Kinase profiling results of kinases in KIF 2PY3A_ABG (FGFR2, PDB code: 2PY3, chain A)
Template Kinase: FGFR2
Template inhibitor: adenosine tetraphosphate

 28 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
STK11CAMK
CDK2CMGC
AURKAOther
NEK2Other
PLK1Other
PLK4Other
STK24STE
ABL1TK
TNK2TK
ALKTK
MERTKTK
EGFRTK
ERBB3TK
EPHA3TK
PTK2TK
FGFR1TK
FGFR2TK
IGF1RTK
INSRTK
METTK
KITTK
RETTK
SRCTK
HCKTK
LCKTK
ZAP70TK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
STK11CAMK
CDK2CMGC
AURKAOther
NEK2Other
PLK1Other
STK24STE
ABL1TK
ALKTK
EGFRTK
EPHA3TK
FGFR1TK
FGFR2TK
HCKTK
IGF1RTK
INSRTK
KITTK
LCKTK
MERTKTK
METTK
PTK2TK
RETTK
SRCTK
TNK2TK
ZAP70TK
IRAK4TKL