Allelic Variants
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There are no related allelic variants
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| Number of involved diseases in the family |
75 |
| Number of LCK related diseases |
2 |
All kinase in this family
LCK
Allelic
Variants |
Disease Description |
Involved kinases
(This family) |
Inhibitor of
Involved Kinases |
Search
Disease |
| Prostate cancer | CDK2, EGFR, FGFR1, FGFR2,
IGF1R | 5 | Link | | Melanoma | EGFR, FGFR1, IGF1R | 2 | Link | | n/a | Measles | CDK2, EIF2AK2, IRAK4 | 2 | Link | | Lung cancer | ALK, CDK2, EGFR | 3 | Link | | n/a | Epithelial cell signaling in Helicobacter pylori infection | EGFR, SRC | 4 | Link | | Leukemia | ABL1, KIT | 2 | Link | | n/a | Hepatitis C | EGFR, EIF2AK2 | 1 | Link | | Gastric cancer | EGFR, FGFR2 | 3 | Link | | Pfeiffer syndrome | FGFR1, FGFR2 | 3 | Link | | Jackson-Weiss syndrome | FGFR1, FGFR2 | 3 | Link | | n/a | Influenza A | EIF2AK2, IRAK4 | 1 | Link | | n/a | Tuberculosis | IRAK4, SRC | 4 | Link | | n/a | Shigellosis | ABL1, SRC | 6 | Link | | n/a | Herpes simplex infection | CDK2, EIF2AK2 | 2 | Link | | Colon cancer | AURKA, SRC | 6 | Link | | n/a | Immunodeficiencies | LCK, ZAP70 | 1 | Link | | n/a | Epstein-Barr virus infection | CDK2, EIF2AK2 | 2 | Link | | n/a | Bladder cancer | DAPK1, EGFR | 2 | Link | | n/a | Pathogenic Escherichia coli infection | ABL1 | 2 | Link | | Osteoglophonic dysplasia | FGFR1 | 1 | Link | | Hypogonadotropic hypogonadism | FGFR1 | 1 | Link | | Beare-Stevenson cutis gyrata syndrome | FGFR2 | 2 | Link | | Trigonocephaly | FGFR1 | 1 | Link | | Apert syndrome | FGFR2 | 2 | Link | | Kallmann syndrome | FGFR1 | 1 | Link | | n/a | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis | FGFR2 | 2 | Link | | n/a | Lethal congenital contractural syndrome | ERBB3 | 1 | Link | | Cataract | EPHA2 | 1 | Link | | n/a | Type I diabetes mellitus | ERBB3 | 1 | Link | | n/a | Choriocarcinoma | EGFR | 1 | Link | | n/a | Esophageal cancer | EGFR | 1 | Link | | n/a | Oral cancer | EGFR | 1 | Link | | n/a | Cervical cancer | EGFR | 1 | Link | | n/a | Glioma | EGFR | 1 | Link | | n/a | Viral myocarditis | ABL1 | 2 | Link | | Adenocarcinoma of lung | EGFR | 1 | Link | | Neuroblastoma | ALK | 1 | Link | | n/a | Laryngeal cancer | EGFR | 1 | Link | | Craniofacial-skeletal-dermatologic dysplasia | FGFR2 | 2 | Link | | Bent bone dysplasia syndrome | FGFR2 | 2 | Link | | SCID | LCK | 1 | Link | | n/a | Thyroid cancer | RET | 1 | Link | | Mastocytosis with associated hematologic disorder | KIT | 1 | Link | | Mast cell leukemia | KIT | 1 | Link | | Piebaldism | KIT | 1 | Link | | Gastrointestinal stromal tumor | KIT | 1 | Link | | n/a | Germ cell tumors | KIT | 1 | Link | | n/a | Renal agenesis and Renal adysplasia | RET | 1 | Link | | Hirschsprung disease | RET | 1 | Link | | Renal agenesis | RET | 1 | Link | | Selective T-cell defect | ZAP70 | 1 | Link | | Pheochromocytoma | RET | 1 | Link | | Multiple endocrine neoplasia | RET | 1 | Link | | n/a | Congenital central hypoventilation syndrome | RET | 1 | Link | | Central hypoventilation syndrome | RET | 1 | Link | | n/a | Medullary thyroid carcinoma | RET | 1 | Link | | IRAK4 deficiency | IRAK4 | 1 | Link | | n/a | Invasive pneumococcal disease | IRAK4 | 1 | Link | | n/a | Scaphocephaly and Axenfeld-Rieger anomaly | FGFR2 | 2 | Link | | n/a | Malignant pleural mesothelioma | IGF1R | 2 | Link | | Scaphocephaly | FGFR2 | 2 | Link | | n/a | Saethre-Chotzen syndrome | FGFR2 | 2 | Link | | Craniosynostosis | FGFR2 | 2 | Link | | Crouzon syndrome | FGFR2 | 2 | Link | | LADD syndrome | FGFR2 | 2 | Link | | n/a | Synovial sarcoma | IGF1R | 2 | Link | | Insulin-like growth factor I | IGF1R | 2 | Link | | n/a | Leishmaniasis | IRAK4 | 1 | Link | | n/a | Chagas disease | IRAK4 | 1 | Link | | n/a | Toxoplasmosis | IRAK4 | 1 | Link | | n/a | Pertussis | IRAK4 | 1 | Link | | Hyperinsulinemic hypoglycemia | INSR | 3 | Link | | n/a | Leprechaunism | INSR | 3 | Link | | Rabson-Mendenhall syndrome | INSR | 3 | Link | | Diabetes mellitus | INSR | 3 | Link |
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