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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TEC 203
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK8 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
TK EGFR 712
TK FES 561
TK FGFR1 478
TK FGFR3 472
CMGC GSK3A 119
CMGC GSK3B 56
CMGC ICK 4
TKL IRAK4 186
TK ITK 363
TK JAK2 849
CMGC MAK 4
STE MAP3K1 1242
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
STE MAP3K5 677
STE MAP3K6 645
CMGC MAPK1 13
CMGC MAPK8 26
CAMK MAPKAPK2 64
CMGC NLK 126
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK6 407
AGC PDPK1 82
CAMK PIM1 38
CAMK PIM3 40
AGC PRKCB 342
AGC PRKCH 355
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
Other SBK1 53
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
Other STK35 202
Other TLK2 440
TK TXK 271
STE YSK4 1162
----LTFMRELGSGLFGVVRLGKWR--------AQY--KVAIKAIR-EGAM-CE--E-D-FI-E------EAKVMMKL--T----HPK--LVQLYGVCT--Q-------------------------------------QKPIY--IVTEFMERG--CLLNFLR----------QR---------------QGHF--SRDVLLSMCQDVCEGMEYLERN--SFIHRDLAARNCLVS----EAGVV---KVSDFGMARYV-------------------L--DDQYTSSSGAKFPVKWCPPEVFN-----YSRFSSKSDVWSFGVLMWEVFTEGRMP---------------FEKY---------TNYEV-VTMVTRGHRLYQPKLAS-----------------------------------------NYVYEVMLRCWQEKPEGRPS------FEDLLRT--I--------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQ--VVAMKKIRLESEEEGV--P-S-TAIR------EISLLKEL--R----HPN--IVSLQDVLM--Q-------------------------------------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLID----DKGTI---KLADFGLARAF-------------------GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD---------SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GKMALNHPYF--------------
---F-DIIGIIGEGTYGQVYKARDK-------DTGE--MVALKKVRLDNEKEGF--P-I-TAIR------EIKILRQL--T----HQS--IINMKEIVT--DKEDAL---------------------------DFKKDKGAFY--LVFEYMDH---DLMGLLE--------SGLV-----------------HF--NENHIKSFMRQLMEGLDYCHKK--NFLHRDIKCSNILLN----NRGQI---KLADFGLARLY------------------SSEESRPYTN---KVITLWYRPPELLL----GEERYTPAIDVWSCGCILGELFT-KKPI---------------FQAN---------QELAQ-LELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------RRKLREEFVFIPAAALDLFDYMLALDPSKRCT------AEQALQCEF-L-------------
----FQKVEKIGEGTYGVVYKARNK-------LTGE--VVALKKIRLDTETEGV--P-S-TAIR------EISLLKEL--N----HPN--IVKLLDVIH--T-------------------------------------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN----TEGAI---KLADFGLARAF-------------------GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD---------SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF--------------
----FQKVEKIGEGTYGVVYKAKNR-------ETGQ--LVALKKIRLDLEMEGV--P-S-TAIR------EISLLKEL--K----HPN--IVRLLDVVH--N-------------------------------------ERKLY--LVFEFLSQ---DLKKYMDS-------TPGS-----------------EL--PLHLIKSYLFQLLQGVSFCHSH--RVIHRDLKPQNLLIN----ELGAI---KLADFGLARAF-------------------GVPLRTYTH---EVVTLWYRAPEILL----GSKFYTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD---------SEIDQ-LFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT------AKTALAHPYF--------------
----YEKLEKIGEGTYGTVFKAKNR-------ETHE--IVALKRVRLDDDDEGV--P-S-SALR------EICLLKEL--K----HKN--IVRLHDVLH--S-------------------------------------DKKLT--LVFEFCDQ---DLKKYFD--------SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHSR--NVLHRDLKPQNLLIN----RNGEL---KLADFGLARAF-------------------GIPVRCYSA---EVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN---------DVDDQ-LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS------AEEALQHPYF--------------
