Kinase profiling results of kinases in KIF 2Z8CA_S91 (INSR, PDB code: 2Z8C, chain A)
Template Kinase: INSR
Template inhibitor: 2-[4-acetamidylphenylamino]-4-[2-benzoylphenylamino]-5-nitropyrimidine hydrochloride

18 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
PLK1Other    
EGFRTK    
ERBB2TK    
PTK2TK    
PTK2BTK    
FGFR1TK    
FGFR3TK    
INSRTK    
JAK2TK    
CSF1RTK    
PDGFRBTK    
SRCTK    
LCKTK    
SYKTK    
ZAP70TK    
ITKTK    
KDRTK    
BRAFTKL    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PLK1Other     
CSF1RTK     
EGFRTK     
ERBB2TK     
FGFR1TK     
FGFR3TK     
INSRTK     
ITKTK     
JAK2TK     
KDRTK     
LCKTK     
PDGFRBTK     
PTK2TK     
PTK2BTK     
SRCTK     
SYKTK     
ZAP70TK     
BRAFTKL