|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK STK17B 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CSNK2A1 39
CMGC MAPK14 24
ILT---SKELGRGKFAVVRQCISKSTGQ-EYAAKFLKKRR-RGQDCRAEILHEIAVLELAKS---CPRVINLHEVYEN------TSEIILILEYAAGGEIFSLCLP-ELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK-IGHACELREIMGTPEYLAPEILN-YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE---DNQETYLNISQVNVDYSEETFSSVS------------------------------QLATDFIQSLLVKNPEKRPTAEICLSHSWL
---FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRREVEIQSHL-R---HPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
---YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLES-EEEGVPSTAIREISLLKEL-R---HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDT-ETEGVPSTAIREISLLKEL-N---HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDD-DDEGVPSSALREICLLKEL-K---HKNIVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
---YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHL-ETFEHPNVVRLFDVCTVSR-TDRETKLTLVFEHVDQ-DLTTYLDK-VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI---KLADFGLARI-YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
---YQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPVK-KKKIKR-----EIKILENLRG---GPNIITLADIVKDP----VSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
---YQNLSPVGSGAYGSVCAAFDTKTGL-RVAVKKLSRPF-QSIIHAKRTYRELRLLKHM-K---HENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
|