----YECVAEIGEGAYGKVFKARDL-------KNGG-RFVALKRVRVQTGEEGM--P-L-STIR------EVAVLRHL--ET-FEHPN--VVRLFDVCT--VSR--------------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK-------VPEP-----------------GV--PTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVT----SSGQI---KLADFGLARI--------------------YSFQMALTS---VVVTLWYRAPEVLL-----QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FRGS---------SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AYSALSHPYF--------------
-EGC-----KVGRGTYGHVYKAKRK-------DGKDDKDYALKQIEGTGISMSA--C------R------EIALLREL--K----HPN--VISLQKVFL--SH-----------------------------------ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV-----------------QL--PRGMVKSLLYQILDGIHYLHAN--WVLHRDLKPANILVMGEGPERGRV---KIADMGFARLFN----------------SPLKPLADLDP---VVVTFWYRAPELLL----GARHYTKAIDIWAIGCIFAELLT-SEPI---------------FHCRQEDIKTSNPYHHDQ-LDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT------SEQAMQDPYF--------------
----YEKLAKIGQGTFGEVFKARHR-------KTGQ--KVALKKVLMENEKEGF--P-I-TALR------EIKILQLL--K----HEN--VVNLIEICR--TKASP-----------------------------YNRCKGSIY--LVFDFCEH---DLAGLLS--------NVLV-----------------KF--TLSEIKRVMQMLLNGLYYIHRN--KILHRDMKAANVLIT----RDGVL---KLADFGLARAFSL---------------AKNSQPNRYTN---RVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN---------TEQHQ-LALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID------SDDALNHDFF--------------
----YEKIGKIGEGSYGVVFKCRNR-------DTGQ--IVAIKKFLESEDDPVI--K-K-IALR------EIRMLKQL--K----HPN--LVNLLEVFR--R-------------------------------------KRRLH--LVFEYCDHT--VLHELDR---------YQR-----------------GV--PEHLVKSITWQTLQAVNFCHKH--NCIHRDVKPENILIT----KHSVI---KLCDFGFARLL-------------------AGPSDYYTD---YVATRWYRSPELLV----GDTQYGPPVDVWAIGCVFAELLS-GVPL---------------WPGK---------SDVDQ-LYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-----------MEPLELKFPNISYPALGLLKGCLHMDPTQRLT------CEQLLHHPYF--------------
----YENLGLVGEGSYGMVMKCRNK-------DTGR--IVAIKKFLESDDDKMV--K-K-IAMR------EIKLLKQL--R----HEN--LVNLLEVCK--K-------------------------------------KKRWY--LVFEFVDHT--ILDDLEL---------FPN-----------------GL--DYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVS----QSGVV---KLCDFGFARTL-------------------AAPGEVYTD---YVATRWYRAPELLV----GDVKYGKAVDVWAIGCLVTEMFM-GEPL---------------FPGD---------SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF------CAELLHHDFF--------------
----YETLGKVGEGSYGTVMKCKHK-------NTGQ--IVAIKIFYERPEQSVN--K---IAMR------EIKFLKQF--H----HEN--LVNLIEVFR--Q-------------------------------------KKKIH--LVFEFIDHT--VLDELQH---------YCH-----------------GL--ESKRLRKYLFQILRAIDYLHSN--NIIHRDIKPENILVS----QSGIT---KLCDFGFARTL-------------------AAPGDIYTD---YVATRWYRAPELVL----KDTSYGKPVDIWALGCMIIEMAT-GNPY---------------LPSS---------SDLDL-LHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQ----------HPKNARKKYPKLNGLLADIVHACLQIDPADRIS------SSDLLHHEYF--------------
----FEILGVVGEGAYGVVLKCRHK-------ETHE--IVAIKKFKDSEENEEV--K-E-TTLR------ELKMLRTL--K----QEN--IVELKEAFR--R-------------------------------------RGKLY--LVFEYVEK---NMLELLE--------EMPN-----------------GV--PPEKVKSYIYQLIKAIHWCHKN--DIVHRDIKPENLLIS----HNDVL---KLCDFGFARNL------------------SEGNNANYTE---YVATRWYRSPELLL-----GAPYGKSVDMWSVGCILGELSD-GQPL---------------FPGE---------SEIDQ-LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL------TEQCLNHPTF--------------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEE--AVAVKIVDMKRAVDCP--E-N-I-KK------EICINKML--N----HEN--VVKFYGHRR--E-------------------------------------GNIQY--LFLEYCSGG--ELFDRIE---------PDI-----------------GM--PEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD----ERDNL---KISDFGLATVFR-----------------YNNRERLLNK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-----------SDS-CQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT------IPDIKKDRW-Y-------------
