKMLK-E--Y-AS--END-HRD-FA-G-------------------------ELEVLCKLG-H------HPN-----IINLLGACK--N----------RGY------LY--IAIEY-APYG--NLL-DFLR-----KSRVLETDP--------AFAREHGTASTL---SSRQLLRFASDAANGMQYLSE--K--QFIHRDLAARNVLVG--ENLAS----KIADFGLSRGE---------------------------------------E-VY--------------VKKTMGRLPVRWMAIESLN------------------YSV----YTTKSDVWSFGVLLWEIVSLGGTP---------------YC-GM------------TCAEL-YEKL-PQGYR----MEQPRNCD------------------------------------------------------------------DEVYE-LMRQCWRDRPYE--RPP-------FA-QIALQ--L------------------
--YL--LLHLLGRGGFSEVYKAFDL-------TEQR-YVAVKIHQLN--K-NW-RDE---KK-ENYHKH--------------------ACREYRIHKEL--D------HPR-----IVKLYDYFS--L---------DTDS------FC--TVLEY-CEGN--DLD-FYLK----QHK-------------------------LM---SEKEARSIIMQIVNALKYLNE--IKPPIIHYDLKPGNILLV--NGTACG-EIKITDFGLSKIMDDD----------------------------SYNSVDGME-LT--------------SQ---GAGTYWYLPPECFVV--------------GKEPPK----ISNKVDVWSVGVIFYQCLY-GRKP---------------FG-HN-------------QSQQ-DILQ-ENTIL----KATEVQFPPK-P-V-VT---------------------------------------------------------PEAKA-FIRRCLAYRKED--RID-------VQ-QLACDPYL------------------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTV-SVAVKCLK-PDVL-SQ--PEA-MDD-FI-R-------------------------EVNAMHSL--D------HRN-----LIRLYGVVL-------------TPP------MK--MVTEL-APLG--SLL-DRLR-----KH-----------------------QGHF---LLGTLSRYAVQVAEGMGYLES--K--RFIHRDLAARNLLLA--TRDLV----KIGDFGLMRAL------------PQ---------------------N--DD-HY--------------VMQEHRKVPFAWCAPESLK------------------TRT----FSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL------------NGSQI-LHKIDKEGER----LPRPEDCP------------------------------------------------------------------QDIYN-VMVQCWAHKPED--RPT-------FV-ALRDF--L------------------
---L-AFIKEIGSGQFGVVHLGEWR--------SHI-QVAIKAIN-E--G-SM--SE---ED-FI-E-------------------------EAKVMMKL--S------HSK-----LVQLYGVCI--Q----------RKP------LY--IVTEF-MENG--CLL-NYLR-----EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER--N--GYIHRDLAARNCLVS--STCIV----KISDFGMTRYV-----------------------------------L--DD-EY--------------VSSFGAKFPIKWSPPEVFL------------------FNK----YSSKSDVWSFGVLMWEVFTEGKMP---------------FE-NK------------SNLQV-VEAI-SEGFR----LYRPHLAP------------------------------------------------------------------MSIYE-VMYSCWHEKPEG--RPT-------FA-ELLR---AV-----------------
---F-TLGRMLGKGEFGSVREAQLK----QEDGSFV-KVAVKMLK-A-DI-IA--SSD-IEE-FL-R-------------------------EAACMKEF--D------HPH-----VAKLVGVSL--R----------SRAKGRLPIPM--VILPF-MKHG--DLH-AFLL-----ASRI------------------GENPFNL---PLQTLIRFMVDIACGMEYLSS--R--NFIHRDLAARNCMLA--EDMTV----CVADFGLSRKI-------------Y---------------------S--GD-YY--------------RQGCASKLPVKWLALESLA------------------DNL----YTVQSDVWAFGVTMWEIMTRGQTP---------------YA-GI------------ENAEI-YNYL-IGGNR----LKQPPECM------------------------------------------------------------------EDVYD-LMYQCWSADPKQ--RPS-------FT-CLRME--L------------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTT-KVAIKTLK-P--G-TM--MP---EA-FL-Q-------------------------EAQIMKKL--R------HDK-----LVPLYAVVS-------------EEP------IY--IVTEF-MSKG--SLL-DFLK-----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--M--NYIHRDLRAANILVG--ENLVC----KIADFGLARLI-----------------------------------E--DN-EY--------------TARQGAKFPIKWTAPEAAL------------------YGR----FTIKSDVWSFGILQTELVTKGRVP---------------YP-GM------------VNREV-LEQV-ERGYR----MPCPQGCP------------------------------------------------------------------ESLHE-LMNLCWKKDPDE--RPT-------FE-YIQSFL--------------------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQI-DVAIKVLK-Q--G-TE--KAD-TEE-MM-R-------------------------EAQIMHQL--D------NPY-----IVRLIGVCQ-------------AEA------LM--LVMEM-AGGG--PLH-KFLV-----GK-----------------------REEI---PVSNVAELLHQVSMGMKYLEE--K--NFVHRDLAARNVLLV--NRHYA----KISDFGLSKAL------------GA---------------------D--DS-YY--------------TARSAGKWPLKWYAPECIN------------------FRK----FSSRSDVWSYGVTMWEALSYGQKP---------------YK-KM------------KGPEV-MAFI-EQGKR----MECPPECP------------------------------------------------------------------PELYA-LMSDCWIYKWED--RPD-------FL-TVEQR--M------------------
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