Kinase profiling results of kinases in KIF 3D94A_D94 (IGF1R, PDB code: 3D94, chain A)
Template Kinase: IGF1R
Template inhibitor: 3-[3-(4-Methyl-piperazin-1-yl)-cyclobutyl]-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-8-ylamine

7 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
ALKTK
IGF1RTK
METTK
RETTK
ITKTK
TEKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
CDC2CMGC     
CDC2CMGC     
ALKTK     
IGF1RTK     
ITKTK     
METTK     
RETTK     
TEKTK