--YI--MSKTLGSGACGEVKLAFER-------KTCK--KVAIKIISKRKFAIGS--A-R-EADPALNVETEIEILKKL--N----HPC--IIKIKNFF---D-------------------------------------AEDYY--IVLELMEGG--ELFDKVV---------GNK-----------------RL--KEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS----SQEEDCLIKITDFGHSKI--------------------LGETSLMRT---LCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH-----------RTQ-VSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKI--PVAIKELR-EATS-PKANK-E-IL-D------EAYVMASV--D----NPH--VCRLLGICL----------------------------------------TSTVQ--LITQLMPFG--CLLDYVR----------EH---------------KDNI--GSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVK----TPQHV---KITDFGLAKLL---------G---------A--EEKEYHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI---------PASEI-SSILEKGERLPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF------------
---L-VLGEQIGRGNFGEVFSGRLR-------ADNT--LVAVKSCR-ETLP-PDLKA-K-FL-Q------EARILKQY--S----HPN--IVRLIGVCT--Q-------------------------------------KQPIY--IVMELVQGG--DFLTFLR----------TE---------------GARL--RVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCLVT----EKNVL---KISDFGMSREE---------A---------D--GVYAASGGLRQVPVKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGASP---------------YPNL---------SNQQT-REFVEKGGRLPCPELCP-----------------------------------------DAVFRLMEQCWAYEPGQRPS------FSTIYQEL----------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT--KVAVKMLK-SDAT-EKDLS-D-LI-S------EMEMMKMIG-K----HKN--IINLLGACT--Q-------------------------------------DGPLY--VIVEYASKG--NLREYLQ----------ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT----EDNVM---KIADFGLARDI---------H---------H--IDYYKKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV---------PVEEL-FKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV--TVAVKMLK-DDAT-DKDLS-D-LV-S------EMEMMKMIG-K----HKN--IINLLGACT--Q-------------------------------------GGPLY--VLVEYAAKG--NLREFLR----------ARRPPGLDYSFDTCKPPEEQL--TFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT----EDNVM---KIADFGLARDV---------H---------N--LDYYKKTTNGRLPVKWMAPEALF-----DRVYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI---------PVEEL-FKLLKEGHRMDKPANCT-----------------------------------------HDLYMIMRECWHAAPSQRPT------FKQLVEDL----------------
----YTDIKVIGNGSFGVVYQARLA-------ETRE--LVAIKKVLQDKRFKNR----------------ELQIMRKL--D----HCN--IVRLRYFFY--SSG---------------------------------EKKDELYLNLVLEYVPETVYRVARHFT--------KAKL-----------------TI--PILYVKVYMYQLFRSLAYIHSQ--GVCHRDIKPQNLLVD---PDTAVL---KLCDFGSAKQ--------------------LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD---------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PLEACAHSFF--------------
----YTDTKVIGNGSFGVVYQAKLC-------DSGE--LVAIKKVLQDKRFKNR----------------ELQIMRKL--D----HCN--IVRLRYFFY--SSG---------------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLD---PDTAVL---KLCDFGSAKQ--------------------LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD---------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF--------------
