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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TYK2 203
TK ALK 1116
TK FER 563
TK FYN 271
TK HCK 241
TK LTK 510
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK RET 724
TK ROS1 1945
TK TNK2 150
-L-KKIRDLGEGHFGKVSLYCYDP--TNDGTGEMVAVKALKA--DCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDN-----DRLVKIGDFGLAKAVPEGHEYY--------------RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL-ERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP--IL
-I-TLIRGLGHGAFGEVYEGQVSG-MPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIISKFNHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLRETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP--GPGRVAKIGDFGMARDI-YRASYY--------------RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP--------------YPSKSNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I-
VI--LGELLGKGNFGEVYKGTLK-------DKTSVAVKTCKE--DLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT--QRQPVYIIMELVSGGDFLTFLRRK-----------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE-----NNVLKISDFGMSRQE--DGGVY--------------SSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCP--------------YPGMTNQQAREQV-ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL--
--LQLIKRLGNGQFGEVWMGTWN-------GNTKVAIKTLKP--GTMSP--ESFLEEAQIMKKLKHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKDG----------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN-----GLICKIADFGLARLI--EDNEY--------------TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP--------------YPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL--
--LKLEKKLGAGQFGEVWMATYN-------KHTKVAVKTMKP--GSMSV--EAFLAEANVMKTLQHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLKSD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-----SLVCKIADFGLARVI--EDNEY--------------TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP--------------YPGMSNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSV-L-
-V-TLLRALGHGAFGEVYEGLVIG-LPGDSSPLQVAIKTLPE--LCSPQDELDFLMEALIISKFRHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLRHSRP-----------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCA--GPSRVAKIGDFGMARDI-YRASYY--------------RRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP--------------YPGRTNQEVLDFV-VGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL--
IV--LKWELGEGAFGKVFLAECHN-LLPEQDKMLVAVKALKE--ASESA-RQDFQREAELLTMLQHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLRSHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ-----GLVVKIGDFGMSRDI-YSTDYY--------------RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP--------------WYQLSNTEAIDCI-TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL--
-I-VLKRELGEGAFGKVFLAECYN-LCPEQDKILVAVKTLKD--ASDNA-RKDFHREAELLTNLQHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLRAHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE-----NLLVKIGDFGMSRDV-YSTDYY--------------RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP--------------WYQLSNNEVIECI-TQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
-I-VLKRELGEGAFGKVFLAECYN-LSPTKDKMLVAVKALKD--PTLAA-RKDFQREAELLTNLQHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-----NLLVKIGDFGMSRDV-YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP--------------WFQLSNTEVIECI-TQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
-L-VLGKTLGEGEFGKVVKATAFH-LKGRAGYTTVAVKMLKE--NASPSELRDLLSEFNVLKQVNHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-----GRKMKISDFGLSRDV-YEEDSY--------------VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP--------------YPGIPPERLFNLL-KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL--
LT--LRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK--GSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARM-----------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-YKNDYY--------------RKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQP--------------YPAHSNLDVLNYV-QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL--
-L-RLLEKLGDGSFGVVRRGEWD---APSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLRKH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT-----RDLVKIGDFGLMRALPQNDDHY--------------VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEP--------------WIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF-L-
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