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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK SRC 203
TK ABL1 261
TK CSF1R 582
TK EPHB1 619
TK EPHB4 615
TK KIT 589
TK PDGFRA 593
TKL RAF1 349
-L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKP-GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L-
--ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
--LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKS-TAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR-----------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI---MNDSNYIVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ----MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL--
-V-KIEEVIGAGEFGEVYKGRLK--LPGKREIYVAIKTLKA-GYSEKQRRDFLSEASIMGQF-DHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN-------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK---FTSASDVWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYR----LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL--
-V-KIEEVIGAGEFGEVCRGRLK--APGKKESCVAIKTLKG-GYTERQRREFLSEASIMGQF-EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLN-------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYR----LPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL--
--LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI---KNDSNYVVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI---MHDSNYVSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
VM--LSTRIGSGSFGTVYKGKWH--------GDVAVKILKVVDPTPEQFQAFRNEVAVLRKT-RHVNILLFMGYMT-KDNLAIVTQWCEGSSLYKHLHVQ-------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK---SRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS-I-
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