----YTTIRQLGDGTYGSVLLGRSI-------ESGE--LIAIKKMKRKFYSWEE--C---MNLR------EVKSLKKL--N----HAN--VVKLKEVIR--E-------------------------------------NDHLY--FIFEYMKE---NLYQLIK--------ERNK-----------------LF--PESAIRNIMYQILQGLAFIHKH--GFFHRDLKPENLLCM----GPELV---KIADFGLARE--------------------IRSKPPYTD---YVSTRWYRAPEVLL----RSTNYSSPIDVWAVGCIMAEVYT-LRPL---------------FPGA---------SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT------ASQALRYPYF--------------
-VGG----NKMGEGGFGVVYKGYVN-------NTT----VAVKKLAAMVDITTE--ELK-QQFD-----QEIKVMAKC--Q----HEN--LVELLGFSS--D-------------------------------------GDDLC--LVYVYMPNG--SLLDRLSC------LDGTP-----------------PL--SWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLD----EAFTA---KISDFGLARASE-----------------KFAQTVMTSR---IVGTTAYMAPEALR------GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH---------REPQL-LLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ-----------
----LTFVQEIGSGQFGLVHLGYWL--------NKD--KVAIKTIR-EGAM-SE--E-D-FI-E------EAEVMMKL--S----HPK--LVQLYGVCL--E-------------------------------------QAPIC--LVFEFMEHG--CLSDYLR----------TQ---------------RGLF--AAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVG----ENQVI---KVSDFGMTRFV-------------------L--DDQYTSSTGTKFPVKWASPEVFS-----FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR---------SNSEV-VEDISTGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPA------FSRLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGE--VVAVKKLQ-HSTE--EHLR-D-FE-R------EIEILKSL--Q----HDN--IVKYKGVCYSAG-------------------------------------RRNLK--LIMEYLPYG--SLRDYLQ----------KH---------------KERI--DHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE----NENRV---KIGDFGLTKVL--------PQ---------D--KEYYKVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM---------IVFHL-IELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPS------FRDLA----LRV------------
----YTTMRQLGDGTYGSVLMGKSN-------ESGE--LVAIKRMKRKFYSWDE--C-M--NLR------EVKSLKKL--N----HAN--VIKLKEVIR--E-------------------------------------NDHLY--FIFEYMKE---NLYQLMK--------DRNK-----------------LF--PESVIRNIMYQILQGLAFIHKH--GFFHRDMKPENLLCM----GPELV---KIADFGLARE--------------------LRSQPPYTD---YVSTRWYRAPEVLL----RSSVYSSPIDVWAVGSIMAELYM-LRPL---------------FPGT---------SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT------ASQALKHPYF--------------
--WL--KGQQIGLGAFSSCYQAQDV-------GTGT--LMAVKQVTYVRNTSSE--Q-E-EVVEAL--REEIRMMSHL--N----HPN--IIRMLGATC--E-------------------------------------KSNYN--LFIEWMAGG--SVAHLLS---------KYG-----------------AF--KESVVINYTEQLLRGLSYLHEN--QIIHRDVKGANLLID----STGQR--LRIADFGAAARLAS---------------KGTGAGEFQGQ---LLGTIAFMAPEVLR-----GQQYGRSCDVWSVGCAIIEMAC-AKPP---------------WNAE---------KHSNH-LALIFKIASATTAPSIPSHLS-------------------------------------PGLRDVALRCLELQPQDRPP------SRELLKHPVF--------------
-ERV-----VLGKGTYGIVYAGRDL-------SNQV--RIAIKEIPERDSRYSQ--P-L-H--E------EIALHKYL--K----HRN--IVQYLGSVS--E-------------------------------------NGYIK--IFMEQVPGG--SLSALLR--------SKWG-----------------PM--KEPTIKFYTKQILEGLKYLHEN--QIVHRDIKGDNVLVN---TYSGVV---KISDFGTSKRL-------------------AGVNPCTET---FTGTLQYMAPEIID---QGPRGYGAPADIWSLGCTIIEMAT-SKPP---------------FHEL-----------GEP-QAAMFKVGMFKIHPEIPEALS-------------------------------------AEARAFILSCFEPDPHKRAT------TAELLREGF-L-------------
