Kinase profiling results of kinases in KIF 1PXLA_CK4 (CDK2, PDB code: 1PXL, chain A)
Template Kinase: CDK2
Template inhibitor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE

 11 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
ROCK1AGC
CDK2CMGC
CDK4CMGC
CDK7CMGC
CDK9CMGC
AURKAOther
AURKBOther
PLK1Other
SRCTK
ZAP70TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
ROCK1AGC 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK4CMGC 
CDK7CMGC 
CDK9CMGC 
AURKAOther 
AURKBOther 
PLK1Other 
SRCTK 
ZAP70TK