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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 LCK related diseases
H00093
Combined immunodeficiencies (CIDs)
OMIM
(153390)
SCID due to LCK deficiency
Summary of query kinase
Query kinase
LCK (
P06239
)
Kinase group
TK
Number of conformation types
3
Number of structural templates
32 (
Total 1329 inhibitors
)
Number of LCK related diseases
2 (
H00093
OMIM:153390
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
27
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
3BYMA_AM0
(LCK)
TK
triazine 34
I
39
145
100
39
145
100
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
3B2WA_9NH
(LCK)
TK
MLS000911569
II
30
32
98
30
32
98
A
1QPEA_PP2
(LCK)
TK
AG 1879
I
29
63
51
29
63
51
A
3KMMA_LHL
(LCK)
TK
AZD_1152HQPA
I
29
99
95
29
99
95
A
3BYOA_AM9
(LCK)
TK
AC1NS8OV
I
28
144
90
28
144
90
A
1QPCA_ANP
(LCK)
TK
Phosphoamino...
I
26
13
75
26
13
75
A
2ZM4A_KSM
(LCK)
TK
BMS-279700
I
25
179
75
25
179
75
A
3ACKA_KSR
(LCK)
TK
AC1O6YMO
I
23
42
56
23
42
56
A
2ZM1A_KSF
(LCK)
TK
DB08055
I
17
153
56
17
153
56
A
2OF4A_979
(LCK)
TK
DB07297
I
14
33
45
14
33
45
A
3AD6A_KSC
(LCK)
TK
Erlotinib
I
13
120
36
13
120
36
A
3ACJA_KSS
(LCK)
TK
6,7-dimethox...
I
13
7
25
13
7
25
A
3AC3A_KSH
(LCK)
TK
imidazo[1,2-...
I
13
105
37
13
105
37
A
3AC8A_KSK
(LCK)
TK
Staurosporine
I
12
96
29
12
96
29
A
3AC2A_KSE
(LCK)
TK
Staurosporine
I
12
96
29
12
96
29
A
3KXZA_925
(LCK)
TK
2e9n
I
12
18
45
12
18
45
A
3AC5A_KZM
(LCK)
TK
Erlotinib
I
11
120
27
11
120
27
A
3AC1A_KZI
(LCK)
TK
Staurosporine
I
11
80
32
11
80
32
A
3AC4A_KZL
(LCK)
TK
imidazo[1,2-...
I
7
86
21
7
86
21
A
2OF2A_547
(LCK)
TK
DB07146
I
7
18
19
7
18
19
A
3MPMA_5LK
(LCK)
TK
GW_2580
I
4
8
11
4
8
11
A
3AD4A_KBM
(LCK)
TK
DNC013259
I
2
8
16
2
8
16
A
3AD5A_5PB
(LCK)
TK
AC1Q24NC
I
1
1
2
1
1
2
E
4
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
E
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
35
190
69
E
2OFVA_242
(LCK)
TK
2ofv
II
28
181
65
28
181
65
E
3BYSA_AM5
(LCK)
TK
Aminopyrimid...
II
20
220
65
20
220
65
E
3BYUA_AM6
(LCK)
TK
Aminopyrimid...
II
19
186
61
19
186
61
F
1
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
F
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
12
142
33