Kinase profiling results of kinases in KIF 2ZYBA_KSL (LCK, PDB code: 2ZYB, chain A)
Template Kinase: LCK
Template inhibitor: DB08056

 36 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
NUAK1CAMK 
DAPK1CAMK 
CDK2CMGC 
MAPK14CMGC 
AURKAOther 
CHUKOther 
EIF2AK2Other 
ABL1TK 
ABL2TK 
TNK2TK 
EGFRTK 
FGFR1TK 
INSRTK 
INSRRTK 
JAK2TK 
CSF1RTK 
KITTK 
PDGFRBTK 
RETTK 
ROS1TK 
FYNTK 
SRCTK 
YES1TK 
LCKTK 
SYKTK 
BMXTK 
BTKTK 
ITKTK 
TXKTK 
NTRK1TK 
NTRK2TK 
NTRK3TK 
IRAK4TKL 
RAF1TKL 
TGFBR1TKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
DAPK1CAMK   
NUAK1CAMK   
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
MAPK14CMGC   
AURKAOther   
CHUKOther   
ABL1TK   
ABL2TK   
BMXTK   
BTKTK   
CSF1RTK   
EGFRTK   
FGFR1TK   
FYNTK   
INSRTK   
INSRRTK   
ITKTK   
JAK2TK   
KITTK   
LCKTK   
NTRK1TK   
NTRK2TK   
NTRK3TK   
PDGFRBTK   
RETTK   
ROS1TK   
SRCTK   
SYKTK   
TNK2TK   
TXKTK   
YES1TK   
IRAK4TKL   
RAF1TKL   
TGFBR1TKL