Kinase profiling results of kinases in KIF 2X39A_X39 (AKT2, PDB code: 2X39, chain A)
Template Kinase: AKT2
Template inhibitor: 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

 6 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
AKT3AGC
ROCK1AGC
ROCK2AGC
JAK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
AKT1AGC
AKT2AGC
AKT3AGC
ROCK1AGC
ROCK2AGC
JAK3TK