----WRLGKLLGQGAFGRVYLCYDV-------DTGR--ELAVKQVQFDPDSPET--S-K-EVNAL---ECEIQLLKNL--L----HER--IVQYYGCLR--DP-----------------------------------QEKTLS--IFMEYMPGG--SIKDQLK---------AYG-----------------AL--TENVTRKYTRQILEGVHYLHSN--MIVHRDIKGANILRD----STGNV---KLGDFGASKRLQ----------------TICLSGTGMKS---VTGTPYWMSPEVIS-----GEGYGRKADIWSVACTVVEMLT-EKPP---------------WAEF------------EA-MAAIFKIATQPTNPKLPPHVS-------------------------------------DYTRDFLKRIFV-EAKLRPS------ADELLRHMF-V-------------
---W-RRGKLLGQGAFGRVYLCYDV-------DTGR--ELASKQVQFDPDSPET--S-K-EVSAL---ECEIQLLKNL--Q----HER--IVQYYGCLR--DR-----------------------------------AEKTLT--IFMEYMPGG--SVKDQLK---------AYG-----------------AL--TESVTRKYTRQILEGMSYLHSN--MIVHRDIKGANILRD----SAGNV---KLGDFGASKRLQ----------------TICMSGTGMRS---VTGTPYWMSPEVIS-----GEGYGRKADVWSLGCTVVEMLT-EKPP---------------WAEY------------EA-MAAIFKIATQPTNPQLPSHIS-------------------------------------EHGRDFLRRIFV-EARQRPS------AEELLTHHF-A-------------
---W-QRGNKIGEGQYGKVYTCISV-------DTGE--LMAMKEIRFQPNDHKT--I-K-ETAD------ELKIFEGI--K----HPN--LVRYFGVEL--H-------------------------------------REEMY--IFMEYCDEG--TLEEVS-----------RL-----------------GL--QEHVIRLYSKQITIAINVLHEH--GIVHRDIKGANIFLT----SSGLI---KLGDFGCSVKLKN---------------NAQTMPGEVNS---TLGTAAYMAPEVITR--AKGEGHGRAADIWSLGCVVIEMVT-GKRP---------------WHEY----------EHNF-QIMYKVGMGHKPPIPERLS---------------------------------------PEGKDFLSHCLESDPKMRWT------ASQLLDHSFV--------------
-DRV-----VLGKGTYGIVYAGRDL-------SNQV--RIAIKEIPERDSRYSQ--P-L-H--E------EIALHKHL--K----HKN--IVQYLGSFS--E-------------------------------------NGFIK--IFMEQVPGG--SLSALLR--------SKWG-----------------PLKDNEQTIGFYTKQILEGLKYLHDN--QIVHRDIKGDNVLIN---TYSGVL---KISDFGTSKRL-------------------AGINPCTET---FTGTLQYMAPEIID---KGPRGYGKAADIWSLGCTIIEMAT-GKPP---------------FYEL-----------GEP-QAAMFKVGMFKVHPEIPESMS-------------------------------------AEAKAFILKCFEPDPDKRAC------ANDLLVDEF-L-------------
-ERL-----VLGKGTYGVVYAGRDR-------HTRV--RIAIKEIPERDSRFSQ--P-L-H--E------EIALHRRL--R----HKN--IVRYLGSAS--Q-------------------------------------GGYLK--IFMEEVPGG--SLSSLLR--------SVWG-----------------PLKDNESTISFYTRQILQGLGYLHDN--HIVHRDIKGDNVLIN---TFSGLL---KISDFGTSKRL-------------------AGITPCTET---FTGTLQYMAPEIID---QGPRGYGKAADIWSLGCTVIEMAT-GRPP---------------FHEL-----------GSP-QAAMFQVGMYKVHPPMPSSLS-------------------------------------AEAQAFLLRTFEPDPRLRAS------AQTLLGDPFL--------------
----YTNLSYIGEGAYGMVCSAYDN-------VNKV--RVAIKKISPFEHQTYC--Q-R-T-LR------EIKILLRF--R----HEN--IIGINDIIR--APT--------------------------------IEQMKDVY--IVQDLMET---DLYKLLK----------TQ-----------------HL--SNDHICYFLYQILRGLKYIHSA--NVLHRDLKPSNLLLN----TTCDL---KICDFGLARVAD----------------PDHDHTGFLTE---YVATRWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK---------HYLDQ-LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE------VEQALAHPYL--------------
----YQNLKPIGSGAQGIVCAAYDA-------ILER--NVAIKKLSRPFQNQTH--A-K-RAYR------ELVLMKCV--N----HKN--IIGLLNVFT--PQKS-------------------------------LEEFQDVY--IVMELMDA---NLCQVIQ-----------M-----------------EL--DHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK----SDCTL---KILDFGLART--------------------AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR---------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VDEALQHPYI--------------
-KVT---SQVLGLGINGKVLQIFNK-------RTQE--KFALKMLQDCPKAR-----------R------EVELHWRA-SQ----CPH--IVRIVDVYE--NLY---------------------------------AGRKCLL--IVMECLDGG--ELFSRIQD-------RGDQ-----------------AF--TEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENLLYT----SKRPNAILKLTDFGFAKE--------------------TTSHNSLTT---PCYTPYYVAPEVLG-----PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FYSN--------HGLAIS-PGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI--------------
