Kinase profiling results of kinases in KIF 3EKKA_GS2 (INSR, PDB code: 3EKK, chain A)
Template Kinase: INSR
Template inhibitor: pyrrolo[2,3-d]pyrimidine deriv., 40

 33 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C C C
RPS6KA1AGC          
RPS6KA1CAMK          
RPS6KA2AGC          
RPS6KA2CAMK          
RPS6KA3AGC          
PLK1Other          
YSK4STE          
TNK1TK          
ALKTK          
LTKTK          
AXLTK          
MERTKTK          
EGFRTK          
ERBB2TK          
ERBB4TK          
PTK2TK          
PTK2BTK          
FERTK          
FESTK          
IGF1RTK          
INSRTK          
INSRRTK          
JAK2TK          
JAK3TK          
CSF1RTK          
KITTK          
ROS1TK          
FYNTK          
SRCTK          
HCKTK          
LCKTK          
ZAP70TK          
TEKTK          
FLT4TK          
MAP3K7TKL          

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
RPS6KA1AGC   
RPS6KA2AGC   
RPS6KA3AGC   
PLK1Other   
ALKTK   
AXLTK   
CSF1RTK   
EGFRTK   
ERBB2TK   
ERBB4TK   
FERTK   
FESTK   
FLT4TK   
FYNTK   
HCKTK   
IGF1RTK   
INSRTK   
INSRRTK   
JAK2TK   
JAK3TK   
KITTK   
LCKTK   
LTKTK   
MERTKTK   
PTK2TK   
PTK2BTK   
ROS1TK   
SRCTK   
TEKTK   
ZAP70TK   
MAP3K7TKL