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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TEC 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKC 43
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CMGC CDK2 4
CAMK CHEK2 220
Other CHUK 15
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
TK EGFR 712
Other EIF2AK2 267
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
CAMK HUNK 61
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
TK LCK 245
TK LTK 510
TK LYN 247
STE MAP2K1 68
STE MAP2K7 120
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
TK MET 1078
CAMK MGC42105 74
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
TK PTK6 191
TKL RAF1 349
TK RET 724
TK ROS1 1945
AGC RPS6KA5 49
AGC RPS6KB1 91
AGC RPS6KB2 67
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17A 61
STE STK24 24
STE STK25 20
Other STK36 4
TK SYK 371
Other TLK2 440
TK TNK1 116
TK TNK2 150
CAMK TSSK1B 12
TK TXK 271
Other ULK3 14
TK YES1 277
TK ZAP70 338
-----LTFMRELGSGLFGVVRLGKW---R-----------------AQY---KVAIKAI---R-E--G-AM-CE---EDFI-E------EAKVMMKL--T---HPKLVQLYGVCT--Q-----------------------------QKP--IYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLER-N--SFIHRDLAARNCLVS--E-----AGVV----KVSDFGMARYV----------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR---FSSKSDVWSFGVLMWEVFTEGR--MP---------------FEKY-----------TNYEVVTMV----TR----GHR----LYQPKLAS-------------------------------------------NYVYEVMLRCWQEKPEGRPS-----FE-DLLRT--I--------------
-----ITMKHKLGGGQYGEVYEGVW---K----------------KYSL---TVAVKTL---K-E--D-TM-EV---EEFL-K------EAAVMKEI--K---HPNLVQLLGVCT--R-----------------------------EPP--FYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG--E-----NHLV----KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI-----------DLSQVYELL----EK----DYR----MERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPS-----FA-EIHQA--F--------------
-----ITMKHKLGGGQYGEVYVGVW---K----------------KYSL---TVAVKTL---K-E--D-TM-EV---EEFL-K------EAAVMKEI--K---HPNLVQLLGVCT--L-----------------------------EPP--FYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG--E-----NHVV----KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI-----------DLSQVYDLL----EK----GYR----MEQPEGCP-------------------------------------------PKVYELMRACWKWSPADRPS-----FA-ETHQA--F--------------
----I-TLIRGLGHGAFGEVYEGQV---SG-----------MPNDPSPL---QVAVKTL---P-E--V-CS-EQD-ELDFL-M------EALIISKF--N---HQNIVRCIGVSL--Q-----------------------------SLP--RFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEE-N--HFIHRDIAARNCLLT--CP--GPGRVA----KIGDFGMARDI-----Y----R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY--MP---------------YPSK-----------SNQEVLEFV----TS----GGR----MDPPKNCP-------------------------------------------GPVYRIMTQCWQHQPEDRPN-----FA-IILER--I--------------
-----FEIGRPLGKGKFGNVYLARE---K----------------QSKF---ILALKVL---FKA--QLEKAGV---EHQLRR------EVEIQSHL--R---HPNILRLYGYFH--D-----------------------------ATR--VYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------KFDEQRTATYITELANALSYCHS-K--RVIHRDIKPENLLLG--S-----AGEL----KIADFGWSV------------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GK--PP---------------FEAN--------------TYQETY----KR----ISR----VEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPM-----LR-EVLEHPWI--------------
-----FEIGRPLGKGKFGNVYLARL---K----------------ESHF---IVALKVL---FKS--Q-IEKEG---LEHQLR-----REIEIQAHL--Q---HPNILRLYNYFH--D-----------------------------ARR--VYLILEYAPRGELYKELQ---KSE----------------------------------------------------------------------KLDEQRTATIIEELADALTYCHD-K--KVIHRDIKPENLLLG--F-----RGEV----KIADFGWSV------------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----GRT---YDEKVDLWCIGVLCYELLV-GY--PP---------------FESA--------------SHSETY----RR----ILK----VDVRFPLSMP-----------------------------------------LGARDLISRLLRYQPLERLP-----LA-QILKHPWV--------------
-----ITLLKELGSGQFGVVQLGKW---K-----------------GQY---DVAVKMI---K-E--G-SM-SE---DEFF-Q------EAQTMMKL--S---HPKLVKFYGVCS--K-----------------------------EYP--IYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLES-H--QFIHRDLAARNCLVD--R-----DLCV----KVSDFGMTRYV----------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK---YSSKSDVWAFGILMWEVFSLGK--QP---------------YDLY-----------DNSQVVLKV----SQ----GHR----LYRPHLAS-------------------------------------------DTIYQIMYSCWHELPEKRPT-----FQ-QLLSS--I--------------
-----YRLEKTLGKGQTGLVKLGVH---C----------------ITGQ---KVAIKIV---NRE--K-LSESV---LMKVER------EIAILKLI--E---HPHVLKLHDVYE--N-----------------------------KKY--LYLVLEHVSGGELFDYLV---KKG----------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHS-Y--SICHRDLKPENLLLD--E-----KNNI----RIADFGMASL-----------QVGDSLL--------------ET---SCGSPHYACPEVIK----GEKY---DGRRADMWSCGVILFALLV-GA--LP---------------FDDD--------------NLRQLL----EK----VKR----GVFHMPHFIP-----------------------------------------PDCQSLLRGMIEVEPEKRLS-----LE-QIQKHPW-Y-------------
-----YRLEKTLGKGQTGLVKLGVH---C----------------VTCQ---KVAIKIV---NRE--K-LSESV---LMKVER------EIAILKLI--E---HPHVLKLHDVYE--N-----------------------------KKY--LYLVLEHVSGGELFDYLV---KKG----------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHS-H--SICHRDLKPENLLLD--E-----KNNI----RIADFGMASL-----------QVGDSLL--------------ET---SCGSPHYACPEVIR----GEKY---DGRKADVWSCGVILFALLV-GA--LP---------------FDDD--------------NLRQLL----EK----VKR----GVFHMPHFIP-----------------------------------------PDCQSLLRGMIEVDAARRLT-----LE-HIQKHIW-Y-------------
-----LTFLKELGTGQFGVVKYGKW---R-----------------GQY---DVAIKMI---K-E--G-SM-SE---DEFI-E------EAKVMMNL--S---HEKLVQLYGVCT--K-----------------------------QRP--IFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLES-K--QFLHRDLAARNCLVN--D-----QGVV----KVSDFGLSRYV----------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGK--MP---------------YERF-----------TNSETAEHI----AQ----GLR----LYRPHLAS-------------------------------------------EKVYTIMYSCWHEKADERPT-----FK-ILLSN--I--------------
-----FQKVEKIGEGTYGVVYKARN---K----------------LTGE---VVALKKI---RLD--T-ETEGV---PSTAIR------EISLLKEL--N---HPNIVKLLDVIH--T-----------------------------ENK--LYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHS-H--RVLHRDLKPQNLLIN--T-----EGAI----KLADFGLARAF----------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RR--AL---------------FPGD-----------SEIDQLFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF--------------
