Kinase profiling results of kinases in KIF 2WGJA_VGH (MET, PDB code: 2WGJ, chain A)
Template Kinase: MET
Template inhibitor: Crizotinib

21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
ALKTK   
LTKTK   
DDR1TK   
EGFRTK   
FERTK   
FESTK   
INSRTK   
JAK1TK   
JAK2TK   
JAK3TK   
METTK   
MUSKTK   
CSF1RTK   
RETTK   
ROS1TK   
NTRK2TK   
NTRK3TK   
TNNI3KTKL   
MAP3K7TKL   
RIPK2TKL   
RIPK4TKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
ALKTK  
CSF1RTK  
EGFRTK  
FERTK  
FESTK  
INSRTK  
JAK1TK  
JAK2TK  
JAK3TK  
LTKTK  
METTK  
MUSKTK  
NTRK2TK  
NTRK3TK  
RETTK  
ROS1TK  
MAP3K7TKL  
RIPK2TKL