-IEP---DRPIGYGAFGVVWSVTDP-------RDGK--RVALKKMPNVFQNLVS--C-K-RVFR------ELKMLCFF--K----HDN--VLSALDILQ--PPH--------------------------------IDYFEEIY--VVTELMQS---DLHKIIV---------SPQ-----------------PL--SSDHVKVFLYQILRGLKYLHSA--GILHRDIKPGNLLVN----SNCVL---KICDFGLARVE------------------ELDESRHMTQ---EVVTQYYRAPEILM----GSRHYSNAIDIWSVGCIFAELLG-RRIL---------------FQAQ---------SPIQQ-LDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS------AKDALAHPYL--------------
----YTRFEKIGQGASGTVYTAMDV-------ATGQ--EVAIKQMNLQQQPKKE--L-I-I--N------EILVMREN--K----NPN--IVNYLDSYL--V-------------------------------------GDELW--VVMEYLAGG--SLTDVVT----------ET-----------------CM--DEGQIAAVCRECLQALEFLHSN--QVIHRDIKSDNILLG----MDGSV---KLTDFGFCAQI-------------------TPEQSKRST---MVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMIE-GEPP---------------YLNE---------NPLRA-LYLIATNGTPELQNPEKLS---------------------------------------AIFRDFLNRCLEMDVEKRGS------AKELLQHQFL--------------
----YTRYEKIGQGASGTVFTATDV-------ALGQ--EVAIKQINLQKQPKKE--L-I-I--N------EILVMKEL--K----NPN--IVNFLDSYL--V-------------------------------------GDELF--VVMEYLAGG--SLTDVVT----------ET-----------------CM--DEAQIAAVCRECLQALEFLHAN--QVIHRDIKSDNVLLG----MEGSV---KLTDFGFCAQI-------------------TPEQSKRST---MVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVE-GEPP---------------YLNE---------NPLRA-LYLIATNGTPELQNPEKLS---------------------------------------PIFRDFLNRCLEMDVEKRGS------AKELLQHPFL--------------
----YTRFEKIGQGASGTVYTALDI-------ATGQ--EVAIKQMNLQQQPKKE--L-I-I--N------EILVMREN--K----NPN--IVNYLDSYL--V-------------------------------------GDELW--VVMEYLAGG--SLTDVVT----------ET-----------------CM--DEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNILLG----MDGSV---KLTDFGFCAQI-------------------TPEQSKRST---MVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVE-GEPP---------------YLNE---------NPLRA-LYLIATNGTPELQNPERLS---------------------------------------AVFRDFLNRCLEMDVDRRGS------AKELLQHPFL--------------
DSYV-----KIGEGSTGIVCLAREK-------HSGR--QVAVKMMDLRKQQRRE--L----LFN------EVVIMRDY--Q----HFN--VVEMYKSYL--V-------------------------------------GEELW--VLMEFLQGG--ALTDIVS----------QV-----------------RL--NEEQIATVCEAVLQALAYLHAQ--GVIHRDIKSDSILLT----LDGRV---KLSDFGFCAQI-------------------SKDVPKRKS---LVGTPYWMAPEVIS-----RSLYATEVDIWSLGIMVIEMVD-GEPP---------------YFSD---------SPVQA-MKRLRDSPPPKLKNSHKVS---------------------------------------PVLRDFLERMLVRDPQERAT------AQELLDHPFL--------------
---F-KFGKILGEGSFSTVVLAREL-------ATSR--EYAIKILEKRHIIKEN--K-VPYVTR------ERDVMSRL--D----HPF--FVKLYFTFQ--D-------------------------------------DEKLY--FGLSYAKNG--ELLKYIR---------KIG-----------------SF--DETCTRFYTAEIVSALEYLHGK--GIIHRDLKPENILLN----EDMHI---QITDFGTAKVLS-----------------PESKQARANS---FVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG------------NE-YLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF---
----YQVGPLLGSGGFGSVYSGIRV-------SDNL--PVAIKHVEKDRISDWG--E-L-PNGTRV--PMEVVLLKKV--S----SGFSGVIRLLDWFE--R-------------------------------------PDSFV--LILERPEPV-QDLFDFIT---------ERG-----------------AL--QEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENILID---LNRGEL---KLIDFGSGA---------------------LLKDTVYTD---FDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD-------------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM--------------