---YI--MSKTLGSGACGEVKLAFE---R----------------KTCK---KVAIKII---SKR--K-FAIGS---AREADPALNVETEIEILKKL--N---HPCIIKIKNFF---D-----------------------------AED--YYIVLELMEGGELFDKVV---GNK----------------------------------------------------------------------RLKEATCKLYFYQMLLAVQYLHE-N--GIIHRDLKPENVLLS--S-----QEEDC-LIKITDFGHSKI-----------LGETSLM--------------RT---LCGTPTYLAPEVLVS--VGTAG---YNRAVDCWSLGVILFICLS-GY--PP---------------FSEH-------------RTQVSLK----DQ----ITS----GKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFT-----TE-EALRHPWL--------------
----W-EMRERLGTGGFGNVCLYQH---R----------------ELDL---KIAIKSC---RLE--L-STKNR---ER-WCH------EIQIMKKL--N---HANVVKACDVPE--ELN------------------------ILIHDV--PLLAMEYCSGGDLRKLLNKPENCC----------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHE-N--KIIHRDLKPENIVLQ--D-----VGGKI-IHKIIDLGYAKD-----------VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKP---YTATVDYWSFGTMVFECIA-GY--RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CE----EMS----GEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQRG-----------------GPVDLTLKQ-----
-----LQFGKTLGAGAFGKVVEATA---FG-----------LGKEDAVL---KVAVKML---K-S--T-AH-ADE-KEALM-S------ELKIMSHLG-Q---HENIVNLLGACT--H-----------------------------GGP--VLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLAS-K--NCIHRDVAARNVLLT--N-----GHVA----KIGDFGLARDI-----M----N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL--NP---------------YPGI-L---------VNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------------------KNIYSIMQACWALEPTHRPT-----FQ-QICSFL----------------
-----LKLLQTIGKGEFGDVMLGDY---R------------------GN---KVAVKCI---K-N--D-AT-AQ----AFL-A------EASVMTQL--R---HSNLVQLLGVIV-EE-----------------------------KGG--LYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEG-N--NFVHRDLAARNVLVS--E-----DNVA----KVSDFGLTKEA----------------S--------------STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGR--VP---------------YPRI-----------PLKDVVPRV----EK----GYK----MDAPDGCP-------------------------------------------PAVYEVMKNCWHLDAAMRPS-----FL-QLREQL----------------
-----YDTGEELGSGQFAVVKKCRE---K----------------STGL---QYAAKFI---KKR--R-TKSSR---RGVSREDI--EREVSILKEI--Q---HPNVITLHEVYE--N-----------------------------KTD--VILILELVAGGELFDFLA---EKE----------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHS-L--QIAHFDLKPENIMLL--D-----RNVPKPRIKIIDFGLAHK-----------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA--SP---------------FLGD--------------TKQETL----AN----VSA----VNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQ-DSLQHPWI--------------
-----YDIGEELGSGQFAIVKKCRE---K----------------STGL---EYAAKFI---KKR--Q-SRASR---RGVSREEI--EREVSILRQV--L---HHNVITLHDVYE--N-----------------------------RTD--VVLILELVSGGELFDFLA---QKE----------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHT-K--KIAHFDLKPENIMLL--D-----KNIPIPHIKLIDFGLAHE-----------IEDGVEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA--SP---------------FLGD--------------TKQETL----AN----ITA----VSYDFDEEFFSQTS-------------------------------------ELAKDFIRKLLVKETRKRLT-----IQ-EALRHPWI--------------
-----YEMGEELGSGQFAIVRKCRQ---K----------------GTGK---EYAAKFI---KKR--R-LSSSR---RGVSREEI--EREVNILREI--R---HPNIITLHDIFE--N-----------------------------KTD--VVLILELVSGGELFDFLA---EKE----------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHS-K--RIAHFDLKPENIMLL--D-----KNVPNPRIKLIDFGIAHK-----------IEAGNEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA--SP---------------FLGE--------------TKQETL----TN----ISA----VNYDFDEEYFSNTS-------------------------------------ELAKDFIRRLLVKDPKRRMT-----IA-QSLEHSWI--------------
-----LRFKEKLGEGQFGEVHLCEV---DSPQDLVSLDFPLNVRKGHPL---LVAVKIL---R-P--D-AT-KNA-RNDFL-K------EVKIMSRL--K---DPNIIRLLGVCV--Q-----------------------------DDP--LCMITDYMENGDLNQFLS----AHQLEDKAAE--------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLAT-L--NFVHRDLATRNCLVG--E-----NFTI----KIADFGMSRNL-----Y----A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRA-QP---------------FGQL-----------TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------------------QGLYELMLRCWSRESEQRPP-----FS-QLHRFL----------------
-----LTFKEKLGEGQFGEVHLCEV---EGMEKFKDKDFALDVSANQPV---LVAVKML---R-A--D-AN-KNA-RNDFL-K------EIKIMSRL--K---DPNIIHLLAVCI--T-----------------------------DDP--LCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSS-L--NFVHRDLATRNCLVG--K-----NYTI----KIADFGMSRNL-----Y----S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQE-QP---------------YSQL-----------SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------------------DSVYKLMLSCWRRDTKNRPS-----FQ-EIHL---LL-------------
----F-KKIKVLGSGAFGTVYKGLW---IP------------EGEKVKI---PVAIKEL---R-E--A-TS-PKA-NKEIL-D------EAYVMASV--D---NPHVCRLLGICL--------------------------------TST--VQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLED-R--RLVHRDLAARNVLVK--T-----PQHV----KITDFGLAKLL-----G----A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS--KP---------------YDGI-----------PASEISSIL----EK----GER----LPQPPICT-------------------------------------------IDVYMIMVKCWMIDADSRPK-----FR-ELI----IEF------------
----F-KEIELIGSGGFGQVFKAKH---R----------------IDGK---TYVIKRV---KYN--N-EKAER---------------EVKALAKL--D---HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC--LFIQMEFCDKGTLEQWIEK-RRGE----------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHS-K--KLIHRDLKPSNIFLV--D-----TKQV----KIGDFGLVTS-----------LKNDGKR--------------TR---SKGTLRYMSPEQIS-----SQD---YGKEVDLYALGLILAELLH-VC-DTA---------------FET------------------SKF----FT----DLR----DGIISDIFDK------------------------------------------KEKTLLQKLLSKKPEDRPN-----TS-EILR----TLT-----------
-----IHIEKIIGSGDSGEVCYGRL---R-------------VPGQRDV---PVAIKAL---K-A--G-YT-ERQ-RRDFL-S------EASIMGQF--D---HPNIIRLEGVVT--R-----------------------------GRL--AMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSD-L--GYVHRDLAARNVLVD--S-----NLVC----KVSDFGLSRVL-----E----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE--RP---------------YWNM-----------TNRDVISSV----EE----GYR----LPAPMGCP-------------------------------------------HALHQLMLDCWHKDRAQRPR-----FS-QIVSVL----------------
