KIDFamMap

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Kinase profiling results of kinases in KIF 3IKAA_0UN (EGFR, PDB code: 3IKA, chain A)
Template Kinase: EGFR Template inhibitor: 2jkk	76 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C	C	C	C	C	C	C	C	C
PDPK1	AGC
RPS6KA1	AGC
RPS6KA1	CAMK
RPS6KA3	AGC
AURKA	Other
NEK5	Other
OXSR1	STE
STK3	STE
PAK1	STE
PAK2	STE
PAK3	STE
SLK	STE
MAP2K5	STE
ABL1	TK
ABL2	TK
TNK1	TK
TNK2	TK
ALK	TK
LTK	TK
CSK	TK
DDR1	TK
DDR2	TK
EGFR	TK
ERBB4	TK
EPHA1	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHA6	TK
EPHA8	TK
EPHB1	TK
EPHB2	TK
EPHB4	TK
EPHB6	TK
PTK2B	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
IGF1R	TK
INSR	TK
INSRR	TK
JAK2	TK
JAK3	TK
MUSK	TK
CSF1R	TK
KIT	TK
PDGFRA	TK
PDGFRB	TK
RET	TK
ROS1	TK
FRK	TK
FGR	TK
FYN	TK
SRC	TK
YES1	TK
BLK	TK
HCK	TK
LCK	TK
LYN	TK
PTK6	TK
SRMS	TK
SYK	TK
ZAP70	TK
BMX	TK
BTK	TK
ITK	TK
TEC	TK
TXK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
LIMK1	TKL
LIMK2	TKL
BRAF	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C
PDPK1	AGC
RPS6KA1	AGC
RPS6KA3	AGC
AURKA	Other
OXSR1	STE
PAK1	STE
PAK2	STE
PAK3	STE
SLK	STE
STK3	STE
ABL1	TK
ABL2	TK
ALK	TK
BLK	TK
BMX	TK
BTK	TK
CSF1R	TK
CSK	TK
DDR2	TK
EGFR	TK
EPHA1	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHA6	TK
EPHA8	TK
EPHB1	TK
EPHB2	TK
EPHB4	TK
ERBB4	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
FGR	TK
FRK	TK
FYN	TK
HCK	TK
IGF1R	TK
INSR	TK
INSRR	TK
ITK	TK
JAK2	TK
JAK3	TK
KIT	TK
LCK	TK
LTK	TK
LYN	TK
MUSK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
PDGFRA	TK
PDGFRB	TK
PTK2B	TK
PTK6	TK
RET	TK
ROS1	TK
SRC	TK
SRMS	TK
SYK	TK
TEC	TK
TNK2	TK
TXK	TK
YES1	TK
ZAP70	TK
BRAF	TKL
LIMK1	TKL