----YQVGAVLGSGGFGTVYAGSRI-------ADGL--PVAVKHVVKERVTEWG--S-L-GGATV---PLEVVLLRKV--GAAGGARG--VIRLLDWFE--R-------------------------------------PDGFL--LVLERPEPA-QDLFDFIT---------ERG-----------------AL--DEPLARRFFAQVLAAVRHCHSC--GVVHRDIKDENLLVD---LRSGEL---KLIDFGSGA---------------------LLKDTVYTD---FDGTRVYSPPEWIR----YHRYHGRSATVWSLGVLLYDMVC-GDIP---------------FEQD-------------------EEILRGRLLFRRRVS---------------------------------------PECQQLIRWCLSLRPSERPS------LDQIAAHPWM--------------
---F-NFLMVLGKGSFGKVMLSERK-------GTDE--LYAVKILKKDVVIQDD--D-V-ECTM-----VEKRVLALP-GK----PPF--LTQLHSCFQ--T-------------------------------------MDRLY--FVMEYVNGG--DLMYHIQ---------QVG-----------------RF--KEPHAVFYAAEIAIGLFFLQSK--GIIYRDLKLDNVMLD----SEGHI---KIADFGMCKEN-------------------IWDGVTTKT---FCGTPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FEGE------------DE-DELFQSIMEHNVAYPKSMS---------------------------------------KEAVAICKGLMTKHPGKRLG------C---------GPEGERDIKEHAFF
----FEFIRVLGKGSFGKVMLARVK-------ETGD--LYAVKVLKKDVILQDD--D-V-ECTM-----TEKRILSLA-RN----HPF--LTQLFCCFQ--T-------------------------------------PDRLF--FVMEFVNGG--DLMFHIQ---------KSR-----------------RF--DEARARFYAAEIISALMFLHDK--GIIYRDLKLDNVLLD----HEGHC---KLADFGMCKEG-------------------ICNGVTTAT---FCGTPDYIAPEILQ-----EMLYGPAVDWWAMGVLLYEMLC-GHAP---------------FEAE------------NE-DDLFEAILNDEVVYPTWLH---------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPF-F-------------
--PD----EVLGSGQFGIVYGGKHR-------KTGR--DVAIKIIDKLRFPTKQ--E-S-QLRN------EVAILQNL--H----HPG--VVNLECMFE--T-------------------------------------PERVF--VVMEKLHGD--MLEMILS--------SEKG-----------------RL--PEHITKFLITQILVALRHLHFK--NIVHCDLKPENVLLA----SADPFPQVKLCDFGFARI--------------------IGEKSFRRS---VVGTPAYLAPEVLR-----NKGYNRSLDMWSVGVIIYVSLS-GTFP---------------FNED---------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS------VDKTLSHPWL--------------
--PD----EVLGSGQFGVVYGGKHR-------KTGR--DVAVKVIDKLRFPTKQ--E-S-QLRN------EVAILQSL--R----HPG--IVNLECMFE--T-------------------------------------PEKVF--VVMEKLHGD--MLEMILS--------SEKG-----------------RL--PERLTKFLITQILVALRHLHFK--NIVHCDLKPENVLLA----SADPFPQVKLCDFGFARI--------------------IGEKSFRRS---VVGTPAYLAPEVLL-----NQGYNRSLDMWSVGVIMYVSLS-GTFP---------------FNED---------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYS------VDKSLSHPWL--------------
-FAD----EVLGSGQFGIVYGGKHR-------KTGR--DVAIKVIDKMRFPTKQ--E-S-QLRN------EVAILQNL--H----HPG--IVNLECMFE--T-------------------------------------PERVF--VVMEKLHGD--MLEMILS--------SEKS-----------------RL--PERITKFMVTQILVALRNLHFK--NIVHCDLKPENVLLA----SAEPFPQVKLCDFGFARI--------------------IGEKSFRRS---VVGTPAYLAPEVLR-----SKGYNRSLDMWSVGVIIYVSLS-GTFP---------------FNED---------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYS------VDKSLSHPWL--------------
----YELVRELGKGTYGKVDLVVYK-------GTGT--KMALKFVNKSKTKLKN--F-----LR------EVSITNSL-SS----SPF--IIKVFDVVF--E------------------------------------TEDCYV--FAQEYAPAG--DLFDIIP---------PQV-----------------GL--PEDTVKRCVQQLGLALDFMHGR--QLVHRDIKPENVLLFD--RECRRV---KLADFGMTR----------------------RVGCRVKR---VSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLT-GNFP---------------WEAA---------SGADAFFEEFVRWQRGRLPGLPSQWRRFT-----------------------------------EPALRMFQRLLALEPERRGP------AKEVF-----RFLKH---------