----V-KIEEVIGAGEFGEVYKGRL---K-------------LPGKREI---YVAIKTL---K-A--G-YS-EKQ-RRDFL-S------EASIMGQF--D---HPNIIRLEGVVT--K-----------------------------SRP--VMIITEFMENGALDSFLR----QN--------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAE-M--NYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRYLQ--DDT----S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE--RP---------------YWDM-----------SNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------AALHQLMLDCWQKDRNSRPR-----FA-EIVNTL----------------
----V-KIEQVIGAGEFGEVCSGHL---K-------------LPGKREI---FVAIKTL---K-S--G-YT-EKQ-RRDFL-S------EASIMGQF--D---HPNVIHLEGVVT--K-----------------------------STP--VMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAD-M--NYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRFLE--DDT----S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE--RP---------------YWDM-----------TNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------SALHQLMLDCWQKDRNHRPK-----FG-QIVNTL----------------
----V-KIEEVIGAGEFGEVCRGRL---K-------------APGKKES---CVAIKTL---K-G--G-YT-ERQ-RREFL-S------EASIMGQF--E---HPNIIRLEGVVT--N-----------------------------SMP--VMILTEFMENGALDSFLR----LN--------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAE-M--SYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRFLE--ENS----S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK---FTSASDAWSYGIVMWEVMSFGE--RP---------------YWDM-----------SNQDVINAI----EQ----DYR----LPPPPDCP-------------------------------------------TSLHQLMLDCWQKDRNARPR-----FP-QVVSAL----------------
-----IKIEEVIGTGSFGEVRQGRL---Q-------------PRGRREQ---TVAIQAL---W-A--G-GA-ESL-QMTFL-G------RAAVLGQF--Q---HPNILRLEGVVT--K-----------------------------SRP--LMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSS-F--AFVHRSLSAHSVLVN--S-----HLVC----KVARLGHSPQG------------------------------------PSCLLRWAAPEVIA-----HGK---HTTSSDVWSFGILMWEVMSYGE--RP---------------YWDM-----------SEQEVLNAI----EQ----EFR----LPPPPGCP-------------------------------------------PGLHLLMLDTWQKDRARRPH-----FD-QLVA---AF-------------
----L-VLGKPLGEGCFGQVVLAEA---IGL---------DKDKPNRVT---KVAVKML---K-S--D-AT-EKD-LSDLI-S------EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------DGP--LYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-K--KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARDI-----H----H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGG--SP---------------YPGV-----------PVEELFKLL----KE----GHR----MDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPT-----FK-QLVEDL----------------
-----LTLGKPLGEGCFGQVVMAEA---VGI---------DKDKPKEAV---TVAVKML---K-D--D-AT-EKD-LSDLV-S------EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------DGP--LYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-Q--KCIHRDLAARNVLVT--E-----NNVM----KIADFGLARDI-----N----N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLMWEIFTLGG--SP---------------YPGI-----------PVEELFKLL----KE----GHR----MDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQRPT-----FK-QLVEDL----------------
-----LTLGKPLGEGCFGQVVMAEA---IGI---------DKDRAAKPV---TVAVKML---K-D--D-AT-DKD-LSDLV-S------EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------GGP--LYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS-Q--KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARDV-----H----N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLLWEIFTLGG--SP---------------YPGI-----------PVEELFKLL----KE----GHR----MDKPANCT-------------------------------------------HDLYMIMRECWHAAPSQRPT-----FK-QLVEDL----------------
----L-VLGKPLGEGCFGQVVRAEA---FGM---------DPARPDQAS---TVAVKML---K-D--N-AS-DKD-LADLV-S------EMEVMKLIG-R---HKNIINLLGVCT--Q-----------------------------EGP--LYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES-R--KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARGV-----H----H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGILLWEIFTLGG--SP---------------YPGI-----------PVEELFSLL----RE----GHR----MDRPPHCP-------------------------------------------PELYGLMRECWHAAPSQRPT-----FK-QLVEAL----------------
-----ITLERRLGTGCFGDVWLGTW---N-----------------GST---KVAVKTL---K-P--G-TM-SP---KAFL-E------EAQVMKLL--R---HDKLVQLYAVVS--------------------------------EEP--IYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMER-M--NYIHRDLRAANILVG--E-----RLAC----KIADFGLARLI----------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR---FTIKSDVWSFGILLTELITKGR--IP---------------YPGM-----------NKREVLEQV----EQ----GYH----MPCPPGCP-------------------------------------------ASLYEAMEQTWRLDPEERPT-----FE-YLQSFL----------------
-----IQLLKRLGSGQFGEVWEGLW---N-----------------NTT---PVAVKTL---K-P--G-SM-DP---NDFL-R------EAQIMKNL--R---HPKLIQLYAVCT--L-----------------------------EDP--IYIITELMRHGSLQEYLQ----ND-------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLES-R--NYIHRDLAARNVLVG--E-----HNIY----KVADFGLARVFK---VD----N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----SNK---FSIKSDVWSFGILLYEIITYGK--MP---------------YSGM-----------TGAQVIQML----AQ----NYR----LPQPSNCP-------------------------------------------QQFYNIMLECWNAEPKERPT-----FE-TLRWK--L--------------
-----LQLIKRLGNGQFGEVWMGTW---N-----------------GNT---KVAIKTL---K-P--G-TM-SP---ESFL-E------EAQIMKKL--K---HDKLVQLYAVVS--------------------------------EEP--IYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIER-M--NYIHRDLRSANILVG--N-----GLIC----KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR--VP---------------YPGM-----------NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEERPT-----FE-YLQSFL----------------
--IGS----RKLGEGSFAKVREGLH---V----------------LTGE---KVAIKVI---DKK--R-AKKDT---YVTKNLR----REGQIQQMI--R---HPNITQLLDILE--T-----------------------------ENS--YYLVMELCPGGNLMHKIY---EKK----------------------------------------------------------------------RLEESEARRYIRQLISAVEHLHR-A--GVVHRDLKIENLLLD--E-----DNNI----KLIDFGLSNCAG--------ILGYSDPF--------------ST---QCGSPAYAAPELLA-----RKK---YGPKIDVWSIGVNMYAMLT-GT--LP---------------FTVE------------PFSLRALY----QK----MVD-----KEMNPLPTQ--LS-------------------------------------TGAISFLRSLLEPDPVKRPN-----IQ-QALANRWL--------------
