Protein Surface  Ribbon
Inhibitor 580
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 2 kinases in KIF 1RW8A_580 (TGFBR1, PDB code: 1RW8, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
TKL        TGFBR1       203 
TKL        BRAF         456 



IV--LQESIGKGRFGEVWRGKWRGEE--VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY--TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK-TL
--ITVGQRIGSGSFGTVYKGKWH---GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST-----KPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK--S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMTGQ----------LPYSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILASI-