Kinase profiling results of kinases in KIF 3EZRA_EZR (CDK2, PDB code: 3EZR, chain A)
Template Kinase: CDK2
Template inhibitor: indazole-benzimidazole, 17

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AKT1AGC 
AKT2AGC 
RPS6KB1AGC 
RPS6KA1AGC 
RPS6KA1CAMK 
CHEK1CAMK 
CDK2CMGC 
CDK4CMGC 
GSK3BCMGC 
MAPK14CMGC 
AURKAOther 
PLK1Other 
ABL1TK 
TNK2TK 
FGFR1TK 
JAK1TK 
JAK2TK 
JAK3TK 
METTK 
FYNTK 
SRCTK 
YES1TK 
BLKTK 
HCKTK 
LCKTK 
LYNTK 
ZAP70TK 
IRAK4TKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
AKT1AGC  
AKT2AGC  
PRKCAAGC  
PRKCBAGC  
PRKCBAGC  
RPS6KA1AGC  
RPS6KB1AGC  
CHEK1CAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK4CMGC  
GSK3BCMGC  
MAPK14CMGC  
AURKAOther  
PLK1Other  
ABL1TK  
BLKTK  
FGFR1TK  
FYNTK  
HCKTK  
JAK1TK  
JAK2TK  
JAK3TK  
LCKTK  
LYNTK  
METTK  
SRCTK  
TNK2TK  
YES1TK  
ZAP70TK  
IRAK4TKL