-----ITMSRELGQGSFGMVYEGVA---KG-----------VVKDEPET---RVAIKTV---N-E--A-AS-MRE-RIEFL-N------EASVMKEF--N---CHHVVRLLGVVS--Q-----------------------------GQP--TLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-N--KFVHRDLAARNCMVA--E-----DFTV----KIGDFGMTRDI-----Y----E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE--QP---------------YQGL-----------SNEQVLRFV----ME----GGL----LDKPDNCP-------------------------------------------DMLFELMRMCWQYNPKMRPS-----FL-EIISS--I--------------
-----ITLLRELGQGSFGMVYEGNA---RD-----------IIKGEAET---RVAVKTV---N-E--S-AS-LRE-RIEFL-N------EASVMKGF--T---CHHVVRLLGVVS--K-----------------------------GQP--TLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-K--KFVHRDLAARNCMVA--H-----DFTV----KIGDFGMTRDI-----Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE--QP---------------YQGL-----------SNEQVLKFV----MD----GGY----LDQPDNCP-------------------------------------------ERVTDLMRMCWQFNPKMRPT-----FL-EIVNLL----------------
----I-SIIRELGQGSFGMVYEGLA---RG-----------LEAGEEST---PVALKTV---N-E--L-AS-PRE-CIEFL-K------EASVMKAF--K---CHHVVRLLGVVS--Q-----------------------------GQP--TLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAA-N--KFVHRDLAARNCMVS--Q-----DFTV----KIGDFGMTRDV-----Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI---FTTHSDVWSFGVVLWEIVTLAE--QP---------------YQGL-----------SNEQVLKFV----MD----GGV----LEELEGCP-------------------------------------------LQLQELMSRCWQPNPRLRPS-----FT-HILD---SI-------------
-----LTFVQEIGSGQFGLVHLGYW---L-----------------NKD---KVAIKTI---R-E--G-AM-SE---EDFI-E------EAEVMMKL--S---HPKLVQLYGVCL--E-----------------------------QAP--ICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEE-A--CVIHRDLAARNCLVG--E-----NQVI----KVSDFGMTRFV----------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK--IP---------------YENR-----------SNSEVVEDI----ST----GFR----LYKPRLAS-------------------------------------------THVYQIMNHCWKERPEDRPA-----FS-RLLRQL----------------
----L-KRIRDLGEGHFGKVELCRY---DP------------EGDNTGE---QVAVKSL---K-P--E-SG-GNH-IADLK-K------EIEILRNL--Y---HENIVKYKGICT-ED------------------------------GGNGIKLIMEFLPSGSLKEYLP----KN--------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGS-R--QYVHRDLAARNVLVE--S-----EHQV----KIGDFGLTKAI----ET----D--KEYY--------------TVKDDRDSPVFWYAPECLM-----QSK---FYIASDVWSFGVTLHELLTYCD--SDSSPMALF-LKMIGPTHGQM-----------TVTRLVNTL----KE----GKR----LPCPPNCP-------------------------------------------DEVYQLMRKCWEFQPSNRTS-----FQ-NLIE---GF-------------
-----LKFLQQLGKGNFGSVEMCRY---DP------------LQDNTGE---VVAVKKL---Q-H--S-TE--EH-LRDFE-R------EIEILKSL--Q---HDNIVKYKGVCYSAG-----------------------------RRN--LKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGT-K--RYIHRDLATRNILVE--N-----ENRV----KIGDFGLTKVL----PQ----D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPS-----FR-DLA----LRV------------
----L-KYISQLGKGNFGSVELCRY---DP------------LGDNTGA---LVAVKQL---Q-H--S-GP-DQ--QRDFQ-R------EIQILKAL--H---SDFIVKYRGVSYGPG-----------------------------RQS--LRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGS-R--RCVHRDLAARNILVE--S-----EAHV----KIADFGLAKLL----PL----D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD--KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EE----GQR----LPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPS-----FS-ALGP---QL-------------
-----YEIDRTIGKGNFAVVKRATH---L----------------VTKA---KVAIKII---DKT--Q-LDEEN---LKKIFR------EVQIMKML--C---HPHIIRLYQVME--T-----------------------------ERM--IYLVTEYASGGEIFDHLV---AHG----------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHC-R--NIVHRDLKAENLLLD--A-----NLNI----KIADFGFSNL-----------FTPGQLL--------------KT---WCGSPPYAAPELFE----GKEY---DGPKVDIWSLGVVLYVLVC-GA--LP---------------FDGS--------------TLQNLR----AR----VLS----GKFRIPFFMS-----------------------------------------TECEHLIRHMLVLDPNKRLS-----ME-QICKHKWM--------------
-----LKLVERLGAGQFGEVWMGYY---N-----------------GHT---KVAVKSL---K-Q--G-SM-SP---DAFL-A------EANLMKQL--Q---HQRLVRLYAVVT--------------------------------QEP--IYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEE-R--NYIHRDLRAANILVS--D-----TLSC----KIADFGLARLI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGR--IP---------------YPGM-----------TNPEVIQNL----ER----GYR----MVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPT-----FD-YLRSV--L--------------
----V-TLLRALGHGAFGEVYEGLV---IG-----------LPGDSSPL---QVAIKTL---P-E--L-CS-PQD-ELDFL-M------EALIISKF--R---HQNIVRCVGLSL--R-----------------------------ATP--RLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEE-N--HFIHRDIAARNCLLS--CA--GPSRVA----KIGDFGMARDI-----Y----R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY--MP---------------YPGR-----------TNQEVLDFV----VG----GGR----MDPPRGCP-------------------------------------------GPVYRIMTQCWQHEPELRPS-----FA-SILERL----------------
-----IKLVKRLGAGQFGEVWMGYY---N-----------------NST---KVAVKTL---K-P--G-TM-SV---QAFL-E------EANLMKTL--Q---HDKLVRLYAVVT--R-----------------------------EEP--IYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIER-K--NYIHRDLRAANVLVS--E-----SLMC----KIADFGLARVI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGK--IP---------------YPGR-----------TNADVMTAL----SQ----GYR----MPRVENCP-------------------------------------------DELYDIMKMCWKEKAEERPT-----FD-YLQSV--L--------------
-----FEKISELGAGNGGVVFKVSH---K----------------PSGL----VMARKL---IHL--E-IKPAI---RNQIIR------ELQVLHEC--N---SPYIVGFYGAFY--S-----------------------------DGE--ISICMEHMDGGSLDQVLK---KAG----------------------------------------------------------------------RIPEQILGKVSIAVIKGLTYLREKH--KIMHRDVKPSNILVN--S-----RGEI----KLCDFGVSG------------QLIDSMA--------------NS---FVGTRSYMSPERLQ-----GTH---YSVQSDIWSMGLSLVEMAV-GR--YP---------------IPPP-----------DAKELELMF----GC----QVE----GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-----LK-QLMVHAFI--------------
---LE--NLGEMGSGTCGQVWKMRF---R----------------KTGH---VIAVKQM---RRS--G-NKEEN---KRI-LM------DLDVVLKS-HD---CPYIVQCFGTFI--T-----------------------------NTD--VFIAMELMGT--CAEKLKK-RMQG----------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEKH--GVIHRDVKPSNILLD--E-----RGQI----KLCDFGISGR-----------LVDSKAK--------------TR---SAGCAAYMAPERIDPPDPTKPD---YDIRADVWSLGISLVELAT-GQ--FP---------------YKNC-------------KTDFEVL----TK----VLQ----EEPPLLPG-HMGFS-------------------------------------GDFQSFVKDCLTKDHRKRPK-----YN-KLLEHSFI--------------
