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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL TGFBR1 203
TK ABL1 261
TK ABL2 288
TKL ACVR1B 207
TK LCK 245
TKL RAF1 349
TKL TGFBR2 269
IV--LQESIGKGRFGEVWRGKWRGEE------VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGT-QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK--TL
--ITMKHKLGGGQYGEVYEGVWKKYSL----TVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCTR----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK---------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQAF--
--ITMKHKLGGGQYGEVYVGVWKKYSL----TVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCTL----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK---------NFIHRDLAARNCLVGENHVVKVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYDLLEKGYR----MEQPEGCP------PKVYELMRACWKWSPADRPSFAETHQAF--
IV--LQEIIGKGRFGEVWRGRWRGGD------VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTIEGMIKLALSAASGLAHLHMEIVGT-QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDA-VTDTIDIAPNQ---RVGTKRYMAPEVLDETINMKHFD---SFKCADIYALGLVYWEIAR-RCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKL----RPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKK--TL
--LKLVERLGAGQFGEVWMGYYN-GHT----KVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT-----QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER---------NYIHRDLRAANILVSDTLSCKIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSVL--
VM--LSTRIGSGSFGTVYKGKWH---G----DVAVKILK-VVDPT-PEQFQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMDYLHAK---------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK--S--R--WSGSQQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LPYSHI-N---NRDQIIFMVGRGYASPDLSKLYKNCP------KAMKRLVADCVKKVKEERPLFPQILSSI--
-I-ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYE-EYASWK--TEK--DIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH---VISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDP-TLSVDDLANSG---QVGTARYMAPEVLESRMNLENVE---SFKQTDVYSMALVLWEMTS-RCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRG----RPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE--RF
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