Kinase profiling results of kinases in KIF 3KB7A_071 (PLK1, PDB code: 3KB7, chain A)
Template Kinase: PLK1
Template inhibitor: MLN_518

 39 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
DMPKAGC       
GRK7AGC       
PDPK1AGC       
CAMK2BCAMK       
CAMK2DCAMK       
CAMK2GCAMK       
HUNKCAMK       
MGC421053       
DAPK1CAMK       
DAPK2CAMK       
DAPK3CAMK       
MAPKAPK23       
PHKG2CAMK       
PRKD1CAMK       
PRKD2CAMK       
PRKD3CAMK       
CHEK2CAMK       
CDK2CMGC       
CDK5CMGC       
MAPK14CMGC       
AURKAOther       
AURKBOther       
CAMKK1Other       
CAMKK2Other       
NEK3Other       
NEK2Other       
EIF2AK2Other       
PLK1Other       
PLK2Other       
PLK3Other       
SLKSTE       
STK10STE       
TNK1TK       
PTK2TK       
FGFR1TK       
FGFR3TK       
INSRTK       
HCKTK       
IRAK4TKL       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
DMPKAGC     
GRK7AGC     
PDPK1AGC     
CAMK2BCAMK     
CAMK2DCAMK     
CAMK2GCAMK     
CHEK2CAMK     
DAPK1CAMK     
DAPK2CAMK     
DAPK3CAMK     
MAPKAPK2CAMK     
PHKG2CAMK     
PRKD1CAMK     
PRKD2CAMK     
PRKD3CAMK     
CDK2CMGC     
CDK5CMGC     
MAPK14CMGC     
AURKAOther     
AURKBOther     
CAMKK1Other     
CAMKK2Other     
NEK2Other     
NEK3Other     
PLK1Other     
PLK2Other     
PLK3Other     
SLKSTE     
STK10STE     
FGFR1TK     
FGFR3TK     
HCKTK     
INSRTK     
PTK2TK     
IRAK4TKL