-----YRLQKTIGKGNFAKVKLARH---V----------------LTGR---EVAVKII---DKT--Q-LNPTS---LQKLFR------EVRIMKIL--N---HPNIVKLFEVIE--T-----------------------------EKT--LYLVMEYASGGEVFDYLV---AHG----------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQ-K--YIVHRDLKAENLLLD--G-----DMNI----KIADFGFSNE-----------FTVGNKL--------------DT---FCGSPPYAAPELFQ----GKKY---DGPEVDVWSLGVILYTLVS-GS--LP---------------FDGQ--------------NLKELR----ER----VLR----GKYRIPFYMS-----------------------------------------TDCENLLKKLLVLNPIKRGS-----LE-QIMKDRWM--------------
-----YRLLKTIGKGNFAKVKLARH---I----------------LTGK---EVAVKII---DKT--Q-LNSSS---LQKLFR------EVRIMKVL--N---HPNIVKLFEVIE--T-----------------------------EKT--LYLVMEYASGGEVFDYLV---AHG----------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQ-K--FIVHRDLKAENLLLD--A-----DMNI----KIADFGFSNE-----------FTFGNKL--------------DT---FCGSPPYAAPELFQ----GKKY---DGPEVDVWSLGVILYTLVS-GS--LP---------------FDGQ--------------NLKELR----ER----VLR----GKYRIPFYMS-----------------------------------------TDCENLLKKFLILNPSKRGT-----LE-QIMKDRWM--------------
-----YRLLRTIGKGNFAKVKLARH---I----------------LTGR---EVAIKII---DKT--Q-LNPSS---LQKLFR------EVRIMKGL--N---HPNIVKLFEVIE--T-----------------------------EKT--LYLVMEYASAGEVFDYLV---SHG----------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQ-K--NIVHRDLKAENLLLD--A-----EANI----KIADFGFSNE-----------FTLGSKL--------------DT---FCGSPPYAAPELFQ----GKKY---DGPEVDIWSLGVILYTLVS-GS--LP---------------FDGH--------------NLKELR----ER----VLR----GKYRVPFYMS-----------------------------------------TDCESILRRFLVLNPAKRCT-----LE-QIMKDKWI--------------
-----LTLGAQIGEGEFGAVLQGEY---L------------------GQ---KVAVKNI---K-C--D-VT-AQ----AFL-D------ETAVMTKM--Q---HENLVRLLGVIL--------------------------------HQG--LYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLES-K--KLVHRDLAARNILVS--E-----DLVA----KVSDFGLAKAE----------------R--------------KGLDSSRLPVKWTAPEALK-----HGK---FTSKSDVWSFGVLLWEVFSYGR--AP---------------YPKM-----------SLKEVSEAV----EK----GYR----MEPPEGCP-------------------------------------------GPVHVLMSSCWEAEPARRPP-----FR-KLAEKL----------------
-----VHFNEVIGRGHFGCVYHGTL---L-------------DNDGKKI---HCAVKSL---N-R--I-TD-IGE-VSQFL-T------EGIIMKDF--S---HPNVLSLLGICL-RS-----------------------------EGS--PLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLAS-K--KFVHRDLAARNCMLD--E-----KFTV----KVADFGLARDM-----Y----D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK---FTTKSDVWSFGVLLWELMTRGA--PP---------------YPDV-----------NTFDITVYL----LQ----GRR----LLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEMRPS-----FS-ELVSR--I--------------
-----YRIRGEIGSGNFSQVKLGIH---S----------------LTKE---KVAIKIL---DKT--K-LDQKT---QRLLSR------EISSMEKL--H---HPNIIRLYEVVE--T-----------------------------LSK--LHLVMEYAGGGELFGKIS---TEG----------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHE-N--QIIHRDLKAENVFYT--S-----NTCV----KVGDFGFSTV-----------SKKGEML--------------NT---FCGSPPYAAPELFR----DEHY---IGIYVDIWALGVLLYFMVT-GT--MP---------------FRAE--------------TVAKLK----KS----ILE----GTYSVPPHV----S-------------------------------------EPCHRLIRGVLQQIPTERYG-----ID-CIMNDEWM--------------
----I-EYVRDIGEGAFGRVFQARA---PG-----------LLPYEPFT---MVAVKML---K-E--E-AS-ADM-QADFQ-R------EAALMAEF--D---NPNIVKLLGVCA--V-----------------------------GKP--MCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSE-R--KFVHRDLATRNCLVG--E-----NMVV----KIADFGLSRNI-----Y----S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL--QP---------------YYGM-----------AHEEVIYYV----RD----GNI----LSCPENCP-------------------------------------------VELYNLMRLCWSKLPADRPS-----FT-SIHRIL----------------
---IV--LKWELGEGAFGKVFLAEC---HN-----------LLPEQDKM---LVAVKAL---K-E--A-SE-SA--RQDFQ-R------EAELLTML--Q---HQHIVRFFGVCT--E-----------------------------GRP--LLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG-L--HFVHRDLATRNCLVG--Q-----GLVV----KIGDFGMSRDI-----Y----S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK--QP---------------WYQL-----------SNTEAIDCI----TQ----GRE----LERPRACP-------------------------------------------PEVYAIMRGCWQREPQQRHS-----IK-DVHARL----------------
----I-VLKRELGEGAFGKVFLAEC---YN-----------LCPEQDKI---LVAVKTL---K-D--A-SD-NA--RKDFH-R------EAELLTNL--Q---HEHIVKFYGVCV--E-----------------------------GDP--LIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS-Q--HFVHRDLATRNCLVG--E-----NLLV----KIGDFGMSRDV-----Y----S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK--QP---------------WYQL-----------SNNEVIECI----TQ----GRV----LQRPRTCP-------------------------------------------QEVYELMLGCWQREPHMRKN-----IK-GIHTL--L--------------
----I-VLKRELGEGAFGKVFLAEC---YN-----------LSPTKDKM---LVAVKAL---K-D--P-TL-AA--RKDFQ-R------EAELLTNL--Q---HEHIVKFYGVCG--D-----------------------------GDP--LIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLAS-Q--HFVHRDLATRNCLVG--A-----NLLV----KIGDFGMSRDV-----Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK--QP---------------WFQL-----------SNTEVIECI----TQ----GRV----LERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQRLN-----IK-EIYKIL----------------
-----YELQETLGKGTYGKVKRATE---R----------------FSGR---VVAIKSI---RKD--K-IKDEQ---DMVHIR-----REIEIMSSL--N---HPHIISIYEVFE--N-----------------------------KDK--IVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHK-N--GVVHRDLKLENILLD--D-----NCNI----KIADFGLSNL-----------YQKDKFL--------------QT---FCGSPLYASPEIVN----GRPY---RGPEVDSWALGVLLYTLVY-GT--MP---------------FDGF--------------DHKNLI----RQ----ISS----GEYREPTQP------------------------------------------SDARGLIRWMLMVNPDRRAT-----IE-DIANHWW-V-------------
-----YEFLETLGKGTYGKVKKARE---S----------------SGR----LVAIKSI---RKD--K-IKDEQ---DLMHIR-----REIEIMSSL--N---HPHIIAIHEVFE--N-----------------------------SSK--IVIVMEYASRGDLYDYIS---ERQ----------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQ-N--RVVHRDLKLENILLD--A-----NGNI----KIADFGLSNL-----------YHQGKFL--------------QT---FCGSPLYASPEIVN----GKPY---TGPEVDSWSLGVLLYILVH-GT--MP---------------FDGH--------------DHKILV----KQ----ISN----GAYREPPK-----P-------------------------------------SDACGLIRWLLMVNPTRRAT-----LE-DVASHWW-V-------------
----F-KFLAVLGRGHFGKVLLSEF---R----------------PSGE---LFAIKAL---KKG--D-IVARD---EVESLM-----CEKRILAAV--TSAGHPFLVNLFGCFQ--T-----------------------------PEH--VCFVMEYSAGGDLMLHIH----SD----------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHE-H--KIVYRDLKLDNLLLD--T-----EGYV----KIADFGLCKEG----------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----DTS---YTRAVDWWGLGVLLYEMLV-GE--SP---------------FPGD--------------DEEEVF----DS----IVN----DEVRYPRFLS-----------------------------------------AEAIGIMRRLLRRNPERRLGSSERDAE-DVKKQPFF--------------
