Kinase profiling results of kinases in KIF 3EKNA_GS3 (INSR, PDB code: 3EKN, chain A)
Template Kinase: INSR
Template inhibitor: pyrrolo[2,3-d]pyrimidine deriv., 1

 90 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C C C C C C C C C C
RPS6KA1AGC                 
RPS6KA1CAMK                 
RPS6KA2AGC                 
RPS6KA2CAMK                 
RPS6KA3AGC                 
PLK1Other                 
STK36Other                 
ULK1Other                 
ULK2Other                 
MAP3K15STE                 
MAP3K6STE                 
YSK4STE                 
STK3STE                 
STK4STE                 
PAK4STE                 
SLKSTE                 
STK24STE                 
ABL1TK                 
TNK1TK                 
TNK2TK                 
ALKTK                 
LTKTK                 
AXLTK                 
MERTKTK                 
TYRO3TK                 
CSKTK                 
MATKTK                 
DDR1TK                 
DDR2TK                 
EGFRTK                 
ERBB2TK                 
ERBB4TK                 
EPHA1TK                 
EPHA3TK                 
EPHB1TK                 
EPHB2TK                 
EPHB3TK                 
EPHB4TK                 
EPHB6TK                 
PTK2TK                 
PTK2BTK                 
FERTK                 
FESTK                 
FGFR1TK                 
FGFR2TK                 
FGFR3TK                 
FGFR4TK                 
IGF1RTK                 
INSRTK                 
INSRRTK                 
JAK1TK                 
JAK2TK                 
JAK3TK                 
TYK2TK                 
METTK                 
MST1RTK                 
MUSKTK                 
CSF1RTK                 
KITTK                 
PDGFRATK                 
PDGFRBTK                 
RETTK                 
ROS1TK                 
FGRTK                 
FYNTK                 
SRCTK                 
YES1TK                 
BLKTK                 
HCKTK                 
LCKTK                 
PTK6TK                 
SRMSTK                 
SYKTK                 
ZAP70TK                 
BMXTK                 
BTKTK                 
ITKTK                 
TECTK                 
TXKTK                 
TEKTK                 
TIE1TK                 
NTRK1TK                 
NTRK2TK                 
FLT4TK                 
KDRTK                 
IRAK4TKL                 
LIMK1TKL                 
LIMK2TKL                 
TNNI3KTKL                 
MAP3K7TKL                 
RIPK2TKL                 
RIPK4TKL                 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
RPS6KA1AGC       
RPS6KA2AGC       
RPS6KA3AGC       
PLK1Other       
ULK1Other       
ULK2Other       
PAK4STE       
SLKSTE       
STK24STE       
STK3STE       
STK4STE       
ABL1TK       
ALKTK       
AXLTK       
BLKTK       
BMXTK       
BTKTK       
CSF1RTK       
CSKTK       
DDR2TK       
EGFRTK       
EPHA1TK       
EPHA3TK       
EPHB1TK       
EPHB2TK       
EPHB3TK       
EPHB4TK       
ERBB2TK       
ERBB4TK       
FERTK       
FESTK       
FGFR1TK       
FGFR2TK       
FGFR3TK       
FGFR4TK       
FGRTK       
FLT4TK       
FYNTK       
HCKTK       
IGF1RTK       
INSRTK       
INSRRTK       
ITKTK       
JAK1TK       
JAK2TK       
JAK3TK       
KDRTK       
KITTK       
LCKTK       
LTKTK       
MATKTK       
MERTKTK       
METTK       
MST1RTK       
MUSKTK       
NTRK1TK       
NTRK2TK       
PDGFRATK       
PDGFRBTK       
PTK2TK       
PTK2BTK       
PTK6TK       
RETTK       
ROS1TK       
SRCTK       
SRMSTK       
SYKTK       
TECTK       
TEKTK       
TNK2TK       
TXKTK       
TYK2TK       
TYRO3TK       
YES1TK       
ZAP70TK       
IRAK4TKL       
LIMK1TKL       
MAP3K7TKL       
RIPK2TKL