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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL TGFBR1 203
TK ABL1 261
TK ABL2 288
TK BMX 422
TK FYN 271
TK LCK 245
TK SRC 270
IV--LQESIGKGRFGEVWRGKWRGEE--VAVKIFSSREERSWFREA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK---TL
--ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EVEEFLKEAAVMKEIKHPNLVQLLGVCTR----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYELLEKDYRMERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F--
--ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK-EDTM-EVEEFLKEAAVMKEIKHPNLVQLLGVCTL----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHVVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYDLLEKGYRMEQPEGCP------PKVYELMRACWKWSPADRPSFAETHQA-F--
--ITLLKELGSGQFGVVQLGKWK-GQYDVAVKMIK-EGSM-SEDEFFQEAQTMMKLSHPKLVKFYGVCSK----EYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDRDLCVKVSDFGMTRYV----L--DDQYVSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QPYDLY-----DNSQVVLKVSQGHRLYRPHLAS------DTIYQIMYSCWHELPEKRPTFQQLLSS-I--
--LQLIKRLGNGQFGEVWMGTWN-GNTKVAIKTLK-PGTM-SPESFLEEAQIMKKLKHDKLVQLYAVVS-----EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR----------VPYPGM-----NNREVLEQVERGYRMPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL---
--LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFLAEANLMKQLQHQRLVRLYAVVT-----QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----TNPEVIQNLERGYRMVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L--
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFLQEAQVMKKLRHEKLVQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VPYPGM-----VNREVLDQVERGYRMPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L--
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