---FR--CCAVLGRGHFGKVLLAEY---K----------------NTNE---MFAIKAL---KKG--D-IVARD---EVDSLM-----CEKRIFETV--NSVRHPFLVNLFACFQ--T-----------------------------KEH--VCFVMEYAAGGDLMMHIH----TD----------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHE-H--KIVYRDLKLDNLLLD--T-----EGFV----KIADFGLCKEG----------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----ETS---YTRAVDWWGLGVLIYEMLV-GE--SP---------------FPGD--------------DEEEVF----DS----IVN----DEVRYPRFLS-----------------------------------------TEAISIMRRLLRRNPERRLGASEKDAE-DVKKHPFF--------------
----F-NFLMVLGKGSFGKVMLADR---K----------------GTEE---LYAIKIL---KKD--V-VIQDD---DVECTM-----VEKRVLALL-DK---PPFLTQLHSCFQ--T-----------------------------VDR--LYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHK-R--GIIYRDLKLDNVMLD--S-----EGHI----KIADFGMCKEH----------MMDGVTT--------------RT---FCGTPDYIAPEIIA-----YQP---YGKSVDWWAYGVLLYEMLA-GQ--PP---------------FDGE--------------DEDELF----QS----IME----HNVSYPKSLS-----------------------------------------KEAVSVCKGLMTKHPAKRLG-----C----------GPEGERDVREHAFF
---FI--FHKVLGKGSFGKVLLGEL---K----------------GRGE---YFAIKAL---KKD--V-VLIDD---DVECTM-----VEKRVLTLA-AE---NPFLTHLICTFQ--T-----------------------------KDH--LFFVMEFLNGGDLMYHIQ---DKG----------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHS-K--GIIYRDLKLDNVLLD--R-----DGHI----KIADFGMCKEN----------IFGESRA--------------ST---FCGTPDYIAPEILQ-----GLK---YTFSVDWWSFGVLLYEMLI-GQ--SP---------------FHGD--------------DEDELF----ES----IRV----DTPHYPRWIT-----------------------------------------KESKDILEKLFEREPTKRLG----VTG-NIKIHPFF--------------
---FI--LHKMLGKGSFGKVFLAEF---K----------------KTNQ---FFAIKAL---KKD--V-VLMDD---DVECTM-----VEKRVLSLA-WE---HPFLTHMFCTFQ--T-----------------------------KEN--LFFVMEYLNGGDLMYHIQ---SCH----------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHS-K--GIVYRDLKLDNILLD--K-----DGHI----KIADFGMCKEN----------MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQK---YNHSVDWWSFGVLLYEMLI-GQ--SP---------------FHGQ--------------DEEELF----HS----IRM----DNPFYPRWLE-----------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF--------------
---PD----EVLGSGQFGIVYGGKH---R----------------KTGR---DVAIKII---DKL--R-FPTKQ---ESQLRN------EVAILQNL--H---HPGVVNLECMFE--T-----------------------------PER--VFVVMEKLHGDMLEMILS--SEKG----------------------------------------------------------------------RLPEHITKFLITQILVALRHLHF-K--NIVHCDLKPENVLLA--S-----ADPFP-QVKLCDFGFARI-----------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----NKG---YNRSLDMWSVGVIIYVSLS-GT--FP---------------FNED----------------EDIH----DQ----IQN----AAFMYPPNPWKEIS-------------------------------------HEAIDLINNLLQVKMRKRYS-----VD-KTLSHPWL--------------
---PD----EVLGSGQFGVVYGGKH---R----------------KTGR---DVAVKVI---DKL--R-FPTKQ---ESQLRN------EVAILQSL--R---HPGIVNLECMFE--T-----------------------------PEK--VFVVMEKLHGDMLEMILS--SEKG----------------------------------------------------------------------RLPERLTKFLITQILVALRHLHF-K--NIVHCDLKPENVLLA--S-----ADPFP-QVKLCDFGFARI-----------IGEKSFR--------------RS---VVGTPAYLAPEVLL-----NQG---YNRSLDMWSVGVIMYVSLS-GT--FP---------------FNED----------------EDIN----DQ----IQN----AAFMYPASPWSHIS-------------------------------------AGAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL--------------
--FAD----EVLGSGQFGIVYGGKH---R----------------KTGR---DVAIKVI---DKM--R-FPTKQ---ESQLRN------EVAILQNL--H---HPGIVNLECMFE--T-----------------------------PER--VFVVMEKLHGDMLEMILS--SEKS----------------------------------------------------------------------RLPERITKFMVTQILVALRNLHF-K--NIVHCDLKPENVLLA--S-----AEPFP-QVKLCDFGFARI-----------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----SKG---YNRSLDMWSVGVIIYVSLS-GT--FP---------------FNED----------------EDIN----DQ----IQN----AAFMYPPNPWREIS-------------------------------------GEAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL--------------
-----IELGRCIGEGQFGDVHQGIY---M-------------SPENPAL---AVAIKTC---K-N--C-TS-DSV-REKFL-Q------EALTMRQF--D---HPHIVKLIGVIT--------------------------------ENP--VWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLES-K--RFVHRDIAARNVLVS--S-----NDCV----KLGDFGLSRYM----------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGV--KP---------------FQGV-----------KNNDVIGRI----EN----GER----LPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSRRPR-----FT-ELKAQL----------------
----F-TLCRKLGSGYFGEVFEGLW---K-----------------DRV---QVAIKVI---S-R--D-NL-LH--QQMLQ-S------EIQAMKKL--R---HKHILALYAVVS--V-----------------------------GDP--VYIITELMAKGSLLELLR----DS-------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLES-Q--NYIHRDLAARNILVG--E-----NTLC----KVGDFGLARLI-------------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH---YSTKSDVWSFGILLHEMFSRGQ--VP---------------YPGM-----------SNHEAFLRV----DA----GYR----MPCPLECP-------------------------------------------PSVHKLMLTCWCRDPEQRPC-----FK-ALRERL----------------
---VM--LSTRIGSGSFGTVYKGKW---H-------------------G---DVAVKIL---K-V-VD-PT-PEQ-FQAFR-N------EVAVLRKT--R---HVNILLFMGYMT--------------------------------KDN--LAIVTQWCEGSSLYKHLH----VQ--------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHA-K--NIIHRDMKSNNIFLH--E-----GLTV----KIGDFGLATVK-----S----R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GE--LP---------------YSHI-N---------NRDQIIFMV----GR----GYASPDLSKLYKNCP-------------------------------------------KAMKRLVADCVKKVKEERPL-----FP-QILSS--I--------------
----L-VLGKTLGEGEFGKVVKATA---FH-----------LKGRAGYT---TVAVKML---K-E--N-AS-PSE-LRDLL-S------EFNVLKQV--N---HPHVIKLYGACS--Q-----------------------------DGP--LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-M--KLVHRDLAARNILVA--E-----GRKM----KISDFGLSRDV-----Y----E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG--NP---------------YPGI-----------PPERLFNLL----KT----GHR----MERPDNCS-------------------------------------------EEMYRLMLQCWKQEPDKRPV-----FA-DISKDL----------------