-LCP---GRELGRGKFAVVRKCIKK-------DSGK--EFAAKFMRKRRKGQDC--R-M-EIIH------EIAVLELA-QD----NPW--VINLHEVYE--T-------------------------------------ASEMI--LVLEYAAGG--EIFDQCVA-------DREE-----------------AF--KEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT----SESPLGDIKIVDFGLSRI--------------------LKNSEELRE---IMGTPEYVAPEILS-----YDPISMATDMWSIGVLTYVMLT-GISP---------------FLGN------------DK-QETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVDFIRTLLVKKPEDRAT------AEECLKHPWL--------------
-ILT---SKELGRGKFAVVRQCISK-------STGQ--EYAAKFLKKRRRGQDC--R-A-EILH------EIAVLELA-KS----CPR--VINLHEVYE--N-------------------------------------TSEII--LILEYAAGG--EIFSLCLP-------ELAE-----------------MV--SENDVIRLIKQILEGVYYLHQN--NIVHLDLKPQNILLS----SIYPLGDIKIVDFGMSRK--------------------IGHACELRE---IMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLT-HTSP---------------FVGE------------DN-QETYLNISQVNVDYSEETFSSVS-----------------------------------QLATDFIQSLLVKNPEKRPT------AEICLSHSWL--------------
----FTKLEKIGKGSFGEVFKGIDN-------RTQK--VVAIKIIDLEEAEDEI--E-D-IQ-Q------EITVLSQC--D----SPY--VTKYYGSYL--K-------------------------------------DTKLW--IIMEYLGGG--SALDLLE----------PG-----------------PL--DETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLS----EHGEV---KLADFGVAGQL-------------------TDTQIKRNT---FVGTPFWMAPEVIK-----QSAYDSKADIWSLGITAIELAR-GEPP---------------HSEL---------HPMKV-LFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI--------------
----YSLLAEIGRGSYGVVYEAVAG-------RSGA--RVAVKKIRCDAPENVE--L----ALA------EFWALTSLKRR----HQN--VVQFEECVL--QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW--FVMEFCEGG--DLNQYVL----------SR-----------------RP--DPATNKSFMLQLTSAIAFLHKN--HIVHRDLKPDNILIT----ERSGTPILKVADFGLSKVCAGLAPRGK--EGNQDNKNVNVNKYWLSS---ACGSDFYMAPEVWE------GHYTAKADIFALGIIIWAMIE-RITF---------------IDSE---------TKKEL-LGTYIKQGTEIVPVGEALLENPKMELHIPQ---------------------KRRTSMSEGIKQLLKDMLAANPQDRPD------AFEL------ETRM----------
--YL--LLHLLGRGGFSEVYKAFDL-------TEQR--YVAVKIHQLNKNWRDE--K-K-ENYHKH-ACREYRIHKEL--D----HPR--IVKLYDYFS--L------------------------------------DTDSFC--TVLEYCEGN--DLDFYLK---------QHK-----------------LM--SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV----NGTACGEIKITDFGLSKIMDDD------------SYNSVDGMELTSQ---GAGTYWYLPPECFVV-GKEPPKISNKVDVWSVGVIFYQCLY-GRKP---------------FGHN----------QSQQ-DILQENTILKATEVQFPPKPVVT-----------------------------------PEAKAFIRRCLAYRKEDRID------VQQLACDPYL--------------
---L-AFIKEIGSGQFGVVHLGEWR--------SHI--QVAIKAIN-EGSM-SE--E-D-FI-E------EAKVMMKL--S----HSK--LVQLYGVCI--Q-------------------------------------RKPLY--IVTEFMENG--CLLNYLR----------EN---------------KGKL--RKEMLLSVCQDICEGMEYLERN--GYIHRDLAARNCLVS----STCIV---KISDFGMTRYV-------------------L--DDEYVSSFGAKFPIKWSPPEVFL-----FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENK---------SNLQV-VEAISEGFRLYRPHLAP-----------------------------------------MSIYEVMYSCWHEKPEGRPT------FAELLR---AV-------------
----WTKGEILGKGAYGTVYCGLTS-------QGQ---LIAVKQVALDTSNKLA--A-E-KEYRKL--QEEVDLLKAL--K----HVN--IVAYLGTCL--Q-------------------------------------ENTVS--IFMEFVPGG--SISSIIN---------RFG-----------------PL--PEMVFCKYTKQILQGVAYLHEN--CVVHRDIKGNNVMLM----PTGII---KLIDFGCARRLAWA-------------GLNGTHSDMLKS---MHGTPYWMAPEVIN-----ESGYGRKSDIWSIGCTVFEMAT-GKPP---------------LASM-----------DRM-AAMFYIGAHRGLMPPLPDHFS-------------------------------------ENAADFVRMCLTRDQHERPS------ALQLLKHSFL--------------
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