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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ROS1 203
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CAMK DAPK1 13
TK FER 563
TK FGFR2 481
TK FYN 271
TK HCK 241
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LTK 510
TKL MAP3K7 36
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK RET 724
TK TNK2 150
LT--LRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLK-K--G-ST----DQEKIEFL-K----EAHLMSKF-N---HPNILKQLGVCL--L-----NEP--QYIILELMEGGDLLTYLR---KARM-----------------ATFYG-PLLTLVDLVDLCVDISKGCVYLERMH---FIHRDLAARNCLVSVKDYTSPR-IV----KIGDFGLARDI--Y-K--NDYY--------------RKRGEGLLPVRWMAPESLM-DGIFTTQSDVWSFGILIWEILTLGHQP---------------YPAH--SNLDVLNYV-QTGGRLEPPRNCP----------------------------DDLWNLMTQCWAQEPDQRPTFHRIQDQL----
-I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS----EQDELDFL-M----EALIISKF-N---HQNIVRCIGVSL--Q-----SLP--RFILLELMAGGDLKSFLR---ETRP-----------------RPSQP-SSLAMLDLLHVARDIACGCQYLEENH---FIHRDIAARNCLLTCP--GPGR-VA----KIGDFGMARDI--Y-R--ASYY--------------RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK--SNQEVLEFV-TSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKA---GV--EHQLRR----EVEIQSHL-R---HPNILRLYGYFH--D-----ATR--VYLILEYAPLGTVYRELQ--KLS--------------------------KFDEQRTATYITELANALSYCHSKR---VIHRDIKPENLLLGS-----AG-EL----KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-----TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETE---GV--PSTAIR----EISLLKEL-N---HPNIVKLLDVIH--T-----ENK--LYLVFEFLHQ-DLKKFMDASALT--------------------------GIPLPLIKSYLFQLLQGLAFCHSHR---VLHRDLKPQNLLINT-----EG-AI----KLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD--SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVP--N-GGGGGGGL--PISTVR----EVALLRRL-EAFEHPNVVRLMDVCA--TSRTDREIK--VTLVFEHVDQ-DLRTYLDKAPPP--------------------------GLPAETIKDLMRQFLRGLDFLHANC---IVHRDLKPENILVTS-----GG-TV----KLADFGLARI-----YSYQMAL--------------TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN--SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMK--R-AVD---CP--ENI-KK----EICINKML-N---HENVVKFYGHRR--E-----GNI--QYLFLEYCSGGELFDRIE--PDI--------------------------GMPEPDAQRFFHQLMAGVVYLHGIG---ITHRDIKPENLLLDE-----RD-NL----KISDFGLATVFR--YNNRERLL--------------NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP----SDSCQEY-SDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
--YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKS---SR--RGVSREDIEREVSILKEI-Q---HPNVITLHEVYE--N-----KTD--VILILELVAGGELFDFLA--EKE--------------------------SLTEEEATEFLKQILNGVYYLHSLQ---IAHFDLKPENIMLLD-----RN-VPKPRIKIIDFGLAHK-----IDFGNEF--------------KN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASP---------------FLGD-----TKQETL-ANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI--
VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTCK-E--D-LP----QELKIKFL-Q----EAKILKQY-D---HPNIVKLIGVCT--Q-----RQP--VYIIMELVSGGDFLTFLR---RK-----------------------K-DELKLKQLVKFSLDAAAGMLYLESKN---CIHRDLAARNCLVGE-----NN-VL----KISDFGMSRQE----D--GGVY--------------SSSGLKQIPIKWTAPEALN-YGRYSSESDVWSFGILLWETFSLGVCP---------------YPGM--TNQQAREQV-ERGYRMSAPQHCP----------------------------EDISKIMMKCWDYKPENRPKFSELQKEL----
--LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT----EKDLSDLV-S----EMEMMKMIGK---HKNIINLLGACT--Q-----DGP--LYVIVEYASKGNLREYLR---ARRPPGMEY--------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLASQK---CIHRDLAARNVLVTE-----NN-VM----KIADFGLARDI--N-N--IDYY--------------KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI--PVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
--LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--G-TM----SP--ESFL-E----EAQIMKKL-K---HDKLVQLYAVVS--------EEP--IYIVTEYMNKGSLLDFLK---DG----------------------EG-RALKLPNLVDMAAQVAAGMAYIERMN---YIHRDLRSANILVGN-----GL-IC----KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM--NNREVLEQV-ERGYRMPCPQDCP----------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL----