---LT--LRLLLGSGAFGEVYEGTA---VDI----------LGVGSGEI---KVAVKTL---K-K--G-ST-DQE-KIEFL-K------EAHLMSKF--N---HPNILKQLGVCL--L-----------------------------NEP--QYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLER-M--HFIHRDLAARNCLVS--VKDYTSPRIV----KIGDFGLARDI-----Y----K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI---FTTQSDVWSFGILIWEILTLGH--QP---------------YPAH-----------SNLDVLNYV----QT----GGR----LEPPRNCP-------------------------------------------DDLWNLMTQCWAQEPDQRPT-----FH-RIQDQL----------------
-----FELLKVLGTGAYGKVFLVRKISGH----------------DTGK---LYAMKVL---KKA--T-IVQKA---KTTEHTR----TERQVLEHI-RQ---SPFLVTLHYAFQ--T-----------------------------ETK--LHLILDYINGGELFTHLS---QRE----------------------------------------------------------------------RFTEHEVQIYVGEIVLALEHLHK-L--GIIYRDIKLENILLD--S-----NGHV----VLTDFGLSKEF---------VADETERA--------------YS---FCGTIEYMAPDIVR---GGDSG---HDKAVDWWSLGVLMYELLT-GA--SP---------------FTVD----------GEKNSQAEIS----RR----ILK----SEPPYPQEMS-----------------------------------------ALAKDLIQRLLMKDPKKRLGCGPRDAD-EIKEHLFF--------------
-----FELLRVLGKGGYGKVFQVRKVTGA----------------NTGK---IFAMKVL---KKA--M-IVRNA---KDTAHTK----AERNILEEV--K---HPFIVDLIYAFQ--T-----------------------------GGK--LYLILEYLSGGELFMQLE---REG----------------------------------------------------------------------IFMEDTACFYLAEISMALGHLHQ-K--GIIYRDLKPENIMLN--H-----QGHV----KLTDFGLCKES----------IHDGTVT--------------HT---FCGTIEYMAPEILM-----RSG---HNRAVDWWSLGALMYDMLT-GA--PP---------------FTGE--------------NRKKTI----DK----ILK----CKLNLPPYLT-----------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF--------------
-----FELLRVLGKGGYGKVFQVRK---V----------------QGTNLGKIYAMKVL---RKA--K-IVRNA---KDTAHTR----AERNILESV--K---HPFIVELAYAFQ--T-----------------------------GGK--LYLILECLSGGELFTHLE---REG----------------------------------------------------------------------IFLEDTACFYLAEITLALGHLHS-Q--GIIYRDLKPENIMLS--S-----QGHI----KLTDFGLCKES----------IHEGAVT--------------HT---FCGTIEYMAPEILV-----RSG---HNRAVDWWSLGALMYDMLT-GS--PP---------------FTAE--------------NRKKTM----DK----IIR----GKLALPPYLT-----------------------------------------PDARDLVKKFLKRNPSQRIGGGPGDAA-DVQRHPFF--------------
-----YDIERTLGKGNFAVVKLARH---R----------------VTKT---QVAIKII---DKT--R-LDSSN---LEKIYR------EVQLMKLL--N---HPHIIKLYQVME--T-----------------------------KDM--LYIVTEFAKNGEMFDYLT---SNG----------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHD-H--HIVHRDLKTENLLLD--G-----NMDI----KLADFGFGNF-----------YKSGEPL--------------ST---WCGSPPYAAPEVFE----GKEY---EGPQLDIWSLGVVLYVLVC-GS--LP---------------FDGP--------------NLPTLR----QR----VLE----GRFRIPFFMS-----------------------------------------QDCESLIRRMLVVDPARRIT-----IA-QIRQHRWM--------------
-----YDIEGTLGKGNFAVVKLGRH---R----------------ITKT---EVAIKII---DKS--Q-LDAVN---LEKIYR------EVQIMKML--D---HPHIIKLYQVME--T-----------------------------KSM--LYLVTEYAKNGEIFDYLA---NHG----------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHG-R--KIVHRDLKAENLLLD--N-----NMNI----KIADFGFGNF-----------FKSGELL--------------AT---WCGSPPYAAPEVFE----GQQY---EGPQLDIWSMGVVLYVLVC-GA--LP---------------FDGP--------------TLPILR----QR----VLE----GRFRIPYFMS-----------------------------------------EDCEHLIRRMLVLDPSKRLT-----IA-QIKEHKWM--------------
-----WEIIGELGDGAFGKVYKAQN---K----------------ETSV---LAAAKVI---DTK--S-EEELE---DYM--V------EIDILASC--D---HPNIVKLLDAFY--Y-----------------------------ENN--LWILIEFCAGGAVDAVML--ELER----------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD-N--KIIHRDLKAGNILFT--L-----DGDI----KLADFGVSAKN----------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IE--PP---------------HHEL-----------NPMRVLLKI----AK----SEP----PTLAQPSRWS-----------------------------------------SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV--------------
-----YDLDKTLGRGHFAVVKLARH---V----------------FTGE---KVAVKVI---DKT--K-LDTLA---TGHLFQ------EVRCMKLV--Q---HPNIVRLYEVID--T-----------------------------QTK--LYLILELGDGGDMFDYIM--KHEE----------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHK-L--HVVHRDLKPENVVFF-EK-----QGLV----KLTDFGFSNK-----------FQPGKKL--------------TT---SCGSLAYSAPEILL----GDEY---DAPAVDIWSLGVILFMLVC-GQ--PP---------------FQEA--------------NDSETL----TM----IMD----CKYTVPSHVS-----------------------------------------KECKDLITRMLQRDPKRRAS-----LE-EIENHPWL--------------
----L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---RVAIKTL---K-P--G-TM-SP---EAFL-Q------EAQVMKKL--R---HEKLVQLYAVVS--------------------------------EEP--IYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVER-M--NYVHRDLRAANILVG--E-----NLVC----KVADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR--VP---------------YPGM-----------VNREVLDQV----ER----GYR----MPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPT-----FE-YLQAF--L--------------
---FA--LGRKLGEGYFGEVWEGLW---L-----------------GSL---PVAIKVI---K-S--A-NM-K---LTDLA-K------EIQTLKGL--R---HERLIRLHAVCS--G-----------------------------GEP--VYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEE-Q--RVVHRDLAARNVLVD--D-----GLAC----KVADFGLARLL----------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV---FSQKSDVWSFGVLLHEVFTYGQ--CP---------------YEGM-----------TNHETLQQI----MR----GYR----LPRPAACP-------------------------------------------AEVYVLMLECWRSSPEERPS-----FA-TLREKL----------------
-----WEIVGELGDGAFGKVYKAKN---K----------------ETGA---LAAAKVI---ETK--S-EEELE---DYI--V------EIEILATC--D---HPYIVKLLGAYY--H-----------------------------DGK--LWIMIEFCPGGAVDAIML--ELDR----------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHS-K--RIIHRDLKAGNVLMT--L-----EGDI----RLADFGVSAKN----------LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IE--PP---------------HHEL-----------NPMRVLLKI----AK----SDP----PTLLTPSKWS-----------------------------------------VEFRDFLKIALDKNPETRPS-----AA-QLLEHPFV--------------
--LCP---GRELGRGKFAVVRKCIK---K----------------DSGK---EFAAKFM---RKR--R-KGQDC---RMEIIH------EIAVLELA-QD---NPWVINLHEVYE--T-----------------------------ASE--MILVLEYAAGGEIFDQCVA-DREE----------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHT-R--DVVHLDLKPQNILLT--S-----ESPLG-DIKIVDFGLSRI-----------LKNSEEL--------------RE---IMGTPEYVAPEILS-----YDP---ISMATDMWSIGVLTYVMLT-GI--SP---------------FLGN--------------DKQETF----LN----ISQ----MNLSYSEEEFDVLS-------------------------------------ESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL--------------
