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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other TTK 203
CAMK CAMK1G 23
CMGC CDK2 4
CMGC CDK5 4
CAMK DAPK3 13
CAMK PHKG2 24
AGC RPS6KA2 59
CAMK STK33 116
---YSILKQIGSGGSSKVFQVLNEKKQ----IYAIKYVNLEEADNQTLDSYRN------EIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNI-DLNSWLK--KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV----DGML---------KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV
-FI--FMEVLGSGAFSEVFLVKQRLTGK---LFALKCIKKSPAFRDSSLE--N------EIAVLKKI-K-HENIVTLEDIYESTTHYYLVMQLVSGGELFDRIL--ERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKI---------MITDFGLSK----MEQNGIMSTACGTPGYVAPEVLA-----------QKPYSKAVDCWSIGVITYILLC-GYPPFYEE---TESKLFEKIKEGYYEFESPFWDDIS----------------------ESAKDFICHLLEKDPNERYT-----CEKALSHPWI
---FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIR------EISLLKEL-N-HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN---TEGAI---------KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
---YEKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALR------EICLLKEL-K-HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN---RNGEL---------KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF
---YEMGEELGSGQFAIVRKCRQKGTGK---EYAAKFIKKRRLSSSRRGVSREEI--EREVNILREI-R-HPNIITLHDIFENKTDVVLILELVSGGELFDFLA--EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL---DKNVPNP-----RIKLIDFGIAHK---IEAGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS----------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI
YDP---KDVIGRGVSSVVRRCVHRATGH---EFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAG-HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT--EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD---DNMQI---------RLSDFGFSCH---LEPGEKLRELCGTPGYLAPEILKCS-----MDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHR---RQILMLRMIMEGQYQFSSPEWDDRS----------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF
---FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM------ERDILAEV-N-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD---EEGHI---------KITDFGLSKEA--IDHDKRAYSFCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS--------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
---YTFGRILGKGSFGIVIEATDKETET---KWAIKKVNKEKAGSSAVKLLER------EVNILKSV-K-HEHIIHLEQVFETPKKMYLVMELCEDGELKEILD--RKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK---SSLIDDNNEINLNIKVTDFGLAVKK-QSRSEAMLQATCGTPIYMAPEVIS-----------AHDYSQQCDIWSIGVVMYMLLR-GEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS----------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL
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