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM----SV--EAFL-A----EANVMKTL-Q---HDKLVKLHAVVT--------KEP--IYIITEFMAKGSLLDFLK---SD----------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQRN---YIHRDLRAANILVSA-----SL-VC----KIADFGLARVI----E--DNEY--------------TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM--SNPEVIRAL-ERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L--
-L-KRIRDLGEGHFGKVELCRYDP---EGDNTGEQVAVKSLK-P--E-SG----GNHIADLK-K----EIEILRNL-Y---HENIVKYKGICT-ED------GGNGIKLIMEFLPSGSLKEYLP---KN-----------------------K-NKINLKQQLKYAVQICKGMDYLGSRQ---YVHRDLAARNVLVES-----EH-QV----KIGDFGLTKAI-ET-D--KEYY--------------TVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM--TVTRLVNTL-KEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE-----EHLRDFE-R----EIEILKSL-Q---HDNIVKYKGVCYSAG-----RRN--LKLIMEYLPYGSLRDYLQ---KH-----------------------K-ERIDHIKLLQYTSQICKGMEYLGTKR---YIHRDLATRNILVEN-----EN-RV----KIGDFGLTKVL-PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM--IVFHLIELL-KNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--S-GP----DQ-QRDFQ-R----EIQILKAL-H---SDFIVKYRGVSYGPG-----RQS--LRLVMEYLPSGCLRDFLQ---RH-----------------------R-ARLDASRLLLYSSQICKGMEYLGSRR---CVHRDLAARNILVES-----EA-HV----KIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-PALCRLLELL-EEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-V-TLLRALGHGAFGEVYEGLVIG--LPGDSSPLQVAIKTLP-E--L-CS----PQDELDFL-M----EALIISKF-R---HQNIVRCVGLSL--R-----ATP--RLILLELMSGGDMKSFLR---HSRP-----------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEENH---FIHRDIAARNCLLSCA--GPSR-VA----KIGDFGMARDI--Y-R--ASYY--------------RRGDRALLPVKWMPPEAFL-EGIFTSKTDSWSFGVLLWEIFSLGYMP---------------YPGR--TNQEVLDFV-VGGGRMDPPRGCP----------------------------GPVYRIMTQCWQHEPELRPSFASILERL----
--IEVEEVVGRGAFGVVCKAKWR---------AKDVAIKQIE-------S----ESERKAFI-V----ELRQLSRV-N---HPNIVKLYGACL---------NP--VCLVMEYAEGGSLYNVLH---GA----------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA-----GGTVL----KICDFGTACDI----------Q--------------THMTNNKGSAAWMAPEVFE-GSNYSEKCDVFSWGIILWEVITR-RKP---------------FDEIGGPAFRIMWAV-HNGTRPPLIKNLP----------------------------KPIESLMTRCWSKDPSQRPSMEEIVKI--M--
-I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-D--A-SD----NA-RKDFH-R----EAELLTNL-Q---HEHIVKFYGVCV--E-----GDP--LIMVFEYMKHGDLNKFLR---AHGPDAV-----------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLASQH---FVHRDLATRNCLVGE-----NL-LV----KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQL--SNNEVIECI-TQGRVLQRPRTCP----------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L--
-I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D--P-TL----AA-RKDFQ-R----EAELLTNL-Q---HEHIVKFYGVCG--D-----GDP--LIMVFEYMKHGDLNKFLR---AHGPDAMIL--------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLASQH---FVHRDLATRNCLVGA-----NL-LV----KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQP---------------WFQL--SNTEVIECI-TQGRVLERPRVCP----------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL----
--IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS----DSVREKFL-Q----EALTMRQF-D---HPHIVKLIGVIT--------ENP--VWIIMELCTLGELRSFLQ---VR-----------------------K-YSLDLASLILYAYQLSTALAYLESKR---FVHRDIAARNVLVSS-----ND-CV----KLGDFGLSRYM----E--DSTY--------------YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV--KNNDVIGRI-ENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL----
-L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS----PSELRDLL-S----EFNVLKQV-N---HPHVIKLYGACS--Q-----DGP--LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARNILVAE-----GR-KM----KISDFGLSRDV--Y-E--EDSY--------------VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI--PPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
-L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ----PEAMDDFI-R----EVNAMHSL-D---HRNLIRLYGVVL--------TPP--MKMVTELAPLGSLLDRLR---KH-----------------------Q-GHFLLGTLSRYAVQVAEGMGYLESKR---FIHRDLAARNLLLAT-----RD-LV----KIGDFGLMRAL-PQ-N--DDHY--------------VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL--NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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