Kinase profiling results of kinases in KIF 3BHUA_MHR (CDK2, PDB code: 3BHU, chain A)
Template Kinase: CDK2
Template inhibitor: Benzo[c][2,7]naphthyridine, 12

 11 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
ROCK2AGC
PDPK1AGC
CDK2CMGC
CDK4CMGC
CDK5CMGC
GSK3BCMGC
MAPK14CMGC
CHUKOther
ABL1TK
SRCTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
ROCK2AGC
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK4CMGC
CDK5CMGC
GSK3BCMGC
MAPK14CMGC
CHUKOther
ABL1TK
SRCTK