-----FTKLEKIGKGSFGEVFKGID---N----------------RTQK---VVAIKII---DLE--E-AEDEI---EDIQ-Q------EITVLSQC--D---SPYVTKYYGSYL--K-----------------------------DTK--LWIIMEYLGGGSALDLLE----PG----------------------------------------------------------------------PLDETQIATILREILKGLDYLHS-E--KKIHRDIKAANVLLS--E-----HGEV----KLADFGVAGQL----------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA---YDSKADIWSLGITAIELAR-GE--PP---------------HSEL-----------HPMKVLFLI----PK----NNP----PTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSFRPT-----AK-ELLKHKFI--------------
----F-TKLDRIGKGSFGEVYKGID---N----------------HTKE---VVAIKII---DLE--E-AEDEI---EDIQ-Q------EITVLSQC--D---SPYITRYFGSYL--K-----------------------------STK--LWIIMEYLGGGSALDLLK----PG----------------------------------------------------------------------PLEETYIATILREILKGLDYLHS-E--RKIHRDIKAANVLLS--E-----QGDV----KLADFGVAGQL----------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA---YDFKADIWSLGITAIELAK-GE--PP---------------NSDL-----------HPMRVLFLI----PK----NSP----PTLEGQHS-------------------------------------------KPFKEFVEACLNKDPRFRPT-----AK-ELLKHKFI--------------
-----YHVLEMIGEGSFGRVYKGRR---K----------------YSAQ---VVALKFI---PKL--G-RSEKE---LRNLQR------EIEIMRGL--R---HPNIVHMLDSFE--T-----------------------------DKE--VVVVTDYAEG-ELFQILE---DDG----------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHS-H--RILHRDMKPQNILLA--K-----GGGI----KLCDFGFARAM----------STNTMVL--------------TS---IKGTPLYMSPELVE-----ERP---YDHTADLWSVGCILYELAV-GT--PP---------------FYAT--------------SIFQLV----SL----ILK----DPVRWPSTIS-----------------------------------------PCFKNFLQGLLTKDPRQRLS-----WP-DLLYHPFI--------------
--TLE---DKELGSGNFGTVKKGYY---Q--------------MKKVVK---TVAVKIL---K-N--E-AN-DPALKDELL-A------EANVMQQL--D---NPYIVRMIGICE--------------------------------AES--WMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE-S--NFVHRDLAARNVLLV--T-----QHYA----KISDFGLSKAL-----R----A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQ--KP---------------YRGM-----------KGSEVTAML----EK----GER----MGCPAGCP-------------------------------------------REMYDLMNLCWTYDVENRPG-----FA-AVE----LRL------------
---YL--LLHLLGRGGFSEVYKAFD---L----------------TEQR---YVAVKIH---QLN--K-NWRDE---KKENYHKH-ACREYRIHKEL--D---HPRIVKLYDYFS--L----------------------------DTDS--FCTVLEYCEGNDLDFYLK---QHK----------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNE-IKPPIIHYDLKPGNILLV--N-----GTACG-EIKITDFGLSKIMDDD---SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVV-GKEPPK---ISNKVDVWSVGVIFYQCLY-GR--KP---------------FGHN------------QSQQDILQ----EN----TIL----KATEVQFPPKPVVT-------------------------------------PEAKAFIRRCLAYRKEDRID-----VQ-QLACDPYL--------------
--VCR---GELLGSGCFGVVHRGLW---T-------------LPSGKSV---PVAVKSLRVGP-E--G-PM-GTE-LGDFL-R------EVSVMMNL--E---HPHVLRLHGLVL--------------------------------GQP--LQMVMELAPLGSLHARLT----AP------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGA-R--GLVHRDLATRNLLLA--S-----PRTI----KVADFGLVRPL----GG----A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGE--EP---------------WAGV-----------PPYLILQRL----ED----RAR----LPRPPLCS-------------------------------------------RALYSLALRCWAPHPADRPS-----FS-HLE----GLL------------
----L-RLLEKLGDGSFGVVRRGEW---D-------------APSGKTV---SVAVKCL---K-PDVL-SQ-PEA-MDDFI-R------EVNAMHSL--D---HRNLIRLYGVVL--------------------------------TPP--MKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLES-K--RFIHRDLAARNLLLA--T-----RDLV----KIGDFGLMRAL----PQ----N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQ--EP---------------WIGL-----------NGSQILHKI---DKE----GER----LPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPT-----FV-ALRDF--L--------------
YLLGI-----NLGEGSYAKVKSAYS---E----------------RLKF---NVAIKII---DRK--K-APADF---LEKFLP-----REIEILAML--N---HCSIIKTYEIFE--T----------------------------SHGK--VYIVMELAVQGDLLELIK---TRG----------------------------------------------------------------------ALHEDEARKKFHQLSLAIKYCHD-L--DVVHRDLKCDNLLLD--K-----DFNI----KLSDFSFSKRCLR------DDSGRMALS--------------KT---FCGSPAYAAPEVLQ----GIPY---QPKVYDIWSLGVILYIMVC-GS--MP---------------YDDS--------------NIKKML----RI----QKE----HRVNFPRSKHLT---------------------------------------GECKDLIYHMLQPDVNRRLH-----ID-EILSHCWM--------------
----L-AFIKEIGSGQFGVVHLGEW---R-----------------SHI---QVAIKAI---N-E--G-SM-SE---EDFI-E------EAKVMMKL--S---HSKLVQLYGVCI--Q-----------------------------RKP--LYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLER-N--GYIHRDLAARNCLVS--S-----TCIV----KISDFGMTRYV----------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGK--MP---------------FENK-----------SNLQVVEAI----SE----GFR----LYRPHLAP-------------------------------------------MSIYEVMYSCWHEKPEGRPT-----FA-ELLR---AV-------------
---FI--LTERLGSGTYATVYKAYA---KK---------------DTRE---VVAIKCV---AKK--S-LNKAS---VENLLT------EIEILKGI--R---HPHIVQLKDFQW--D-----------------------------SDN--IYLIMEFCAGGDLSRFIH---TRR----------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHE-R--NISHLDLKPQNILLSSLE-----KPHL----KLADFGFAQH-----------MSPWDEK--------------HV---LRGSPLYMAPEMVC-----QRQ---YDARVDLWSMGVILYEALF-GQ--PP---------------FASR-----------SFSELEEKI----RS----NRV----IELPLRPLLS-----------------------------------------RDCRDLLQRLLERDPSRRIS-----FQ-DFFAHPWV--------------
----L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---KVAIKTL---K-P--G-TM-MP---EAFL-Q------EAQIMKKL--R---HDKLVPLYAVVS--------------------------------EEP--IYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIER-M--NYIHRDLRAANILVG--E-----NLVC----KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR--VP---------------YPGM-----------VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDERPT-----FE-YIQSFL----------------
-LIAD----IELGCGNFGSVRQGVY---R--------------MRKKQI---DVAIKVL---K-Q--G-TE-KAD-TEEMM-R------EAQIMHQL--D---NPYIVRLIGVCQ--------------------------------AEA--LMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEE-K--NFVHRDLAARNVLLV--N-----RHYA----KISDFGLSKAL----GA----D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK---FSSRSDVWSYGVTMWEALSYGQ--KP---------------YKKM-----------KGPEVMAFI----EQ----GKR----MECPPECP-------------------------------------------PELYALMSDCWIYKWEDRPD-----FL-TVEQR--M--------------
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